Center of Infectious Disease and Signaling Research

Research Output 1989 2019

2010
36 Citations (Scopus)

Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

Cheung, C-H., Chen, H. H., Cheng, L. T., Lyu, K. W., Kanwar, J. R. & Chang, J-Y., 2010 Apr 15, In : Molecular cancer. 9, 77.

Research output: Contribution to journalArticle

HT29 Cells
tanespimycin
Neoplasms
Cell Line
Down-Regulation
2009
22 Citations (Scopus)

Advances in Aurora kinase inhibitor patents

Coumar, M. S., Cheung, C-H., Chang, J-Y. & Hsieh, H. P., 2009 Mar 1, In : Expert Opinion on Therapeutic Patents. 19, 3, p. 321-356 36 p.

Research output: Contribution to journalReview article

Aurora Kinases
Patents
Pharmaceutical Chemistry
Mitosis
Literature
9 Citations (Scopus)

Alpha-fetoprotein response in advanced hepatocellular carcinoma receiving cytostatic agent

Chen, L. T., Shiah, H. S., Chao, Y., Chang, J. Y., Cheng, L. T. & Whang-Peng, J., 2009 Dec 20, In : Journal of Clinical Oncology. 27, 36, p. e271

Research output: Contribution to journalLetter

alpha-Fetoproteins
Cytostatic Agents
Liver Neoplasms
Tumor Biomarkers
Hepatocellular Carcinoma
83 Citations (Scopus)

Aurora kinase inhibitors in preclinical and clinical testing

Cheung, C. H. A., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 Apr 1, In : Expert Opinion on Investigational Drugs. 18, 4, p. 379-398 20 p.

Research output: Contribution to journalReview article

Aurora Kinases
Mitosis
Genomic Instability
Neoplasms
Carcinogenesis
47 Citations (Scopus)

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity

Chiang, Y. K., Kuo, C. C., Wu, Y. S., Chen, C. T., Coumar, M. S., Wu, J. S., Hsieh, H. P., Chang, C. Y., Jseng, H. Y., Wu, M. H., Leou, J. S., Song, J. S., Chang, J. Y., Lyu, P. C., Chao, Y. S. & Wu, S. Y., 2009 Jul 23, In : Journal of Medicinal Chemistry. 52, 14, p. 4221-4233 13 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Chemical Databases
KB Cells
Computer-Aided Design
G2 Phase
37 Citations (Scopus)
Cholangiocarcinoma
Chronic Hepatitis
Incidence
Neoplasms
Chronic Hepatitis B
54 Citations (Scopus)

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

Cheung, C-H., Chen, H. H., Kuo, C. C., Chang, C. Y., Coumar, M. S., Hsieh, H. P. & Chang, J-Y., 2009 Jul 3, In : Molecular cancer. 8, 43.

Research output: Contribution to journalArticle

Therapeutic Uses
Tubulin
Microtubules
Polymers
Caspases
71 Citations (Scopus)

Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach

Wu, Y. S., Coumar, M. S., Chang, J. Y., Sun, H. Y., Kuo, F. M., Kuo, C. C., Chen, Y. J., Chang, C. Y., Hsiao, C. L., Liou, J. P., Chen, C. P., Yao, H. T., Chiang, Y. K., Tan, U. K., Chen, C. T., Chu, C. Y., Wu, S. Y., Yeh, T. K., Lin, C. Y. & Hsieh, H. P., 2009 Aug 13, In : Journal of Medicinal Chemistry. 52, 15, p. 4941-4945 5 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Heterografts
Neoplasms
Pharmacokinetics
Cell Line
12 Citations (Scopus)

Synthesis and structure-activity relationships of 1-benzyl-4,5,6- trimethoxyindoles as a novel class of potent antimitotic agents

Lai, M. J., Kuo, C. C., Yeh, T. K., Hsieh, H. P., Chen, L. T., Pan, W. Y., Hsu, K. Y., Chang, J-Y. & Liou, J. P., 2009 Apr 17, In : ChemMedChem. 4, 4, p. 588-593 6 p.

Research output: Contribution to journalArticle

Antimitotic Agents
Colchicine
Structure-Activity Relationship
Inhibitory Concentration 50
Tubulin
2008
6 Citations (Scopus)

A novel peroxisome proliferator-activated receptor α/γ agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells

Kao, Y. H., Hsieh, H. P., Chitlimalla, S. K., Pan, W. Y., Kuo, C. C., Tsai, Y. C., Lin, W. H., Chuang, S. E. & Chang, J. Y., 2008 Feb 1, In : Anti-Cancer Drugs. 19, 2, p. 151-158 8 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Peroxisome Proliferator-Activated Receptors
Human Activities
KB Cells
Neoplasms
57 Citations (Scopus)

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors

Liou, J. P., Wu, Z. Y., Kuo, C. C., Chang, C. Y., Lu, P. Y., Chen, C. M., Hsieh, H. P. & Chang, J. Y., 2008 Jul 24, In : Journal of Medicinal Chemistry. 51, 14, p. 4351-4355 5 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Inhibitory Concentration 50
Colchicine
Cell Line
Neoplasms
45 Citations (Scopus)

Human DNA polymerase η activity and translocation is regulated by phosphorylation

Chen, Y. W., Cleaver, J. E., Hatahet, Z., Honkanen, R. E., Chang, J. Y., Yen, Y. & Chou, K. M., 2008 Oct 28, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16578-16583 6 p.

Research output: Contribution to journalArticle

gemcitabine
DNA-Directed DNA Polymerase
Phosphorylation
Cisplatin
Protein Interaction Domains and Motifs
2 Citations (Scopus)

Modern staging and utility of PET imaging in esophageal cancer management

Chang, K. Y., Chang, J. Y., Chao, J. & Yen, Y., 2008 Oct, In : JNCCN Journal of the National Comprehensive Cancer Network. 6, 9, p. 862-869 8 p.

Research output: Contribution to journalArticle

Esophageal Neoplasms
Neoadjuvant Therapy
Fluorodeoxyglucose F18
Positron-Emission Tomography
Neoplasms
24 Citations (Scopus)

Synthesis and structure-activity relationships of 2-amino-1- aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents

Reddy, G. R., Kuo, C. C., Tan, U. K., Coumar, M. S., Chang, C. Y., Chiang, Y. K., Lai, M. J., Yeh, J. Y., Wu, S. Y., Chang, J-Y., Liou, J. P. & Hsieh, H. P., 2008 Dec 25, In : Journal of Medicinal Chemistry. 51, 24, p. 8163-8167 5 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Cell Line
Colchicine
Tubulin
Pharmaceutical Preparations
4 Citations (Scopus)

Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N′-Bis(2- chloroethyl)-N-nitrosurea in camptothecin-resistant cells

Ma, L. C., Kuo, C. C., Liu, J. F., Chen, L. T. & Chang, J. Y., 2008 Aug 1, In : Molecular Pharmacology. 74, 2, p. 517-526 10 p.

Research output: Contribution to journalArticle

Camptothecin
Methyltransferases
Carmustine
Methyl-CpG-Binding Protein 2
DNA
2007
57 Citations (Scopus)

4- And 5-aroylindoles as novel classes of potent antitubulin agents

Liou, J. P., Wu, C. Y., Hsieh, H. P., Chang, C. Y., Chen, C. M., Kuo, C. C. & Chang, J. Y., 2007 Sep 6, In : Journal of Medicinal Chemistry. 50, 18, p. 4548-4552 5 p.

Research output: Contribution to journalArticle

Inhibitory Concentration 50
Tubulin Modulators
Colchicine
Tubulin
Polymerization
58 Citations (Scopus)
Sulfonamides
Human Activities
Microtubules
Phosphorylation
Multidrug Resistance-Associated Proteins
32 Citations (Scopus)

Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil

Chen, C. C., Chen, L. T., Tsou, T. C., Pan, W. Y., Kuo, C. C., Liu, J. F., Yeh, S. C., Tsai, F. Y., Hsieh, H. P. & Chang, J-Y., 2007 Jul 31, In : British Journal of Cancer. 97, 3, p. 334-344 11 p.

Research output: Contribution to journalArticle

oxaliplatin
Fluorouracil
Stomach Neoplasms
Cell Line
Thymidylate Synthase
25 Citations (Scopus)

Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

Chien, S. C., Chang, J. Y., Kuo, C. C., Hsieh, C. C., Yang, N. S. & Kuo, Y. H., 2007 Feb 26, In : Tetrahedron Letters. 48, 9, p. 1567-1569 3 p.

Research output: Contribution to journalArticle

Chamaecyparis
Monoterpenes
Skeleton
Cells
Inhibitory Concentration 50
41 Citations (Scopus)

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

Juang, S. H., Lung, C. C., Hsu, P. C., Hsu, K. S., Li, Y. C., Hong, P. C., Shiah, H. S., Kuo, C. C., Huang, C. W., Wang, Y. C., Huang, L., Chen, T. S., Chen, S. F., Fu, K. C., Hsu, C. L., Lin, M. J., Chang, C. J., Ashendel, C. L., Chan, T. C. K., Chou, K. M. & 1 others, Chang, J. C., 2007 Jan 1, In : Molecular Cancer Therapeutics. 6, 1, p. 193-202 10 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia Mutated Proteins
Nuclear Proteins
Protein Kinases
DNA Damage
DNA Breaks
1 Citation (Scopus)

Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy

Chang, W. S. W., Chou, R. H., Wu, C. W. & Chang, J-Y., 2007 Oct 1, In : Expert Opinion on Therapeutic Patents. 17, 10, p. 1227-1240 14 p.

Research output: Contribution to journalReview article

Tissue Kallikreins
Biomarkers
Physiological Phenomena
Patents
Alternative Splicing
48 Citations (Scopus)

Mitochondria-mediated and p53-associated apoptosis induced in human cancer cells by a novel selenophene derivative, D-501036

Shiah, H. S., Lee, W. S., Juang, S. H., Hong, P. C., Lung, C. C., Chang, C. J., Chou, K. M. & Chang, J. Y., 2007 Mar 1, In : Biochemical Pharmacology. 73, 5, p. 610-619 10 p.

Research output: Contribution to journalArticle

Mitochondria
Cells
Apoptosis
Derivatives
Apoptosis Regulatory Proteins
19 Citations (Scopus)

Tamoxifen accelerates proteasomal degradation of O6- methylguanine DNA methyltransferase in human cancer cells

Kuo, C. C., Liu, J. F., Shiah, H. S., Li-Chen, M. & Chang, J. Y., 2007 Nov 15, In : International Journal of Cancer. 121, 10, p. 2293-2300 8 p.

Research output: Contribution to journalArticle

Methyltransferases
Tamoxifen
Protein Methyltransferases
DNA
Neoplasms
2006
42 Citations (Scopus)

2-Amino and 2′-aminocombretastatin derivatives as potent antimitotic agents

Chang, J. Y., Yang, M. F., Chang, C. Y., Chen, C. M., Kuo, C. C. & Liou, J. P., 2006 Oct 1, In : Journal of Medicinal Chemistry. 49, 21, p. 6412-6415 4 p.

Research output: Contribution to journalArticle

Antimitotic Agents
Inhibitory Concentration 50
Tubulin Modulators
Colchicine
Structure-Activity Relationship
61 Citations (Scopus)

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Chang, J. Y., Hsieh, H. P., Chang, C. Y., Hsu, K. S., Chiang, Y. F., Chen, C. M., Kuo, C. C. & Liou, J. P., 2006 Nov 16, In : Journal of Medicinal Chemistry. 49, 23, p. 6656-6659 4 p.

Research output: Contribution to journalArticle

Sulfonamides
Tubulin Modulators
KB Cells
Colchicine
Microtubules
64 Citations (Scopus)

Antitubulin agents for the treatment of cancer - A medicinal chemistry update

Mahindroo, N., Liou, J. P., Chang, J-Y. & Hsieh, H. P., 2006 May 1, In : Expert Opinion on Therapeutic Patents. 16, 5, p. 647-691 45 p.

Research output: Contribution to journalReview article

Pharmaceutical Chemistry
Microtubules
patent
cancer
chemistry
14 Citations (Scopus)

C 35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines

Hsieh, C. L., Tseng, M. H., Shao, Y. Y., Chang, J-Y., Kuo, C. C., Chang, C. Y. & Kuo, Y. H., 2006 Nov 1, In : Journal of Natural Products. 69, 11, p. 1611-1613 3 p.

Research output: Contribution to journalArticle

Cupressaceae
Terpenes
Human Activities
Cells
KB Cells
22 Citations (Scopus)
Topoisomerase I Inhibitors
DNA Repair Enzymes
Camptothecin
Methyltransferases
DNA
69 Citations (Scopus)

In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells

Chen, Y. L., Lin, S. Z., Chang, J-Y., Cheng, Y. L., Tsai, N. M., Chen, S. P., Chang, W. L. & Harn, H. J., 2006 Jul 28, In : Biochemical Pharmacology. 72, 3, p. 308-319 12 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Lung Neoplasms
Cells
Non-Small Cell Lung Carcinoma
Bupleurum
11 Citations (Scopus)

Phase I and pharmacokinetic study of oral thalidomide in patients with advanced hepatocellular carcinoma

Shiah, H. S., Chao, Y., Chen, L. T., Yao, T. J., Huang, J. D., Chang, J. Y., Chen, P. J., Chuang, T. R., Chin, Y. H., Whang-Peng, J. & Liu, T. W., 2006 Nov, In : Cancer Chemotherapy and Pharmacology. 58, 5, p. 654-664 11 p.

Research output: Contribution to journalArticle

Thalidomide
Pharmacokinetics
Hepatocellular Carcinoma
Toxicity
Maximum Tolerated Dose
5 Citations (Scopus)

Phase I-II trial of weekly gemcitabine plus high-dose 5-fluorouracil and leucovorin in advanced pancreatic cancer

Shiah, H. S., Cheng, A. L., Hsu, C., Hsu, C. H., Liu, T. W., Chang, J. Y., Jan, C. M., Chao, Y., Yu, W. L., Chuang, T. R., Whang-Peng, J. & Chen, L. T., 2006 Mar, In : Journal of Gastroenterology and Hepatology (Australia). 21, 3, p. 531-536 6 p.

Research output: Contribution to journalArticle

gemcitabine
Leucovorin
Pancreatic Neoplasms
Fluorouracil
Maximum Tolerated Dose
41 Citations (Scopus)

Phase II study of gemcitabine plus vinorelbine in the treatment of cisplatin-resistant nasopharyngeal carcinoma

Wang, C. C., Chang, J. Y., Liu, T. W., Lin, C. Y., Yu, Y. C. & Hong, R. L., 2006 Jan 1, In : Head and Neck. 28, 1, p. 74-80 7 p.

Research output: Contribution to journalArticle

gemcitabine
Cisplatin
Febrile Neutropenia
Therapeutics
Neutropenia
5 Citations (Scopus)

Phase I study of biweekly gemcitabine followed by oxaliplatin and simplified 48-h infusion of fluorouracil/leucovorin for advanced pancreatic cancer

Ch'ang, H. J., Wang, C. C., Cheng, A. L., Hsu, C., Lu, Y. S., Chang, M. C., Lin, J. T., Wang, H. P., Shiah, H. S., Liu, T. W., Chang, J-Y., Whang-Peng, J. & Chen, L. T., 2006 Jan 1, In : Journal of Gastroenterology and Hepatology (Australia). 21, 5, p. 874-879 6 p.

Research output: Contribution to journalArticle

oxaliplatin
gemcitabine
Leucovorin
Pancreatic Neoplasms
Fluorouracil
16 Citations (Scopus)

Statistical quality control process for traditional Chinese medicine

Tse, S. K., Chang, J. Y., Su, W. L., Chow, S. C., Hsiung, C. & Lu, Q., 2006 Dec 1, In : Journal of Biopharmaceutical Statistics. 16, 6, p. 861-874 14 p.

Research output: Contribution to journalArticle

Statistical Quality Control
Traditional Chinese Medicine
Chinese Traditional Medicine
Quality Control
Confidence
35 Citations (Scopus)

Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents

Liou, J. P., Mahindroo, N., Chang, C. W., Guo, F. M., Lee, S. W. H., Tan, U. K., Yeh, T. K., Kuo, C. C., Chang, Y. W., Lu, P. H., Tung, Y. S., Lin, K. T., Chang, J-Y. & Hsieh, H. P., 2006 Oct 1, In : ChemMedChem. 1, 10, p. 1106-1118 13 p.

Research output: Contribution to journalArticle

Oxygen Compounds
Antimitotic Agents
Carbamates
Sulfides
Structure-Activity Relationship
7 Citations (Scopus)

Synthesis of new camptothecin analogues with the E-lactone ring replaced by α,β-cyclohexenone

Bacherikov, V. A., Tsai, T. J., Chang, J-Y., Chou, T. C., Lee, R. Z. & Su, T. L., 2006 Sep 25, In : European Journal of Organic Chemistry. 19, p. 4490-4499 10 p.

Research output: Contribution to journalArticle

Osmium
Camptothecin
Type I DNA Topoisomerase
Cell growth
Lactones
2005
109 Citations (Scopus)

Cytotoxic triterpenes from the aerial roots of Ficus microcarpa

Chiang, Y. M., Chang, J-Y., Kuo, C. C., Chang, C. Y. & Kuo, Y. H., 2005 Jan 1, In : Phytochemistry. 66, 4, p. 495-501 7 p.

Research output: Contribution to journalArticle

Ficus microcarpa
Ficus
Triterpenes
triterpenoids
Antennas
69 Citations (Scopus)

Four new 6-nor-5(6→7)abeo-abietane type diterpenes and antitumoral cytotoxic diterpene constituents from the bark of Taiwania cryptomerioides

Chang, C. I., Chang, J. Y., Kuo, C. C., Pan, W. Y. & Kuo, Y. H., 2005 Jan 1, In : Planta Medica. 71, 1, p. 72-76 5 p.

Research output: Contribution to journalArticle

Abietane Diterpenes
Diterpenes
Bearings (structural)
Aldehydes
Inhibitory Concentration 50
6 Citations (Scopus)

Hepatocellular carcinoma associated with acquired von Willebrand disease and extreme thrombocytosis [2]

Chen, C. C., Chang, J. Y., Liu, K. J., Chan, C., Ho, C. H., Lee, S. C. & Chen, L. T., 2005 Jun 1, In : Annals of Oncology. 16, 6, p. 988-989 2 p.

Research output: Contribution to journalLetter

Paraneoplastic Syndromes
Thrombocytosis
von Willebrand Diseases
Liver Neoplasms
Hepatocellular Carcinoma
1 Citation (Scopus)

Long-term complete remission of metastatic gastric cancer after weekly docetaxel, 24 h infusion of high-dose 5-FU/leucovorin and cisplatin [5]

Chan, C. H., Liu, T. W., Chen, L. T., Chang, J. Y. & Whang-Peng, J., 2005 Sep, In : Journal of Gastroenterology and Hepatology (Australia). 20, 9, p. 1470-1471 2 p.

Research output: Contribution to journalLetter

docetaxel
Digestive System Surgical Procedures
Retroperitoneal Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Remission Induction
11 Citations (Scopus)

Pulmonary embolism after transcatheter arterial chemoembolization

Shiah, H. S., Liu, T. W., Chen, L. T., Chang, J-Y., Liu, J. M., Chuang, T. R., Lee, W. S. & Whang-Peng, J., 2005 Dec 1, In : European Journal of Cancer Care. 14, 5, p. 440-442 3 p.

Research output: Contribution to journalArticle

Pulmonary Embolism
Liver
Hepatic Insufficiency
Renal Cell Carcinoma
Fever
26 Citations (Scopus)

Synthesis and antitumor activity of 5-(9-acridinylamino)anisidine derivatives

Bacherikov, V. A., Chang, J. Y., Lin, Y. W., Chen, C. H., Pan, W. Y., Dong, H., Lee, R. Z., Chou, T. C. & Su, T. L., 2005 Dec 1, In : Bioorganic and Medicinal Chemistry. 13, 23, p. 6513-6520 8 p.

Research output: Contribution to journalArticle

Bearings (structural)
Tumors
Derivatives
Acridines
Type II DNA Topoisomerase
31 Citations (Scopus)

α-fetoprotein response predicts survival benefits of thalidomide in advanced hepatocellular carcinoma

Chen, L. T., Liu, T. W., Chao, Y., Shiah, H. S., Chang, J-Y., Juang, S. H., Chen, S. C., Chuang, T. R., Chin, Y. H. & Whang-Peng, J., 2005 Aug 1, In : Alimentary Pharmacology and Therapeutics. 22, 3, p. 217-226 10 p.

Research output: Contribution to journalArticle

Fetal Proteins
Thalidomide
Hepatocellular Carcinoma
Survival
Intention to Treat Analysis
2004
17 Citations (Scopus)

A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells

Juang, S. H., Pan, W. Y., Kuo, C. C., Liou, J. P., Hung, Y. M., Chen, L. T., Hsieh, H. P. & Chang, J-Y., 2004 Jul 15, In : Biochemical Pharmacology. 68, 2, p. 293-303 11 p.

Research output: Contribution to journalArticle

Caspases
Squamous Cell Carcinoma
Up-Regulation
Chemical activation
Cells
181 Citations (Scopus)

BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo

Kuo, C. C., Hsieh, H. P., Pan, W. Y., Chen, C. P., Liou, J. P., Lee, S. J., Chang, Y. L., Chen, L. T., Chen, C. T. & Chang, J. Y., 2004 Jul 1, In : Cancer Research. 64, 13, p. 4621-4628 8 p.

Research output: Contribution to journalArticle

Antimitotic Agents
Human Activities
KB Cells
Neoplasms
Colchicine
161 Citations (Scopus)

Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents

Liou, J. P., Chang, Y. L., Kuo, F. M., Chang, C. W., Tseng, H. Y., Wang, C. C., Yang, Y. N., Chang, J. Y., Lee, S. J. & Hsieh, H. P., 2004 Aug 12, In : Journal of Medicinal Chemistry. 47, 17, p. 4247-4257 11 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Stomach
Substitution reactions
Skeleton
Polymerization
53 Citations (Scopus)

Hepatocellular carcinoma with intra-atrial tumor thrombi: A report of three cases responsive to thalidomide treatment and literature review

Chang, J-Y., Ka, W. S., Chao, T. Y., Liu, T. W., Chuang, T. R. & Chen, L. T., 2004 Jan 1, In : Oncology. 67, 3-4, p. 320-326 7 p.

Research output: Contribution to journalArticle

Thalidomide
Hepatocellular Carcinoma
Thrombosis
Inferior Vena Cava
Neoplasms
70 Citations (Scopus)

Phase II study of weekly oxaliplatin and 24-h infusion of high-dose 5-fluorouracil and folinic acid in the treatment of advanced gastric cancer

Chao, Y., Yeh, K. H., Chang, C. J., Chen, L. T., Chao, T. Y., Wu, M. F., Chang, C. S., Chang, J-Y., Chung, C. Y., Kao, W. Y., Hsieh, R. K. & Cheng, A. L., 2004 Aug 2, In : British Journal of Cancer. 91, 3, p. 453-458 6 p.

Research output: Contribution to journalArticle

oxaliplatin
Leucovorin
Fluorouracil
Stomach Neoplasms
Therapeutics
83 Citations (Scopus)

Salvinal, a Novel Microtubule Inhibitor Isolated from Salvia miltiorrhizae Bunge (Danshen), with Antimitotic Activity in Multidrug-Sensitive and -Resistant Human Tumor Cells

Chang, J. Y., Chang, C. Y., Kuo, C. C., Chen, L. T., Wein, Y. S. & Kuo, Y. H., 2004 Jan 1, In : Molecular Pharmacology. 65, 1, p. 77-84 8 p.

Research output: Contribution to journalArticle

Salvia miltiorrhiza
Antimitotic Agents
Microtubules
Neoplasms
Multidrug Resistance-Associated Proteins
98 Citations (Scopus)

Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents

Liou, J. P., Chang, J. Y., Chang, C. W., Chang, C. Y., Mahindroo, N., Kuo, F. M. & Hsieh, H. P., 2004 May 20, In : Journal of Medicinal Chemistry. 47, 11, p. 2897-2905 9 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Antimitotic Agents
Structure-Activity Relationship
Benzophenones
Lead compounds