Research Output

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., 2017 May 15, In : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., 2014 Apr 28, In : Cancer Letters. 346, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer

Tang, Y. A., Wen, W. L., Chang, J. W., Wei, T. T., Tan, Y. H. C., Salunke, S., Chen, C. T., Chen, C. S. & Wang, Y. C., 2010, In : PloS one. 5, 9, p. 1-13 13 p., e12417.

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)

A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways

Chen, J. Y., Tang, Y. A., Huang, S. M., Juan, H. F., Wu, L. W., Sun, Y. C., Wang, S. C., Wu, K. W., Balraj, G., Chang, T. T., Li, W. S., Cheng, H. C. & Wang, Y. C., 2011 Jan 15, In : Cancer Research. 71, 2, p. 473-483 11 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

A Synthetic Podophyllotoxin Derivative Exerts Anti-Cancer Effects by Inducing Mitotic Arrest and Pro-Apoptotic ER Stress in Lung Cancer Preclinical Models

Chen, J. Y., Tang, Y. A., Li, W. S., Chiou, Y. C., Shieh, J. M. & Wang, Y. C., 2013 Apr 30, In : PloS one. 8, 4, e62082.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Deregulation of SLIT2-mediated Cdc42 activity is associated with esophageal cancer metastasis and poor prognosis

Tseng, R. C., Chang, J. M., Chen, J. H., Huang, W. R., Tang, Y. A., Kuo, I. Y., Yan, J. J., Lai, W. W. & Wang, Y. C., 2015 Jan 1, In : Journal of Thoracic Oncology. 10, 1, p. 189-198 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer

Yang, Y. C., Tang, Y. A., Shieh, J. M., Lin, R. K., Hsu, H. S. & Wang, Y. C., 2014 Sep, In : Journal of Thoracic Oncology. 9, 9, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer

Lin, R. K., Wu, C. Y., Chang, J. W., Juan, L. J., Hsu, H. S., Chen, C. Y., Lu, Y. Y., Tang, Y. A., Yang, Y. C., Yang, P. C. & Wang, Y. C., 2010 Jul 15, In : Cancer Research. 70, 14, p. 5807-5817 11 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer

Tang, Y. A., Chen, C. H., Sun, H. S., Cheng, C. P., Tseng, V. S., Hsu, H. S., Su, W. C., Lai, W. W. & Wang, Y. C., 2015, In : Nucleic acids research. 43, 3, p. 1593-1608 16 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer

Tang, Y. A., Chen, Y. F., Bao, Y., Mahara, S., Yatim, S. M. J. M., Oguz, G., Lee, P. L., Feng, M., Cai, Y., Tan, E. Y., Fong, S. S., Yang, Z. H., Lan, P., Wu, X. J. & Yu, Q., 2018 Jun 26, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. E5990-E5999

Research output: Contribution to journalArticle

Open Access
42 Citations (Scopus)

Lack of association of C-Met-N375S sequence variant with lung cancer susceptibility and prognosis

Shieh, J. M., Tang, Y. A., Yang, T. H., Chen, C. Y., Hsu, H. S., Tan, Y. H. C., Salgia, R. & Wang, Y. C., 2013, In : International Journal of Medical Sciences. 10, 8, p. 988-994 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer

Tang, Y. A., Lin, R. K., Tsai, Y. T., Hsu, H. S., Yang, Y. C., Chen, C. Y. & Wang, Y. C., 2012 Aug 15, In : Clinical Cancer Research. 18, 16, p. 4325-4333 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models

Shieh, J. M., Wei, T. T., Tang, Y. A., Huang, S. M., Wen, W. L., Chen, M. Y., Cheng, H. C., Salunke, S. B., Chen, C. S., Lin, P., Chen, C. T. & Wang, Y. C., 2012 Jan 18, In : PloS one. 7, 1, e30240.

Research output: Contribution to journalArticle

17 Citations (Scopus)
79 Citations (Scopus)

Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer

Jen, J., Lin, L. L., Chen, H. T., Liao, S. Y., Lo, F. Y., Tang, Y. A., Su, W. C., Salgia, R., Hsu, C. L., Huang, H. C., Juan, H. F. & Wang, Y. C., 2016 May 5, In : Oncogene. 35, 18, p. 2357-2369 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37

Tzeng, H. T., Li, T. H., Tang, Y. A., Tsai, C. H., Lu, P. J. F., Lai, W. W., Chiang, C. W. & Wang, Y. C., 2017, In : Oncotarget. 8, 65, p. 108556-108570 15 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Promoter hypermethylation is the predominant mechanism in hMLH1 and hMSH2 deregulation and is a poor prognostic factor in nonsmoking lung cancer

Hsu, H. S., Wen, C. K., Tang, Y. A., Lin, R. K., Li, W. Y., Hsu, W. H. & Wang, Y. C., 2005 Aug 1, In : Clinical Cancer Research. 11, 15, p. 5410-5416 7 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Role of extracellular signal-regulated kinase (ERK) signaling in nucleotide excision repair and genotoxicity in response to As(III) and Pb(II)

Li, J. P., Wang, C. Y., Tang, Y. A., Lin, Y. W. & Yang, J. L., 2008 Dec 24, In : Pure and Applied Chemistry. 80, 12, p. 2735-2750 16 p.

Research output: Contribution to journalArticle

Open Access

The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients

Lin, R. K., Hsieh, Y. S., Lin, P., Hsu, H. S., Chen, C. Y., Tang, Y. A., Lee, C. F. & Wang, Y. C., 2010 Feb 1, In : Journal of Clinical Investigation. 120, 2, p. 521-532 12 p.

Research output: Contribution to journalArticle

147 Citations (Scopus)