Research Output 1973 2019

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2009
18 Citations (Scopus)

Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities

Su, W. C., Liu, W. L., Cheng, C. W., Chou, Y. B., Hung, K. H., Huang, W. H., Wu, C. L., Li, Y. T., Shiau, A. L. & Lai, M. Y., 2009 Sep 3, In : FEBS Letters. 583, 17, p. 2793-2798 6 p.

Research output: Contribution to journalArticle

Ribavirin
Sirolimus
Interferons
Gamma Subunit Interferon-Stimulated Gene Factor 3
Raptors
13 Citations (Scopus)

Solution structure and backbone dynamics of streptopain: Insight into diverse substrate specificity

Wang, C. C., Houng, H. C., Chen, C. L., Wang, P. J., Kuo, C. F., Lin, Y. S., Wu, J. J., Lin, M. T., Liu, C. C., Huang, W. & Chuang, W. J., 2009 Apr 17, In : Journal of Biological Chemistry. 284, 16, p. 10957-10967 11 p.

Research output: Contribution to journalArticle

streptopain
Substrate Specificity
Substrates
X-Rays
X rays
14 Citations (Scopus)

The effects of DNA formulation and administration route on cancer therapeutic efficacy with xenogenic EGFR DNA vaccine in a lung cancer animal model

Lai, M-D., Yen, M. C., Lin, C. M., Tu, C. F., Wang, C. C., Lin, P. S., Yang, H. J. & Lin, C. C., 2009 Jan 30, In : Genetic Vaccines and Therapy. 7, 2.

Research output: Contribution to journalArticle

DNA Vaccines
Epidermal Growth Factor Receptor
Lung Neoplasms
Animal Models
DNA
4 Citations (Scopus)

The IL-8 production by streptococcal pyrogenic exotoxin B

Chang, C. W., Wu, S. Y., Chuang, W-J., Lin, Y-S., Wu, S. Y., Liu, C-C., Tsai, P-J. & Lin, M. T., 2009 Nov 1, In : Experimental Biology and Medicine. 234, 11, p. 1316-1326 11 p.

Research output: Contribution to journalArticle

Caspase 8
Interleukin-8
Chemical activation
CD95 Antigens
Phosphorylation
30 Citations (Scopus)

Thrombin induces nestin expression via the transactivation of EGFR signalings in rat vascular smooth muscle cells

Huang, Y. L., Shi, G. Y., Lee, H., Jiang, M-J., Huang, B-M., Wu, H-L. & Yang, H. Y., 2009 Jun 1, In : Cellular Signalling. 21, 6, p. 954-968 15 p.

Research output: Contribution to journalArticle

Nestin
Vascular Smooth Muscle
Thrombin
Transcriptional Activation
Smooth Muscle Myocytes
18 Citations (Scopus)

Transthyretin-driven oncolytic adenovirus suppresses tumor growth in orthotopic and ascites models of hepatocellular carcinoma

Hsieh, J. L., Lee, C. H., Teo, M. L., Lin, Y. J., Huang, Y. S., Wu, C. L. & Shiau, A. L., 2009 Apr 30, In : Cancer Science. 100, 3, p. 537-545 9 p.

Research output: Contribution to journalArticle

Prealbumin
Ascites
Adenoviridae
Hepatocellular Carcinoma
Growth
34 Citations (Scopus)

α-Tocopheryl succinate and derivatives mediate the transcriptional repression of androgen receptor in prostate cancer cells by targeting the PP2A-JNK-Sp1-signaling axis

Huang, P. H., Wang, D., Chuang, H. C., Wei, S., Kulp, S. K. & Chen, C. S., 2009 Jul 15, In : Carcinogenesis. 30, 7, p. 1125-1131 7 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Androgen Receptors
Succinic Acid
Vitamin E
Prostatic Neoplasms
8 Citations (Scopus)

α-tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion

Wang, D., Chuang, H. C., Weng, S. C., Huang, P. H., Hsieh, H. Y., Kulp, S. K. & Chen, C. S., 2009 Sep 24, In : Journal of Medicinal Chemistry. 52, 18, p. 5642-5648 7 p.

Research output: Contribution to journalArticle

Succinic Acid
Cell Adhesion
Breast Neoplasms
Chromans
Pharmacology
2008
37 Citations (Scopus)

Amelioration of collagen-induced arthritis in rats by adenovirus-mediated PTEN gene transfer

Wang, C-R., Shiau, A-L., Chen, S. Y., Lin, L. L., Tai, M. H., Shieh, G. S., Lin, P. R., Yo, Y. T., Lee, C. H., Kuo, S. M., Liu, M-F., Jou, I. M., Yang, C-Y., Shen, P. C., Lee, H. L. & Wu, C-L., 2008 Jun 1, In : Arthritis and Rheumatism. 58, 6, p. 1650-1656 7 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Adenoviridae
Phosphatidylinositol 3-Kinase
Vascular Endothelial Growth Factor A
Genes
3 Citations (Scopus)

Angiostatin K1-3 induces E-selectin via AP1 and Ets1: A mediator for anti-angiogenic action of K1-3

Chen, Y. H., Huang, Y. H., Wu, H. L., Wu, M. P., Chang, W. T., Kuo, Y. Z., Lu, K. C. & Wu, L. W., 2008 Oct 24, In : Journal of Thrombosis and Haemostasis. 6, 11, p. 1953-1961 9 p.

Research output: Contribution to journalArticle

Angiostatins
E-Selectin
Caveolin 1
Messenger RNA
Angiogenesis Inhibitors
32 Citations (Scopus)

An iron-binding protein, Dpr, decreases hydrogen peroxide stress and protects Streptococcus pyogenes against multiple stresses

Tsou, C. C., Chiang-Ni, C., Lin, Y. S., Chuang, W. J., Lin, M. T., Liu, C. C. & Wu, J. J., 2008 Sep 1, In : Infection and Immunity. 76, 9, p. 4038-4045 8 p.

Research output: Contribution to journalArticle

Iron-Binding Proteins
Streptococcus pyogenes
Hydrogen Peroxide
Iron
Peroxides
53 Citations (Scopus)

A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells

Wei, S., Yang, H. C., Chuang, H. C., Yang, J., Kulp, S. K., Lu, P. J., Lai, M. D. & Chen, C. S., 2008 Sep 26, In : Journal of Biological Chemistry. 283, 39, p. 26759-26770 12 p.

Research output: Contribution to journalArticle

Thiazolidinediones
Cyclin D1
Cells
Degradation
Neoplasms
11 Citations (Scopus)

A novel transcript of mouse interleukin-20 receptor acts on glomerular mesangial cells as an aggravating factor in lupus nephritis

Wei, C. C. & Chang, M-S., 2008 Sep 5, In : Genes and Immunity. 9, 8, p. 668-679 12 p.

Research output: Contribution to journalArticle

Lupus Nephritis
Mesangial Cells
Inbred NZB Mouse
B-Lymphocytes
Spleen
16 Citations (Scopus)

Caspase-3 enhances lung metastasis and cell migration in a protease-independent mechanism through the ERK pathway

Cheng, Y. J., Lee, C. H., Lin, Y. P., Huang, J. Y., Su, C. C., Chang, W. T. & Yang, B. C., 2008 Sep 15, In : International Journal of Cancer. 123, 6, p. 1278-1285 8 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Caspase 3
Cell Movement
Peptide Hydrolases
Neoplasm Metastasis
126 Citations (Scopus)

Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway

Chen, C. L., Lin, C. F., Chang, W. T., Huang, W. C., Teng, C. F. & Lin, Y. S., 2008 Apr 15, In : Blood. 111, 8, p. 4365-4374 10 p.

Research output: Contribution to journalArticle

Thioredoxins
Ceramides
p38 Mitogen-Activated Protein Kinases
MAP Kinase Kinase Kinase 5
Chemical activation
25 Citations (Scopus)

Characterization and comparative studies of zebrafish and human recombinant dihydrofolate reductases - Inhibition by folic acid and polyphenols

Kao, T. T., Wang, K. C., Chang, W. N., Lin, C. Y., Chen, B. H., Wu, H. L., Shi, G. Y., Tsai, J. N. & Fu, T. F., 2008 Mar 1, In : Drug Metabolism and Disposition. 36, 3, p. 508-516 9 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Polyphenols
Zebrafish
Folic Acid
Folic Acid Antagonists
16 Citations (Scopus)

Conditionally replicating E1B-deleted adenovirus driven by the squamous cell carcinoma antigen 2 promoter for uterine cervical cancer therapy

Hsu, K. F., Wu, C. L., Huang, S. C., Hsieh, J. L., Huang, Y. S., Chen, Y. F., Shen, M. R., Chung, W. J., Chou, C. Y. & Shiau, A. L., 2008 Aug 18, In : Cancer Gene Therapy. 15, 8, p. 526-534 9 p.

Research output: Contribution to journalArticle

Adenoviridae
Uterine Cervical Neoplasms
Neoplasms
Therapeutics
SCID Mice
30 Citations (Scopus)

Degradation of complement 3 by streptococcal pyrogenic exotoxin B inhibits complement activation and neutrophil opsonophagocytosis

Kuo, C. F., Lin, Y. S., Chuang, W. J., Wu, J. J. & Tsao, N., 2008 Mar 1, In : Infection and Immunity. 76, 3, p. 1163-1169 7 p.

Research output: Contribution to journalArticle

Complement C3
Complement Activation
Neutrophils
Serum
Zymosan
21 Citations (Scopus)

Delivery of noncarrier naked DNA vaccine into the skin by supersonic flow induces a polarized T helper type 1 immune response to cancer

Lin, C. C., Yen, M. C., Lin, C. M., Huang, S. S., Yang, H. J., Chow, N. H. & Lai, M. D., 2008 Jun 1, In : Journal of Gene Medicine. 10, 6, p. 679-689 11 p.

Research output: Contribution to journalArticle

DNA Vaccines
Skin
Firearms
Neoplasms
DNA
17 Citations (Scopus)
Benzo(a)pyrene
Regulatory T-Lymphocytes
Immunity
Carcinoma
Lymphoid Tissue
17 Citations (Scopus)

Emergence of fluoroquinolone resistance in group B streptococcal isolates in Taiwan

Wu, H. M., Janapatla, R. P., Ho, Y. R., Hung, K. H., Wu, C. W., Yan, J. J. & Wu, J. J., 2008 May 1, In : Antimicrobial agents and chemotherapy. 52, 5, p. 1888-1890 3 p.

Research output: Contribution to journalArticle

Fluoroquinolones
Taiwan
Levofloxacin
Mutation
14 Citations (Scopus)

Epidermal growth factor up-regulates the expression of nestin through the Ras-Raf-ERK signaling axis in rat vascular smooth muscle cells

Huang, Y. L., Shi, G. Y., Jiang, M-J., Lee, H., Chou, Y. W., Wu, H-L. & Yang, H. Y., 2008 Dec 12, In : Biochemical and Biophysical Research Communications. 377, 2, p. 361-366 6 p.

Research output: Contribution to journalArticle

Nestin
Vascular Smooth Muscle
Epidermal Growth Factor
Smooth Muscle Myocytes
Muscle
42 Citations (Scopus)

Expression of Cry5B protein from Bacillus thuringiensis in plant roots confers resistance to root-knot nematode

Li, X. Q., Tan, A., Voegtline, M., Bekele, S., Chen, C-S. & Aroian, R. V., 2008 Oct 1, In : Biological Control. 47, 1, p. 97-102 6 p.

Research output: Contribution to journalArticle

crystal proteins
plant parasitic nematodes
root-knot nematodes
Bacillus thuringiensis
protein synthesis
5 Citations (Scopus)

Group A streptococcal infection caused by emm1 strains among children in southern Taiwan

Lin, H. C., Wang, S-M., Lin, Y. L., Lin, Y-S., Wu, J. J., Chuang, W-J., Lin, M. T. & Liu, C-C., 2008 Dec 1, In : European Journal of Clinical Microbiology and Infectious Diseases. 27, 12, p. 1253-1256 4 p.

Research output: Contribution to journalArticle

Streptococcal Infections
Streptococcus
Taiwan
Molecular Epidemiology
Erythromycin
40 Citations (Scopus)

IL-19 is involved in the pathogenesis of endotoxic shock

Hsing, C. H., Chiu, C. J., Chang, L. Y., Hsu, C. C. & Chang, M-S., 2008 Jan 1, In : Shock. 29, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

Septic Shock
Lung
Liver
Neutrophils
Epithelial Cells
32 Citations (Scopus)

IL-20 may contribute to the pathogenesis of human intervertebral disc herniation

Huang, K. Y., Lin, R. M., Chen, W. Y., Lee, C. L., Yan, J. J. & Chang, M. S., 2008 Sep 1, In : Spine. 33, 19, p. 2034-2040 7 p.

Research output: Contribution to journalArticle

Intervertebral Disc
Interleukin-1
Intervertebral Disc Displacement
Interleukin-6
Interleukin-8
170 Citations (Scopus)
Gold
Nanoparticles
Electrons
Neoplasms
Melanoma
19 Citations (Scopus)

Interleukin-20 induced cell death in renal epithelial cells and was associated with acute renal failure

Li, H. H., Hsu, Y. H., Wei, C. C., Lee, P. T., Chen, W. C. & Chang, M. S., 2008 Jul 1, In : Genes and Immunity. 9, 5, p. 395-404 10 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Cell Death
Epithelial Cells
Kidney
Transforming Growth Factors
19 Citations (Scopus)

Interleukin-20 targets renal cells and is associated with chronic kidney disease

Wei, C. C., Li, H. H., Hsu, Y-H., Hsing, C. H., Sung, J-M. & Chang, M-S., 2008 Sep 26, In : Biochemical and Biophysical Research Communications. 374, 3, p. 448-453 6 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Kidney
Rats
Epithelial Cells
Fibroblasts
30 Citations (Scopus)

Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis

Li, H. H., Cheng, H. H., Sun, K. H., Wei, C. C., Li, C. F., Chen, W. C., Wu, W. M. & Chang, M. S., 2008 Nov 1, In : Clinical Immunology. 129, 2, p. 277-285 9 p.

Research output: Contribution to journalArticle

Lupus Nephritis
Mesangial Cells
Systemic Lupus Erythematosus
Interleukin-10
Inbred NZB Mouse
23 Citations (Scopus)

In vitro benzyl alcohol cytotoxicity: Implications for intravitreal use of triamcinolone acetonide

Chang, Y-S., Wu, C-L., Tseng, S. H., Kuo, P. Y. & Tseng, S. Y., 2008 Jun 1, In : Experimental Eye Research. 86, 6, p. 942-950 9 p.

Research output: Contribution to journalArticle

Benzyl Alcohol
Triamcinolone Acetonide
Retinal Pigments
Epithelial Cells
Suspensions
116 Citations (Scopus)

Lectin-like domain of thrombomodulin binds to its specific ligand Lewis y antigen and neutralizes lipopolysaccharide-induced inflammatory response

Shi, C. S., Shi, G. Y., Hsiao, S. M., Kao, Y. C., Kuo, K. L., Chih-Yuan, M., Kuo, C. H., Chang, B. I., Chang, C. F., Lin, C. H., Wong, C. H. & Wu, H. L., 2008 Nov 1, In : Blood. 112, 9, p. 3661-3670 10 p.

Research output: Contribution to journalArticle

Thrombomodulin
Lectins
Lipopolysaccharides
Ligands
Antigens
26 Citations (Scopus)

Lysophosphatidic acid stimulates thrombomodulin lectin-like domain shedding in human endothelial cells

Wu, H. L., Lin, C. I., Huang, Y. L., Chen, P. S., Kuo, C. H., Chen, M. S., Wu, G. C. C., Shi, G. Y., Yang, H. Y. & Lee, H., 2008 Feb 29, In : Biochemical and Biophysical Research Communications. 367, 1, p. 162-168 7 p.

Research output: Contribution to journalArticle

Thrombomodulin
Endothelial cells
Lectins
Endothelial Cells
Endothelial Growth Factors
6 Citations (Scopus)

Mutation of human plasminogen kringle 1-5 enhances anti-angiogenic action via increased interaction with integrin αvβ3

Chang, P. C., Chang, Y. J., Wu, H-L., Chang, C. W., Lin, C. I., Wang, W. C. & Shi, G. Y., 2008 Apr 1, In : Thrombosis and Haemostasis. 99, 4, p. 729-738 10 p.

Research output: Contribution to journalArticle

Kringles
Integrins
Mutation
Endothelial Cells
Angiostatins
126 Citations (Scopus)

Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells

Chang, C. C., Shieh, G. S., Wu, P., Lin, C. C., Shiau, A. L. & Wu, C. L., 2008 Aug 1, In : Cancer Research. 68, 15, p. 6281-6291 11 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Matrix Metalloproteinases
Neoplasms
Fibroblast Growth Factor 4
Neoplasm Metastasis
23 Citations (Scopus)

Protein kinase Cε mediates polymeric fibronectin assembly on the surface of blood-borne rat breast cancer cells to promote pulmonary metastasis

Huang, L., Cheng, H-C., Isom, R., Chen, C. S., Levine, R. A. & Pauli, B. U., 2008 Mar 21, In : Journal of Biological Chemistry. 283, 12, p. 7616-7627 12 p.

Research output: Contribution to journalArticle

Fibronectins
Protein Kinase C
Rats
Blood
Cells
42 Citations (Scopus)

Salmonella choleraesuis as an anticancer agent in a syngeneic model of orthotopic hepatocellular carcinoma

Lee, C. H., Wu, C-L. & Shiau, A-L., 2008 Feb 15, In : International Journal of Cancer. 122, 4, p. 930-935 6 p.

Research output: Contribution to journalArticle

Salmonella
Antineoplastic Agents
Hepatocellular Carcinoma
Neoplasms
Interferons
4 Citations (Scopus)

Streptococcal pyrogenic exotoxin B cleaves human S-adenosylhomocysteine hydrolase and induces hypermethioninemia

Hsu, J. F., Chuang, W. J., Shiesh, S. C., Lin, Y. S., Liu, C. C., Wang, C. C., Fu, T. N., Tsai, J. H., Tsai, W. L., Huang, Y. J., Hsieh, Y. H., Wu, J. J., Lin, M. T. & Huang, W., 2008 Aug 1, In : Journal of Infectious Diseases. 198, 3, p. 367-374 8 p.

Research output: Contribution to journalArticle

Adenosylhomocysteinase
Cysteine Proteases
Impetigo
Myositis
Pharyngitis
14 Citations (Scopus)

Streptococcal pyrogenic exotoxin B-induced apoptosis in A549 cells is mediated through αvβ3 integrin and Fas

Tsai, W. H., Chang, C. W., Lin, Y. S., Chuang, W. J., Wu, J. J., Liu, C. C., Tsai, P. J. & Lin, M. T., 2008 Apr 1, In : Infection and Immunity. 76, 4, p. 1349-1357 9 p.

Research output: Contribution to journalArticle

Integrins
Apoptosis
Anti-Idiotypic Antibodies
A549 Cells
erythrogenic toxin
19 Citations (Scopus)

Subconjunctival mitomycin C before pterygium excision: An ultrastructural study

Chang, Y. S., Chen, W. C., Tseng, S. H., Sze, C. I. & Wu, C. L., 2008 May 1, In : Cornea. 27, 4, p. 471-475 5 p.

Research output: Contribution to journalArticle

Pterygium
Mitomycin
Injections
Recurrence
Elastic Tissue
18 Citations (Scopus)
p38 Mitogen-Activated Protein Kinases
Virus Replication
Hepatitis B virus
Antiviral Agents
Hepatocellular Carcinoma
8 Citations (Scopus)

The association of C (-260)→T polymorphism in CD14 promoter and Chlamydia pneumoniae infection in ischemic stroke patients

Lin, T. M., Chen, C-H., Wu, H-L., Wang, C. H., Chen, Y. L. & Eng, H. L., 2008 Oct 1, In : American Journal of Clinical Pathology. 130, 4, p. 595-601 7 p.

Research output: Contribution to journalArticle

Chlamydophila pneumoniae
Chlamydia Infections
Chaperonin 60
Stroke
Genotype
23 Citations (Scopus)

The distribution of interleukin-19 in healthy and neoplastic tissue

Hsing, C. H., Li, H. H., Hsu, Y. H., Ho, C. L., Chuang, S. S., Lan, K. M. & Chang, M. S., 2008 Nov 1, In : Cytokine. 44, 2, p. 221-228 8 p.

Research output: Contribution to journalArticle

Interleukins
Tissue
Squamous Cell Carcinoma
Tumors
Mouth
4 Citations (Scopus)

The opposing effects of lipopolysaccharide on the antitumor therapeutic efficacy of DNA vaccine

Lin, C. C., Yang, H. J., Tu, C. F. & Lai, M. D., 2008 Mar 1, In : DNA and Cell Biology. 27, 3, p. 151-157 7 p.

Research output: Contribution to journalArticle

DNA Vaccines
Lipopolysaccharides
Plasmids
Toll-Like Receptor 4
Therapeutics
11 Citations (Scopus)

The prevalence of erythromycin resistance in group B streptococcal isolates at a university hospital in Taiwan

Janapatla, R. P., Ho, Y. R., Yan, J. J., Wu, H. M. & Wu, J. J., 2008 Dec 1, In : Microbial Drug Resistance. 14, 4, p. 293-297 5 p.

Research output: Contribution to journalArticle

Erythromycin
Taiwan
Streptococcus agalactiae
Clindamycin
Streptogramin Group B
20 Citations (Scopus)
Streptococcus pyogenes
Streptococcus
Cytokines
Interleukin-18
Interleukin-12
8 Citations (Scopus)

The transcriptional terminator sequences downstream of the covR gene terminate covR/S operon transcription to generate covR monocistronic transcripts in Streptococcus pyogenes

Chiang-Ni, C., Tsou, C. C., Lin, Y. S., Chuang, W. J., Lin, M. T., Liu, C. C. & Wu, J. J., 2008 Dec 31, In : Gene. 427, 1-2, p. 99-103 5 p.

Research output: Contribution to journalArticle

Genetic Terminator Regions
Streptococcus pyogenes
Operon
RNA
Genes
51 Citations (Scopus)

Toll-like receptor 4 mediates an antitumor host response induced by Salmonella choleraesuis

Lee, C. H., Wu, C-L. & Shiau, A-L., 2008 Mar 15, In : Clinical Cancer Research. 14, 6, p. 1905-1912 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Inbred C3H Mouse
Salmonella
Neoplasms
Chemokine CXCL9
12 Citations (Scopus)

Treatment with dextromethorphan improves endothelial function, inflammation and oxidative stress in male heavy smokers

Liu, P. Y., Lin, C. C., Tsai, W. C., Li, Y. H., Lin, L. J., Shi, G. Y., Hong, J. S., Chen, J. H. & Wu, H. L., 2008 Sep 30, In : Journal of Thrombosis and Haemostasis. 6, 10, p. 1685-1692 8 p.

Research output: Contribution to journalArticle

Dextromethorphan
Oxidative Stress
Inflammation
Dilatation
Smoking
26 Citations (Scopus)

Tumor-selective replication of an oncolytic adenovirus carrying Oct-3/4 response elements in murine metastatic bladder cancer models

Wu, C. L., Shieh, G. S., Chang, C. C., Yo, Y. T., Su, C. H., Chang, M. Y., Huang, Y. H., Wu, P. & Shiau, A. L., 2008 Feb 15, In : Clinical Cancer Research. 14, 4, p. 1228-1238 11 p.

Research output: Contribution to journalArticle

Response Elements
Urinary Bladder Neoplasms
Adenoviridae
Neoplasms
Cell Line