Center of Infectious Disease and Signaling Research

Research Output 1989 2019

2004
57 Citations (Scopus)

Three New Oleanane-Type Triterpenes from Ludwigia octovalvis with Cytotoxic Activity against Two Human Cancer Cell Lines

Chang, C. I., Kuo, C. C., Chang, J-Y. & Kuo, Y. H., 2004 Jan 1, In : Journal of Natural Products. 67, 1, p. 91-93 3 p.

Research output: Contribution to journalArticle

Onagraceae
Oleanolic Acid
Triterpenes
Cells
Cell Line
2003
19 Citations (Scopus)

Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent

Chang, J-Y., Hsieh, H. P., Pan, W. Y., Liou, J. P., Bey, S. J., Chen, L. T., Liu, J. F. & Song, J. S., 2003 Jun 15, In : Biochemical Pharmacology. 65, 12, p. 2009-2019 11 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Cytotoxins
Tubulin
Polymerization
Camptothecin

Erratum: Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents (Bioorganic and Medicinal Chemistry Letters (2003) 13 (101) PII S0960894X02008508)

Hsieh, H. P., Liou, J. P., Lin, Y. T., Mahindroo, N., Chang, J-Y., Yang, Y. N., Chern, S. S., Tan, U. K., Chang, C. W., Chen, T. W., Lin, C. H., Chang, Y. Y. & Wang, C. C., 2003 Mar 10, In : Bioorganic and Medicinal Chemistry Letters. 13, 5, 1 p.

Research output: Contribution to journalComment/debate

25 Citations (Scopus)

New analogues of AHMA as potential antitumor agents: Synthesis and biological activity

Chang, J. Y., Lin, C. F., Pan, W. Y., Bacherikov, V., Chou, T. C., Chen, C. H., Dong, H., Cheng, S. Y., Tasi, T. J., Lin, Y. W., Chen, K. T., Chen, L. T. & Su, T. L., 2003 Nov 17, In : Bioorganic and Medicinal Chemistry. 11, 23, p. 4959-4969 11 p.

Research output: Contribution to journalArticle

2-toluidine
Bioactivity
Antineoplastic Agents
Acridines
Type II DNA Topoisomerase
72 Citations (Scopus)

Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

Hsieh, H. P., Liou, J. P., Lin, Y. T., Mahindroo, N., Chang, J. Y., Yang, Y. N., Chern, S. S., Tan, U. K., Chang, C. W., Chen, T. W., Lin, C. H., Chang, Y. Y. & Wang, C. C., 2003 Jan 6, In : Bioorganic and Medicinal Chemistry Letters. 13, 1, p. 101-105 5 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Cells
Derivatives
Cell Line
Hydrogen Bonding
2002
67 Citations (Scopus)

2,2′-Diphenyl-1-picrylhydrazyl radical-scavenging active components from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) hulls

Kuo, C. C., Chiang, W., Liu, G. P., Chien, Y. L., Chang, J-Y., Lee, C. K., Lo, J. M., Huang, S. L., Shih, M. C. & Kuo, Y. H., 2002 Oct 9, In : Journal of Agricultural and Food Chemistry. 50, 21, p. 5850-5855 6 p.

Research output: Contribution to journalArticle

Coix
Coix lacryma-jobi
1-Butanol
Scavenging
butanol
30 Citations (Scopus)

Antitumor AHMA linked to DNA minor groove binding agents: Synthesis and biological evaluation

Rastogi, K., Chang, J. Y., Pan, W. Y., Chen, C. H., Chou, T. C., Chen, L. T. & Su, T. L., 2002 Sep 26, In : Journal of Medicinal Chemistry. 45, 20, p. 4485-4493 9 p.

Research output: Contribution to journalArticle

Netropsin
DNA
Type II DNA Topoisomerase
Solubility
Cell Line
17 Citations (Scopus)

A phase I study of weekly docetaxel, 24-hour infusion of high-dose fluorouracil/leucovorin and cisplatin in patients with advanced gastric cancer

Chen, L. T., Liu, T. W., Wu, C. W., Chung, T. R., Shiah, H. S., Jan, C. M., Ming Liu, J., Whang-Peng, J. & Chang, J-Y., 2002 Dec 1, In : Oncology. 63, 3, p. 239-247 9 p.

Research output: Contribution to journalArticle

docetaxel
Leucovorin
Fluorouracil
Cisplatin
Stomach Neoplasms
5 Citations (Scopus)

Non-surgical treatment for afferent loop syndrome in recurrent gastric cancer complicated by peritoneal carcinomatosis: Percutaneous transhepatic duodenal drainage followed by 24-hour infusion of high-dose fluorouracil and leucovorin

Lee, K. D., Liu, T. W., Wu, C. W., Tiu, C. M., Liu, J. M., Chung, T. R., Chang, J. Y., Whang-Peng, J. & Chen, L. T., 2002 Aug 26, In : Annals of Oncology. 13, 7, p. 1151-1155 5 p.

Research output: Contribution to journalArticle

Afferent Loop Syndrome
Leucovorin
Fluorouracil
Stomach Neoplasms
Drainage
49 Citations (Scopus)

Novel mutation of topoisomerase I in rendering cells resistant to camptothecin

Chang, J. Y., Liu, J. F., Juang, S. H., Liu, T. W. & Chen, L. T., 2002 Jul 1, In : Cancer Research. 62, 13, p. 3716-3721 6 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
Mutation
Cell Line
Topotecan
12 Citations (Scopus)

Phase II and pharmacokinetic study of GL331 in previously treated Chinese gastric cancer patients

Liu, J., Chen, L., Chao, Y., Li, A., Wu, C., Liu, T. S., Shiah, H., Chang, J., Chen, J., Wu, H., Lin, W., Lan, C. & Whang-Peng, J., 2002 May 6, In : Cancer Chemotherapy and Pharmacology. 49, 5, p. 425-428 4 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Stomach Neoplasms
Pharmaceutical Preparations
Sepsis
Type II DNA Topoisomerase
2001

Immunohistochemical studies of Na + /I - symporter in human thyroid tissues - A correlation with clinical thyroid scintigraphy

Lee, C. H., Yang, A. H., Chang, J-Y., Huang, C. L. & Chi, C. W., 2001 Jul 12, In : Chinese Medical Journal (Taipei). 64, 3, p. 141-146 6 p.

Research output: Contribution to journalArticle

Symporters
Radionuclide Imaging
Thyroid Gland
Nodular Goiter
Papillary Carcinoma
35 Citations (Scopus)

The p38 mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumor necrosis factor in osteoblasts

Chae, H. J., Chae, S. W., Chin, H. Y., Bang, B. G., Cho, S. B., Han, K. S., Kim, S. C., Tae, K. C., Lee, K. H., Kim, D. E., Im, M. K., Lee, S. J., Chang, J. Y., Lee, Y. M., Kim, H. M., Kim, H. H., Lee, Z. H. & Kim, H. R., 2001 Feb 13, In : Bone. 28, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Osteoblasts
Interleukin-6
Tumor Necrosis Factor-alpha
Osteocalcin
2000
30 Citations (Scopus)

Unique biochemical, cytotoxic, and antitumor activity of camptothecin and 4β-amino-4'-O-demethylepipodophyllotoxin conjugates

Chang, J-Y., Guo, X., Chen, H. X., Jiang, Z., Fu, Q., Wang, H. K., Bastow, K. F., Zhu, X. K., Guan, J., Lee, K. H. & Cheng, Y. C., 2000 Mar 1, In : Biochemical Pharmacology. 59, 5, p. 497-508 12 p.

Research output: Contribution to journalArticle

Camptothecin
Type II DNA Topoisomerase
Etoposide
DNA Breaks
Cells
1998
2 Citations (Scopus)

Acquired hemophilia A: Report of two cases

Chen, Y. C., Chang, J. Y., Hsueh, E. J., Wan, H. L. & Chao, T. Y., 1998 Sep 1, In : Chinese Medical Journal (Taipei). 61, 9, p. 538-544 7 p.

Research output: Contribution to journalArticle

Hemorrhage
Factor VIII
Cyclophosphamide
Uterus
Episiotomy
1996

Allogeneic bone marrow transplantation for fourteen patients with severe aplastic anemia

Hsueh, E. J., Hwang, W. S., Huang, S. H., Chao, T. Y., Chang, J-Y. & Wang, C. C., 1996 Apr 1, In : Chinese Medical Journal (Taipei). 57, 4, p. 247-253 7 p.

Research output: Contribution to journalArticle

Aplastic Anemia
Homologous Transplantation
Bone Marrow Transplantation
Graft vs Host Disease
Transplants
51 Citations (Scopus)

Camptothecin resistance involving steps subsequent to the formation of protein-linked DNA breaks in human camptothecin-resistant KB cell lines

Beidler, D. R., Chang, J-Y., Zhou, B. S. & Cheng, Y. C., 1996 Jan 15, In : Cancer Research. 56, 2, p. 345-353 9 p.

Research output: Contribution to journalArticle

KB Cells
Camptothecin
DNA Breaks
Cell Line
Proteins
41 Citations (Scopus)

Down regulation of bcl-2 by p53 in nasopharyngeal carcinoma and lack of detection of its specific t(14;18) chromosomal translocation in fixed tissues

Harn, H. J., Ho, L. I., Liu, C. A., Liu, G. C., Lin, F. G., Lin, J. J., Chang, J. Y. & Lee, W. H., 1996 Jan 1, In : Histopathology. 28, 4, p. 317-323 7 p.

Research output: Contribution to journalArticle

Genetic Translocation
Down-Regulation
Chromosomes, Human, Pair 18
bcl-2 Genes
Chromosomes, Human, Pair 14
1 Citation (Scopus)

Examination of pericardial effusions by cytology and immunocytochemistry.

Chen, L. M., Chao, T. Y., Chiang, J. H., Nieh, S., Chang, J-Y., Hwang, S. H., Hseuh, E. J. & Wang, C. C., 1996 Jan 1, In : Zhonghua yi xue za zhi = Chinese medical journal; Free China ed. 58, 4, p. 248-253 6 p.

Research output: Contribution to journalArticle

Pericardial Effusion
Cell Biology
Immunohistochemistry
Neoplasms
Macrophages
28 Citations (Scopus)

Expression of Epstein-Barr virus-encoded RNAs as a marker for metastatic undifferentiated nasopharyngeal carcinoma

Chao, T. Y., Chow, K. C., Chang, J-Y., Wang, C. C., Tsao, T. Y., Harn, H. J. & Chi, K. H., 1996 Jul 1, In : Cancer. 78, 1, p. 24-29 6 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
RNA
Carcinoma
Squamous Cell Carcinoma
In Situ Hybridization
164 Citations (Scopus)

Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain

Yang, C. Y., Wong, C. S., Chang, J. Y. & Ho, S. T., 1996 Apr, In : Canadian Journal of Anaesthesia. 43, 4, p. 379-383 5 p.

Research output: Contribution to journalArticle

Ketamine
Morphine
Cell Division
Pain
Analgesia
1995
4 Citations (Scopus)

Combination chemoimmunotherapy with interferon-alpha and cisplatin in patients with advanced non-small cell lung cancer

Chao, T. Y., Hwang, W. S., Yang, M. J., Chang, J. Y., Wang, C. C., Hseuh, E. J., Huang, S. H. & Chen, W. C., 1995 Jan 1, In : Chinese Medical Journal (Taipei). 56, 4, p. 232-238 7 p.

Research output: Contribution to journalArticle

Interferon-alpha
Non-Small Cell Lung Carcinoma
Cisplatin
Squamous Cell Carcinoma
Adenocarcinoma
4 Citations (Scopus)

Diagnosis of disseminated candidiasis by fine needle aspiration of lymph node and by splenic imprint in a patient with acute promyelocytic leukemia

Chao, T. Y., Chang, J. Y., Yu, C. Y. & Tsao, T. Y., 1995 Jan 1, In : Acta Haematologica. 94, 3, p. 148-151 4 p.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
Candidiasis
Fine Needle Biopsy
Lymph Nodes
Spleen
49 Citations (Scopus)

Differential expression of the human metastasis adhesion molecule CD44V in normal and carcinomatous stomach mucosa of chinese subjects

Harn, HJ. J., Ho, LI. I., Chang, JY. Y., Wu, CW. W., Jiang, SY. Y., Lee, HS. S. & Lee, WH. H., 1995 Mar 1, In : Cancer. 75, 5, p. 1065-1071 7 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Mucous Membrane
Adenocarcinoma
Stomach
Neoplasm Metastasis
15 Citations (Scopus)

Effects of indomethacin on lymphokine-activated killer cell activities in cancer patients

Chao, T. Y., Ting, C. S., Yeh, M. Y., Chang, J. Y., Wang, C. C. & Chu, T. M., 1995 Jan 1, In : Tumor Biology. 16, 4, p. 230-242 13 p.

Research output: Contribution to journalArticle

Lymphokine-Activated Killer Cells
Indomethacin
Lymphokines
Neoplasms
Dinoprostone
89 Citations (Scopus)

Epstein-Barr virus-associated gastric adenocarcinoma in Taiwan

Harn, H. J., Chang, J-Y., Wang, M. W., Ho, L. I., Lee, H. S., Chiang, J. H. & Lee, W. H., 1995 Jan 1, In : Human Pathology. 26, 3, p. 267-271 5 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Taiwan
Stomach
Adenocarcinoma
Complement 3d Receptors
1 Citation (Scopus)

Primary non-Hodgkin's lymphoma of the mediastinum: A clinicopathological report of six cases

Juan, M. T., Sheu, L. F., Chang, J-Y. & Hwang, W. S., 1995 Jan 1, In : Chinese Medical Journal (Taipei). 55, 4, p. 325-330 6 p.

Research output: Contribution to journalArticle

Mediastinum
Non-Hodgkin's Lymphoma
Young Adult
Immunoglobulin lambda-Chains
B-Lymphocytes
1993
13 Citations (Scopus)
Topoisomerase II Inhibitors
Type II DNA Topoisomerase
Antineoplastic Agents
Derivatives
DNA

Erratum: Characterization of camptothecin-resistant Chinese hamster lung cells (Biochemical Pharmacology Vol. 43 (1992) 2443-2452)

Chang, J. Y., Dethlefsen, L. A., Barley, L. R., Zhou, B. S. & Cheng, Y. C., 1993 Jan 1, In : Biochemical Pharmacology. 45, 3, 1 p.

Research output: Contribution to journalComment/debate

Camptothecin
Cricetulus
Pharmacology
Lung
1992
76 Citations (Scopus)

Characterization of camptothecin-resistant chinese hamster lung cells

Chang, J. Y., Dethlefsen, L. A., Barley, L. R., Zhou, B. S. & Cheng, Y. C., 1992 Jun 9, In : Biochemical Pharmacology. 43, 11, p. 2443-2452 10 p.

Research output: Contribution to journalArticle

Camptothecin
Cricetulus
Type I DNA Topoisomerase
Lung
Etoposide
1991
66 Citations (Scopus)

Antitumor Agents. 120. New 4-Substituted Benzylamine and Benzyl Ether Derivatives of 4′-O-Demethylepipodophyollotoxin as Potent Inhibitors of Human DNA Topoisomerase II

Zhou, X. M., Wang, Z. Q., Lee, K. H., Chang, J-Y., Chen, H. X. & Cheng, Y. C., 1991 Dec 1, In : Journal of Medicinal Chemistry. 34, 12, p. 3346-3350 5 p.

Research output: Contribution to journalArticle

Topoisomerase II Inhibitors
Type II DNA Topoisomerase
Antineoplastic Agents
Ether
Oxygen Compounds
46 Citations (Scopus)

Effect of 4β-Arylamino Derivatives of 4′-O-Demethylepipodophyllotoxin on Human DNA Topoisomerase II, Tubulin Polymerization, KB Cells, and Their Resistant Variants

Chang, J. Y., Han, F. S., Liu, S. Y., Wang, Z. Q., Lee, K. H. & Cheng, Y. C., 1991 Apr 1, In : Cancer Research. 51, 7, p. 1755-1759 5 p.

Research output: Contribution to journalArticle

KB Cells
Type II DNA Topoisomerase
Etoposide
Tubulin
Polymerization
61 Citations (Scopus)

Menadione-induced DNA damage in a human tumor cell line

Ngo, E. O., Sun, T. P., Chang, J. Y., Wang, C. C., Chi, K. H., Cheng, A. L. & Nutter, L. M., 1991 Oct 24, In : Biochemical Pharmacology. 42, 10, p. 1961-1968 8 p.

Research output: Contribution to journalArticle

Vitamin K 3
Tumor Cell Line
DNA Damage
Tumors
Cells
1990
106 Citations (Scopus)

Antitumor Agents. 111.† New 4-Hydroxylated and 4-Halogenated Anilino Derivatives of 4'-Demethylepipodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II

Lee, K. H., Beers, S. A., Mori, M., Wang, Z. Q., Kuo, Y. H., Li, L., Liu, S. Y., Chang, J-Y., Han, F. S. & Cheng, Y. C., 1990 Jan 1, In : Journal of Medicinal Chemistry. 33, 5, p. 1364-1368 5 p.

Research output: Contribution to journalArticle

Topoisomerase II Inhibitors
Type II DNA Topoisomerase
Antineoplastic Agents
Etoposide
Podophyllotoxin
120 Citations (Scopus)

Antitumor Agents. 113. New 4β-Arylamino Derivatives of 4-O-Demethylepipodophyllotoxin and Related Compounds as Potent Inhibitors of Human DNA Topoisomerase II

Wang, Z. Q., Kuo, Y. H., Schnur, D., Bowen, J. P., Liu, S. Y., Han, F. S., Chang, J. Y., Cheng, Y. C. & Lee, K. H., 1990 Jan 1, In : Journal of Medicinal Chemistry. 33, 9, p. 2660-2666 7 p.

Research output: Contribution to journalArticle

Topoisomerase II Inhibitors
Type II DNA Topoisomerase
Etoposide
Antineoplastic Agents
Sulfur Compounds
1989
66 Citations (Scopus)

Direct comparisons of peripheral T-cell lymphoma with diffuse B-cell lymphoma of comparable histological grades - Should peripheral T-cell lymphoma be considered separately?

Cheng, A. L., Chen, Y. C., Wang, C. H., Su, I. J., Hsieh, H. C., Chang, J. Y., Hwang, W. S., Su, W. C., Liu, T. W., Tien, H. F., Tsai, W., Shen, M. C. & Liu, C. H., 1989 Jan 1, In : Journal of Clinical Oncology. 7, 6, p. 725-731 7 p.

Research output: Contribution to journalArticle

Peripheral T-Cell Lymphoma
B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Induction Chemotherapy
Histiocytic Sarcoma