Center of Infectious Disease and Signaling Research

Research Output 1989 2019

2015
18 Citations (Scopus)

Novel Nrf2/ARE Activator, trans-Coniferylaldehyde, Induces a HO-1-Mediated Defense Mechanism through a Dual p38α/MAPKAPK-2 and PK-N3 Signaling Pathway

Chen, H. H., Wang, T. C., Lee, Y. C., Shen, P. T., Chang, J-Y., Yeh, T. K., Huang, C. H., Chang, H. H., Cheng, S. Y., Lin, C. Y., Shih, C., Chen, C. T., Liu, W. M., Chen, C. H. & Kuo, C. C., 2015 Aug 14, In : Chemical Research in Toxicology. 28, 9, p. 1681-1692 12 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Antioxidants
Edible Plants
Oxidative stress
p38 Mitogen-Activated Protein Kinases
11 Citations (Scopus)

Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model

Chang, K. M., Chen, H. H., Wang, T. C., Chen, I. L., Chen, Y. T., Yang, S. C., Chen, Y. L., Chang, H. H., Huang, C. H., Chang, J-Y., Shih, C., Kuo, C. C. & Tzeng, C. C., 2015 Dec 1, In : European Journal of Medicinal Chemistry. 106, p. 60-74 15 p.

Research output: Contribution to journalArticle

Bearings (structural)
Coumarins
Oximes
Antioxidants
Luciferases
11 Citations (Scopus)

O6-methylguanine DNA methyltransferase repairs platinum-DNA adducts following cisplatin treatment and predicts prognoses of nasopharyngeal carcinoma

Chen, S. H., Kuo, C. C., Li, C. F., Cheung, C. H. A., Tsou, T. C., Chiang, H. C., Yang, Y. N., Chang, S. L., Lin, L. C., Pan, H. Y., Chang, K. Y. & Chang, J. Y., 2015 Sep 1, In : International Journal of Cancer. 137, 6, p. 1291-1305 15 p.

Research output: Contribution to journalArticle

Methyltransferases
Platinum
DNA Repair
DNA
Protein Methyltransferases
2013
11 Citations (Scopus)

Activation of PPAR-α induces cell cycle arrest and inhibits transforming growth factor-β1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells

Lien, S. C., Wei, S. Y., Chang, S. F., Chang, M. D. T., Chang, J. Y. & Chiu, J. J., 2013 May 1, In : Cellular Signalling. 25, 5, p. 1252-1263 12 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Transforming Growth Factors
Cell Cycle Checkpoints
Smooth Muscle Myocytes
Phenotype
14 Citations (Scopus)

Allergies and Risk of Head and Neck Cancer: An Original Study plus Meta-Analysis

Hsiao, J. R., Ou, C. Y., Lo, H. I., Huang, C. C., Lee, W. T., Huang, J. S., Chen, K. C., Wong, T. Y., Tsai, S. T., Yen, C. J., Wu, Y. H., Hsueh, W. T., Yang, M. W., Wu, S. Y., Chang, J. Y., Chang, K. Y., Lin, C. L., Wang, F. T., Wang, Y. H., Weng, Y. L. & 2 others, Yang, H. C. & Chang, J. S., 2013 Feb 1, In : PloS one. 8, 2, e55138.

Research output: Contribution to journalArticle

Allergies
Head and Neck Neoplasms
meta-analysis
hypersensitivity
Meta-Analysis
15 Citations (Scopus)

A Novel Synthetic Microtubule Inhibitor, MPT0B214 Exhibits Antitumor Activity in Human Tumor Cells through Mitochondria-Dependent Intrinsic Pathway

Chiang, N. J., Lin, C. I., Liou, J. P., Kuo, C. C., Chang, C. Y., Chen, L. T. & Chang, J. Y., 2013 Mar 12, In : PloS one. 8, 3, e58953.

Research output: Contribution to journalArticle

Mitochondria
tubulin
Human Activities
Microtubules
microtubules
36 Citations (Scopus)
cathepsin S
Xanthine Oxidase
Autophagy
Cell death
DNA Damage
33 Citations (Scopus)

Caffeic acid phenethyl ester suppresses proliferation and survival of TW2.6 human oral cancer cells via inhibition of akt signaling

Kuo, Y. Y., Lin, H. P., Huo, C., Su, L. C., Yang, J., Hsiao, P. H., Chiang, H. C., Chung, C. J., Wang, H. D., Chang, J. Y., Chen, Y. W. & Chuu, C. P., 2013 May, In : International journal of molecular sciences. 14, 5, p. 8801-8817 17 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
esters
Esters
cancer
Cells
30 Citations (Scopus)

Cholestane-3β, 5α, 6β-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells

Lin, C. Y., Huo, C., Kuo, L. K., Hiipakka, R. A., Jones, R. B., Lin, H. P., Hung, Y., Su, L. C., Tseng, J. C., Kuo, Y. Y., Wang, Y. L., Fukui, Y., Kao, Y. H., Kokontis, J. M., Yeh, C. C., Chen, L., Yang, S. D., Fu, H. H., Chen, Y. W., Tsai, K. K. C. & 2 others, Chang, J. Y. & Chuu, C. P., 2013 Jun 13, In : PloS one. 8, 6, e65734.

Research output: Contribution to journalArticle

prostatic neoplasms
Prostatic Neoplasms
Cells
cadherins
cells
16 Citations (Scopus)

Dissecting the EGFR-PI3K-AKT pathway in oral cancer highlights the role of the EGFR variant III and its clinical relevance

Chang, K. Y., Tsai, S. Y., Chen, S. H., Tsou, H. H., Yen, C. J., Liu, K. J., Fang, H. L., Wu, H. C., Chuang, B. F., Chou, S. W., Tang, C. K., Liu, S. Y., Lu, P. J., Yen, C. Y. & Chang, J. Y., 2013 Jul 2, In : Journal of biomedical science. 20, 1, 43.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Mouth Neoplasms
Phosphatidylinositols
Epidermal Growth Factor Receptor
Phosphotransferases
37 Citations (Scopus)

Epigenetic regulation of the X-linked tumour suppressors BEX1 and LDOC1 in oral squamous cell carcinoma

Lee, C. H., Wong, T. S., Chan, J. Y. W., Lu, S. C., Lin, P., Cheng, A. J., Chen, Y. J., Chang, J. S. M., Hsiao, S. H., Leu, Y. W., Li, C. I., Hsiao, J-R. & Chang, J-Y., 2013 Jul 1, In : Journal of Pathology. 230, 3, p. 298-309 12 p.

Research output: Contribution to journalArticle

Epigenomics
Squamous Cell Carcinoma
Neoplasms
Methylation
High-Throughput Screening Assays
31 Citations (Scopus)

Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors

Chen, Y. T., Chen, Y. F., Chiu, W. T., Liu, K. Y., Liu, Y. L., Chang, J. Y., Chang, H. C. & Shen, M. R., 2013 Jul 15, In : Cancer Research. 73, 14, p. 4500-4509 10 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Microtubules
Calcium
Uterine Cervical Neoplasms
Epithelial Cells
21 Citations (Scopus)

MPT0B098, a novel microtubule inhibitor that destabilizes the hypoxia-inducible factor-1α mRNA through decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR

Cheng, Y. C., Liou, J. P., Kuo, C. C., Lai, W. Y., Shih, K. H., Chang, C. Y., Pan, W. Y., Tseng, T-C. & Chang, J-Y., 2013 Jul 1, In : Molecular Cancer Therapeutics. 12, 7, p. 1202-1212 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
RNA-Binding Proteins
Microtubules
Messenger RNA
Sulfonamides
43 Citations (Scopus)

Randomised clinical trial: Comparison of two everolimus dosing schedules in patients with advanced hepatocellular carcinoma

Shiah, H. S., Chen, C. Y., Dai, C. Y., Hsiao, C. F., Lin, Y. J., Su, W. C., Chang, J. Y., Whang-Peng, J., Lin, P. W., Huang, J. D. & Chen, L. T., 2013 Jan 1, In : Alimentary Pharmacology and Therapeutics. 37, 1, p. 62-73 12 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Appointments and Schedules
Randomized Controlled Trials
Hepatitis B Surface Antigens
Alanine Transaminase
2012
4 Citations (Scopus)

Application of Suzuki arylation, Sonogashira ethynylation and Rosenmund-von Braun cyanation in the exploration of substitution effects on the anticancer activity of 2-aroylquinolines

Lee, H. Y., Lee, L. W., Nien, C. Y., Kuo, C. C., Lin, P. Y., Chang, C. Y., Chang, J. Y. & Liou, J. P., 2012 Jan 1, In : Organic and Biomolecular Chemistry. 10, 48, p. 9593-9600 8 p.

Research output: Contribution to journalArticle

colchicine
Colchicine
Tubulin
Substitution reactions
substitutes
14 Citations (Scopus)

Arginine deprivation as a new treatment strategy for head and neck cancer

Huang, C-C., Tsai, S-T., Kuo, C. C., Chang, J. S., Jin, Y. T., Chang, J-Y. & Hsiao, J-R., 2012 Dec 1, In : Oral Oncology. 48, 12, p. 1227-1235 9 p.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Head and Neck Neoplasms
Arginine
Squamous Cell Carcinoma
Therapeutics
7 Citations (Scopus)

Differences in the frequencies of K-ras c12-13 genotypes by gender and pathologic phenotypes in colorectal tumors measured using the allele discrimination method

Chow, L., Lin, P-C., Chang, J. S., Chu, P. Y., Lee, P. K., Chen, S. N., Cheng, Y. M., Lee, J-C., Chang, J-Y. & Liu, T. W., 2012 Jan 1, In : Environmental and Molecular Mutagenesis. 53, 1, p. 22-31 10 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Alleles
Genotype
Phenotype
Mutation
13 Citations (Scopus)

Modulation of chemotactic and pro-inflammatory activities of endothelial progenitor cells by hepatocellular carcinoma

Shih, Y. T., Wang, M. C., Peng, H. H., Chen, T. F., Chen, L., Chang, J-Y. & Chiu, J. J., 2012 Mar 1, In : Cellular Signalling. 24, 3, p. 779-793 15 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
CCR6 Receptors
Endothelial Cells
Stem Cells
Chemotaxis
10 Citations (Scopus)

Targeted Casp8AP2 methylation increases drug resistance in mesenchymal stem cells and cancer cells

Lee, K. D., Pai, M. Y., Hsu, C. C., Chen, C. C., Chen, Y. L., Chu, P. Y., Lee, C. H., Chen, L. T., Chang, J-Y., Huang, T. H. M., Hsiao, S. H. & Leu, Y. W., 2012 Jun 15, In : Biochemical and Biophysical Research Communications. 422, 4, p. 578-585 8 p.

Research output: Contribution to journalArticle

Methylation
Stem cells
Mesenchymal Stromal Cells
Drug Resistance
Cells
42 Citations (Scopus)

Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway

Chen, K. L., Chang, W. S. W., Cheung, C-H., Lin, C. C., Huang, C. C., Yang, Y. N., Kuo, C. P., Kuo, C. C., Chang, Y. H., Liu, K. J., Wu, C. M. & Chang, J-Y., 2012 Apr 1, In : Cancer Letters. 317, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

cathepsin S
MAP Kinase Signaling System
Autophagy
Neoplasms
Apoptosis
2011
12 Citations (Scopus)

2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors

Chuang, H. Y., Chang, J-Y., Lai, M. J., Kuo, C. C., Lee, H. Y., Hsieh, H. P., Chen, Y. J., Chen, L. T., Pan, W. Y. & Liou, J. P., 2011 Mar 7, In : ChemMedChem. 6, 3, p. 450-456 7 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Inhibitory Concentration 50
Cells
Lead compounds
Colchicine
42 Citations (Scopus)

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., 2011 Dec 22, In : Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Sulfones
Sulfides
HT29 Cells
Tubulin
32 Citations (Scopus)

Antimutagenic constituents of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with potential cancer chemopreventive activity

Chen, H. H., Chiang, W., Chang, J. Y., Chien, Y. L., Lee, C. K., Liu, K. J., Cheng, Y. T., Chen, T. F., Kuo, Y. H. & Kuo, C. C., 2011 Jun 22, In : Journal of Agricultural and Food Chemistry. 59, 12, p. 6444-6452 9 p.

Research output: Contribution to journalArticle

Coix
Coix lacryma-jobi
antimutagenic activity
hulls
neoplasms
34 Citations (Scopus)

Aurora kinase inhibitor patents and agents in clinical testing: An update (2009 - 10)

Cheung, C-H., Coumar, M. S., Chang, J-Y. & Hsieh, H. P., 2011 Jun 1, In : Expert Opinion on Therapeutic Patents. 21, 6, p. 857-884 28 p.

Research output: Contribution to journalReview article

Aurora Kinases
Patents
Neoplasms
Cell Cycle
Databases
8 Citations (Scopus)

BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities

Hu, C. B., Chen, C. P., Yeh, T. K., Song, J. S., Chang, C. Y., Chuu, J. J., Tung, F. F., Ho, P. Y., Chen, T. W., Lin, C. H., Wang, M. H., Chang, K. Y., Huang, C. L., Lin, H. L., Li, W. T., Hwang, D. R., Chern, J. H., Hwang, L. L., Chang, J. Y., Chao, Y. S. & 1 others, Chen, C. T., 2011 Jan 1, In : Cancer Science. 102, 1, p. 182-191 10 p.

Research output: Contribution to journalArticle

Antimitotic Agents
Antineoplastic Agents
Neoplasms
Tubulin
Nude Mice
13 Citations (Scopus)

BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Cheung, C. H. A., Lin, W. H., HsuJohn, J. T. A., Hour, T. C., Yeh, T. K., Ko, S., Lien, T. W., Coumar, M. S., Liu, J. F., Lai, W. Y., Shiao, H. Y., Lee, T. R., Hsieh, H. P. & Chang, J. Y., 2011 Aug 24, In : PloS one. 6, 8, e23485.

Research output: Contribution to journalArticle

Aurora Kinases
phosphotransferases (kinases)
Cells
neoplasms
Neoplasms
13 Citations (Scopus)

Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors

Kuo, C. C., Wu, T., Chen, L. T., Shiah, H. S., Wu, C. M., Cheng, Y. T., Pan, W. Y., Liu, J. F., Chen, K. L., Yang, Y. N., Chen, S. N. & Chang, J. Y., 2011 Dec 15, In : Free Radical Biology and Medicine. 51, 12, p. 2195-2209 15 p.

Research output: Contribution to journalArticle

Carmustine
Autophagy
Cell death
Oxidation-Reduction
Tumors
18 Citations (Scopus)

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

Lee, H. Y., Chang, J. Y., Chang, L. Y., Lai, W. Y., Lai, M. J., Shih, K. H., Kuo, C. C., Chang, C. Y. & Liou, J. P., 2011 May 7, In : Organic and Biomolecular Chemistry. 9, 9, p. 3154-3157 4 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Antimitotic Agents
disrupting
Stilbenes
stilbene
5 Citations (Scopus)

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C-H., Chen, L. T. & Chang, J-Y., 2011 Oct 1, In : Cancer Letters. 309, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

DNA Repair
Drug Resistance
DNA
KB Cells
Neoplasms
16 Citations (Scopus)

Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer

Charoenfuprasert, S., Yang, Y. Y., Lee, Y. C., Chao, K. C., Chu, P. Y., Lai, C. R., Hsu, K. F., Chang, K. C., Chen, Y. C., Chen, L. T., Chang, J. Y., Leu, S. J. & Shih, N. Y., 2011 Aug 18, In : Oncogene. 30, 33, p. 3570-3584 15 p.

Research output: Contribution to journalArticle

Neoplasm Antigens
Ovarian Neoplasms
Carcinogenesis
Phosphotransferases
Salts
13 Citations (Scopus)

Induction chemotherapy with gemcitabine, oxaliplatin, and 5-fluorouracil/leucovorin followed by concomitant chemoradiotherapy in patients with locally advanced pancreatic cancer: A Taiwan cooperative oncology group phase II study

Ch'Ang, H. J., Lin, Y. L., Wang, H. P., Chiu, Y. F., Chang, M. C., Hsu, C. H., Tien, Y. W., Chen, J. S., Hsieh, R. K., Lin, P. W., Shan, Y-S., Cheng, A. L., Chang, J-Y., Whang-Peng, J., Hwang, T. L. & Chen, L. T., 2011 Dec 1, In : International Journal of Radiation Oncology Biology Physics. 81, 5

Research output: Contribution to journalArticle

oxaliplatin
gemcitabine
Induction Chemotherapy
Leucovorin
Taiwan
46 Citations (Scopus)

Investigations of survivin: The past, present and future

Cheung, C. H. A., Cheng, L. T., Chang, K. Y., Chen, H. H. & Chang, J. Y., 2011 Jan 1, In : Frontiers in Bioscience. 16, 3, p. 952-961 10 p.

Research output: Contribution to journalArticle

Cells
Neoplasms
Aurora Kinase B
Oncology
Chemotherapy
3 Citations (Scopus)

Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana

Hsien, C. L., Tseng, M. H., Pan, R. N., Chang, J. Y., Kuo, C. C., Lee, T. H. & Kuo, Y. H., 2011 Jan 26, In : Tetrahedron Letters. 52, 4, p. 515-517 3 p.

Research output: Contribution to journalArticle

Cupressaceae
KB Cells
Sesquiterpenes
Diterpenes
Terpenes
76 Citations (Scopus)

Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo

Chang, K. Y., Tsai, S. Y., Wu, C. M., Yen, C. J., Chuang, B. F. & Chang, J. Y., 2011 Nov 15, In : Clinical Cancer Research. 17, 22, p. 7116-7126 11 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Head and Neck Neoplasms
Human Activities
Growth
Autophagy
3 Citations (Scopus)

Novel terpenoids from Calocedrus macrolepis var. formosana

Hsieh, C. L., Tseng, M. H., Pan, R. N., Chang, J. Y., Kuo, C. C., Lee, T. H. & Kuo, Y. H., 2011 Oct 1, In : Chemistry and Biodiversity. 8, 10, p. 1901-1907 7 p.

Research output: Contribution to journalArticle

Cupressaceae
KB Cells
Diterpenes
Terpenes
Bioactivity
56 Citations (Scopus)

Scaffold-hopping strategy: Synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents

Tung, Y. S., Coumar, M. S., Wu, Y. S., Shiao, H. Y., Chang, J-Y., Liou, J. P., Shukla, P., Chang, C. W., Chang, C. Y., Kuo, C. C., Yeh, T. K., Lin, C. Y., Wu, J. S., Wu, S. Y., Liao, C. C. & Hsieh, H. P., 2011 Apr 28, In : Journal of Medicinal Chemistry. 54, 8, p. 3076-3080 5 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Nitrogen
Drug Design
Biological Availability
Pharmaceutical Preparations
26 Citations (Scopus)

Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents

Lai, M. J., Chang, J-Y., Lee, H. Y., Kuo, C. C., Lin, M. H., Hsieh, H. P., Chang, C. Y., Wu, J. S., Wu, S. Y., Shey, K. S. & Liou, J. P., 2011 Sep 1, In : European Journal of Medicinal Chemistry. 46, 9, p. 3623-3629 7 p.

Research output: Contribution to journalArticle

Indoles
Colchicine
Antineoplastic Agents
Multiple Drug Resistance
Tubulin
2 Citations (Scopus)

Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Hsieh, C. C., Lee, H. Y., Nien, C. Y., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 2011 Mar 1, In : Molecules. 16, 3, p. 2274-2284 11 p.

Research output: Contribution to journalArticle

cultured cells
Antineoplastic Agents
cancer
Cells
Cell Line
2010
63 Citations (Scopus)

5-Amino-2-Aroylquinolines as highly potent tubulin polymerization inhibitors

Nien, C. Y., Chen, Y. C., Kuo, C. C., Hsieh, H. P., Chang, C. Y., Wu, J. S., Wu, S. Y., Liou, J. P. & Chang, J-Y., 2010 Mar 11, In : Journal of Medicinal Chemistry. 53, 5, p. 2309-2313 5 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Inhibitory Concentration 50
Cell Line
Colchicine
Tubulin
11 Citations (Scopus)

Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91

Yeh, T. K., Li, C. M., Chen, C. P., Chuu, J. J., Huang, C. L., Wang, H. S., Shen, C. C., Lee, T. Y., Chang, C. Y., Chang, C. M., Chao, Y. S., Lin, C. T., Chang, J. Y. & Chen, C. T., 2010 Feb 1, In : Pharmacological Research. 61, 2, p. 108-115 8 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Camptothecin
Lactones
Topoisomerase I Inhibitors
Neoplasms
20 Citations (Scopus)

Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: Implication for carcinogenesis

Wang, Y. C., Tsai, Y. S., Huang, J. L., Lee, K. W., Kuo, C. C., Wang, C. S., Huang, A. M., Chang, J. Y., Jong, Y. J. & Lin, C. S., 2010 Apr 1, In : Oral Oncology. 46, 4, p. 255-262 8 p.

Research output: Contribution to journalArticle

Arecoline
Prometaphase
M Phase Cell Cycle Checkpoints
Spindle Apparatus
Carcinogenesis
26 Citations (Scopus)

Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes

Cheung, C-H., Wu, S. Y., Lee, T. R., Chang, C. Y., Wu, J. S., Hsieh, H. P. & Chang, J-Y., 2010 Nov 1, In : PloS one. 5, 9, p. 1-11 11 p., e12564.

Research output: Contribution to journalArticle

drug resistance
Tubulin
tubulin
Drug Resistance
Microtubules
24 Citations (Scopus)

Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells

Hsieh, C. C., Kuo, Y. H., Kuo, C. C., Chen, L. T., Cheung, C-H., Chao, T. Y., Lin, C. H., Pan, W. Y., Chang, C. Y., Chien, S. C., Chen, T. W., Lung, C. C. & Chang, J-Y., 2010 May 1, In : Biochemical Pharmacology. 79, 9, p. 1261-1271 11 p.

Research output: Contribution to journalArticle

Caspase 8
Skeleton
Microtubules
Cells
Neoplasms
19 Citations (Scopus)

Cytotoxic C35 terpenoid cryptotrione from the bark of cryptomeria japonica

Chen, C. C., Wu, J. H., Yang, N. S., Chang, J. Y., Kuo, C. C., Wang, S. Y. & Kuo, Y. H., 2010 Jun 18, In : Organic Letters. 12, 12, p. 2786-2789 4 p.

Research output: Contribution to journalArticle

Cryptomeria
Sesquiterpenes
Terpenes
musculoskeletal system
Skeleton
30 Citations (Scopus)

Design and synthesis of α-ketoamides as cathepsin s inhibitors with potential applications against tumor invasion and angiogenesis

Chen, J. C., Uang, B. J., Lyu, P. C., Chang, J-Y., Liu, K. J., Kuo, C. C., Hsieh, H. P., Wang, H. C., Cheng, C. S., Chang, Y. H., Chang, M. D. T., Chang, W. S. W. & Lin, C. C., 2010 Jun 10, In : Journal of Medicinal Chemistry. 53, 11, p. 4545-4549 5 p.

Research output: Contribution to journalArticle

cathepsin S
Cathepsins
Neoplasms
Inhibitory Concentration 50
Cell Movement
17 Citations (Scopus)

MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover

Lung, J., Liu, K. J., Chang, J-Y., Leu, S. J. & Shih, N. Y., 2010 Jan 1, In : FEBS Journal. 277, 20, p. 4308-4321 14 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Carrier Proteins
Genes
Proteins
Cell Fractionation
6 Citations (Scopus)

Paclitaxel and carboplatin-induced complete remission in peritoneal carcinomatosis of unknown origin: A report of two cases and review of the literature

Wu, Y. Y., Chang, J. Y. & Chao, T. Y., 2010 Mar 1, In : Tumori. 96, 2, p. 336-339 4 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Gastrointestinal Tract
Carcinoma
Omentum
69 Citations (Scopus)

Recent advances in anti-survivin treatments for cancer

Kanwar, R. K., Cheung, C-H., Chang, J-Y. & Kanwar, J. R., 2010 Jun 18, In : Current Medicinal Chemistry. 17, 15, p. 1509-1515 7 p.

Research output: Contribution to journalArticle

Cells
Tumors
Apoptosis
Neoplasms
Chemotherapy
48 Citations (Scopus)
STAT3 Transcription Factor
Transcriptional Activation
Molecular Biology
Interleukin-6
Up-Regulation
19 Citations (Scopus)

Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents

Chang, J. Y., Lai, M. J., Chang, Y. T., Lee, H. Y., Cheng, Y. C., Kuo, C. C., Su, M. C., Chang, C. Y. & Liou, J. P., 2010 Aug 1, In : MedChemComm. 1, 2, p. 152-155 4 p.

Research output: Contribution to journalArticle

Tubulin
Antineoplastic Agents
Inhibitory Concentration 50
Colchicine
Binding Sites