Research Output 1973 2019

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2019
1 Citation (Scopus)

Amelioration of experimentally induced arthritis by reducing reactive oxygen species production through the intra-articular injection of water-soluble fullerenol

Kuo, W. S., Weng, C-T., Chen, J. H., Wu, C-L., Shiau, A-L., Hsieh, J. L., So, E. C., Wu, P-T. & Chen, S. Y., 2019 Jun, In : Nanomaterials. 9, 6, 909.

Research output: Contribution to journalArticle

Open Access
Reactive Oxygen Species
Oxygen
Water
Nitric oxide
Cartilage

A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish

Lee, G. H., Chang, C. L., Chiu, W. T., Hsiao, T. H., Chen, P. Y., Wang, K. C., Kuo, C. H., Chen, B. H., Shi, G. Y., Wu, H. L. & Fu, T. F., 2019 Aug 26, In : Journal of biomedical science. 26, 1, 60.

Research output: Contribution to journalArticle

Open Access
Thrombomodulin
Germ Layers
Blastomeres
Organogenesis
Zebrafish

Blocking IL-19 signaling ameliorates allergen-induced airway inflammation

Weng, Y. H., Chen, W. Y., Lin, Y. L., Wang, J-Y. & Chang, M-S., 2019 Jan 1, In : Frontiers in Immunology. 10, APR, 968.

Research output: Contribution to journalArticle

Open Access
Allergens
Asthma
Inflammation
Cytokines
Rodentia

eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons

Yang, Q., Yu, C. H., Zhao, F., Dang, Y., Wu, C., Xie, P., Sachs, M. S. & Liu, Y., 2019 Sep 26, In : Nucleic acids research. 47, 17, p. 9243-9258 16 p.

Research output: Contribution to journalArticle

Open Access
Protein Biosynthesis
Codon
Ribosomes
Neurospora
Proteins

Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking

Kuo, Y. H., Shiau, A. L., Tung, C. L., Su, Y. C., Li, C. F., Su, B. H., Tsao, C. J., Wu, C. L., Feng, Y. H. & Wu, P., 2019 Jun, In : Oncology Letters. 17, 6, p. 5740-5746 7 p.

Research output: Contribution to journalArticle

Open Access
Squamous Cell Carcinoma
Lung Neoplasms
Smoking
Non-Small Cell Lung Carcinoma
Neoplasms

Identification and characterization of a secreted M28 aminopeptidase protein in Acanthamoeba

Huang, J. M., Chang, Y. T., Shih, M. H., Lin, W. C. & Huang, F. C., 2019 Jun 1, In : Parasitology Research. 118, 6, p. 1865-1874 10 p.

Research output: Contribution to journalArticle

Acanthamoeba
Aminopeptidases
aminopeptidases
Proteins
proteins
2 Citations (Scopus)

Nasogastric tube dislodgment detection in rehabilitation patients based on fog computing with warning sensors and fuzzy petri net

Li, C. M., Ho, Y-R., Chen, W. L., Lin, C. H., Chen, M. Y. & Chen, Y. Z., 2019 Jan 1, In : Sensors and Materials. 31, 1, p. 117-130 14 p.

Research output: Contribution to journalArticle

Open Access
Petri nets
fog
warning
Fog
Patient rehabilitation

Oct4 upregulates osteopontin via Egr1 and is associated with poor outcome in human lung cancer

Feng, Y. H., Su, Y. C., Lin, S. F., Lin, P. R., Wu, C-L., Tung, C. L., Li, C. F., Shieh, G. S. & Shiau, A-L., 2019 Aug 9, In : BMC cancer. 19, 1, 791.

Research output: Contribution to journalArticle

Open Access
Osteopontin
Lung Neoplasms
Up-Regulation
Growth
Genes

Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8

Wang, H. C., Lin, Y. L., Hsu, C. C., Chao, Y. J., Hou, Y. C., Chiu, T. J., Huang, P. H., Tang, M. J., Chen, L. T. & Shan, Y. S., 2019 Jan 1, In : Theranostics. 9, 24, p. 7168-7183 16 p.

Research output: Contribution to journalArticle

Open Access
Pancreatic Stellate Cells
Plasminogen Activator Inhibitor 1
Interleukin-8
Pancreatic Neoplasms
Up-Regulation
Open Access
Phosphoric Monoester Hydrolases
Urinary Bladder Neoplasms
Nuclear Localization Signals
Proteins
Ubiquitination

Prothymosin α promotes STAT3 acetylation to induce cystogenesis in Pkd1-deficient mice

Chen, Y. C., Su, Y. C., Shieh, G. S., Su, B. H., Su, W. C., Huang, P. H., Jiang, S. T., Shiau, A. L. & Wu, C. L., 2019 Nov 1, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 13051-13061 11 p.

Research output: Contribution to journalArticle

Acetylation
Polycystic Kidney Diseases
STAT3 Transcription Factor
Kidney
Cysts
4 Citations (Scopus)
Thrombomodulin
Hydrogels
Hydrogel
Hyaluronic Acid
Gelatin

The role of vascular smooth muscle cell membrane-bound thrombomodulin in neointima formation

Wang, K. C., Chen, P. S., Chao, T. H., Luo, C. Y., Chung, H. C., Tseng, S. Y., Huang, T. Y., Lin, Y. L., Shi, G. Y., Wu, H. L. & Li, Y. H., 2019 Aug, In : Atherosclerosis. 287, p. 54-63 10 p.

Research output: Contribution to journalArticle

Thrombomodulin
Neointima
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Membrane

Tumor Endothelial Marker 1 (TEM1/Endosialin/CD248) Enhances Wound Healing by Interacting with Platelet-Derived Growth Factor Receptors

Hong, Y. K., Lee, Y. C., Cheng, T. L., Lai, C. H., Hsu, C. K., Kuo, C. H., Hsu, Y. Y., Li, J. T., Chang, B. I., Ma, C. Y., Lin, S. W., Wang, K. C., Shi, G. Y. & Wu, H. L., 2019 Oct, In : Journal of Investigative Dermatology. 139, 10, p. 2204-2214.e7

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor Receptors
Tumor Biomarkers
Wound Healing
Tumors
Fibroblasts
2018
1 Citation (Scopus)

A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli

Kuo, C. J., Wang, S. T., Lin, C. M., Chiu, H. C., Huang, C. R., Lee, D. Y., Chang, G. D., Chou, T. C., Chen, J. W. & Chen, C. S., 2018 Mar 1, In : Cell Death and Disease. 9, 3, 381.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Fumarates
Virulence
Caenorhabditis elegans
Escherichia coli Infections
4 Citations (Scopus)

Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation

Wang, S. M., Lim, S. W., Wang, Y. H., Lin, H. Y., Lai, M. D., Ko, C. Y. & Wang, Y-M., 2018 Jun, In : Redox Biology. 16, p. 104-112 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-delta
Oxidative stress
Reactive Oxygen Species
Astrocytes
Oxidative Stress
7 Citations (Scopus)

Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect

Tseng, P. L., Wu, W. H., Hu, T. H., Chen, C. W., Cheng, H. C., Li, C. F., Tsai, W. H., Tsai, H. J., Hsieh, M. C., Chuang, J. H. & Chang, W. T., 2018 Dec 1, In : Scientific reports. 8, 1, 3081.

Research output: Contribution to journalArticle

Succinate Dehydrogenase
Hepatocellular Carcinoma
Neoplasms
Glycolysis
Energy Metabolism
1 Citation (Scopus)

Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus

Su, J. C., Huang, Y. T., Chen, C-S., Chiu, H. C. & Shiau, C. W., 2018 Jan 1, In : Molecules. 23, 1, 27.

Research output: Contribution to journalArticle

Methicillin
staphylococcus
antibiotics
Methicillin-Resistant Staphylococcus aureus
Anti-Bacterial Agents
Bioluminescence
Enterohemorrhagic Escherichia coli
Escherichia coli
Animals
Hemolytic-Uremic Syndrome
3 Citations (Scopus)

Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression

Su, Y. C., Feng, Y. H., Wu, H. T., Huang, Y. S., Tung, C. L., Wu, P., Chang, C. J., Shiau, A. L. & Wu, C. L., 2018 Dec 1, In : Scientific reports. 8, 1, 6586.

Research output: Contribution to journalArticle

Liver Neoplasms
Hepatocellular Carcinoma
Neoplasms
Fatty Acids
Monounsaturated Fatty Acids

Estrogen and mechanical loading-related regulation of estrogen receptor-β and apoptosis in tendinopathy

Hsieh, J. L., Jou, I. M., Wu, C-L., Wu, P-T., Shiau, A-L., Chong, H. E., Lo, Y. T., Shen, P. C. & Chen, S. Y., 2018 Oct 1, In : PloS one. 13, 10, e0204603.

Research output: Contribution to journalArticle

Tendinopathy
Estrogen Receptors
estrogens
Tendons
Estrogens

Evaluating virulence and pathogenesis of Aeromonas Infection in a Caenorhabditis elegans model

Chen, Y. W., Ko, W-C., Chen, C-S. & Chen, P-L., 2018 Dec 1, In : Journal of Visualized Experiments. 2018, 142, e58768.

Research output: Contribution to journalArticle

Aeromonas
Caenorhabditis elegans
Toxicity
Virulence
Poisons
1 Citation (Scopus)

Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation

Weng, T. Y., Wu, H. F., Li, C. Y., Hung, Y. H., Chang, Y. W., Chen, Y. L., Hsu, H. P., Chen, Y. H., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2018 Dec 1, In : Scientific reports. 8, 1, 8216.

Research output: Contribution to journalArticle

Mutation
Neoplasms
B-Lymphocytes
Lung
Cytokines
1 Citation (Scopus)

Plasminogen/thrombomodulin signaling enhances VEGF expression to promote cutaneous wound healing

Cheng, T. L., Chen, P. K., Huang, W. K., Kuo, C. H., Cho, C. F., Wang, K. C., Shi, G. Y., Wu, H. L. & Lai, C. H., 2018 Dec 1, In : Journal of Molecular Medicine. 96, 12, p. 1333-1344 12 p.

Research output: Contribution to journalArticle

Thrombomodulin
Plasminogen
Wound Healing
Vascular Endothelial Growth Factor A
Skin
1 Citation (Scopus)

Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity

Tu, L. H., Tseng, N. H., Tsai, Y. R., Lin, T. W., Lo, Y. W., Charng, J. L., Hsu, H. T., Chen, Y. S., Chen, R. J., Wu, Y. T., Chan, Y. T., Chen, C. S., Fang, J. M. & Chen, Y. R., 2018 Oct 5, In : European Journal of Medicinal Chemistry. 158, p. 393-404 12 p.

Research output: Contribution to journalArticle

Dissociative Disorders
Cytotoxicity
Amyloid
Amides
Alzheimer Disease
1 Citation (Scopus)

RIOK-1 is a suppressor of the p38 MAPK innate immune pathway in Caenorhabditis elegans

Chen, Y. W., Ko, W-C., Chen, C-S. & Chen, P-L., 2018 Apr 17, In : Frontiers in Immunology. 9, APR, 774.

Research output: Contribution to journalArticle

Caenorhabditis elegans
p38 Mitogen-Activated Protein Kinases
Infection
Genetic Epistasis
Aeromonas
6 Citations (Scopus)

Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells

Sun, Z., Wang, C. Y., Lawson, D. A., Kwek, S., Velozo, H. G., Owyong, M., Lai, M. D., Fong, L., Wilson, M., Su, H., Werb, Z. & Cooke, D. L., 2018 Jan 1, In : Oncotarget. 9, 13, p. 10945-10961 17 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Transcriptome
Endothelial Cells
Breast Neoplasms
Genes
1 Citation (Scopus)

The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells

Pai, V. C., Lo, I. C., Huang, Y. W., Tsai, I. C., Cheng, H. P., Shi, G. Y., Wu, H-L. & Jiang, M-J., 2018 Feb 13, In : Journal of biomedical science. 25, 1, 306361.

Research output: Contribution to journalArticle

Thrombomodulin
Chondroitin Sulfates
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
1 Citation (Scopus)

The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition

Tseng, P. L., Chen, C. W., Hu, K. H., Cheng, H. C., Lin, Y. H., Tsai, W. H., Cheng, T. J., Wu, W. H., Yeh, C. W., Lin, C. C., Tsai, H. J., Chang, H. C., Chuang, J. H., Shan, Y. S. & Chang, W. T., 2018 Apr 10, In : Oncotarget. 9, 27, p. 18949-18969 21 p.

Research output: Contribution to journalArticle

Hexokinase
Deoxyglucose
Energy Metabolism
Enzymes
Neoplasms

The establishment of a lung colonization assay for circulating tumor cell visualization in lung tissues

Lin, T. C., Liao, Y. C., Chang, W-T., Yang, C. H., Cheng, L. H., Cheng, M. & Cheng, H-C., 2018 Jun 18, In : Journal of Visualized Experiments. 2018, 136, e56761.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Tumors
Assays
Visualization
Cells
1 Citation (Scopus)

VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function

Wang, Y., Tzeng, H., Tsai, C., Cheng, H., Lai, W., Liu, H. & Wang, Y., 2018 Nov 1, In : Cancer Letters. 437, p. 79-88

Research output: Contribution to journalArticle

2017
6 Citations (Scopus)

A disease model of muscle necrosis caused by aeromonas dhakensis infection in caenorhabditis elegans

Chen, P. L., Chen, Y. W., Ou, C. C., Lee, T. M., Wu, C. J., Ko, W. C. & Chen, C. S., 2017 Jan 4, In : Frontiers in Microbiology. 7, JAN, 2058.

Research output: Contribution to journalArticle

Aeromonas
Caenorhabditis elegans
Necrosis
Muscles
RNA Interference
5 Citations (Scopus)

Anti-IL-20 monoclonal antibody inhibited inflammation and protected against cartilage destruction in murine models of osteoarthritis

Hsu, Y-H., Yang, Y. Y., Huwang, M. H., Weng, Y. H., Jou, I. M., Wu, P-T., Lin, T. Y., Wu, L-W. & Chang, M-S., 2017 Apr 1, In : PLoS ONE. 12, 4, e0175802.

Research output: Contribution to journalArticle

osteoarthritis
Cartilage
interleukins
cartilage
Osteoarthritis

Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma

Chiu, Y. S., Hsing, C. H., Li, C. F., Lee, C. Y., Hsu, Y. H. & Chang, M. S., 2017 Dec 1, In : Scientific reports. 7, 1, 17609.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Monoclonal Antibodies
Growth
Cyclin D1
Neoplasms
7 Citations (Scopus)

Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells

Hung, Y. H., Huang, H. L., Chen, W. C., Yen, M. C., Cho, C. Y., Weng, T. Y., Wang, C. Y., Chen, Y. L., Chen, L. T. & Lai, M. D., 2017 Feb, In : Oncology Reports. 37, 2, p. 969-978 10 p.

Research output: Contribution to journalArticle

Cyclin A2
Argininosuccinate Lyase
Cytoplasm
Liver
Growth
13 Citations (Scopus)

Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer

Lu, C. S., Shieh, G. S., Wang, C. T., Su, B. H., Su, Y. C., Chen, Y. C., Su, W. C., Wu, P., Yang, W. H., Shiau, A. L. & Wu, C. L., 2017 Jan 1, In : Oncotarget. 8, 19, p. 30844-30858 15 p.

Research output: Contribution to journalArticle

Drug Resistance
Urinary Bladder Neoplasms
Cisplatin
Recurrence
Neoplasms
15 Citations (Scopus)

Codon usage regulates protein structure and function by affecting translation elongation speed in Drosophila cells

Zhao, F., Yu, C. H. & Liu, Y., 2017 Jan 1, In : Nucleic acids research. 45, 14, p. 8484-8492 9 p.

Research output: Contribution to journalArticle

Codon
Drosophila
Proteins
Protein Biosynthesis
Cell-Free System
13 Citations (Scopus)

Cyclin D1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer

Shan, Y. S., Hsu, H. P., Lai, M. D., Hung, Y. H., Wang, C. Y., Yen, M. C. & Chen, Y. L., 2017 Jan 1, In : Oncology Letters. 14, 4, p. 4517-4526 10 p.

Research output: Contribution to journalArticle

Cyclin D1
Stomach Neoplasms
Cyclin D2
Stomach
Cyclin D
6 Citations (Scopus)
Neuroprotective Agents
Stroke
Tumor Necrosis Factor-alpha
Middle Cerebral Artery Infarction
Interleukin-10
1 Citation (Scopus)
Tendinopathy
Weight-Bearing
Hindlimb
Collagenases
Achilles Tendon
14 Citations (Scopus)

Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis

Tzeng, H. T., Tsai, C. H., Yen, Y-T., Cheng, H-C., Chen, Y. C., Pu, S. W., Wang, Y. S., Shan, Y-S., Tseng, Y-L., Su, W-C., Lai, W-W., Wu, L-W. & Wang, Y-C., 2017 May 1, In : Clinical Cancer Research. 23, 9, p. 2335-2345 11 p.

Research output: Contribution to journalArticle

Thrombospondin 1
Endothelial Cells
Neoplasm Metastasis
Tumor Microenvironment
Exocytosis
2 Citations (Scopus)

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition

Chang, Y. T., Shiu, J. H., Huang, C. H., Chen, Y. C., Chen, C. Y., Chang, Y. S. & Chuang, W. J., 2017 Apr, In : PloS one. 12, 4, e0175321.

Research output: Contribution to journalArticle

integrins
Integrins
Platelets
Disintegrins
mutants
8 Citations (Scopus)

Evodiamine Exerts an Anti-Hepatocellular Carcinoma Activity through a WWOX-Dependent Pathway

Hu, C-Y., Wu, H. T., Su, Y. C., Lin, C-H., Chang, C-J. & Wu, C-L., 2017 Jul 14, In : Molecules (Basel, Switzerland). 22, 7

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
cancer
mice
Bearings (structural)
Catenins
10 Citations (Scopus)

GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis

Shahi, P., Wang, C. Y., Chou, J., Hagerling, C., Gonzalez Velozo, H., Ruderisch, A., Yu, Y., Lai, M. D. & Werb, Z., 2017 Oct 5, In : Oncogene. 36, 40, p. 5567-5575 9 p.

Research output: Contribution to journalArticle

Semaphorins
Breast
Epithelial Cells
Breast Neoplasms
Neoplasm Metastasis
23 Citations (Scopus)

HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

Wu, D., Huang, R. T., Hamanaka, R. B., Krause, M., Oh, M. J., Kuo, C-H., Nigdelioglu, R., Meliton, A. Y., Witt, L., Dai, G., Civelek, M., Prabhakar, N. R., Fang, Y. & Mutlu, G. M., 2017 May 30, In : eLife. 6, e25217.

Research output: Contribution to journalArticle

Open Access
Hypoxia-Inducible Factor 1
Endothelial cells
Vascular Endothelium
Swine
Endothelial Cells
10 Citations (Scopus)

HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans

Chen, H. D., Kao, C. Y., Liu, B. Y., Huang, S. W., Kuo, C. J., Ruan, J. W., Lin, Y. H., Huang, C. R., Chen, Y. H., Wang, H. D., Aroian, R. V. & Chen, C. S., 2017 Feb 1, In : Autophagy. 13, 2, p. 371-385 15 p.

Research output: Contribution to journalArticle

Autophagy
Epithelium
Caenorhabditis elegans
Immunotoxins
Recycling
13 Citations (Scopus)

IL-6 ameliorates acute lung injury in influenza virus infection

Yang, M. L., Wang, C. T., Yang, S. J., Leu, C. H., Chen, S. H., Wu, C. L. & Shiau, A. L., 2017 Mar 6, In : Scientific reports. 7, 43829.

Research output: Contribution to journalArticle

Acute Lung Injury
Virus Diseases
Orthomyxoviridae
Interleukin-6
Lung
5 Citations (Scopus)

Increased risk of brain cancer incidence in stroke patients: A clinical case series, population-based and longitudinal follow-up study

Chen, C. W., Cheng, T. J., Ho, C. H., Wang, J. J., Weng, S. F., Hou, Y. C., Cheng, H. C., Chio, C. C., Shan, Y. S. & Chang, W. T., 2017 Jan 1, In : Oncotarget. 8, 65, p. 108989-108999 11 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Stroke
Incidence
Population
Confidence Intervals
5 Citations (Scopus)

Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants

Lin, T. H., Yang, R. S., Tu, H. J., Liou, H. C., Lin, Y. M., Chuang, W-J. & Fu, W. M., 2017 Jan 1, In : European Journal of Pharmacology. 804, p. 94-101 8 p.

Research output: Contribution to journalArticle

Osteoclasts
Integrins
Osteoporosis
Bone Resorption
Osteogenesis
1 Citation (Scopus)

Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy

Hsu, Y. H., Li, H. H., Sung, J. M., Chen, W. Y., Hou, Y. C., Weng, Y. H., Lai, W. T., Wu, C. H. & Chang, M. S., 2017 Mar 3, In : Experimental and Molecular Medicine. 49, 3, e310.

Research output: Contribution to journalArticle

Podocytes
Diabetic Nephropathies
Interleukins
Medical problems
Blood Glucose