Research Output 1973 2019

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2006
34 Citations (Scopus)

Low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model

Shieh, G. S., Shiau, A. L., Yo, Y. T., Lin, P. R., Chang, C. C., Tzai, T. S. & Wu, C. L., 2006 Oct 15, In : Cancer Research. 66, 20, p. 9957-9966 10 p.

Research output: Contribution to journalArticle

Cytosine Deaminase
Telomerase
Etoposide
Transgenes
Urinary Bladder Neoplasms
133 Citations (Scopus)

Neutrophils and macrophages promote angiogenesis in the early stage of endometriosis in a mouse model

Lin, Y. J., Lai, M-D., Lei, H. Y. & Wing, L. Y. C., 2006 Mar 1, In : Endocrinology. 147, 3, p. 1278-1286 9 p.

Research output: Contribution to journalArticle

Choristoma
Endometriosis
Neutrophils
Macrophages
Chemokine CXCL2
61 Citations (Scopus)

Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor

Tseng, P. H., Wang, Y. C., Weng, S. C., Weng, J. R., Chen, C. S., Brueggemeier, R. W., Shapiro, C. L., Chen, C. Y., Dunn, S. E., Pollak, M. & Chen, C. S., 2006 Nov 24, In : Molecular Pharmacology. 70, 5, p. 1534-1541 8 p.

Research output: Contribution to journalArticle

Celecoxib
1-Phosphatidylinositol 4-Kinase
Breast Neoplasms
IGF Type 1 Receptor
Cyclooxygenase 2
28 Citations (Scopus)

Peroxisome proliferator-activated receptor γ-independent repression of prostate-specific antigen expression by thiazolidinediones in prostate cancer cells

Yang, C. C., Ku, C. Y., Wei, S., Shiau, C. W., Chen, C-S., Pinzone, J. J., Ringel, M. D. & Chen, C. S., 2006 May 1, In : Molecular Pharmacology. 69, 5, p. 1564-1570 7 p.

Research output: Contribution to journalArticle

troglitazone
Thiazolidinediones
Peroxisome Proliferator-Activated Receptors
Prostate-Specific Antigen
Prostatic Neoplasms
38 Citations (Scopus)
Platelet Activating Factor
Exons
Myocardial Infarction
Genes
Coronary Artery Disease
11 Citations (Scopus)

Predicting the redox state and secondary structure of cysteine residues in proteins using NMR chemical shifts

Wang, C. C., Chen, J. H., Yin, S. H. & Chuang, W-J., 2006 Apr 1, In : Proteins: Structure, Function and Genetics. 63, 1, p. 219-226 8 p.

Research output: Contribution to journalArticle

Chemical shift
Oxidation-Reduction
Cysteine
Nuclear magnetic resonance
Proteins
30 Citations (Scopus)

Preparation of amino-acid-type selective isotope labeling of protein expressed in Pichia pastoris

Chen, C. Y., Cheng, C. H., Chen, Y. C., Lee, J. C., Chou, S. H., Huang, W. & Chuang, W. J., 2006 Jan 1, In : Proteins: Structure, Function and Genetics. 62, 1, p. 279-287 9 p.

Research output: Contribution to journalArticle

Isotope Labeling
Pichia
Isotopes
Labeling
Amino Acids
9 Citations (Scopus)

Promoter analysis of interleukin 19

Chen, P. J., Wei, C. C., Wang, C., Chen, F. W., Hsu, Y-H. & Chang, M-S., 2006 Jun 9, In : Biochemical and Biophysical Research Communications. 344, 3, p. 713-720 8 p.

Research output: Contribution to journalArticle

Interleukins
Interleukin-10
Luciferases
Genetic Promoter Regions
Transcription Factors
22 Citations (Scopus)

Streptococcal mitogenic exotoxin, SmeZ, is the most susceptible M1T1 streptococcal superantigen to degradation by the streptococcal cysteine protease, SpeB

Nooh, M. M., Aziz, R. K., Kotb, M., Eroshkin, A., Chuang, W. J., Proft, T. & Kansal, R., 2006 Nov 17, In : Journal of Biological Chemistry. 281, 46, p. 35281-35288 8 p.

Research output: Contribution to journalArticle

Exotoxins
Superantigens
Cysteine Proteases
Degradation
Streptococcus
11 Citations (Scopus)

Streptococcal pyrogenic exotoxin B causes mitochondria damage to polymorphonuclear cells preventing phagocytosis of Group A streptococcus

Chiang-Ni, C., Wang, C. H., Tsai, P. J., Chuang, W. J., Lin, Y. S., Lin, M. T., Liu, C. C. & Wu, J. J., 2006 Jun 1, In : Medical Microbiology and Immunology. 195, 2, p. 55-63 9 p.

Research output: Contribution to journalArticle

streptopain
Cytophagocytosis
Streptococcus
Mitochondria
Phagocytosis
36 Citations (Scopus)

Streptococcal pyrogenic exotoxin B cleaves properdin and inhibits complement-mediated opsonophagocytosis

Tsao, N., Tsai, W. H., Lin, Y. S., Chuang, W. J., Wang, C. H. & Kuo, C. F., 2006 Jan 20, In : Biochemical and Biophysical Research Communications. 339, 3, p. 779-784 6 p.

Research output: Contribution to journalArticle

Properdin
Serum
Bacteria
erythrogenic toxin
Alternative Complement Pathway
27 Citations (Scopus)

The association between rainfall rate and occurrence of an enterovirus epidemic due to a contaminated well

Jean, J. S., Guo, H. R., Chen, S. H., Liu, C. C., Chang, W. T., Yang, Y. J. & Huang, M. C., 2006 Dec 1, In : Journal of Applied Microbiology. 101, 6, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

Enterovirus
Groundwater
Enterovirus Infections
Logistic Models
Drinking Water
27 Citations (Scopus)

The putative chloride channel hCLCA2 has a single C-terminal transmembrane segment

Elble, R. C., Walia, V., Cheng, H-C., Connon, C. J., Mundhenk, L., Gruber, A. D. & Pauli, B. U., 2006 Oct 6, In : Journal of Biological Chemistry. 281, 40, p. 29448-29454 7 p.

Research output: Contribution to journalArticle

Chloride Channels
Cell membranes
Amino Acids
Endoplasmic Reticulum
Cell Membrane
23 Citations (Scopus)

Thrombomodulin plays an important role in arterial remodeling and neointima formation in mouse carotid ligation model

Li, Y. H., Liu, S. L., Shi, G. Y., Tseng, G. H., Liu, P. Y. & Wu, H. L., 2006 Jan 1, In : Thrombosis and Haemostasis. 95, 1, p. 128-133 6 p.

Research output: Contribution to journalArticle

Thrombomodulin
Neointima
Ligation
Protein C
Thrombin
29 Citations (Scopus)

Tissue microarray analysis of interleukin-20 expression

Hsing, C. H., Ho, C-L., Chang, L. Y., Lee, Y. L., Chuang, S. S. & Chang, M-S., 2006 Jul 1, In : Cytokine. 35, 1-2, p. 44-52 9 p.

Research output: Contribution to journalArticle

Tissue Array Analysis
Microarrays
Tissue
Cells
interleukin 20
20 Citations (Scopus)

Triamcinolone acetonide suspension toxicity to corneal endothelial cells

Chang, Y-S., Tseng, S. Y., Tseng, S. H., Wu, C-L. & Chen, M. F., 2006 Sep 1, In : Journal of Cataract and Refractive Surgery. 32, 9, p. 1549-1555 7 p.

Research output: Contribution to journalArticle

Triamcinolone Acetonide
Suspensions
Endothelial Cells
Benzyl Alcohol
Corneal Endothelial Cell Loss
101 Citations (Scopus)

Ultrasound stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt pathway in osteoblasts

Tang, C. H., Yang, R. S., Huang, T. H., Lu, D. Y., Chuang, W. J., Huang, T. F. & Fu, W. M., 2006 Jun 22, In : Molecular Pharmacology. 69, 6, p. 2047-2057 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Focal Adhesion Protein-Tyrosine Kinases
Cyclooxygenase 2
Osteoblasts
Osteogenesis
19 Citations (Scopus)

Urine prothymosin-alpha as novel tumor marker for detection and follow-up of bladder cancer

Tzai, T. S., Tsai, Y-S., Shiau, A-L., Wu, C-L., Shieh, G. S. & Tsai, H. T., 2006 Feb 1, In : Urology. 67, 2, p. 294-299 6 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
Urinary Bladder Neoplasms
Urine
Urinary Tract Infections
Neoplasms
2005
101 Citations (Scopus)

Aqueous dispersions of magnetite nanoparticles with NH3 + surfaces for magnetic manipulations of biomolecules and MRI contrast agents

Shieh, D-B., Cheng, F. Y., Su, C. H., Yeh, C-S., Wu, M. T., Wu, Y. N., Tsai, C. Y., Wu, C-L., Chen, D-H. & Chou, C-H., 2005 Dec 1, In : Biomaterials. 26, 34, p. 7183-7191 9 p.

Research output: Contribution to journalArticle

Magnetite Nanoparticles
Magnetite nanoparticles
Biomolecules
Dispersions
Nanoparticles
48 Citations (Scopus)

Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation

Lin, C. F., Chen, C. L., Chang, W. T., Jan, M. S., Hsu, L. J., Wu, R. H., Fang, Y. T., Tang, M. J., Chang, W. C. & Lin, Y. S., 2005 Jun 24, In : Journal of Biological Chemistry. 280, 25, p. 23758-23765 8 p.

Research output: Contribution to journalArticle

Caspase 2
Ceramides
Etoposide
Chemical activation
Apoptosis
548 Citations (Scopus)

Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical applications

Cheng, F. Y., Su, C. H., Yang, Y. S., Yeh, C. S., Tsai, C. Y., Wu, C. L., Wu, M. T. & Shieh, D. B., 2005 Mar 1, In : Biomaterials. 26, 7, p. 729-738 10 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Magnetite
Dispersions
Nanoparticles
Infrared spectrometers
30 Citations (Scopus)

Cordyceps sinensis mycelium protects mice from group A streptococcal infection

Kuo, C. F., Chen, C. C., Luo, Y. H., Huang, R. Y., Chuang, W. J., Sheu, C. C. & Lin, Y. S., 2005 Aug 1, In : Journal of Medical Microbiology. 54, 8, p. 795-802 8 p.

Research output: Contribution to journalArticle

Cordyceps
Streptococcal Infections
Mycelium
Streptococcus
Infection
80 Citations (Scopus)

Detection of IL-20 and its receptors on psoriatic skin

Wei, C. C., Chen, W. Y., Wang, Y. C., Chen, P. J., Lee, J. Y. Y., Wong, T. W., Chen, W. C., Wu, J. C., Chen, G. Y., Chang, M. S. & Lin, Y. C., 2005 Oct 1, In : Clinical Immunology. 117, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

Keratinocytes
Skin
CD8-Positive T-Lymphocytes
Dermatitis
Psoriasis
36 Citations (Scopus)

Effects of oligopeptide permease in group A streptococcal infection

Wang, C. H., Lin, C. Y., Luo, Y. H., Tsai, P-J., Lin, Y-S., Lin, M. T., Chuang, W-J., Liu, C-C. & Wu, J. J., 2005 May 1, In : Infection and Immunity. 73, 5, p. 2881-2890 10 p.

Research output: Contribution to journalArticle

Streptococcal Infections
Streptococcus
Operon
ATP-Binding Cassette Transporters
Membrane Transport Proteins
13 Citations (Scopus)

Enhancement of humoral and cellular immune responses by an oral Salmonella choleraesuis vaccine expressing porcine prothymosin α

Shiau, A-L., Chen, C. C., Yo, Y. T., Chu, C. Y., Wang, S. Y. & Wu, C-L., 2005 Dec 1, In : Vaccine. 23, 48-49, p. 5563-5571 9 p.

Research output: Contribution to journalArticle

Salmonella Vaccines
Salmonella enterica
Humoral Immunity
humoral immunity
Cellular Immunity
57 Citations (Scopus)

Evidence of human thrombomodulin domain as a novel angiogenic factor

Shi, C. S., Shi, G. Y., Chang, Y. S., Han, H. S., Kuo, C. H., Liu, C., Huang, H. C., Chang, Y. J., Chen, P. S. & Wu, H. L., 2005 Apr 5, In : Circulation. 111, 13, p. 1627-1636 10 p.

Research output: Contribution to journalArticle

Thrombomodulin
Angiogenesis Inducing Agents
Endothelial Cells
Human Umbilical Vein Endothelial Cells
Epidermal Growth Factor
23 Citations (Scopus)

Frequency and clinicopathologic correlates of ErbB1, ErbB2, and ErbB3 immunoreactivity in urothelial tumors of upper urinary tract

Tsai, Y. S., Tzai, T. S., Chow, N. H. & Wu, C. L., 2005 Dec 1, In : Urology. 66, 6, p. 1197-1202 6 p.

Research output: Contribution to journalArticle

Urinary Tract
Disease-Free Survival
Carcinoma
Survival
Disease Progression
100 Citations (Scopus)

Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes

Wang, H. C., Chang, W. T., Chang, W. W., Wu, H. C., Huang, W., Lei, H. Y., Lai, M. D., Fausto, N. & Su, I. J., 2005 Apr 1, In : Hepatology. 41, 4, p. 761-770 10 p.

Research output: Contribution to journalArticle

Cyclin A
Hepatitis B virus
Hepatocytes
Up-Regulation
Endoplasmic Reticulum Stress
10 Citations (Scopus)

HHR23A, a human homolog of Saccharomyces cerevisiae Rad23, regulates xeroderma pigmentosum C protein and is required for nucleotide excision repair

Hsieh, H. C., Hsieh, Y. H., Huang, Y. H., Shen, F. C., Tsai, H. N., Tsai, J. H., Lai, Y. T., Wang, Y. T., Chuang, W-J. & Huang, W-Y., 2005 Sep 16, In : Biochemical and Biophysical Research Communications. 335, 1, p. 181-187 7 p.

Research output: Contribution to journalArticle

Xeroderma Pigmentosum
Protein C
DNA Repair
Yeast
Saccharomyces cerevisiae
197 Citations (Scopus)

Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes

Chen, C. S., Weng, S. C., Tseng, P. H., Lin, H. P. & Chen, C. S., 2005 Dec 1, In : Journal of Biological Chemistry. 280, 46, p. 38879-38887 9 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Acetylation
Histone Deacetylase Inhibitors
Histone Deacetylases
Histones
39 Citations (Scopus)

IL-24 inhibits the growth of hepatoma cells in vivo

Chen, W. Y., Cheng, Y. T., Lei, H. Y., Chang, C. P., Wang, C. W. & Chang, M. S., 2005 Sep 1, In : Genes and Immunity. 6, 6, p. 493-499 7 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Growth
Electroporation
Neoplasms
Genes
18 Citations (Scopus)

Inhibition of adipogenesis by RGD-dependent disintegrin

Lin, Y. T., Tang, C. H., Chuang, W. J., Wang, S. M., Huang, T. F. & Fu, W. M., 2005 Nov 15, In : Biochemical Pharmacology. 70, 10, p. 1469-1478 10 p.

Research output: Contribution to journalArticle

Disintegrins
Adipogenesis
Adipocytes
Focal Adhesion Protein-Tyrosine Kinases
Adhesion
59 Citations (Scopus)

Inhibition of tumor formation by snake venom disintegrin

Yang, R. S., Tang, C. H., Chuang, W-J., Huang, T-H., Peng, H. C., Huang, T. F. & Fu, W. M., 2005 Jan 1, In : Toxicon. 45, 5, p. 661-669 9 p.

Research output: Contribution to journalArticle

Disintegrins
Snake Venoms
Tumors
Cells
Bone
74 Citations (Scopus)

Interleukin-19 upregulates keratinocyte growth factor and is associated with psoriasis

Li, H. H., Lin, Y. C., Chen, P. J., Hsiao, C. H., Lee, Y-Y., Chen, W. C., Tzung, T. Y., Wu, J. C. & Chang, M-S., 2005 Sep 1, In : British Journal of Dermatology. 153, 3, p. 591-595 5 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 7
Interleukins
Psoriasis
Up-Regulation
Keratinocytes
5 Citations (Scopus)

LrrA, a novel leucine-rich repeat protein involved in cytoskeleton remodeling, is required for multicellular morphogenesis in Dictyostelium discoideum

Liu, C. I., Cheng, T. L., Chen, S. Z., Huang, Y. C. & Chang, W. T., 2005 Sep 1, In : Developmental Biology. 285, 1, p. 238-251 14 p.

Research output: Contribution to journalArticle

Dictyostelium
Cytoskeleton
Morphogenesis
Actins
Fluorescence
24 Citations (Scopus)
Pulmonary Surfactant-Associated Protein D
Alveolar Epithelial Cells
Toll-Like Receptor 4
Mites
Alveolar Macrophages
9 Citations (Scopus)

Novel autoregulatory function of hepatitis B virus M protein on surface gene expression

Huang, T. J., Lu, C. C., Tsai, J. C., Yao, W. J., Lu, X., Lai, M. D., Liu, H. S. & Shiau, A. L., 2005 Jul 29, In : Journal of Biological Chemistry. 280, 30, p. 27742-27754 13 p.

Research output: Contribution to journalArticle

Viruses
Hepatitis B virus
Gene expression
Membrane Proteins
Gene Expression
20 Citations (Scopus)

Novel strategy for generation and titration of recombinant adeno-associated virus vectors

Shiau, A. L., Liu, P. S. & Wu, C. L., 2005 Jan 1, In : Journal of Virology. 79, 1, p. 193-201 9 p.

Research output: Contribution to journalArticle

Dependovirus
titration
viruses
Helper Viruses
Suid Herpesvirus 1
7 Citations (Scopus)
Caspase 9
Cisplatin
Transcriptional Activation
Apoptosis
Acetylation
79 Citations (Scopus)

Prophylactic adenovirus-mediated human kallistatin gene therapy suppresses rat arthritis by inhibiting angiogenesis and inflammation

Wang, C-R., Chen, S. Y., Wu, C-L., Liu, M-F., Jin, Y. T., Chao, L. & Chao, J., 2005 Apr 1, In : Arthritis and Rheumatism. 52, 4, p. 1319-1324 6 p.

Research output: Contribution to journalArticle

Human Adenoviruses
Genetic Therapy
Arthritis
Inflammation
Ankle Joint
32 Citations (Scopus)

Simple and efficient DNA vector-based RNAi systems in mammalian cells

Wu, M. T., Wu, R. H., Hung, C. F., Cheng, T. L., Tsai, W. H. & Chang, W. T., 2005 Apr 29, In : Biochemical and Biophysical Research Communications. 330, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

RNA Interference
Small Interfering RNA
Cells
DNA
Genes
10 Citations (Scopus)
Matrix Metalloproteinase 3
Smoking Cessation
Myocardial Infarction
Angiotensin-Converting Enzyme Inhibitors
Genes
68 Citations (Scopus)

Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors

Lu, Q., Wang, D. S., Chen, C-S., Hu, Y. D. & Chen, C. S., 2005 Aug 25, In : Journal of Medicinal Chemistry. 48, 17, p. 5530-5535 6 p.

Research output: Contribution to journalArticle

Phenylbutyrates
Histone Deacetylase Inhibitors
Histone Deacetylases
trichostatin A
Volatile Fatty Acids
78 Citations (Scopus)
Thrombospondin 1
Transgenes
Salmonella
Melanoma
Growth
56 Citations (Scopus)

Systemic administration of attenuated Salmonella choleraesuis in combination with cisplatin for cancer therapy

Lee, C. H., Wu, C-L., Tai, Y. S. & Shiau, A-L., 2005 May 1, In : Molecular Therapy. 11, 5, p. 707-716 10 p.

Research output: Contribution to journalArticle

Salmonella
Cisplatin
Neoplasms
Therapeutics
Hepatocellular Carcinoma
97 Citations (Scopus)

The novel targets for anti-angiogenesis of genistein on human cancer cells

Su, S. J., Yeh, T. M., Chuang, W. J., Ho, C. L., Chang, K. L., Cheng, H. L., Liu, H. S., Cheng, H. L., Hsu, P. Y. & Chow, N. H., 2005 Jan 15, In : Biochemical Pharmacology. 69, 2, p. 307-318 12 p.

Research output: Contribution to journalArticle

Isoflavones
Genistein
Angiogenesis Inhibitors
Cells
Angiostatins
21 Citations (Scopus)

Therapeutic inhibition of hepatitis B virus surface antigen expression by RNA interference

Cheng, T. L., Chang, W. W., Su, I. J., Lai, M-D., Huang, W-Y., Lei, H. Y. & Chang, W-T., 2005 Oct 28, In : Biochemical and Biophysical Research Communications. 336, 3, p. 820-830 11 p.

Research output: Contribution to journalArticle

Surface Antigens
Hepatitis B Surface Antigens
RNA Interference
Viruses
Hepatitis B virus
178 Citations (Scopus)

Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARγ

Shiau, C. W., Yang, C. C., Kulp, S. K., Chen, K. F., Chen, C. S., Huang, J. W. & Chen, C. S., 2005 Feb 15, In : Cancer Research. 65, 4, p. 1561-1569 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferators
troglitazone
Prostatic Neoplasms
Apoptosis
Aptitude
52 Citations (Scopus)

Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis

Jou, I. M., Shiau, A. L., Chen, S. Y., Wang, C. R., Shieh, D. B., Tsai, C. S. & Wu, C. L., 2005 Jan 1, In : Arthritis and Rheumatism. 52, 1, p. 339-344 6 p.

Research output: Contribution to journalArticle

Thrombospondin 1
Experimental Arthritis
Genes
Transforming Growth Factors
Therapeutics
8 Citations (Scopus)

Toll-like receptor 4 plays an anti-HBV role in a murine model of acute hepatitis B virus expression

Chang, W. W., Su, I. J., Lai, M-D., Chang, W-T., Huang, W-Y. & Lei, H. Y., 2005 Nov 14, In : World journal of gastroenterology. 11, 42, p. 6631-6637 7 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Hepatitis B virus
Inbred C3H Mouse
Nitric Oxide Synthase Type II
Hepatocytes