Research Output 1973 2019

Filter
Article
2019

Amelioration of experimentally induced arthritis by reducing reactive oxygen species production through the intra-articular injection of water-soluble fullerenol

Kuo, W. S., Weng, C-T., Chen, J. H., Wu, C-L., Shiau, A-L., Hsieh, J. L., So, E. C., Wu, P-T. & Chen, S. Y., 2019 Jun 1, In : Nanomaterials. 9, 6, 909.

Research output: Contribution to journalArticle

Open Access
Reactive Oxygen Species
Oxygen
Water
Nitric oxide
Cartilage

Blocking IL-19 signaling ameliorates allergen-induced airway inflammation

Weng, Y. H., Chen, W. Y., Lin, Y. L., Wang, J-Y. & Chang, M-S., 2019 Jan 1, In : Frontiers in Immunology. 10, APR, 968.

Research output: Contribution to journalArticle

Open Access
Allergens
Asthma
Inflammation
Cytokines
Rodentia

Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking

Kuo, Y. H., Shiau, A-L., Tung, C. L., Su, Y. C., Li, C. F., Su, B. H., Tsao, C. J., Wu, C-L., Feng, Y. H. & Wu, P., 2019 Jun 1, In : Oncology Letters. 17, 6, p. 5740-5746 7 p.

Research output: Contribution to journalArticle

Open Access
Squamous Cell Carcinoma
Lung Neoplasms
Smoking
Non-Small Cell Lung Carcinoma
Neoplasms
1 Citation (Scopus)

Nasogastric tube dislodgment detection in rehabilitation patients based on fog computing with warning sensors and fuzzy petri net

Li, C. M., Ho, Y-R., Chen, W. L., Lin, C. H., Chen, M. Y. & Chen, Y. Z., 2019 Jan 1, In : Sensors and Materials. 31, 1, p. 117-130 14 p.

Research output: Contribution to journalArticle

Open Access
Petri nets
fog
warning
Fog
Patient rehabilitation
Open Access
Phosphoric Monoester Hydrolases
Urinary Bladder Neoplasms
Nuclear Localization Signals
Proteins
Ubiquitination
2 Citations (Scopus)
Thrombomodulin
Hydrogels
Hydrogel
Hyaluronic Acid
Gelatin

The role of vascular smooth muscle cell membrane-bound thrombomodulin in neointima formation

Wang, K. C., Chen, P-S., Chao, T-H., Luo, C. Y., Chung, H. C., Tseng, S. Y., Huang, T. Y., Lin, Y. L., Shi, G. Y., Wu, H-L. & Li, Y-H., 2019 Aug 1, In : Atherosclerosis. 287, p. 54-63 10 p.

Research output: Contribution to journalArticle

Thrombomodulin
Neointima
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Membrane

Tumor Endothelial Marker 1 (TEM1/Endosialin/CD248) Enhances Wound Healing by Interacting with Platelet-Derived Growth Factor Receptors

Hong, Y. K., Lee, Y-C., Cheng, T. L., Lai, C-H., Hsu, C-K., Kuo, C. H., Hsu, Y. Y., Li, J. T., Chang, B. I., Ma, C. Y., Lin, S. W., Wang, K. C., Shi, G. Y. & Wu, H-L., 2019 Jan 1, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor Receptors
Tumor Biomarkers
Wound Healing
Tumors
Fibroblasts
2018

A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli

Kuo, C. J., Wang, S. T., Lin, C. M., Chiu, H. C., Huang, C. R., Lee, D. Y., Chang, G. D., Chou, T. C., Chen, J-W. & Chen, C-S., 2018 Mar 1, In : Cell Death and Disease. 9, 3, 381.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Fumarates
Virulence
Caenorhabditis elegans
Escherichia coli Infections
4 Citations (Scopus)

Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation

Wang, S. M., Lim, S. W., Wang, Y. H., Lin, H. Y., Lai, M. D., Ko, C. Y. & Wang, Y-M., 2018 Jun 1, In : Redox Biology. 16, p. 104-112 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-delta
Oxidative stress
Reactive Oxygen Species
Astrocytes
Oxidative Stress
5 Citations (Scopus)

Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect

Tseng, P. L., Wu, W. H., Hu, T. H., Chen, C. W., Cheng, H-C., Li, C. F., Tsai, W. H., Tsai, H. J., Hsieh, M. C., Chuang, J. H. & Chang, W-T., 2018 Dec 1, In : Scientific reports. 8, 1, 3081.

Research output: Contribution to journalArticle

Succinate Dehydrogenase
Hepatocellular Carcinoma
Neoplasms
Glycolysis
Energy Metabolism
1 Citation (Scopus)

Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus

Su, J. C., Huang, Y. T., Chen, C-S., Chiu, H. C. & Shiau, C. W., 2018 Jan 1, In : Molecules. 23, 1, 27.

Research output: Contribution to journalArticle

Methicillin
staphylococcus
antibiotics
Methicillin-Resistant Staphylococcus aureus
Anti-Bacterial Agents

Detection of enterohemorrhagic escherichia coli colonization in murine host by non-invasive in vivo bioluminescence system

Kuo, C. J., Wang, S. T. & Chen, C-S., 2018 Apr 9, In : Journal of Visualized Experiments. 2018, 134, e56169.

Research output: Contribution to journalArticle

Bioluminescence
Enterohemorrhagic Escherichia coli
Escherichia coli
Animals
Hemolytic-Uremic Syndrome
2 Citations (Scopus)

Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression

Su, Y. C., Feng, Y. H., Wu, H. T., Huang, Y. S., Tung, C. L., Wu, P., Chang, C-J., Shiau, A-L. & Wu, C-L., 2018 Dec 1, In : Scientific reports. 8, 1, 6586.

Research output: Contribution to journalArticle

Liver Neoplasms
Hepatocellular Carcinoma
Neoplasms
Fatty Acids
Monounsaturated Fatty Acids

Estrogen and mechanical loading-related regulation of estrogen receptor-β and apoptosis in tendinopathy

Hsieh, J. L., Jou, I. M., Wu, C-L., Wu, P-T., Shiau, A-L., Chong, H. E., Lo, Y. T., Shen, P. C. & Chen, S. Y., 2018 Oct 1, In : PloS one. 13, 10, e0204603.

Research output: Contribution to journalArticle

Tendinopathy
Estrogen Receptors
estrogens
Tendons
Estrogens

Evaluating virulence and pathogenesis of Aeromonas Infection in a Caenorhabditis elegans model

Chen, Y. W., Ko, W-C., Chen, C-S. & Chen, P-L., 2018 Dec 1, In : Journal of Visualized Experiments. 2018, 142, e58768.

Research output: Contribution to journalArticle

Aeromonas
Caenorhabditis elegans
Toxicity
Virulence
Poisons
4 Citations (Scopus)

Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes

Chang, M. M., Lin, C. N., Fang, C. C., Chen, M., Liang, P. I., Li, W. M., Yeh, B. W., Cheng, H-C., Huang, B-M., Wu, W. J. & Chen, Y. M. A., 2018 Dec 1, In : Scientific reports. 8, 1, 6960.

Research output: Contribution to journalArticle

Glycine N-Methyltransferase
Hepatocytes
Aristolochic Acids
Liver
aristolochic acid I

Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation

Weng, T. Y., Wu, H. F., Li, C. Y., Hung, Y. H., Chang, Y. W., Chen, Y. L., Hsu, H-P., Chen, Y-H., Wang, C. Y., Chang, J-Y. & Lai, M-D., 2018 Dec 1, In : Scientific reports. 8, 1, 8216.

Research output: Contribution to journalArticle

Mutation
Neoplasms
B-Lymphocytes
Lung
Cytokines

Plasminogen/thrombomodulin signaling enhances VEGF expression to promote cutaneous wound healing

Cheng, T. L., Chen, P. K., Huang, W. K., Kuo, C. H., Cho, C. F., Wang, K. C., Shi, G. Y., Wu, H-L. & Lai, C-H., 2018 Dec 1, In : Journal of Molecular Medicine. 96, 12, p. 1333-1344 12 p.

Research output: Contribution to journalArticle

Thrombomodulin
Plasminogen
Wound Healing
Vascular Endothelial Growth Factor A
Skin

Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity

Tu, L. H., Tseng, N. H., Tsai, Y. R., Lin, T. W., Lo, Y. W., Charng, J. L., Hsu, H. T., Chen, Y. S., Chen, R. J., Wu, Y. T., Chan, Y. T., Chen, C-S., Fang, J. M. & Chen, Y. R., 2018 Oct 5, In : European Journal of Medicinal Chemistry. 158, p. 393-404 12 p.

Research output: Contribution to journalArticle

Dissociative Disorders
Cytotoxicity
Amyloid
Amides
Alzheimer Disease
1 Citation (Scopus)

RIOK-1 is a suppressor of the p38 MAPK innate immune pathway in Caenorhabditis elegans

Chen, Y. W., Ko, W-C., Chen, C-S. & Chen, P-L., 2018 Apr 17, In : Frontiers in Immunology. 9, APR, 774.

Research output: Contribution to journalArticle

Caenorhabditis elegans
p38 Mitogen-Activated Protein Kinases
Infection
Genetic Epistasis
Aeromonas
4 Citations (Scopus)

Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells

Sun, Z., Wang, C. Y., Lawson, D. A., Kwek, S., Velozo, H. G., Owyong, M., Lai, M-D., Fong, L., Wilson, M., Su, H., Werb, Z. & Cooke, D. L., 2018 Jan 1, In : Oncotarget. 9, 13, p. 10945-10961 17 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Transcriptome
Endothelial Cells
Breast Neoplasms
Genes
1 Citation (Scopus)

The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells

Pai, V. C., Lo, I. C., Huang, Y. W., Tsai, I. C., Cheng, H. P., Shi, G. Y., Wu, H-L. & Jiang, M-J., 2018 Feb 13, In : Journal of biomedical science. 25, 1, 306361.

Research output: Contribution to journalArticle

Thrombomodulin
Chondroitin Sulfates
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
1 Citation (Scopus)

The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition

Tseng, P. L., Chen, C. W., Hu, K. H., Cheng, H-C., Lin, Y. H., Tsai, W. H., Cheng, T. J., Wu, W. H., Yeh, C. W., Lin, C. C., Tsai, H. J., Chang, H. C., Chuang, J. H., Shan, Y-S. & Chang, W-T., 2018 Apr 10, In : Oncotarget. 9, 27, p. 18949-18969 21 p.

Research output: Contribution to journalArticle

Hexokinase
Deoxyglucose
Energy Metabolism
Enzymes
Neoplasms

The establishment of a lung colonization assay for circulating tumor cell visualization in lung tissues

Lin, T. C., Liao, Y. C., Chang, W-T., Yang, C. H., Cheng, L. H., Cheng, M. & Cheng, H-C., 2018 Jun 18, In : Journal of Visualized Experiments. 2018, 136, e56761.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Tumors
Assays
Visualization
Cells

VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function

Wang, Y., Tzeng, H., Tsai, C., Cheng, H., Lai, W., Liu, H. & Wang, Y., 2018 Nov 1, In : Cancer Letters. 437, p. 79-88

Research output: Contribution to journalArticle

2017
5 Citations (Scopus)

A disease model of muscle necrosis caused by aeromonas dhakensis infection in caenorhabditis elegans

Chen, P-L., Chen, Y. W., Ou, C. C., Lee, T-M., Wu, C. J., Ko, W-C. & Chen, C-S., 2017 Jan 4, In : Frontiers in Microbiology. 7, JAN, 2058.

Research output: Contribution to journalArticle

Aeromonas
Caenorhabditis elegans
Necrosis
Muscles
RNA Interference
5 Citations (Scopus)

Anti-IL-20 monoclonal antibody inhibited inflammation and protected against cartilage destruction in murine models of osteoarthritis

Hsu, Y-H., Yang, Y. Y., Huwang, M. H., Weng, Y. H., Jou, I. M., Wu, P-T., Lin, T. Y., Wu, L-W. & Chang, M-S., 2017 Apr 1, In : PLoS ONE. 12, 4, e0175802.

Research output: Contribution to journalArticle

osteoarthritis
Cartilage
interleukins
cartilage
Osteoarthritis

Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma

Chiu, Y. S., Hsing, C. H., Li, C. F., Lee, C. Y., Hsu, Y-H. & Chang, M-S., 2017 Dec 1, In : Scientific reports. 7, 1, 17609.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Monoclonal Antibodies
Growth
Cyclin D1
Neoplasms
7 Citations (Scopus)

Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells

Hung, Y. H., Huang, H. L., Chen, W. C., Yen, M. C., Cho, C. Y., Weng, T. Y., Wang, C. Y., Chen, Y. L., Chen, L. T. & Lai, M-D., 2017 Feb 1, In : Oncology Reports. 37, 2, p. 969-978 10 p.

Research output: Contribution to journalArticle

Cyclin A2
Argininosuccinate Lyase
Cytoplasm
Liver
Growth
11 Citations (Scopus)

Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer

Lu, C. S., Shieh, G. S., Wang, C. T., Su, B. H., Su, Y. C., Chen, Y. C., Su, W-C., Wu, P., Yang, W-H., Shiau, A-L. & Wu, C-L., 2017 Jan 1, In : Oncotarget. 8, 19, p. 30844-30858 15 p.

Research output: Contribution to journalArticle

Drug Resistance
Urinary Bladder Neoplasms
Cisplatin
Recurrence
Neoplasms
14 Citations (Scopus)

Codon usage regulates protein structure and function by affecting translation elongation speed in Drosophila cells

Zhao, F., Yu, C. & Liu, Y., 2017 Jan 1, In : Nucleic acids research. 45, 14, p. 8484-8492 9 p.

Research output: Contribution to journalArticle

Codon
Drosophila
Proteins
Protein Biosynthesis
Cell-Free System
12 Citations (Scopus)

Cyclin D1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer

Shan, Y-S., Hsu, H-P., Lai, M-D., Hung, Y. H., Wang, C. Y., Yen, M. C. & Chen, Y. L., 2017 Jan 1, In : Oncology Letters. 14, 4, p. 4517-4526 10 p.

Research output: Contribution to journalArticle

Cyclin D1
Stomach Neoplasms
Cyclin D2
Stomach
Cyclin D
4 Citations (Scopus)
Neuroprotective Agents
Stroke
Tumor Necrosis Factor-alpha
Middle Cerebral Artery Infarction
Interleukin-10
Tendinopathy
Weight-Bearing
Hindlimb
Collagenases
Achilles Tendon
13 Citations (Scopus)

Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis

Tzeng, H. T., Tsai, C. H., Yen, Y-T., Cheng, H-C., Chen, Y. C., Pu, S. W., Wang, Y. S., Shan, Y-S., Tseng, Y-L., Su, W-C., Lai, W-W., Wu, L-W. & Wang, Y-C., 2017 May 1, In : Clinical Cancer Research. 23, 9, p. 2335-2345 11 p.

Research output: Contribution to journalArticle

Thrombospondin 1
Endothelial Cells
Neoplasm Metastasis
Tumor Microenvironment
Exocytosis
2 Citations (Scopus)

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition

Chang, Y. T., Shiu, J. H., Huang, C. H., Chen, Y. C., Chen, C. Y., Chang, Y. S. & Chuang, W-J., 2017 Apr 1, In : PLoS ONE. 12, 4, e0175321.

Research output: Contribution to journalArticle

integrins
Integrins
Platelets
Disintegrins
mutants
6 Citations (Scopus)

Evodiamine Exerts an Anti-Hepatocellular Carcinoma Activity through a WWOX-Dependent Pathway

Hu, C-Y., Wu, H. T., Su, Y. C., Lin, C-H., Chang, C-J. & Wu, C-L., 2017 Jul 14, In : Molecules (Basel, Switzerland). 22, 7

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
cancer
mice
Bearings (structural)
Catenins
8 Citations (Scopus)

GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis

Shahi, P., Wang, C. Y., Chou, J., Hagerling, C., Gonzalez Velozo, H., Ruderisch, A., Yu, Y., Lai, M-D. & Werb, Z., 2017 Oct 5, In : Oncogene. 36, 40, p. 5567-5575 9 p.

Research output: Contribution to journalArticle

Semaphorins
Breast
Epithelial Cells
Breast Neoplasms
Neoplasm Metastasis
9 Citations (Scopus)

HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans

Chen, H. D., Kao, C. Y., Liu, B. Y., Huang, S. W., Kuo, C. J., Ruan, J-W., Lin, Y. H., Huang, C. R., Chen, Y-H., Wang, H. D., Aroian, R. V. & Chen, C-S., 2017 Feb 1, In : Autophagy. 13, 2, p. 371-385 15 p.

Research output: Contribution to journalArticle

Autophagy
Epithelium
Caenorhabditis elegans
Immunotoxins
Recycling
12 Citations (Scopus)

IL-6 ameliorates acute lung injury in influenza virus infection

Yang, M. L., Wang, C. T., Yang, S. J., Leu, C. H., Chen, S., Wu, C-L. & Shiau, A-L., 2017 Mar 6, In : Scientific reports. 7, 43829.

Research output: Contribution to journalArticle

Acute Lung Injury
Virus Diseases
Orthomyxoviridae
Interleukin-6
Lung
3 Citations (Scopus)

Increased risk of brain cancer incidence in stroke patients: A clinical case series, population-based and longitudinal follow-up study

Chen, C. W., Cheng, T. J., Ho, C. H., Wang, J. J., Weng, S. F., Hou, Y. C., Cheng, H-C., Chio, C. C., Shan, Y-S. & Chang, W-T., 2017 Jan 1, In : Oncotarget. 8, 65, p. 108989-108999 11 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Stroke
Incidence
Population
Confidence Intervals
4 Citations (Scopus)

Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants

Lin, T. H., Yang, R. S., Tu, H. J., Liou, H. C., Lin, Y. M., Chuang, W-J. & Fu, W. M., 2017 Jan 1, In : European Journal of Pharmacology. 804, p. 94-101 8 p.

Research output: Contribution to journalArticle

Osteoclasts
Integrins
Osteoporosis
Bone Resorption
Osteogenesis
1 Citation (Scopus)

Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy

Hsu, Y-H., Li, H. H., Sung, J-M., Chen, W. Y., Hou, Y. C., Weng, Y. H., Lai, W. T., Wu, C-H. & Chang, M-S., 2017 Mar 3, In : Experimental and Molecular Medicine. 49, 3, e310.

Research output: Contribution to journalArticle

Podocytes
Diabetic Nephropathies
Interleukins
Medical problems
Blood Glucose
2 Citations (Scopus)

Knockdown of toll-like receptor 4 signaling pathways ameliorate bone graft rejection in a mouse model of allograft transplantation

Hsieh, J. L., Shen, P. C., Wu, P-T., Jou, I. M., Wu, C-L., Shiau, A-L., Wang, C-R., Chong, H. E., Chuang, S. H., Peng, J. S. & Chen, S. Y., 2017 Apr 10, In : Scientific reports. 7, 46050.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Graft Rejection
Allografts
Transplantation
Bone and Bones
5 Citations (Scopus)

Monocytic thrombomodulin promotes cell adhesion through interacting with its ligand, Lewis y

Lin, W. L., Chen, C. C., Shi, G. Y., Ma, C. Y., Chang, C-F. & Wu, H-L., 2017 Apr 1, In : Immunology and Cell Biology. 95, 4, p. 372-379 8 p.

Research output: Contribution to journalArticle

Thrombomodulin
Cell Adhesion
Ligands
Leukocytes
Endothelium
10 Citations (Scopus)

Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling

Hsu, H-P., Lai, M-D., Lee, J-C., Yen, M. C., Weng, T. Y., Chen, W. C., Fang, J. H. & Chen, Y. L., 2017 Dec 1, In : Scientific reports. 7, 1, 5823.

Research output: Contribution to journalArticle

Mucin-2
Colonic Neoplasms
Interleukin-6
Neoplasm Metastasis
Checkpoint Kinase 2
3 Citations (Scopus)

Neuroprotective Effects of Betulin in Pharmacological and Transgenic Caenorhabditis elegans Models of Parkinson’s Disease

Tsai, C. W., Tsai, R. T., Liu, S. P., Chen, C-S., Tsai, M. C., Chien, S. H., Hung, H. S., Lin, S. Z., Shyu, W. C. & Fu, R. H., 2017 Dec 1, In : Cell Transplantation. 26, 12, p. 1903-1918 16 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Neuroprotective Agents
Parkinson Disease
Pharmacology
Dopaminergic Neurons
9 Citations (Scopus)

One-dimensional poly(L-lysine)-block-poly(L-threonine) assemblies exhibit potent anticancer activity by enhancing membranolysis

Chen, Y. F., Shiau, A-L., Chang, S-J., Fan, N. S., Wang, C. T., Wu, C-L. & Jan, J-S., 2017 Jun 1, In : Acta Biomaterialia. 55, p. 283-295 13 p.

Research output: Contribution to journalArticle

Threonine
Lysine
Neoplasms
Membranes
Mitochondrial Membranes

P53-derived hybrid peptides induce apoptosis of synovial fibroblasts in the rheumatoid joint

Chen, S. Y., Shiau, A-L., Wu, C-L. & Wang, C-R., 2017 Jan 1, In : Oncotarget. 8, 70, p. 115413-115419 7 p.

Research output: Contribution to journalArticle

Fibroblasts
Joints
Apoptosis
Peptides
Rheumatoid Arthritis