Center of Infectious Disease and Signaling Research

Research Output 1989 2019

Article
5 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J-Y. & Liou, J. P., 2019 Jan 15, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
67 Citations (Scopus)

2,2′-Diphenyl-1-picrylhydrazyl radical-scavenging active components from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) hulls

Kuo, C. C., Chiang, W., Liu, G. P., Chien, Y. L., Chang, J-Y., Lee, C. K., Lo, J. M., Huang, S. L., Shih, M. C. & Kuo, Y. H., 2002 Oct 9, In : Journal of Agricultural and Food Chemistry. 50, 21, p. 5850-5855 6 p.

Research output: Contribution to journalArticle

Coix
Coix lacryma-jobi
1-Butanol
Scavenging
butanol
12 Citations (Scopus)

2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors

Chuang, H. Y., Chang, J-Y., Lai, M. J., Kuo, C. C., Lee, H. Y., Hsieh, H. P., Chen, Y. J., Chen, L. T., Pan, W. Y. & Liou, J. P., 2011 Mar 7, In : ChemMedChem. 6, 3, p. 450-456 7 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Inhibitory Concentration 50
Cells
Lead compounds
Colchicine
42 Citations (Scopus)

2-Amino and 2′-aminocombretastatin derivatives as potent antimitotic agents

Chang, J. Y., Yang, M. F., Chang, C. Y., Chen, C. M., Kuo, C. C. & Liou, J. P., 2006 Oct 1, In : Journal of Medicinal Chemistry. 49, 21, p. 6412-6415 4 p.

Research output: Contribution to journalArticle

Antimitotic Agents
Inhibitory Concentration 50
Tubulin Modulators
Colchicine
Structure-Activity Relationship
6 Citations (Scopus)

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J-Y., Liou, J. P. & Lee, H. Y., 2016 Jan 1, In : Organic and Biomolecular Chemistry. 14, 2, p. 716-723 8 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Dione
Tubulin
Antineoplastic Agents
Inhibitory Concentration 50
57 Citations (Scopus)

4- And 5-aroylindoles as novel classes of potent antitubulin agents

Liou, J. P., Wu, C. Y., Hsieh, H. P., Chang, C. Y., Chen, C. M., Kuo, C. C. & Chang, J. Y., 2007 Sep 6, In : Journal of Medicinal Chemistry. 50, 18, p. 4548-4552 5 p.

Research output: Contribution to journalArticle

Inhibitory Concentration 50
Tubulin Modulators
Colchicine
Tubulin
Polymerization
63 Citations (Scopus)

5-Amino-2-Aroylquinolines as highly potent tubulin polymerization inhibitors

Nien, C. Y., Chen, Y. C., Kuo, C. C., Hsieh, H. P., Chang, C. Y., Wu, J. S., Wu, S. Y., Liou, J. P. & Chang, J-Y., 2010 Mar 11, In : Journal of Medicinal Chemistry. 53, 5, p. 2309-2313 5 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Inhibitory Concentration 50
Cell Line
Colchicine
Tubulin
42 Citations (Scopus)

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., 2011 Dec 22, In : Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Sulfones
Sulfides
HT29 Cells
Tubulin
61 Citations (Scopus)

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Chang, J. Y., Hsieh, H. P., Chang, C. Y., Hsu, K. S., Chiang, Y. F., Chen, C. M., Kuo, C. C. & Liou, J. P., 2006 Nov 16, In : Journal of Medicinal Chemistry. 49, 23, p. 6656-6659 4 p.

Research output: Contribution to journalArticle

Sulfonamides
Tubulin Modulators
KB Cells
Colchicine
Microtubules
8 Citations (Scopus)

A comprehensive analysis on the association between tobacco-free betel quid and risk of head and neck cancer in Taiwanese men

Wu, Y. H., Yen, C. J., Hsiao, J. R., Ou, C. Y., Huang, J. S., Wong, T. Y., Tsai, S. T., Huang, C. C., Lee, W. T., Chen, K. C., Fang, S. Y., Wu, J. L., Hsueh, W. T., Lin, F. C., Yang, M. W., Chang, J. Y., Liao, H. C., Wu, S. Y., Lin, C. L., Wang, Y. H. & 4 others, Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2016 Oct, In : PloS one. 11, 10, 0164937.

Research output: Contribution to journalArticle

betel
Tobacco
Head and Neck Neoplasms
Mastication
tobacco
2 Citations (Scopus)

Acquired hemophilia A: Report of two cases

Chen, Y. C., Chang, J. Y., Hsueh, E. J., Wan, H. L. & Chao, T. Y., 1998 Sep 1, In : Chinese Medical Journal (Taipei). 61, 9, p. 538-544 7 p.

Research output: Contribution to journalArticle

Hemorrhage
Factor VIII
Cyclophosphamide
Uterus
Episiotomy
11 Citations (Scopus)

Activation of PPAR-α induces cell cycle arrest and inhibits transforming growth factor-β1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells

Lien, S. C., Wei, S. Y., Chang, S. F., Chang, M. D. T., Chang, J. Y. & Chiu, J. J., 2013 May 1, In : Cellular Signalling. 25, 5, p. 1252-1263 12 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Transforming Growth Factors
Cell Cycle Checkpoints
Smooth Muscle Myocytes
Phenotype
14 Citations (Scopus)

Allergies and Risk of Head and Neck Cancer: An Original Study plus Meta-Analysis

Hsiao, J. R., Ou, C. Y., Lo, H. I., Huang, C. C., Lee, W. T., Huang, J. S., Chen, K. C., Wong, T. Y., Tsai, S. T., Yen, C. J., Wu, Y. H., Hsueh, W. T., Yang, M. W., Wu, S. Y., Chang, J. Y., Chang, K. Y., Lin, C. L., Wang, F. T., Wang, Y. H., Weng, Y. L. & 2 others, Yang, H. C. & Chang, J. S., 2013 Feb 1, In : PloS one. 8, 2, e55138.

Research output: Contribution to journalArticle

Allergies
Head and Neck Neoplasms
meta-analysis
hypersensitivity
Meta-Analysis
2 Citations (Scopus)

Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer

Liao, H. C., Wu, S-Y., Ou, C-Y., Hsiao, J-R., Huang, J-S., Tsai, S-T., Huang, C-C., Wang, D-Y., Lee, W-T., Chen, K-C., Fang, S-Y., Wu, J-L., Huang, T-T., Wu, Y-H., Hsueh, W-T., Yen, C-J., Yang, M-W., Lin, F-C., Lai, Y-H., Chang, J-Y. & 6 others, Lin, C. L., Wang, Y. H., Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2016 Sep 1, In : Cancer Causes and Control. 27, 9, p. 1105-1115 11 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Immunoglobulin E
Hypersensitivity
Serum
Odds Ratio

Allogeneic bone marrow transplantation for fourteen patients with severe aplastic anemia

Hsueh, E. J., Hwang, W. S., Huang, S. H., Chao, T. Y., Chang, J-Y. & Wang, C. C., 1996 Apr 1, In : Chinese Medical Journal (Taipei). 57, 4, p. 247-253 7 p.

Research output: Contribution to journalArticle

Aplastic Anemia
Homologous Transplantation
Bone Marrow Transplantation
Graft vs Host Disease
Transplants
1 Citation (Scopus)
Cell Polarity
Cell Movement
Tubulin
Pseudopodia
Acetylation
17 Citations (Scopus)

A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells

Juang, S. H., Pan, W. Y., Kuo, C. C., Liou, J. P., Hung, Y. M., Chen, L. T., Hsieh, H. P. & Chang, J-Y., 2004 Jul 15, In : Biochemical Pharmacology. 68, 2, p. 293-303 11 p.

Research output: Contribution to journalArticle

Caspases
Squamous Cell Carcinoma
Up-Regulation
Chemical activation
Cells
58 Citations (Scopus)
Sulfonamides
Human Activities
Microtubules
Phosphorylation
Multidrug Resistance-Associated Proteins
6 Citations (Scopus)

A novel peroxisome proliferator-activated receptor α/γ agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells

Kao, Y. H., Hsieh, H. P., Chitlimalla, S. K., Pan, W. Y., Kuo, C. C., Tsai, Y. C., Lin, W. H., Chuang, S. E. & Chang, J. Y., 2008 Feb 1, In : Anti-Cancer Drugs. 19, 2, p. 151-158 8 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Peroxisome Proliferator-Activated Receptors
Human Activities
KB Cells
Neoplasms
15 Citations (Scopus)

A Novel Synthetic Microtubule Inhibitor, MPT0B214 Exhibits Antitumor Activity in Human Tumor Cells through Mitochondria-Dependent Intrinsic Pathway

Chiang, N. J., Lin, C. I., Liou, J. P., Kuo, C. C., Chang, C. Y., Chen, L. T. & Chang, J. Y., 2013 Mar 12, In : PloS one. 8, 3, e58953.

Research output: Contribution to journalArticle

Mitochondria
tubulin
Human Activities
Microtubules
microtubules
32 Citations (Scopus)

Antimutagenic constituents of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with potential cancer chemopreventive activity

Chen, H. H., Chiang, W., Chang, J. Y., Chien, Y. L., Lee, C. K., Liu, K. J., Cheng, Y. T., Chen, T. F., Kuo, Y. H. & Kuo, C. C., 2011 Jun 22, In : Journal of Agricultural and Food Chemistry. 59, 12, p. 6444-6452 9 p.

Research output: Contribution to journalArticle

Coix
Coix lacryma-jobi
antimutagenic activity
hulls
neoplasms
11 Citations (Scopus)

Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91

Yeh, T. K., Li, C. M., Chen, C. P., Chuu, J. J., Huang, C. L., Wang, H. S., Shen, C. C., Lee, T. Y., Chang, C. Y., Chang, C. M., Chao, Y. S., Lin, C. T., Chang, J. Y. & Chen, C. T., 2010 Feb 1, In : Pharmacological Research. 61, 2, p. 108-115 8 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Camptothecin
Lactones
Topoisomerase I Inhibitors
Neoplasms
106 Citations (Scopus)

Antitumor Agents. 111.† New 4-Hydroxylated and 4-Halogenated Anilino Derivatives of 4'-Demethylepipodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II

Lee, K. H., Beers, S. A., Mori, M., Wang, Z. Q., Kuo, Y. H., Li, L., Liu, S. Y., Chang, J-Y., Han, F. S. & Cheng, Y. C., 1990 Jan 1, In : Journal of Medicinal Chemistry. 33, 5, p. 1364-1368 5 p.

Research output: Contribution to journalArticle

Topoisomerase II Inhibitors
Type II DNA Topoisomerase
Antineoplastic Agents
Etoposide
Podophyllotoxin
120 Citations (Scopus)

Antitumor Agents. 113. New 4β-Arylamino Derivatives of 4-O-Demethylepipodophyllotoxin and Related Compounds as Potent Inhibitors of Human DNA Topoisomerase II

Wang, Z. Q., Kuo, Y. H., Schnur, D., Bowen, J. P., Liu, S. Y., Han, F. S., Chang, J. Y., Cheng, Y. C. & Lee, K. H., 1990 Jan 1, In : Journal of Medicinal Chemistry. 33, 9, p. 2660-2666 7 p.

Research output: Contribution to journalArticle

Topoisomerase II Inhibitors
Type II DNA Topoisomerase
Etoposide
Antineoplastic Agents
Sulfur Compounds
66 Citations (Scopus)

Antitumor Agents. 120. New 4-Substituted Benzylamine and Benzyl Ether Derivatives of 4′-O-Demethylepipodophyollotoxin as Potent Inhibitors of Human DNA Topoisomerase II

Zhou, X. M., Wang, Z. Q., Lee, K. H., Chang, J-Y., Chen, H. X. & Cheng, Y. C., 1991 Dec 1, In : Journal of Medicinal Chemistry. 34, 12, p. 3346-3350 5 p.

Research output: Contribution to journalArticle

Topoisomerase II Inhibitors
Type II DNA Topoisomerase
Antineoplastic Agents
Ether
Oxygen Compounds
13 Citations (Scopus)
Topoisomerase II Inhibitors
Type II DNA Topoisomerase
Antineoplastic Agents
Derivatives
DNA
30 Citations (Scopus)

Antitumor AHMA linked to DNA minor groove binding agents: Synthesis and biological evaluation

Rastogi, K., Chang, J. Y., Pan, W. Y., Chen, C. H., Chou, T. C., Chen, L. T. & Su, T. L., 2002 Sep 26, In : Journal of Medicinal Chemistry. 45, 20, p. 4485-4493 9 p.

Research output: Contribution to journalArticle

Netropsin
DNA
Type II DNA Topoisomerase
Solubility
Cell Line
4 Citations (Scopus)

A phase i clinical study of immunotherapy for advanced colorectal cancers using carcinoembryonic antigen-pulsed dendritic cells mixed with tetanus toxoid and subsequent IL-2 treatment John T Kung

Liu, K. J., Chao, T. Y., Chang, J. Y., Cheng, A. L., Ch'Ang, H. J., Kao, W. Y., Wu, Y. C., Yu, W. L., Chung, T. R. & Whang-Peng, J., 2016 Aug 24, In : Journal of biomedical science. 23, 1, 64.

Research output: Contribution to journalArticle

Tetanus Toxoid
Carcinoembryonic Antigen
Immunotherapy
Dendritic Cells
Interleukin-2
17 Citations (Scopus)

A phase I study of weekly docetaxel, 24-hour infusion of high-dose fluorouracil/leucovorin and cisplatin in patients with advanced gastric cancer

Chen, L. T., Liu, T. W., Wu, C. W., Chung, T. R., Shiah, H. S., Jan, C. M., Ming Liu, J., Whang-Peng, J. & Chang, J-Y., 2002 Dec 1, In : Oncology. 63, 3, p. 239-247 9 p.

Research output: Contribution to journalArticle

docetaxel
Leucovorin
Fluorouracil
Cisplatin
Stomach Neoplasms
4 Citations (Scopus)

Application of Suzuki arylation, Sonogashira ethynylation and Rosenmund-von Braun cyanation in the exploration of substitution effects on the anticancer activity of 2-aroylquinolines

Lee, H. Y., Lee, L. W., Nien, C. Y., Kuo, C. C., Lin, P. Y., Chang, C. Y., Chang, J. Y. & Liou, J. P., 2012 Jan 1, In : Organic and Biomolecular Chemistry. 10, 48, p. 9593-9600 8 p.

Research output: Contribution to journalArticle

colchicine
Colchicine
Tubulin
Substitution reactions
substitutes
20 Citations (Scopus)

Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: Implication for carcinogenesis

Wang, Y. C., Tsai, Y. S., Huang, J. L., Lee, K. W., Kuo, C. C., Wang, C. S., Huang, A. M., Chang, J. Y., Jong, Y. J. & Lin, C. S., 2010 Apr 1, In : Oral Oncology. 46, 4, p. 255-262 8 p.

Research output: Contribution to journalArticle

Arecoline
Prometaphase
M Phase Cell Cycle Checkpoints
Spindle Apparatus
Carcinogenesis
14 Citations (Scopus)

Arginine deprivation as a new treatment strategy for head and neck cancer

Huang, C-C., Tsai, S-T., Kuo, C. C., Chang, J. S., Jin, Y. T., Chang, J-Y. & Hsiao, J-R., 2012 Dec 1, In : Oral Oncology. 48, 12, p. 1227-1235 9 p.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Head and Neck Neoplasms
Arginine
Squamous Cell Carcinoma
Therapeutics
36 Citations (Scopus)
cathepsin S
Xanthine Oxidase
Autophagy
Cell death
DNA Damage
8 Citations (Scopus)

BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities

Hu, C. B., Chen, C. P., Yeh, T. K., Song, J. S., Chang, C. Y., Chuu, J. J., Tung, F. F., Ho, P. Y., Chen, T. W., Lin, C. H., Wang, M. H., Chang, K. Y., Huang, C. L., Lin, H. L., Li, W. T., Hwang, D. R., Chern, J. H., Hwang, L. L., Chang, J. Y., Chao, Y. S. & 1 others, Chen, C. T., 2011 Jan 1, In : Cancer Science. 102, 1, p. 182-191 10 p.

Research output: Contribution to journalArticle

Antimitotic Agents
Antineoplastic Agents
Neoplasms
Tubulin
Nude Mice
181 Citations (Scopus)

BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo

Kuo, C. C., Hsieh, H. P., Pan, W. Y., Chen, C. P., Liou, J. P., Lee, S. J., Chang, Y. L., Chen, L. T., Chen, C. T. & Chang, J. Y., 2004 Jul 1, In : Cancer Research. 64, 13, p. 4621-4628 8 p.

Research output: Contribution to journalArticle

Antimitotic Agents
Human Activities
KB Cells
Neoplasms
Colchicine
13 Citations (Scopus)

BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Cheung, C. H. A., Lin, W. H., HsuJohn, J. T. A., Hour, T. C., Yeh, T. K., Ko, S., Lien, T. W., Coumar, M. S., Liu, J. F., Lai, W. Y., Shiao, H. Y., Lee, T. R., Hsieh, H. P. & Chang, J. Y., 2011 Aug 24, In : PloS one. 6, 8, e23485.

Research output: Contribution to journalArticle

Aurora Kinases
phosphotransferases (kinases)
Cells
neoplasms
Neoplasms
14 Citations (Scopus)

C 35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines

Hsieh, C. L., Tseng, M. H., Shao, Y. Y., Chang, J-Y., Kuo, C. C., Chang, C. Y. & Kuo, Y. H., 2006 Nov 1, In : Journal of Natural Products. 69, 11, p. 1611-1613 3 p.

Research output: Contribution to journalArticle

Cupressaceae
Terpenes
Human Activities
Cells
KB Cells
33 Citations (Scopus)

Caffeic acid phenethyl ester suppresses proliferation and survival of TW2.6 human oral cancer cells via inhibition of akt signaling

Kuo, Y. Y., Lin, H. P., Huo, C., Su, L. C., Yang, J., Hsiao, P. H., Chiang, H. C., Chung, C. J., Wang, H. D., Chang, J. Y., Chen, Y. W. & Chuu, C. P., 2013 May, In : International journal of molecular sciences. 14, 5, p. 8801-8817 17 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
esters
Esters
cancer
Cells
51 Citations (Scopus)

Camptothecin resistance involving steps subsequent to the formation of protein-linked DNA breaks in human camptothecin-resistant KB cell lines

Beidler, D. R., Chang, J-Y., Zhou, B. S. & Cheng, Y. C., 1996 Jan 15, In : Cancer Research. 56, 2, p. 345-353 9 p.

Research output: Contribution to journalArticle

KB Cells
Camptothecin
DNA Breaks
Cell Line
Proteins
26 Citations (Scopus)

Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes

Cheung, C-H., Wu, S. Y., Lee, T. R., Chang, C. Y., Wu, J. S., Hsieh, H. P. & Chang, J-Y., 2010 Nov 1, In : PloS one. 5, 9, p. 1-11 11 p., e12564.

Research output: Contribution to journalArticle

drug resistance
Tubulin
tubulin
Drug Resistance
Microtubules
8 Citations (Scopus)
cathepsin S
Protein-Tyrosine Kinases
Endosomes
Epidermal Growth Factor
STAT3 Transcription Factor
24 Citations (Scopus)

Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells

Hsieh, C. C., Kuo, Y. H., Kuo, C. C., Chen, L. T., Cheung, C-H., Chao, T. Y., Lin, C. H., Pan, W. Y., Chang, C. Y., Chien, S. C., Chen, T. W., Lung, C. C. & Chang, J-Y., 2010 May 1, In : Biochemical Pharmacology. 79, 9, p. 1261-1271 11 p.

Research output: Contribution to journalArticle

Caspase 8
Skeleton
Microtubules
Cells
Neoplasms
25 Citations (Scopus)

Changes in DNA methylation are associated with the development of drug resistance in cervical cancer cells

Chen, C. C., Lee, K. D., Pai, M. Y., Chu, P. Y., Hsu, C. C., Chiu, C. C., Chen, L. T., Chang, J-Y., Hsiao, S. H. & Leu, Y. W., 2015 Oct 13, In : Cancer Cell International. 15, 1, 98.

Research output: Contribution to journalArticle

DNA Methylation
Drug Resistance
Uterine Cervical Neoplasms
Methylation
oxaliplatin
76 Citations (Scopus)

Characterization of camptothecin-resistant chinese hamster lung cells

Chang, J. Y., Dethlefsen, L. A., Barley, L. R., Zhou, B. S. & Cheng, Y. C., 1992 Jun 9, In : Biochemical Pharmacology. 43, 11, p. 2443-2452 10 p.

Research output: Contribution to journalArticle

Camptothecin
Cricetulus
Type I DNA Topoisomerase
Lung
Etoposide
30 Citations (Scopus)

Cholestane-3β, 5α, 6β-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells

Lin, C. Y., Huo, C., Kuo, L. K., Hiipakka, R. A., Jones, R. B., Lin, H. P., Hung, Y., Su, L. C., Tseng, J. C., Kuo, Y. Y., Wang, Y. L., Fukui, Y., Kao, Y. H., Kokontis, J. M., Yeh, C. C., Chen, L., Yang, S. D., Fu, H. H., Chen, Y. W., Tsai, K. K. C. & 2 others, Chang, J. Y. & Chuu, C. P., 2013 Jun 13, In : PloS one. 8, 6, e65734.

Research output: Contribution to journalArticle

prostatic neoplasms
Prostatic Neoplasms
Cells
cadherins
cells
3 Citations (Scopus)

Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways

Su, W-P., Ho, Y. C., Wu, C. K., Hsu, S. H., Shiu, J. L., Huang, J. C., Chang, S-B., Chiu, W-T., Hung, J-J., Liu, T., Wu, W-S., Wu, P. Y., Su, W-C., Chang, J-Y. & Liaw, H-J., 2017 Dec 1, In : Scientific reports. 7, 1, 3879.

Research output: Contribution to journalArticle

Fanconi Anemia
Recombinational DNA Repair
Cisplatin
Fanconi Anemia Complementation Group D2 Protein
Genes
4 Citations (Scopus)

Combination chemoimmunotherapy with interferon-alpha and cisplatin in patients with advanced non-small cell lung cancer

Chao, T. Y., Hwang, W. S., Yang, M. J., Chang, J. Y., Wang, C. C., Hseuh, E. J., Huang, S. H. & Chen, W. C., 1995 Jan 1, In : Chinese Medical Journal (Taipei). 56, 4, p. 232-238 7 p.

Research output: Contribution to journalArticle

Interferon-alpha
Non-Small Cell Lung Carcinoma
Cisplatin
Squamous Cell Carcinoma
Adenocarcinoma
13 Citations (Scopus)

Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors

Kuo, C. C., Wu, T., Chen, L. T., Shiah, H. S., Wu, C. M., Cheng, Y. T., Pan, W. Y., Liu, J. F., Chen, K. L., Yang, Y. N., Chen, S. N. & Chang, J. Y., 2011 Dec 15, In : Free Radical Biology and Medicine. 51, 12, p. 2195-2209 15 p.

Research output: Contribution to journalArticle

Carmustine
Autophagy
Cell death
Oxidation-Reduction
Tumors
32 Citations (Scopus)

Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil

Chen, C. C., Chen, L. T., Tsou, T. C., Pan, W. Y., Kuo, C. C., Liu, J. F., Yeh, S. C., Tsai, F. Y., Hsieh, H. P. & Chang, J-Y., 2007 Jul 31, In : British Journal of Cancer. 97, 3, p. 334-344 11 p.

Research output: Contribution to journalArticle

oxaliplatin
Fluorouracil
Stomach Neoplasms
Cell Line
Thymidylate Synthase
18 Citations (Scopus)

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

Lee, H. Y., Chang, J. Y., Chang, L. Y., Lai, W. Y., Lai, M. J., Shih, K. H., Kuo, C. C., Chang, C. Y. & Liou, J. P., 2011 May 7, In : Organic and Biomolecular Chemistry. 9, 9, p. 3154-3157 4 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Antimitotic Agents
disrupting
Stilbenes
stilbene