Research Output 1973 2019

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2010
24 Citations (Scopus)

Imaging live cell membranes via surface plasmon-enhanced fluorescence and phase microscopy

He, R. Y., Lin, C. Y., Su, Y. D., Chiu, K. C., Chang, N. S., Wu, H. L. & Chen, S. J., 2010 Feb 15, In : Optics Express. 18, 4, p. 3649-3659 11 p.

Research output: Contribution to journalArticle

microscopy
fluorescence
microscopes
sensitivity
numerical aperture
23 Citations (Scopus)

Immunomagnetic reduction assay using high-Tc superconducting-quantum-interference-device-based magnetosusceptometry

Chieh, J. J., Yang, S. Y., Horng, H. E., Yu, C. Y., Lee, C. L., Wu, H-L., Hong, C. Y. & Yang, H. C., 2010 Apr 1, In : Journal of Applied Physics. 107, 7, 074903.

Research output: Contribution to journalArticle

interference
magnetic signals
sensitivity
markers
magnetometers
28 Citations (Scopus)

Inhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin

Shiau, A. L., Teo, M. L., Chen, S. Y., Wang, C. R., Hsieh, J. L., Chang, M. Y., Chang, C. J., Chao, J., Chao, L., Wu, C. L. & Lee, C. H., 2010 May 31, In : BMC cancer. 10, 245.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Lung
Neoplasms
Lentivirus
Cell Movement
40 Citations (Scopus)

Interleukin-20 antibody is a potential therapeutic agent for experimental arthritis

Hsu, Y. H. & Chang, M. S., 2010 Nov 1, In : Arthritis and Rheumatism. 62, 11, p. 3311-3321 11 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Antibodies
Arthritis
Therapeutics
Th17 Cells
51 Citations (Scopus)

Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis

Hsieh, J. L., Shen, P. C., Shiau, A. L., Jou, I. M., Lee, C. H., Wang, C. R., Teo, M. L. & Wu, C. L., 2010 Oct, In : Journal of Orthopaedic Research. 28, 10, p. 1300-1306 7 p.

Research output: Contribution to journalArticle

Thrombospondin 1
Osteoarthritis
Disease Progression
Genes
Synovial Membrane
40 Citations (Scopus)

Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis

Wang, C-R., Shiau, A-L., Chen, S. Y., Cheng, Z. S., Li, Y. T., Lee, C. H., Yo, Y. T., Lo, C. W., Lin, Y-S., Juan, H. Y., Chen, Y-L. & Wu, C-L., 2010 Oct 1, In : Gene Therapy. 17, 10, p. 1225-1233 9 p.

Research output: Contribution to journalArticle

Galectin 1
Galectin 3
Lentivirus
Experimental Arthritis
Small Interfering RNA
109 Citations (Scopus)

Intramyocardial peptide nanofiber injection improves postinfarction ventricular remodeling and efficacy of bone marrow cell therapy in pigs

Lin, Y. D., Yeh, M. L., Yang, Y. J., Tsai, D. C., Chu, T. Y., Shih, Y. Y., Chang, M. Y., Liu, Y. W., Tang, A. C. L., Chen, T. Y., Luo, C. Y., Chang, K. C., Chen, J. H., Wu, H. L., Hung, T. K. & Hsieh, P. C. H., 2010 Sep 14, In : Circulation. 122, 11 SUPPL. 1, p. S132-S141

Research output: Contribution to journalArticle

Nanofibers
Ventricular Remodeling
Cell- and Tissue-Based Therapy
Bone Marrow Cells
Swine
27 Citations (Scopus)

Loss of E-Cadherin and β-Catenin is correlated with poor prognosis of ampullary neoplasms

Hsu, H-P., Shan, Y-S., Jin, Y. T., Lai, M-D. & Lin, P. W., 2010 Apr 1, In : Journal of Surgical Oncology. 101, 5, p. 356-362 7 p.

Research output: Contribution to journalArticle

Catenins
Cadherins
Neoplasms
Recurrence
Staining and Labeling
15 Citations (Scopus)

Molecular mimicry between streptococcal pyrogenic exotoxin B and endothelial cells

Luo, Y. H., Chuang, W. J., Wu, J. J., Lin, M. T., Liu, C. C., Lin, P. Y., Roan, J. N., Wong, T. W., Chen, Y. L. & Lin, Y. S., 2010 Oct 1, In : Laboratory Investigation. 90, 10, p. 1492-1506 15 p.

Research output: Contribution to journalArticle

Molecular Mimicry
B-Lymphocytes
Endothelial Cells
Monoclonal Antibodies
Bovine Serum Albumin
17 Citations (Scopus)

Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival

Hsu, H-P., Shan, Y-S., Lai, M-D. & Lin, P. W., 2010 Jul 15, In : Cancer Biology and Therapy. 10, 2, p. 144-154 11 p.

Research output: Contribution to journalArticle

Osteopontin
Macrophages
Survival
Neoplasms
Macrophage Migration-Inhibitory Factors
20 Citations (Scopus)

Oxidative stress and metal ions regulate a ferritin-like gene, dpr, in Streptococcus pyogenes

Tsou, C. C., Chiang-Ni, C., Lin, Y. S., Chuang, W. J., Lin, M. T., Liu, C. C. & Wu, J. J., 2010 Apr 1, In : International Journal of Medical Microbiology. 300, 4, p. 259-264 6 p.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Peroxides
Ferritins
Hydrogen Peroxide
Oxidative Stress
48 Citations (Scopus)
STAT3 Transcription Factor
Transcriptional Activation
Molecular Biology
Interleukin-6
Up-Regulation
15 Citations (Scopus)

Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells

Feng, Y. H., Tsao, C. J., Wu, C-L., Chang, J. G., Lu, P-J., Yeh, K. T., Shieh, G. S., Shiau, A-L. & Lee, J-C., 2010 Sep 1, In : Cancer Science. 101, 9, p. 2033-2038 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Colonic Neoplasms
HCT116 Cells
Proteins
HT29 Cells
21 Citations (Scopus)

Stimulation of ribosomal frameshifting by antisense LNA

Yu, C. H., Noteborn, M. H. M. & Olsthoorn, R. C. L., 2010 Dec 1, In : Nucleic acids research. 38, 22, p. 8277-8283 7 p.

Research output: Contribution to journalArticle

Ribosomal Frameshifting
Oligonucleotides
Acids
RNA
Antisense Oligonucleotides
16 Citations (Scopus)

Structures of human MST3 kinase in complex with adenine, ADP and Mn 2+

Ko, T. P., Jeng, W-Y., Liu, C. I., Lai, M-D., Wu, C. L., Chang, W. J., Shr, H. L., Lu, T. J. & Wang, A. H. J., 2010 Feb 17, In : Acta Crystallographica Section D: Biological Crystallography. 66, 2, p. 145-154 10 p.

Research output: Contribution to journalArticle

Adenine
Adenosine Diphosphate
Catalytic Domain
Phosphotransferases
Ligands
14 Citations (Scopus)

Study of cell-biosubstrate contacts via surface plasmon polariton phase microscopy

Su, Y. D., Chiu, K. C., Chang, N-S., Wu, H-L. & Chen, S. J., 2010 Sep 13, In : Optics Express. 18, 19, p. 20125-20135 11 p.

Research output: Contribution to journalArticle

polaritons
microscopy
cells
surface plasmon resonance
apoptosis
2 Citations (Scopus)

Study on mechanical properties of thrombomodulin-transfected cancer cells by atomic force microscopy

Lin, C. C., Yin, T. I., Lin, Y. D., Lin, T. I., Chen, Y. T., Lin, J. F., Wu, H. L. & Chang, H. C., 2010 Nov 15, In : Journal of Medical and Biological Engineering. 30, 5, p. 313-319 7 p.

Research output: Contribution to journalArticle

Atomic force microscopy
Glycoproteins
Cells
Mechanical properties
Cell adhesion
31 Citations (Scopus)
Nitric Oxide Synthase Type III
Lipopolysaccharides
Brain
Ischemia
Endothelial Cells
8 Citations (Scopus)

Thrombomodulin is upregulated in cardiomyocytes during cardiac hypertrophy and prevents the progression of contractile dysfunction

Li, Y. H., Chung, H. C., Luo, C. Y., Chao, T. H., Shyu, K. G., Shi, G. Y. & Wu, H. L., 2010 Dec 1, In : Journal of Cardiac Failure. 16, 12, p. 980-990 11 p.

Research output: Contribution to journalArticle

Thrombomodulin
Cardiomegaly
Cardiac Myocytes
Constriction
Left Ventricular Dysfunction
37 Citations (Scopus)

Toll-like receptor 4 signaling promotes tumor growth

Lee, C. H., Wu, C. L. & Shiau, A. L., 2010 Jan 1, In : Journal of Immunotherapy. 33, 1, p. 73-82 10 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Growth
Neoplasms
Macrophages
NF-kappa B
32 Citations (Scopus)

WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans

Chen, C. S., Bellier, A., Kao, C. Y., Yang, Y. L., Chen, H. D., Los, F. C. O. & Aroian, R. V., 2010 Mar 2, In : PloS one. 5, 3, e9494.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Modulators
toxins
insulin
Insulin
2009
33 Citations (Scopus)

Aberrant Prothymosin-alpha Expression in Human Bladder Cancer

Tsai, Y-S., Jou, Y. C., Lee, G. F., Chen, Y. C., Shiau, A-L., Tsai, H. T., Wu, C-L. & Tzai, T. S., 2009 Jan 1, In : Urology. 73, 1, p. 188-192 5 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Staining and Labeling
prothymosin alpha
Transitional Cell Carcinoma
Neoplasms
37 Citations (Scopus)

Adenovirus-mediated kallistatin gene transfer ameliorates disease progression in a rat model of osteoarthritis induced by anterior cruciate ligament transection

Hsieh, J. L., Shen, P. C., Shiau, A-L., Jou, I. M., Lee, C. H., Teo, M. L., Wang, C-R., Chao, J., Chao, L. & Wu, C-L., 2009 Feb 1, In : Human Gene Therapy. 20, 2, p. 147-158 12 p.

Research output: Contribution to journalArticle

Anterior Cruciate Ligament
Adenoviridae
Osteoarthritis
Disease Progression
Genes
7 Citations (Scopus)

Amelioration of experimental arthritis by a telomerase-dependent conditionally replicating adenovirus that targets synovial fibroblasts

Chen, S. Y., Shiau, A-L., Shieh, G. S., Su, C. H., Lee, C. H., Lee, H. L., Wang, C-R. & Wu, C-L., 2009 Nov 1, In : Arthritis and Rheumatism. 60, 11, p. 3290-3302 13 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Telomerase
Adenoviridae
Fibroblasts
Rheumatoid Arthritis
54 Citations (Scopus)

A novel cancer therapy by skin delivery of indoleamine 2,3-dioxygenase siRNA

Yen, M. C., Lin, C. C., Chen, Y. L., Huang, S. S., Yang, H. J., Chang, C. P., Lei, H. Y. & Lai, M. D., 2009 Jan 15, In : Clinical Cancer Research. 15, 2, p. 641-649 9 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Skin Neoplasms
Small Interfering RNA
Neoplasms
Therapeutics
100 Citations (Scopus)

Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells

Hsu, K-F., Wu, C-L., Huang, S. C., Wu, C. M., Hsiao, J-R., Yo, Y. T., Chen, Y-H., Shiau, A-L. & Chou, C-Y., 2009 May 16, In : Autophagy. 5, 4, p. 451-460 10 p.

Research output: Contribution to journalArticle

Cathepsin L
Autophagy
Uterine Cervical Neoplasms
Cell Death
Cathepsin B
12 Citations (Scopus)
Streptococcus pyogenes
Taiwan
Epidemiology
Scarlet Fever
Pharyngitis
27 Citations (Scopus)

Dextromethorphan reduces oxidative stress and inhibits atherosclerosis and neointima formation in mice

Liu, S. L., Li, Y. H., Shi, G. Y., Tang, S. H., Jiang, S. J., Huang, C. W., Liu, P. Y., Hong, J. S. & Wu, H. L., 2009 Apr 1, In : Cardiovascular Research. 82, 1, p. 161-169 9 p.

Research output: Contribution to journalArticle

Dextromethorphan
Neointima
Atherosclerosis
Oxidative Stress
Macrophages
118 Citations (Scopus)
Synaptotagmin I
Brain-Derived Neurotrophic Factor
Running
Learning
Neuronal Plasticity
8 Citations (Scopus)
Integrins
Mutation
Platelets
Platelet Aggregation
Hydrogen
14 Citations (Scopus)

emm1/sequence type 28 strains of group A streptococci that express covR at early stationary phase are associated with increased growth and earlier speB secretion

Chiang-Ni, C., Zheng, P. X., Ho, Y. R., Wu, H. M., Chuang, W. J., Lin, Y. S., Lin, M. T., Liu, C. C. & Wu, J. J., 2009 Oct 1, In : Journal of Clinical Microbiology. 47, 10, p. 3161-3169 9 p.

Research output: Contribution to journalArticle

Streptococcus
Growth
Necrotizing Fasciitis
Multilocus Sequence Typing
Streptococcus pyogenes
12 Citations (Scopus)

Enhancement of antitumor immune response by targeted interleukin-12 electrogene transfer through antiHER2 single-chain antibody in a murine bladder tumor model

Tsai, Y. S., Shiau, A. L., Chen, Y. F., Tsai, H. T., Lee, H. L., Tzai, T. S. & Wu, C. L., 2009 Aug 27, In : Vaccine. 27, 39, p. 5383-5392 10 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
interleukin-12
Interleukin-12
Urinary Bladder Neoplasms
immune response

Enhancement of vascular formation but not improvement of ventricular function of infarcted rat hearts by a high dose of adenovirus-carried VEGF transgene

Sung, R. J., Chen, S-H., Luo, C-Y., Wang, J-N., Wu, C-L., Chen, Y. H., Su, R. J., Li, H. J. & Tsai, M-L., 2009 Jan 1, In : Chinese Journal of Physiology. 52, SUPPL. 5, p. 384-394 11 p.

Research output: Contribution to journalArticle

Ventricular Function
Transgenes
Adenoviridae
Vascular Endothelial Growth Factor A
Blood Vessels
5 Citations (Scopus)

Epidemiology of and prenatal molecular distinction between invasive and colonizing group B streptococci in the Netherlands and Taiwan

Van Elzakker, E., Yahiaoui, R., Visser, C., Oostvogel, P., Muller, A., Ho, Y. R., Wu, J. J. & Van Belkum, A., 2009 Aug 1, In : European Journal of Clinical Microbiology and Infectious Diseases. 28, 8, p. 921-928 8 p.

Research output: Contribution to journalArticle

Genomic Islands
Streptococcus agalactiae
Molecular Epidemiology
Taiwan
Netherlands
6 Citations (Scopus)

Epitope analysis of the rat dipeptidyl peptidase IV monoclonal antibody 6A3 that blocks pericellular fibronectin-mediated cancer cell adhesion

Hung, T. T., Wu, J. Y., Liu, J. F. & Cheng, H-C., 2009 Nov 1, In : FEBS Journal. 276, 22, p. 6548-6559 12 p.

Research output: Contribution to journalArticle

Dipeptidyl Peptidase 4
Cell adhesion
Fibronectins
Cell Adhesion
Rats
24 Citations (Scopus)

Ets-1 mediates platelet-derived growth factor-BB-induced thrombomodulin expression in human vascular smooth muscle cells

Lo, I. C., Lin, T. M., Chou, L. H., Liu, S. L., Wu, L. W., Shi, G. Y., Wu, H. L. & Jiang, M. J., 2009 Mar 1, In : Cardiovascular Research. 81, 4, p. 771-779 9 p.

Research output: Contribution to journalArticle

Thrombomodulin
Vascular Smooth Muscle
Smooth Muscle Myocytes
Phosphatidylinositol 3-Kinase
Sirolimus
20 Citations (Scopus)

Exploitation of a microfluidic device capable of generating size-tunable droplets for gene delivery

Wu, H. W., Huang, Y. C., Wu, C. L. & Lee, G. B., 2009 Jan 1, In : Microfluidics and Nanofluidics. 7, 1, p. 45-56 12 p.

Research output: Contribution to journalArticle

microfluidic devices
exploitation
Microfluidics
genes
delivery
20 Citations (Scopus)

Humoral immune responses inhibit the antitumor activities mediated by salmonella enterica serovar choleraesuis

Lee, C. H., Wu, C-L., Chen, S. & Shiau, A-L., 2009 May 1, In : Journal of Immunotherapy. 32, 4, p. 376-388 13 p.

Research output: Contribution to journalArticle

Salmonella enterica
Humoral Immunity
Salmonella
Adaptive Immunity
Neoplasms
63 Citations (Scopus)

Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans

Bellier, A., Chen, C. S., Kao, C. Y., Cinar, H. N. & Aroian, R. V., 2009 Dec 1, In : PLoS pathogens. 5, 12, e1000689.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Up-Regulation
Hypoxia
Oxygen
Bacterial Toxins
18 Citations (Scopus)

Identification and characterization of the mitochondrial targeting sequence and mechanism in human citrate synthase

Cheng, T. L., Liao, C. C., Tsai, W. H., Lin, C. C., Yeh, C. W., Teng, C. F. & Chang, W. T., 2009 Aug 1, In : Journal of Cellular Biochemistry. 107, 5, p. 1002-1015 14 p.

Research output: Contribution to journalArticle

Citrate (si)-Synthase
Mitochondria
Genes
Threonine
Serine
45 Citations (Scopus)

IL-20 Is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke

Chen, W. Y. & Chang, M. S., 2009 Apr 15, In : Journal of Immunology. 182, 8, p. 5003-5012 10 p.

Research output: Contribution to journalArticle

Stroke
Glioblastoma
Hypoxia
interleukin 20
Up-Regulation
39 Citations (Scopus)

Late outgrowth endothelial cells derived from wharton jelly in human umbilical cord reduce neointimal formation after vascular injury: Involvement of pigment epithelium-derived factor

Wang, S. H., Lin, S. J., Chen, Y. H., Lin, F. Y., Shih, J. C., Wu, C. C., Wu, H. L. & Chen, Y. L., 2009 Jun 1, In : Arteriosclerosis, thrombosis, and vascular biology. 29, 6, p. 816-822 7 p.

Research output: Contribution to journalArticle

Wharton Jelly
Umbilical Cord
Vascular System Injuries
Endothelial Cells
Neointima
89 Citations (Scopus)
Glycyrrhiza
licorice
autophagy
Autophagy
prostatic neoplasms
2 Citations (Scopus)

Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition

Wei, C. C. & Chang, M. S., 2009 Jan 1, In : Genes and Immunity. 10, 3, p. 237-247 11 p.

Research output: Contribution to journalArticle

Calcium Oxalate
Epithelial Cells
Calcium
Kidney
Tumor Necrosis Factor-alpha
17 Citations (Scopus)

Multitarget therapy of malignant cancers by the head-to-tail tandem array multiple shRNAs expression system

Cheng, T. L., Teng, C. F., Tsai, W. H., Yeh, C. W., Wu, M. P., Hsu, H. C., Hung, C. F. & Chang, W. T., 2009 Jun 1, In : Cancer Gene Therapy. 16, 6, p. 516-531 16 p.

Research output: Contribution to journalArticle

Gene Targeting
Small Interfering RNA
Genes
Neoplasms
HEK293 Cells
26 Citations (Scopus)

Nestin serves as a prosurvival determinant that is linked to the cytoprotective effect of epidermal growth factor in rat vascular smooth muscle cells.

Huang, Y. L., Wu, C. M., Shi, G. Y., Wu, G. C. C., Lee, H., Jiang, M-J., Wu, H-L. & Yang, H. Y., 2009 Jan 1, In : Journal of biochemistry. 146, 3, p. 307-315 9 p.

Research output: Contribution to journalArticle

Nestin
Vascular Smooth Muscle
Epidermal Growth Factor
Smooth Muscle Myocytes
Muscle
56 Citations (Scopus)

Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells

Chuang, J. Y., Wu, C. H., Lai, M-D., Chang, W. C. & Hung, J-J., 2009 Nov 1, In : International Journal of Cancer. 125, 9, p. 2066-2076 11 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
Cell Line
Annexin A5
Product Packaging
17 Citations (Scopus)

Procaspase 8 and bax are up-regulated by distinct pathways in streptococcal pyrogenic exotoxin B-induced apoptosis

Chang, C. W., Tsai, W. H., Chuang, W. J., Lin, Y. S., Wu, J. J., Liu, C. C., Tsai, P. J. & Lin, M. T., 2009 Nov 27, In : Journal of Biological Chemistry. 284, 48, p. 33195-33205 11 p.

Research output: Contribution to journalArticle

Caspase 8
Small Interfering RNA
Phosphorylation
Apoptosis
Tyrosine
17 Citations (Scopus)

Prognostic Relevance of Prothymosin-α Expression in Human Upper Urinary Tract Transitional Cell Carcinoma

Jou, Y. C., Tung, C. L., Tsai, Y-S., Shen, C. H., Syue-Yi, C., Shiau, A-L., Tsai, H. T., Wu, C-L. & Tzai, T. S., 2009 Oct 1, In : Urology. 74, 4, p. 951-957 7 p.

Research output: Contribution to journalArticle

Transitional Cell Carcinoma
Urinary Tract
Confidence Intervals
Survival
3-hydroxyphenyltrimethylammonium
9 Citations (Scopus)

Recombinant zebrafish γ-glutamyl hydrolase exhibits properties and catalytic activities comparable with those of mammalian enzyme

Kao, T. T., Chang, W. N., Wu, H. L., Shi, G. Y. & Fu, T. N., 2009 Feb 1, In : Drug Metabolism and Disposition. 37, 2, p. 302-309 8 p.

Research output: Contribution to journalArticle

Hydrolases
Zebrafish
Enzymes
Folic Acid
Folic Acid Antagonists