Research Output 1973 2019

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2017
2 Citations (Scopus)

Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy

Hsu, Y. H., Li, H. H., Sung, J. M., Chen, W. Y., Hou, Y. C., Weng, Y. H., Lai, W. T., Wu, C. H. & Chang, M. S., 2017 Mar 3, In : Experimental and Molecular Medicine. 49, 3, e310.

Research output: Contribution to journalArticle

Podocytes
Diabetic Nephropathies
Interleukins
Medical problems
Blood Glucose
4 Citations (Scopus)

Knockdown of toll-like receptor 4 signaling pathways ameliorate bone graft rejection in a mouse model of allograft transplantation

Hsieh, J. L., Shen, P. C., Wu, P-T., Jou, I. M., Wu, C-L., Shiau, A-L., Wang, C-R., Chong, H. E., Chuang, S. H., Peng, J. S. & Chen, S. Y., 2017 Apr 10, In : Scientific reports. 7, 46050.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Graft Rejection
Allografts
Transplantation
Bone and Bones
6 Citations (Scopus)

Monocytic thrombomodulin promotes cell adhesion through interacting with its ligand, Lewis y

Lin, W. L., Chen, C. C., Shi, G. Y., Ma, C. Y., Chang, C-F. & Wu, H-L., 2017 Apr 1, In : Immunology and Cell Biology. 95, 4, p. 372-379 8 p.

Research output: Contribution to journalArticle

Thrombomodulin
Cell Adhesion
Ligands
Leukocytes
Endothelium
11 Citations (Scopus)

Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling

Hsu, H. P., Lai, M. D., Lee, J. C., Yen, M. C., Weng, T. Y., Chen, W. C., Fang, J. H. & Chen, Y. L., 2017 Dec 1, In : Scientific reports. 7, 1, 5823.

Research output: Contribution to journalArticle

Mucin-2
Colonic Neoplasms
Interleukin-6
Neoplasm Metastasis
Checkpoint Kinase 2
5 Citations (Scopus)

Neuroprotective Effects of Betulin in Pharmacological and Transgenic Caenorhabditis elegans Models of Parkinson’s Disease

Tsai, C. W., Tsai, R. T., Liu, S. P., Chen, C. S., Tsai, M. C., Chien, S. H., Hung, H. S., Lin, S. Z., Shyu, W. C. & Fu, R. H., 2017 Dec 1, In : Cell Transplantation. 26, 12, p. 1903-1918 16 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Neuroprotective Agents
Parkinson Disease
Pharmacology
Dopaminergic Neurons
35 Citations (Scopus)

NOTCH1 is a mechanosensor in adult arteries

Mack, J. J., Mosqueiro, T. S., Archer, B. J., Jones, W. M., Sunshine, H., Faas, G. C., Briot, A., Aragón, R. L., Su, T., Romay, M. C., McDonald, A. I., Kuo, C. H., Lizama, C. O., Lane, T. F., Zovein, A. C., Fang, Y., Tarling, E. J., De Aguiar Vallim, T. Q., Navab, M., Fogelman, A. M. & 2 others, Bouchard, L. S. & Iruela-Arispe, M. L., 2017 Dec 1, In : Nature communications. 8, 1, 1620.

Research output: Contribution to journalArticle

Open Access
arteries
shear stress
Shear stress
Calcium Signaling
Arteries
9 Citations (Scopus)

One-dimensional poly(L-lysine)-block-poly(L-threonine) assemblies exhibit potent anticancer activity by enhancing membranolysis

Chen, Y. F., Shiau, A. L., Chang, S-J., Fan, N. S., Wang, C. T., Wu, C. L. & Jan, J. S., 2017 Jun 1, In : Acta Biomaterialia. 55, p. 283-295 13 p.

Research output: Contribution to journalArticle

Threonine
Lysine
Neoplasms
Membranes
Mitochondrial Membranes

P53-derived hybrid peptides induce apoptosis of synovial fibroblasts in the rheumatoid joint

Chen, S. Y., Shiau, A. L., Wu, C. L. & Wang, C. R., 2017 Jan 1, In : Oncotarget. 8, 70, p. 115413-115419 7 p.

Research output: Contribution to journalArticle

Fibroblasts
Joints
Apoptosis
Peptides
Rheumatoid Arthritis
6 Citations (Scopus)

Peripheral arterial disease screening for hemodialysis patients using a fractional-order integrator and transition probability decision-making model

Wu, J. X., Li, C. M., Chen, G. C., Ho, Y-R. & Lin, C. H., 2017 Apr 1, In : IET Systems Biology. 11, 2, p. 69-66 4 p.

Research output: Contribution to journalArticle

Peripheral Arterial Disease
Fractional Order
Transition Probability
Screening
Renal Dialysis
7 Citations (Scopus)

Protein Mimetic and Anticancer Properties of Monocyte-Targeting Peptide Amphiphile Micelles

Poon, C., Chowdhuri, S., Kuo, C-H., Fang, Y., Alenghat, F. J., Hyatt, D., Kani, K., Gross, M. E. & Chung, E. J., 2017 Dec 11, In : ACS Biomaterials Science and Engineering. 3, 12, p. 3273-3282 10 p.

Research output: Contribution to journalArticle

Amphiphiles
Chemokine CCL2
Micelles
Pulse amplitude modulation
Peptides
3 Citations (Scopus)

PSMB5 plays a dual role in cancer development and immunosuppression

Wang, C. Y., Li, C. Y., Hsu, H. P., Cho, C. Y., Yen, M. C., Weng, T. Y., Chen, W. C., Hung, Y. H., Lee, K. T., Hung, J. H., Chen, Y. L. & Lai, M. D., 2017 Jan 1, In : American Journal of Cancer Research. 7, 11, p. 2103-2120 18 p.

Research output: Contribution to journalArticle

Immunosuppression
Neoplasms
Proteasome Endopeptidase Complex
Computational Biology
Macrophages
11 Citations (Scopus)
Fibronectins
Polymerization
Lung Neoplasms
Lewis Lung Carcinoma
Apoptosis
2 Citations (Scopus)

Recombinant adeno-associated virus vector carrying the thrombomodulin lectin-like domain for the treatment of abdominal aortic aneurysm

Lai, C. H., Wang, K. C., Kuo, C. H., Lee, F. T., Cheng, T. L., Chang, B. I., Yang, Y. J., Shi, G. Y. & Wu, H. L., 2017 Jul 1, In : Atherosclerosis. 262, p. 62-70 9 p.

Research output: Contribution to journalArticle

Thrombomodulin
Dependovirus
Abdominal Aortic Aneurysm
Lectins
Angiotensin II
3 Citations (Scopus)
Thrombomodulin
Apolipoproteins E
Atherosclerosis
Endothelial Cells
Autophagy
6 Citations (Scopus)

Silencing of argininosuccinate lyase inhibits colorectal cancer formation

Huang, H. L., Chen, W. C., Hsu, H. P., Cho, C. Y., Hung, Y. H., Wang, C. Y. & Lai, M. D., 2017 Jan, In : Oncology Reports. 37, 1, p. 163-170 8 p.

Research output: Contribution to journalArticle

Argininosuccinate Lyase
Colorectal Neoplasms
Colonic Neoplasms
Nitric Oxide
Small Interfering RNA

Skin Delivery of Clec4a Small Hairpin RNA Elicited an Effective Antitumor Response by Enhancing CD8+ Immunity In Vivo

Weng, T. Y., Li, C. J., Li, C. Y., Hung, Y. H., Yen, M. C., Chang, Y. W., Chen, Y. H., Chen, Y. L., Hsu, H. P., Chang, J. Y. & Lai, M. D., 2017 Dec, In : Molecular Therapy - Nucleic Acids. 9, p. 419-427 9 p.

Research output: Contribution to journalArticle

Small Interfering RNA
Immunity
Skin
Neoplasms
DNA Vaccines

Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients

Wang, C. Y., Shahi, P., Huang, J. T. W., Phan, N. N., Sun, Z., Lin, Y. C., Lai, M. D. & Werb, Z., 2017 Jan 1, In : Molecular and Clinical Oncology. 6, 1, p. 7-18 12 p.

Research output: Contribution to journalArticle

Achaete-Scute Complex Genome Region
Neoplasms
Colonic Neoplasms
Breast Neoplasms
Brain Neoplasms
4 Citations (Scopus)

TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1

Huang, P. H., Lu, P. J., Ding, L. Y., Chu, P. C., Hsu, W. Y., Chen, C. S., Tsao, C. C., Chen, B. H., Lee, C. T., Shan, Y. S. & Chen, C. S., 2017 Apr 20, In : Oncogene. 36, 16, p. 2202-2214 13 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Epigenomics
Phenotype
Epithelial-Mesenchymal Transition
gemcitabine
22 Citations (Scopus)

Voltage-gated calcium channels: Novel targets for cancer therapy

Phan, N. N., Wang, C. Y., Chen, C. F., Sun, Z., Lai, M. D. & Lin, Y. C., 2017 Jan 1, In : Oncology Letters. 14, 2, p. 2059-2074 16 p.

Research output: Contribution to journalArticle

Calcium Channels
Genes
Neoplasms
Brain Neoplasms
Kidney Neoplasms
5 Citations (Scopus)

ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression

Shahi, P., Wang, C. Y., Lawson, D. A., Slorach, E. M., Lu, A., Yu, Y., Lai, M. D., Velozo, H. G. & Werb, Z., 2017 Mar 21, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 12, p. 3169-3174 6 p.

Research output: Contribution to journalArticle

Down-Regulation
Breast Neoplasms
GATA3 Transcription Factor
Breast
Epithelial Cells
2016
31 Citations (Scopus)

Amelioration of Experimental Autoimmune Arthritis Through Targeting of Synovial Fibroblasts by Intraarticular Delivery of MicroRNAs 140-3p and 140-5p

Peng, J. S., Chen, S. Y., Wu, C. L., Chong, H. E., Ding, Y. C., Shiau, A. L. & Wang, C. R., 2016 Feb 1, In : Arthritis and Rheumatology. 68, 2, p. 370-381 12 p.

Research output: Contribution to journalArticle

Experimental Arthritis
MicroRNAs
Fibroblasts
Arthritis
Rheumatoid Arthritis
16 Citations (Scopus)

A novel hepatokine, HFREP1, plays a crucial role in the development of insulin resistance and type 2 diabetes

Wu, H. T., Ou, H. Y., Hung, H. C., Su, Y. C., Lu, F. H., Wu, J. S., Yang, Y. C., Wu, C. L. & Chang, C. J., 2016 Aug 1, In : Diabetologia. 59, 8, p. 1732-1742 11 p.

Research output: Contribution to journalArticle

Fibrinogen
Type 2 Diabetes Mellitus
Insulin Resistance
Hepatocytes
Glucose Intolerance
8 Citations (Scopus)

Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis

Hsu, Y. H., Chiu, Y. S., Chen, W. Y., Huang, K. Y., Jou, I. M., Wu, P. T., Wu, C. H. & Chang, M. S., 2016 Apr 14, In : Scientific reports. 6, 24339.

Research output: Contribution to journalArticle

Fracture Healing
Bone Fractures
Monoclonal Antibodies
Osteoblasts
Osteogenesis
6 Citations (Scopus)

Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury

Wang, S. M., Hsu, J. Y. C., Ko, C. Y., Chiu, N. E., Kan, W. M., Lai, M. D. & Wang, J. M., 2016 Nov 1, In : Molecular Neurobiology. 53, 9, p. 5912-5927 16 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-delta
Spinal Cord Injuries
Neuroglia
Astrocytes
Cicatrix
23 Citations (Scopus)

Bilateral photoplethysmography analysis for peripheral arterial stenosis screening with a fractional-order integrator and info-gap decision-making

Wu, J. X., Li, C. M., Ho, Y-R., Wu, M. J., Huang, P. T. & Lin, C. H., 2016 Apr 15, In : IEEE Sensors Journal. 16, 8, p. 2691-2700 10 p., 7369951.

Research output: Contribution to journalArticle

Photoplethysmography
integrators
decision making
Screening
screening
10 Citations (Scopus)

Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin

Chen, W. C., Hsu, H. P., Li, C. Y., Yang, Y. J., Hung, Y. H., Cho, C. Y., Wang, C. Y., Weng, T. Y. & Lai, M. D., 2016 Nov, In : International Journal of Oncology. 49, 5, p. 1881-1889 9 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Integrins
Ovarian Neoplasms
Growth
Anoikis
12 Citations (Scopus)
Obese Mice
Adenosine Monophosphate
Protein Kinases
AMP-Activated Protein Kinases
Endothelial Cells
56 Citations (Scopus)

Codon usage is an important determinant of gene expression levels largely through its effects on transcription

Zhoua, Z., Danga, Y., Zhou, M., Li, L., Yu, C., Fu, J., Chen, S. & Liu, Y., 2016 Oct 11, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 41, p. E6117-E6125

Research output: Contribution to journalArticle

Codon
Gene Expression
Protein Biosynthesis
Genome
Neurospora
9 Citations (Scopus)

Cyclic stretch facilitates myogenesis in C2C12 myoblasts and rescues Thiazolidinedione-Inhibited Myotube Formation

Chang, Y. J., Chen, Y. J., Huang, C. W., Fan, S. C., Huang, B. M., Chang, W. T., Tsai, Y. S., Su, F. C. & Wu, C. C., 2016 Mar 21, In : Frontiers in Bioengineering and Biotechnology. 4, MAR, 27.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Muscle Development
Myoblasts
Skeletal Muscle Fibers
Response Elements
16 Citations (Scopus)

Differential expression pattern of THBS1 and THBS2 in lung cancer: Clinical outcome and a systematic-analysis of microarray databases

Weng, T. Y., Wang, C. Y., Hung, Y. H., Chen, W. C., Chen, Y. L. & Lai, M. D., 2016 Aug, In : PloS one. 11, 8, e0161007.

Research output: Contribution to journalArticle

Thrombospondin 1
lung neoplasms
Microarray Analysis
Microarrays
adenocarcinoma
2 Citations (Scopus)

Dynamic evolution of D-dimer level in cerebrospinal fluid predicts poor outcome in patients with spontaneous intracerebral hemorrhage combined with intraventricular hemorrhage

Chen, C. W., Wu, E. H., Huang, J., Chang, W. T., Ao, K. H., Cheng, T. J. & Yang, W., 2016 Jul 1, In : Journal of Clinical Neuroscience. 29, p. 149-154 6 p.

Research output: Contribution to journalArticle

Cerebral Hemorrhage
Cerebrospinal Fluid
Hemorrhage
Mortality
Survivors
12 Citations (Scopus)

Elovl6 is a poor prognostic predictor in breast cancer

Feng, Y. H., Chen, W. Y., Kuo, Y. H., Tung, C. L., Tsao, C. J., Shiau, A. L. & Wu, C. L., 2016 Jul, In : Oncology Letters. 12, 1, p. 207-212 6 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Obesity
Lymph Nodes
Lipogenesis
Mastectomy
2 Citations (Scopus)
Streptococcus pyogenes
Streptococcus
Taiwan
Epidemiology
Molecular Typing
19 Citations (Scopus)

Exercise in an electrotactic flow chamber ameliorates age-related degeneration in Caenorhabditis elegans

Chuang, H. S., Kuo, W. J., Lee, C. L., Chu, I. H. & Chen, C. S., 2016 Jun 16, In : Scientific reports. 6, 28064.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Lipofuscin
Oxidative Stress
Neurosciences
Geriatrics
11 Citations (Scopus)

Graphene quantum dots conjugated with polymers for two-photon properties under two-photon excitation

Kuo, W. S., Hsu, C. L. L., Chen, H. H., Chang, C. Y., Kao, H. F., Chou, L. C. S., Chen, Y. C., Chen, S. J., Chang, W. T., Tseng, S. W., Wang, J. Y. & Pu, Y. C., 2016 Oct 14, In : Nanoscale. 8, 38, p. 16874-16880 7 p.

Research output: Contribution to journalArticle

Graphite
Graphene
Semiconductor quantum dots
Polymers
Photons
3 Citations (Scopus)

Improved antithrombotic activity and diminished bleeding side effect of a PEGylated αiIbβ3 antagonist, disintegrin

Hsu, C. C., Chuang, W. J., Chung, C. H., Chang, C. H., Peng, H. C. & Huang, T. F., 2016 Jul 1, In : Thrombosis Research. 143, p. 3-10 8 p.

Research output: Contribution to journalArticle

Disintegrins
Hemorrhage
Half-Life
Platelet Aggregation
rhodostomin
3 Citations (Scopus)

Intraarticular overexpression of Smad7 ameliorates experimental arthritis

Chen, S. Y., Shiau, A. L., Wu, C. L. & Wang, C. R., 2016 Oct 12, In : Scientific reports. 6, 35163.

Research output: Contribution to journalArticle

Experimental Arthritis
Joints
Crohn Disease
Rheumatoid Arthritis
Arthritis
4 Citations (Scopus)

In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA

Chang, H. C., Huang, Y. T., Chen, C. S., Chen, Y. W., Huang, Y. T., Su, J. C., Teng, L. J., Shiau, C. W. & Chiu, H. C., 2016 Feb 1, In : Journal of Antimicrobial Chemotherapy. 71, 2, p. 449-459 11 p., dkv367.

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Caenorhabditis elegans
Anti-Bacterial Agents
Staphylococcus epidermidis
In Vitro Techniques
7 Citations (Scopus)

Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia

Chen, M. C., Chen, Y. L., Wang, T. W., Hsu, H. P. & Lai, M. D., 2016 Oct, In : Oncology Reports. 36, 4, p. 1997-2008 12 p.

Research output: Contribution to journalArticle

Hyperbilirubinemia
Bile Acids and Salts
Adenocarcinoma
Membranes
GTP-Binding Proteins
10 Citations (Scopus)

MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer

Cho, C. Y., Lee, K. T., Chen, W. C., Wang, C. Y., Chang, Y. S., Huang, H. L., Hsu, H. P., Yen, M. C., Lai, M. Z. & Lai, M. D., 2016 Mar 22, In : Oncotarget. 7, 12, p. 14586-14604 19 p.

Research output: Contribution to journalArticle

Phosphotransferases
Breast Neoplasms
Proline
Growth
Down-Regulation
5 Citations (Scopus)
Enterohemorrhagic Escherichia coli
Innate Immunity
Lipopolysaccharides
Mutation
Enzymes
6 Citations (Scopus)

Myeloid thrombomodulin lectin-like domain inhibits osteoclastogenesis and inflammatory bone loss

Cheng, T. L., Lai, C. H., Shieh, S. J., Jou, Y. B., Yeh, J. L., Yang, A. L., Wang, Y. H., Wang, C. Z., Chen, C. H., Shi, G. Y., Ho, M. L. & Wu, H. L., 2016 Jun 17, In : Scientific reports. 6, 28340.

Research output: Contribution to journalArticle

Thrombomodulin
Lectins
Osteogenesis
Bone and Bones
Experimental Arthritis
8 Citations (Scopus)

Over-expression of prothymosin-α antagonizes TGFβ signalling to promote the development of emphysema

Su, B. H., Tseng, Y. L., Shieh, G. S., Chen, Y. C., Wu, P., Shiau, A. L. & Wu, C. L., 2016 Feb 1, In : Journal of Pathology. 238, 3, p. 412-422 11 p.

Research output: Contribution to journalArticle

Emphysema
Transforming Growth Factors
Tissue Inhibitor of Metalloproteinase-3
Matrix Metalloproteinase 3
Histone Deacetylases
3 Citations (Scopus)

Peroxisome proliferator-activated receptor γ level contributes to structural integrity and component production of elastic fibers in the aorta

Tai, H. C., Tsai, P. J., Chen, J. Y., Lai, C. H., Wang, K. C., Teng, S. H., Lin, S. C., Chang, A. Y. W., Jiang, M. J., Li, Y. H., Wu, H. L., Maeda, N. & Tsai, Y. S., 2016 Jun 1, In : Hypertension. 67, 6, p. 1298-1308 11 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Elastic Tissue
Abdominal Aortic Aneurysm
Aorta
Angiotensin II
Chemical shift
Oxidation-Reduction
Cysteine
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
15 Citations (Scopus)

Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells

Chu, P. C., Yang, M. C., Kulp, S. K., Salunke, S. B., Himmel, L. E., Fang, C. S., Jadhav, A. M., Shan, Y. S., Lee, C. T., Lai, M. D., Shirley, L. A., Bekaii-Saab, T. & Chen, C. S., 2016 Jul 28, In : Oncogene. 35, 30, p. 3897-3908 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Small Interfering RNA
integrin-linked kinase
Heterogeneous-Nuclear Ribonucleoproteins
G-Quadruplexes
5 Citations (Scopus)

Snake Venom Disintegrin Inhibits the Activation of Toll-Like Receptors and Alleviates Sepsis through Integrin alphaVbeta3 Blockade

Hsu, C. C., Chuang, W. J., Chung, C. H., Chang, C. H., Peng, H. C. & Huang, T. F., 2016 Mar 18, In : Scientific reports. 6, 23387.

Research output: Contribution to journalArticle

Integrin alphaVbeta3
Disintegrins
Snake Venoms
Toll-Like Receptors
Sepsis
1 Citation (Scopus)

Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage

Chen, C. L., Wu, Y. Y., Lin, C. F., Kuo, C. F., Han, C. L., Wang, S., Chuang, W. J., Chen, C. Y., Wu, J. J., Tsai, P. J., Liu, C. C. & Lin, Y. S., 2016 May 16, In : Scientific reports. 6, 26026.

Research output: Contribution to journalArticle

Protein S
Macrophages
streptopain
Streptococcus
Phagocytosis
7 Citations (Scopus)

Suppression of Tumor Growth and Muscle Wasting in a Transgenic Mouse Model of Pancreatic Cancer by the Novel Histone Deacetylase Inhibitor AR-42

Henderson, S. E., Ding, L. Y., Mo, X., Bekaii-Saab, T., Kulp, S. K., Chen, C. S. & Huang, P. H., 2016 Jan 1, In : Neoplasia (United States). 18, 12, p. 765-774 10 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Pancreatic Neoplasms
Transgenic Mice
Muscles
Histone Deacetylases
25 Citations (Scopus)

Systematic analysis of gene expression alterations and clinical outcomes for long-chain acyl-coenzyme A synthetase family in cancer

Chen, W. C., Wang, C. Y., Hung, Y. H., Weng, T. Y., Yen, M. C. & Lai, M. D., 2016 May 1, In : PloS one. 11, 5, e0155660.

Research output: Contribution to journalArticle

Coenzyme A Ligases
acyl coenzyme A
ligases
Gene expression
prognosis