Research Output 1973 2019

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2016
10 Citations (Scopus)

Thrombomodulin promotes focal adhesion kinase activation and contributes to angiogenesis by binding to fibronectin

Hsu, Y. Y., Shi, G. Y., Wang, K. C., Ma, C. Y., Cheng, T. L. & Wu, H. L., 2016 Jan 1, In : Oncotarget. 7, 42, p. 68122-68139 18 p.

Research output: Contribution to journalArticle

Thrombomodulin
Focal Adhesion Protein-Tyrosine Kinases
Fibronectins
Cell Adhesion
Cell Movement
15 Citations (Scopus)

Toll-like receptor 4 is essential in the development of abdominal aortic aneurysm

Lai, C. H., Wang, K. C., Lee, F. T., Tsai, H. W., Ma, C. Y., Cheng, T. L., Chang, B. I., Yang, Y. J., Shi, G. Y. & Wu, H. L., 2016 Jan 7, In : PloS one. 11, 1, e0146565.

Research output: Contribution to journalArticle

aneurysm
Toll-Like Receptor 4
Abdominal Aortic Aneurysm
Vascular Smooth Muscle
Smooth Muscle Myocytes
23 Citations (Scopus)

Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots

Kuo, W. S., Chang, C-Y., Chen, H. H., Hsu, C-L., Wang, J-Y., Kao, H. F., Chou, L. C. S., Chen, Y-C., Chen, S. J., Chang, W-T., Tseng, S. W., Wu, P-C. & Pu, Y. C., 2016 Nov 9, In : ACS Applied Materials and Interfaces. 8, 44, p. 30467-30474 8 p.

Research output: Contribution to journalArticle

Photodynamic therapy
Graphite
Graphene
Contrast Media
Semiconductor quantum dots
2015
5 Citations (Scopus)

Acarbose Decreases the Rheumatoid Arthritis Risk of Diabetic Patients and Attenuates the Incidence and Severity of Collagen-induced Arthritis in Mice

Chen, H. H., Chen, D. Y., Chao, Y. H., Chen, Y. M., Wu, C. L., Lai, K. L., Lin, C. H. & Lin, C. C., 2015 Dec 18, In : Scientific reports. 5, 18288.

Research output: Contribution to journalArticle

Acarbose
Experimental Arthritis
Rheumatoid Arthritis
Incidence
Diabetes Mellitus
12 Citations (Scopus)
Aeromonas
Taiwan
Diarrhea
HT29 Cells
Anti-Infective Agents
4 Citations (Scopus)
Intra-Articular Injections
Experimental Arthritis
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Joints
13 Citations (Scopus)

A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y-C., Lin, S. J., Su, W-C., Lai, M-D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J-J., 2015 Jan 1, In : Oncotarget. 6, 15, p. 13671-13687 17 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Endoplasmic Reticulum Stress
Cyclin A2
Growth
Neoplasm Metastasis
5 Citations (Scopus)

Anti-IL-20 monoclonal antibody suppresses prostate cancer growth and bone osteolysis in murine models

Hsu, Y. H., Wu, C. Y., Hsing, C. H., Lai, W. T., Wu, L. W. & Chang, M. S., 2015 Oct 6, In : PloS one. 10, 10, e0139871.

Research output: Contribution to journalArticle

Bone Neoplasms
Osteolysis
prostatic neoplasms
interleukins
monoclonal antibodies
10 Citations (Scopus)

Argininosuccinate lyase is a potential therapeutic target in breast cancer

Huang, H. L., Chen, W. C., Hsu, H. P., Cho, C. Y., Hung, Y. H., Wang, C. Y. & Lai, M. D., 2015 Dec 1, In : Oncology Reports. 34, 6, p. 3131-3139 9 p.

Research output: Contribution to journalArticle

Argininosuccinate Lyase
Breast Neoplasms
Cyclin A2
Small Interfering RNA
Autophagy
17 Citations (Scopus)

Argininosuccinate synthetase 1 suppression and arginine restriction inhibit cell migration in gastric cancer cell lines

Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Chen, W. C., Fang, J. H., Weng, T. Y. & Chen, Y. L., 2015 Apr 30, In : Scientific reports. 5, 9783.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Stomach Neoplasms
Cell Movement
Arginine
Cell Line
40 Citations (Scopus)

Cell surface nucleolin facilitates enterovirus 71 binding and infection

Su, P. Y., Wang, Y. F., Huang, S. W., Lo, Y. C., Wang, Y. H., Wu, S. R., Shieh, D. B., Chen, S. H., Wang, J. R., Lai, M. D. & Chang, C. F., 2015 Jan 1, In : Journal of Virology. 89, 8, p. 4527-4538 12 p.

Research output: Contribution to journalArticle

Enterovirus
Infection
infection
cells
Enterovirus Infections
1 Citation (Scopus)

Clustered regularly interspaced short palindromic repeats are emm type-specific in highly prevalent group A streptococci

Zheng, P. X., Chan, Y. C., Chiou, C. S., Chiang-Ni, C., Wang, S. Y., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2015 Dec 1, In : PloS one. 10, 12, e0145223.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Streptococcus
molecular epidemiology
loci
nucleic acids
157 Citations (Scopus)

Codon Usage Influences the Local Rate of Translation Elongation to Regulate Co-translational Protein Folding

Yu, C. H., Dang, Y., Zhou, Z., Wu, C., Zhao, F., Sachs, M. S. & Liu, Y., 2015 Sep 3, In : Molecular Cell. 59, 5, p. 744-754 11 p.

Research output: Contribution to journalArticle

Protein Folding
Codon
Ribosomes
Messenger RNA
Neurospora
32 Citations (Scopus)

Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma

Tsai, C. F., Hsieh, T. H., Lee, J. N., Hsu, C. Y., Wang, Y. C., Kuo, K. K., Wu, H. L., Chiu, C. C., Tsai, E. M. & Kuo, P. L., 2015 Dec 9, In : Journal of Agricultural and Food Chemistry. 63, 48, p. 10388-10398 11 p.

Research output: Contribution to journalArticle

phthalates
Curcumin
curcumin
Neoplastic Stem Cells
hepatoma
6 Citations (Scopus)

Development of Recombinant Adeno-Associated Virus Serotype 2/8 Carrying Kringle Domains of Human Plasminogen for Sustained Expression and Cancer Therapy

Kuo, C. H., Chang, B. I., Lee, F. T., Chen, P. K., Lee, J. S., Shi, G. Y. & Wu, H. L., 2015 Sep 1, In : Human Gene Therapy. 26, 9, p. 603-613 11 p.

Research output: Contribution to journalArticle

Kringles
Dependovirus
Angiostatins
Plasminogen
Heterografts
9 Citations (Scopus)
Protein Isoforms
Adenocarcinoma
Recurrence
Neoplasms
Reverse Transcription
6 Citations (Scopus)

Effect of Size-Dependent Photodestructive Efficacy by Gold Nanomaterials with Multiphoton Laser

Chang, W-T., Chen, S. J., Chang, C-Y., Liu, Y. H., Chen, C. H., Yang, C. H., Chou, L. C. S., Chang, J. C., Cheng, L. C., Kuo, W. S. & Wang, J-Y., 2015 Aug 12, In : ACS Applied Materials and Interfaces. 7, 31, p. 17318-17329 12 p.

Research output: Contribution to journalArticle

Nanostructured materials
Gold
Lasers
Photons
Cells
2 Citations (Scopus)

Effects of methionine restriction and endurance exercise on bones of ovariectomized rats: A study of histomorphometry, densitometry, and biomechanical properties

Huang, T. H., Su, I. H., Lewis, J. L., Chang, M. S., Hsu, A. T., Perrone, C. E. & Ables, G. P., 2015 Sep 1, In : Journal of Applied Physiology. 119, 5, p. 517-526 10 p.

Research output: Contribution to journalArticle

Densitometry
Methionine
Bone and Bones
Estrogens
Diet
4 Citations (Scopus)

Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels

Sun, Z., Lawson, D. A., Sinclair, E., Wang, C. Y., Lai, M. D., Hetts, S. W., Higashida, R. T., Dowd, C. F., Halbach, V. V., Werb, Z., Su, H. & Cooke, D. L., 2015 Sep 1, In : Biotechnology Reports. 7, p. 157-165 9 p., 106.

Research output: Contribution to journalArticle

Transcriptome
Endothelial Cells
Biopsy
Flow Cytometry
Leukocytes
3 Citations (Scopus)

Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of the MDR1 promoter activity

Su, B. H., Shieh, G. S., Tseng, Y. L., Shiau, A. L. & Wu, C. L., 2015 Jan 1, In : Oncotarget. 6, 35, p. 38308-38326 19 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Etoposide
Adenoviridae
Neoplasms
Combination Drug Therapy
11 Citations (Scopus)

FGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis

Kuo, C. H., Sung, M. C., Chen, P. K., Chang, B. I., Lee, F. T., Cho, C. F., Hsieh, T. T., Huang, Y. C., Li, Y. H., Shi, G. Y., Luo, C. Y. & Wu, H. L., 2015 Jan 1, In : Cardiovascular Research. 105, 1, p. 107-117 11 p.

Research output: Contribution to journalArticle

Thrombomodulin
Protein C
Human Umbilical Vein Endothelial Cells
Syndecan-4
Receptor, Fibroblast Growth Factor, Type 1
15 Citations (Scopus)

Increased expression of argininosuccinate synthetase protein predicts poor prognosis in human gastric cancer

Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Luo, Y. P. & Chen, Y. L., 2015 Jan 1, In : Oncology Reports. 33, 1, p. 49-57 9 p.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Stomach Neoplasms
Neoplasms
Proteins
Neoplasm Staging
8 Citations (Scopus)

Kallistatin ameliorates influenza virus pathogenesis by inhibition of kallikrein-related peptidase 1-mediated cleavage of viral hemagglutinin

Leu, C. H., Yang, M. L., Chung, N. H., Huang, Y. J., Su, Y. C., Chen, Y. C., Lin, C. C., Shieh, G. S., Chang, M. Y., Wang, S. W., Chang, Y., Chao, J., Chao, L., Wu, C. L. & Shiau, A. L., 2015 Sep 1, In : Antimicrobial agents and chemotherapy. 59, 9, p. 5619-5630 12 p.

Research output: Contribution to journalArticle

Viral Hemagglutinins
Kallikreins
Orthomyxoviridae
Peptide Hydrolases
Hemagglutinins
11 Citations (Scopus)

Lewis y promotes migration of oral cancer cells by glycosylation of epidermal growth factor receptore0120162

Lin, W. L., Lin, Y. S., Shi, G. Y., Chang, C. F. & Wu, H. L., 2015 Mar 23, In : PloS one. 10, 3, e0120162.

Research output: Contribution to journalArticle

Glycosylation
Mouth Neoplasms
epidermal growth factor
glycosylation
Epidermal Growth Factor Receptor
5 Citations (Scopus)

Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans

Yu, H., Lai, H. J., Lin, T. W., Chen, C-S. & Lo, S. J., 2015 Aug 15, In : Biochemical Journal. 470, 1, p. 145-154 10 p.

Research output: Contribution to journalArticle

Deoxyribonucleases
Caenorhabditis elegans
Gonads
Genes
Apoptosis
36 Citations (Scopus)

Mechanosensitive PPAP2B regulates endothelial responses to atherorelevant hemodynamic forces

Wu, C., Huang, R. T., Kuo, C. H., Kumar, S., Kim, C. W., Lin, Y. C., Chen, Y. J., Birukova, A., Birukov, K. G., Dulin, N. O., Civelek, M., Lusis, A. J., Loyer, X., Tedgui, A., Dai, G., Jo, H. & Fang, Y., 2015 Jul 1, In : Circulation Research. 117, 4, p. e41-e53

Research output: Contribution to journalArticle

Open Access
Phosphatidate Phosphatase
Hemodynamics
Lysophosphatidic Acid Receptors
Coronary Artery Disease
Endothelium
15 Citations (Scopus)

Membrane-Bound Thrombomodulin Regulates Macrophage Inflammation in Abdominal Aortic Aneurysm

Wang, K. C., Li, Y. H., Shi, G. Y., Tsai, H. W., Luo, C. Y., Cheng, M. H., Ma, C. Y., Hsu, Y. Y., Cheng, T. L., Chang, B. I., Lai, C. H. & Wu, H. L., 2015 Nov 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 11, p. 2412-2422 11 p.

Research output: Contribution to journalArticle

Thrombomodulin
Abdominal Aortic Aneurysm
Macrophages
Inflammation
Membranes
30 Citations (Scopus)

Meta-analysis of public microarray datasets reveals voltage-gated calcium gene signatures in clinical cancer patients

Wang, C. Y., Lai, M. D., Phan, N. N., Sun, Z. & Lin, Y. C., 2015 Jul 6, In : PloS one. 10, 7, e0125766.

Research output: Contribution to journalArticle

Calcium Channels
Microarrays
meta-analysis
calcium channels
Meta-Analysis
16 Citations (Scopus)

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

Ogbechi, J., Ruf, M. T., Hall, B. S., Bodman-Smith, K., Vogel, M., Wu, H. L., Stainer, A., Esmon, C. T., Ahnström, J., Pluschke, G. & Simmonds, R. E., 2015 Jul 1, In : PLoS pathogens. 11, 7, e1005011.

Research output: Contribution to journalArticle

Buruli Ulcer
Thrombomodulin
Fibrin
Endothelial Cells
Protein C
17 Citations (Scopus)

Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis

Li, Y. R., Chen, D. Y., Chu, C. L., Li, S., Chen, Y. K., Wu, C-L. & Lin, C. C., 2015 Dec 1, In : Journal of Nutritional Biochemistry. 26, 12, p. 1467-1478 12 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Therapeutic Uses
Dendritic Cells
Collagen
T-cells
7 Citations (Scopus)
Nestin
Adenocarcinoma
Neoplasm Metastasis
Cyclin-Dependent Kinase 5
Neoplasms
4 Citations (Scopus)

Optical detection of metastatic cancer cells using a scanned laser pico-projection system

Huang, C. L., Chiu, W. T., Lo, Y. L., Chuang, C. H., Chen, Y. B., Chang, S. J., Ke, T. T., Cheng, H. C. & Wu, H. L., 2015 Mar 1, In : Laser Physics Letters. 12, 3, 035602.

Research output: Contribution to journalArticle

Projection systems
projection
cancer
Cells
Lasers
8 Citations (Scopus)

Potent antitumor activity of Oct4 and hypoxia dual-regulated oncolytic adenovirus against bladder cancer

Lu, C. S., Hsieh, J. L., Lin, C. Y., Tsai, H. W., Su, B. H., Shieh, G. S., Su, Y. C., Lee, C. H., Chang, M. Y., Wu, C. L. & Shiau, A. L., 2015 Apr 4, In : Gene Therapy. 22, 4, p. 305-315 11 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Adenoviridae
Response Elements
Neoplastic Stem Cells
Cell Hypoxia
4 Citations (Scopus)

Prothymosin-α overexpression contributes to the development of insulin resistance

Su, Y. C., Ou, H. Y., Wu, H. T., Wu, P., Chen, Y. C., Su, B. H., Shiau, A. L., Chang, C. J. & Wu, C. L., 2015 Nov, In : Journal of Clinical Endocrinology and Metabolism. 100, 11, p. 4114-4123 10 p.

Research output: Contribution to journalArticle

Insulin Resistance
Insulin
Medical problems
Toll-Like Receptor 4
High Fat Diet
16 Citations (Scopus)

Recombinant thrombomodulin inhibits lipopolysaccharide-induced inflammatory response by blocking the functions of CD14

Ma, C. Y., Chang, W. E., Shi, G. Y., Chang, B. Y., Cheng, S. E., Shih, Y. T. & Wu, H-L., 2015 Feb 15, In : Journal of Immunology. 194, 4, p. 1905-1915 11 p.

Research output: Contribution to journalArticle

Thrombomodulin
Lipopolysaccharides
Threonine
Serine
Macrophages
15 Citations (Scopus)

Role of spinal CXCL1 (GROα) in opioid tolerance a human-to-rodent translational study

Lin, C. P., Kang, K. H., Lin, T. H., Wu, M. Y., Liou, H. C., Chuang, W. J., Sun, W. Z. & Fu, W. M., 2015 Mar 4, In : Anesthesiology. 122, 3, p. 666-676 11 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Rodentia
Morphine
Cerebrospinal Fluid
Chemokines
11 Citations (Scopus)

SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor

Chiang, C. Y., Pan, C. C., Chang, H. Y., Lai, M-D., Tzai, T. S., Tsai, Y-S., Ling, P., Liu, H-S., Lee, B-F., Cheng, H-L., Ho, C-L., Chen, S-H. & Chow, N-H., 2015 Dec 15, In : Clinical Cancer Research. 21, 24, p. 5601-5611 11 p.

Research output: Contribution to journalArticle

src Homology Domains
Epidermal Growth Factor Receptor
Glutamic Acid
Biomarkers
Carcinoma
6 Citations (Scopus)

The iNOS/Src/FAK axis contributes to lithium chloride-mediated macrophage migration

Chen, H. C., Chien, W. C., Chang, M. Y., Hsieh, M. Y., Lai, M-D., Maa, M. C. & Leu, T-H., 2015 May 1, In : Nitric Oxide - Biology and Chemistry. 47, p. 58-64 7 p.

Research output: Contribution to journalArticle

Lithium Chloride
Macrophages
kenpaullone
Peritoneal Macrophages
Phosphorylation
17 Citations (Scopus)

Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer

Chen, W. C., Chang, Y. S., Hsu, H. P., Yen, M. C., Huang, H. L., Cho, C. Y., Wang, C. Y., Weng, T. Y., Lai, P. T., Chen, C. S., Lin, Y. J. & Lai, M. D., 2015 Jan 1, In : Oncotarget. 6, 40, p. 42923-42937 15 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Liver Neoplasms
Integrins
Neoplastic Stem Cells
Neoplasms
31 Citations (Scopus)
Osteopontin
Stomach Neoplasms
Macrophages
Neoplasms
U937 Cells
8 Citations (Scopus)

Thrombomodulin promotes corneal epithelial wound healing

Huang, Y. H., Ching-Chang, I., Kuo, C. H., Hsu, Y. Y., Lee, F. T., Shi, G. Y., Tseng, S. H. & Wu, H. L., 2015 Mar 27, In : PloS one. 10, 3, e0122491.

Research output: Contribution to journalArticle

Thrombomodulin
tissue repair
Wound Healing
cornea
growth factors
11 Citations (Scopus)

Thrombomodulin promotes diabetic wound healing by regulating toll-like receptor 4 expression

Cheng, T. L., Lai, C-H., Chen, P. K., Cho, C. F., Hsu, Y. Y., Wang, K. C., Lin, W. L., Chang, B. I., Liu, S. K., Wu, Y. T., Hsu, C-K., Shi, G. Y. & Wu, H-L., 2015 Jan 1, In : Journal of Investigative Dermatology. 135, 6, p. 1668-1675 8 p.

Research output: Contribution to journalArticle

Thrombomodulin
Toll-Like Receptor 4
Keratinocytes
Wound Healing
Glucose
16 Citations (Scopus)

Transcription factor snail regulates tumor necrosis factor α-mediated synovial fibroblast activation in the rheumatoid joint

Chen, S. Y., Shiau, A-L., Li, Y. T., Lin, C. C., Jou, I. M., Liu, M-F., Wu, C-L. & Wang, C-R., 2015 Jan 1, In : Arthritis and Rheumatology. 67, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Tumor Necrosis Factor-alpha
Fibroblasts
Joints
Synovial Membrane
2014
26 Citations (Scopus)

Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease

Fu, R. H., Wang, Y. C., Chen, C. S., Tsai, R. T., Liu, S. P., Chang, W. L., Lin, H. L., Lu, C. H., Wei, J. R., Wang, Z. W., Shyu, W. C. & Lin, S. Z., 2014 Jul, In : Neuropharmacology. 82, p. 108-120 13 p.

Research output: Contribution to journalArticle

Synucleins
Nerve Degeneration
Dopaminergic Neurons
Parkinson Disease
Animal Models
26 Citations (Scopus)
Aeromonas hydrophila
Aeromonas
Taiwan
gentamicin A
Wounds and Injuries
6 Citations (Scopus)
Nonesterified Fatty Acids
Liver
Hep G2 Cells
High Fat Diet
Sterol Regulatory Element Binding Protein 1
4 Citations (Scopus)

Adenovirus-mediated prothymosin α gene transfer inhibits the development of atherosclerosis in apoe-deficient mice

Chang, M. Y., Yang, Y. S., Tsai, M. L., Lee, C. H., Chang, C. J., Shiau, A. L. & Wu, C. L., 2014 Mar 15, In : International Journal of Biological Sciences. 10, 4, p. 358-366 9 p.

Research output: Contribution to journalArticle

gene transfer
Apolipoproteins E
Adenoviridae
atherosclerosis
antioxidant
19 Citations (Scopus)

A methionine-restricted diet and endurance exercise decrease bone mass and extrinsic strength but increase intrinsic strength in growing male rats

Huang, T-H., Lewis, J. L., Lin, H. S., Kuo, L. T., Mao, S. W., Tai, Y. S., Chang, M-S., Ables, G. P., Perrone, C. E. & Yang, R. S., 2014 Jan 1, In : Journal of Nutrition. 144, 5, p. 621-630 10 p.

Research output: Contribution to journalArticle

Methionine
Diet
Bone and Bones
Bone Density
Body Weight
10 Citations (Scopus)

A novel cancer therapeutic using thrombospondin 1 in dendritic cells

Weng, T. Y., Huang, S. S., Yen, M. C., Lin, C. C., Chen, Y. L., Lin, C. M., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2014 Jan 1, In : Molecular Therapy. 22, 2, p. 292-302 11 p.

Research output: Contribution to journalArticle

Thrombospondin 1
Dendritic Cells
Neoplasms
Small Interfering RNA
Therapeutics
3 Citations (Scopus)
Clustered Regularly Interspaced Short Palindromic Repeats
Erythromycin
Streptococcus
Nucleic Acids
Streptococcus pyogenes