Department of Cell Biology and Anatomy

Research Output 1982 2019

2019

Acute and long-term treadmill running differentially induce c-Fos expression in region- and time-dependent manners in mouse brain

Tsai, S. F., Liu, Y. W. & Kuo, Y. M., 2019 Nov 1, In : Brain Structure and Function. 224, 8, p. 2677-2689 13 p.

Research output: Contribution to journalArticle

Running
Periaqueductal Gray
Brain
Lateral Hypothalamic Area
Motor Cortex
1 Citation (Scopus)

A hydrolyzed chicken extract CMI-168 enhances learning and memory in middle-aged mice

Tsai, S. F., Chang, C. Y., Yong, S. M., Lim, A. L., Nakao, Y., Chen, S. J. & Kuo, Y. M., 2019 Jan, In : Nutrients. 11, 1, 27.

Research output: Contribution to journalArticle

Open Access
middle-aged adults
chicken meat
Meat
Chickens
ingredients
1 Citation (Scopus)

A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism

Chou, P. Y., Lin, S. R., Lee, M. H., Schultz, L., Sze, C-I. & Chang, N-S., 2019 Jul 17, In : Cell Communication and Signaling. 17, 1, 76.

Research output: Contribution to journalArticle

Open Access
Brain
Agglomeration
Chemical activation
Apoptosis
Cell Movement

Arsenic compounds induce apoptosis through caspase pathway activation in MA-10 leydig tumor cells

Mu, Y. F., Chen, Y. H., Chang, M. M., Chen, Y. C. & Huang, B. M., 2019 Jan 1, In : Oncology Letters. 18, 1, p. 944-954 11 p.

Research output: Contribution to journalArticle

Leydig Cell Tumor
Arsenicals
Caspases
Testicular Neoplasms
Apoptosis

Aspirin enhances trophoblast invasion and represses soluble fms-like tyrosine kinase 1 production: a putative mechanism for preventing preeclampsia

Su, M. T., Wang, C. Y., Tsai, P. Y., Chen, T. Y., Tsai, H. L. & Kuo, P. L., 2019 Dec 1, In : Journal of hypertension. 37, 12, p. 2461-2469 9 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-1
Trophoblasts
Pre-Eclampsia
Aspirin
Metalloproteases

CCN1 triggers adaptive autophagy in cardiomyocytes to curb its apoptotic activities

Su, B. C., Hsu, P. L. & Mo, F. E., 2019 Jan 1, (Accepted/In press) In : Journal of Cell Communication and Signaling.

Research output: Contribution to journalArticle

Curbs
Autophagy
Cardiac Myocytes
Integrins
Acridine Orange
2 Citations (Scopus)

Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by downregulating p150 glued

Chen, T. Y., Lien, W-C., Cheng, H. L., Kuan, D-S., Sheu, S. Y. & Wang, C-Y., 2019 Jul 1, In : Journal of Cellular Physiology. 234, 7, p. 10445-10457 13 p.

Research output: Contribution to journalArticle

Chloroquine
Cell growth
Microtubules
Retina
Nucleation

Chronic exposure to high fat diet triggers myelin disruption and interleukin-33 upregulation in hypothalamus

Huang, H. T., Tsai, S. F., Wu, H. T., Huang, H. Y., Hsieh, H. H., Kuo, Y. M., Chen, P. S., Yang, C. S. & Tzeng, S. F., 2019 Jul 10, In : BMC Neuroscience. 20, 1, 33.

Research output: Contribution to journalArticle

Open Access
High Fat Diet
Myelin Sheath
Hypothalamus
Up-Regulation
Oligodendroglia

Cordycepin enhances radiosensitivity in oral squamous carcinoma cells by inducing autophagy and apoptosis through cell cycle arrest

Ho, S. Y., Wu, W. S., Lin, L. C., Wu, Y. H., Chiu, H. W., Yeh, Y. L., Huang, B. M. & Wang, Y. J., 2019 Nov 1, In : International journal of molecular sciences. 20, 21, 5366.

Research output: Contribution to journalArticle

Open Access
Radiation Tolerance
Autophagy
apoptosis
Cell death
radiation tolerance

Cordycepin-induced unfolded protein response-dependent cell death, and AKT/MAPK-mediated drug resistance in mouse testicular tumor cells

Chang, M. M., Pan, B. S., Wang, C-Y. & Huang, B-M., 2019 Jul 1, In : Cancer medicine. 8, 8, p. 3949-3964 16 p.

Research output: Contribution to journalArticle

Open Access
Unfolded Protein Response
Testicular Neoplasms
Drug Resistance
Cell Death
Apoptosis Regulatory Proteins

Editorial: WW Domain Proteins in Signaling, Cancer Growth, Neural Diseases, and Metabolic Disorders

Chang, N. S., Lin, R., Sze, C. I. & Aqeilan, R. I., 2019 Aug 2, In : Frontiers in Oncology. 9, 719.

Research output: Contribution to journalEditorial

Open Access
3 Citations (Scopus)

Elevated miR-200a and miR-141 inhibit endocrine gland-derived vascular endothelial growth factor expression and ciliogenesis in preeclampsia

Wang, C-Y., Tsai, P., Chen, T. Y., Tsai, H. L., Kuo, P-L. & Su, M-T., 2019 Jun 15, In : Journal of Physiology. 597, 12, p. 3069-3083 15 p.

Research output: Contribution to journalArticle

Endocrine-Gland-Derived Vascular Endothelial Growth Factor
Pre-Eclampsia
Cilia
Trophoblasts
Placenta

Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer’s Disease Model Cells

Ting, L. L., Lu, H. T., Yen, S. F., Ngo, T. H., Tu, F. Y., Tsai, I. S., Tsai, Y. H., Chang, F. Y., Li, X. J., Li, S., Lee, C. K., Kao, S. H., Kuo, Y. M. & Lin, Y. F., 2019 Nov 1, In : Molecular Neurobiology. 56, 11, p. 7572-7582 11 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Alzheimer Disease
Pathology
Amyloid
Protein C
Open Access
alpha-2-HS-Glycoprotein
diabetes mellitus
Gestational Diabetes
Cell growth
Medical problems
5 Citations (Scopus)
Fibroblast Growth Factor 9
Corpus Striatum
Huntington Disease
Oxidative stress
Oxidative Stress

Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells

Kuo, P-L., Tseng, J. Y., Chen, H. I., Wu, C. Y., Omar, H. A., Wang, C-Y., Cheng, H. Y., Hsu, C. C., Fu, T-F. & Teng, Y. N., 2019 Mar 1, In : Biochimie. 158, p. 1-9 9 p.

Research output: Contribution to journalArticle

Androgen Receptors
Estrogen Receptors
Genes
Dihydrotestosterone
Genetic Promoter Regions

Preventive hypothermia as a neuroprotective strategy for paclitaxel-induced peripheral neuropathy

Beh, S. T., Kuo, Y-M., Chang, W. S. W., Wilder-Smith, E., Tsao, C. H., Tsai, C. H., Chen, L. T. & Liao, L. D., 2019 Jul 1, In : Pain. 160, 7, p. 1505-1521 17 p.

Research output: Contribution to journalArticle

Peripheral Nervous System Diseases
Paclitaxel
Hypothermia
Induced Hypothermia
Drug Therapy

Primary culture of rat adrenocortical cells and assays of steroidogenic functions

Chen, Y. C. & Huang, B-M., 2019 Mar 1, In : Journal of Visualized Experiments. 2019, 145, e59016.

Research output: Contribution to journalArticle

Rats
Assays
Animals
Hormones
Physiology
1 Citation (Scopus)

Propofol may increase caspase and MAPK pathways, and suppress the Akt pathway to induce apoptosis in MA‑10 mouse Leydig tumor cells

Kang, F. C., Wang, S. C., So, E. C., Chang, M. M., Wong, K. L., Cheng, K. S., Chen, Y. C. & Huang, B. M., 2019 Jun 1, In : Oncology Reports. 41, 6, p. 3565-3574 10 p.

Research output: Contribution to journalArticle

Leydig Cell Tumor
Propofol
Caspases
Mitogen-Activated Protein Kinases
Apoptosis

Regeneration of rete ridges in Lanyu pig (Sus scrofa): Insights for human skin wound healing

Lin, C. H., Chiu, P. Y., Hsueh, Y-Y., Shieh, S-J., Wu, C-C., Wong, T-W., Chuong, C. M. & Hughes, M. W., 2019 Apr 1, In : Experimental Dermatology. 28, 4, p. 472-479 8 p.

Research output: Contribution to journalArticle

Sus scrofa
Proliferating Cell Nuclear Antigen
Wound Healing
Alkaline Phosphatase
Regeneration
1 Citation (Scopus)

Regulation of septin phosphorylation: SEPT12 phosphorylation in sperm septin assembly

Lin, C. H., Shen, Y. R., Wang, H. Y., Chiang, C-W., Wang, C-Y. & Kuo, P-L., 2019 Jan 1, In : Cytoskeleton. 76, 1, p. 137-142 6 p.

Research output: Contribution to journalReview article

Septins
Spermatozoa
Phosphorylation
Sumoylation
Sperm Motility

Shear-Induced CCN1 Promotes Atheroprone Endothelial Phenotypes and Atherosclerosis

Hsu, P., Chen, J., Wang, C., Wu, H. & Mo, F-E., 2019 Jun 18, In : Circulation. 139, 25, p. 2877-2891

Research output: Contribution to journalArticle

3 Citations (Scopus)

Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment

Chou, P. Y., Lai, F. J., Chen, Y. A., Sie, Y. D., Kuo, H. L., Su, W. P., Wu, C. Y., Liu, T. Y., Wen, K. Y., Hsu, L-J., Sze, C-I. & Chang, N-S., 2019 Dec 1, In : Cell Death Discovery. 5, 1, 97.

Research output: Contribution to journalArticle

Open Access
Neoplasms
Cellular Microenvironment
Hyaluronoglucosaminidase
Growth
Neoplasm Metastasis

The Role of Methylated Circulating Nucleic Acids as a Potential Biomarker in Alzheimer’s Disease

Pai, M-C., Kuo, Y-M., Wang, I. F., Chiang, P-M. & Tsai, K-J., 2019 Apr 1, In : Molecular Neurobiology. 56, 4, p. 2440-2449 10 p.

Research output: Contribution to journalArticle

Nucleic Acids
Alzheimer Disease
Biomarkers
Amyloid
Relapsing-Remitting Multiple Sclerosis

Topically Applied Cross-Linked Hyaluronan Attenuates the Formation of Spinal Epidural Fibrosis in a Swine Model of Laminectomy

Lin, C. L., Jou, I. M., Wu, C. Y., Kuo, Y. R., Yang, S. C., Lee, J. S., Tu, Y. K., Chen, S. C. & Huang, Y. H., 2019 Dec 1, In : Scientific reports. 9, 1, 14613.

Research output: Contribution to journalArticle

Open Access
Laminectomy
Hyaluronic Acid
Fibrosis
Swine
Cicatrix

Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma

Chen, M., Yang, M. H., Chang, M-M., Tyan, Y. C. & Chen, Y. M. A., 2019 Sep 1, In : Toxicology and Applied Pharmacology. 378, 114607.

Research output: Contribution to journalReview article

Glycine N-Methyltransferase
Tumor Suppressor Genes
Liver
Tumors
Hepatocellular Carcinoma
2018
2 Citations (Scopus)

16-Hydroxycleroda-3,13-dien-15,16-olide induces anoikis in human renal cell carcinoma cells: Involvement of focal adhesion disassembly and signaling

Chen, Y. C., Huang, B-M., Lee, W. C. & Chen, Y. C., 2018 Jan 1, In : OncoTargets and Therapy. 11, p. 7679-7690 12 p.

Research output: Contribution to journalArticle

Anoikis
Focal Adhesions
Renal Cell Carcinoma
Paxillin
Vinculin
2 Citations (Scopus)

7-hydroxy-staurosporine, UCN-01, induces DNA damage response, and autophagy in human osteosarcoma U2-OS cells

Lien, W-C., Chen, T. Y., Sheu, S. Y., Lin, T. C., Kang, F. C., Yu, C. H., Kuan, D-S., Huang, B-M. & Wang, C-Y., 2018 Jun 1, In : Journal of Cellular Biochemistry. 119, 6, p. 4729-4741 13 p.

Research output: Contribution to journalArticle

Autophagy
Osteosarcoma
DNA Damage
DNA
Ataxia Telangiectasia
6 Citations (Scopus)

Bioadhesive Polymersome for Localized and Sustained Drug Delivery at Pathological Sites with Harsh Enzymatic and Fluidic Environment via Supramolecular Host–Guest Complexation

Zhu, M., Wei, K., Lin, S., Chen, X., Wu, C-C., Li, G. & Bian, L., 2018 Feb 15, In : Small. 14, 7, 1702288.

Research output: Contribution to journalArticle

Polycaprolactone
Cyclodextrins
Fluidics
Complexation
Drug delivery
5 Citations (Scopus)

Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation

Wu, Y. H., Wu, W. S., Lin, L. C., Liu, C. S., Ho, S. Y., Wang, B. J., Huang, B. M., Yeh, Y. L., Chiu, H. W., Yang, W. L. & Wang, Y. J., 2018 Apr 27, In : Journal of Experimental and Clinical Cancer Research. 37, 1, 91.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Mouth Neoplasms
Radiation Tolerance
Oncogene Proteins
Autophagy
10 Citations (Scopus)

Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation in Keloid Fibroblasts

Hsu, C. K., Lin, H. H., Harn, H. I., Ogawa, R., Wang, Y. K., Ho, Y. T., Chen, W. R., Lee, Y. C., Lee, J. Y. Y., Shieh, S. J., Cheng, C. M., McGrath, J. A. & Tang, M. J., 2018 Jan, In : Journal of Investigative Dermatology. 138, 1, p. 208-218 11 p.

Research output: Contribution to journalArticle

Caveolin 1
Keloid
Fibroblasts
Chemical activation
trichostatin A
5 Citations (Scopus)

Coincidence Detection of Membrane Stretch and Extracellular pH by the Proton-Sensing Receptor OGR1 (GPR68)

Wei, W. C., Bianchi, F., Wang, Y. K., Tang, M. J., Ye, H. & Glitsch, M. D., 2018 Dec 3, In : Current Biology. 28, 23, p. 3815-3823.e4

Research output: Contribution to journalArticle

protons
Protons
Membranes
receptors
Acidification

Comparison of Calcium Balancing Strategies During Hypothermic Acclimation of Tilapia (Oreochromis mossambicus) and Goldfish (Carassius auratus)

Han, T., Wu, C., Tsai, H., Cheng, Y., Chen, W., Lin, T., Wang, C., Lee, J., Hwang, P. & Lu, F., 2018, In : Frontiers in Physiology. 9

Research output: Contribution to journalArticle

8 Citations (Scopus)

FGF9/FGFR2 increase cell proliferation by activating ERK1/2, Rb/E2F1, and cell cycle pathways in mouse Leydig tumor cells

Chang, M. M., Lai, M. S., Hong, S. Y., Pan, B. S., Huang, H., Yang, S. H., Wu, C. C., Sun, H. S., Chuang, J. I., Wang, C. Y. & Huang, B. M., 2018 Nov 1, In : Cancer Science. 109, 11, p. 3503-3518 16 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Leydig Cell Tumor
Fibroblast Growth Factor Receptors
Retinoblastoma
Fibroblast Growth Factor 2
3 Citations (Scopus)

Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington's Disease

Yusuf, I. O., Cheng, P. H., Chen, H. M., Chang, Y. F., Chang, C. Y., Yang, H. I., Lin, C. W., Tsai, S. J., Chuang, J. I., Wu, C. C., Huang, B. M., Sun, H. S. & Yang, S. H., 2018 Aug 1, In : Cellular Physiology and Biochemistry. 48, 2, p. 605-617 13 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Corpus Striatum
Huntington Disease
Cell Death
MAP Kinase Signaling System
1 Citation (Scopus)
Ganoderma
Reishi
Oxidative stress
Ligation
Oxidative Stress
1 Citation (Scopus)

Glioblastoma cells labeled by robust Raman tags for enhancing imaging contrast

Huang, L. C., Chang, Y. C., Wu, Y. S., Sun, W. L., Liu, C. C., Sze, C. I. & Chen, S. Y., 2018 May 1, In : Biomedical Optics Express. 9, 5, p. 2142-2153 12 p., #320430.

Research output: Contribution to journalArticle

Glioblastoma
cells
Computer-Assisted Surgery
surgery
marking
4 Citations (Scopus)

Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes

Chang, M. M., Lin, C. N., Fang, C. C., Chen, M., Liang, P. I., Li, W. M., Yeh, B. W., Cheng, H. C., Huang, B. M., Wu, W. J. & Chen, Y. M. A., 2018 Dec 1, In : Scientific reports. 8, 1, 6960.

Research output: Contribution to journalArticle

Glycine N-Methyltransferase
Hepatocytes
Aristolochic Acids
Liver
aristolochic acid I
3 Citations (Scopus)
Amino Acid Transport System X-AG
High Fat Diet
Neuroglia
Lactic Acid
Hippocampus
6 Citations (Scopus)

High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice

Tsai, S. F., Wu, H. T., Chen, P. C., Chen, Y. W., Yu, M., Wang, T. F., Wu, S. Y., Tzeng, S. F. & Kuo, Y. M., 2018 Dec 1, In : Brain Research. 1700, p. 66-77 12 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
High Fat Diet
Neuronal Plasticity
Neuroglia
Hippocampus
6 Citations (Scopus)

Hypertension accelerates Alzheimer's disease-related pathologies in pigs and 3xTg mice

Shih, Y. H., Wu, S. Y., Yu, M., Huang, S. H., Lee, C. W., Jiang, M-J., Lin, P-Y., Yang, T. T. & Kuo, Y-M., 2018 Mar 20, In : Frontiers in Aging Neuroscience. 10, MAR, 73.

Research output: Contribution to journalArticle

Alzheimer Disease
Swine
Pathology
Hypertension
Serum Amyloid A Protein
3 Citations (Scopus)

Hypoxia-Preconditioned Human Umbilical Vein Endothelial Cells Protect Against Neurovascular Damage After Hypoxic Ischemia in Neonatal Brain

Lee, Y. C., Chang, Y. C., Wu, C-C. & Huang, C-C., 2018 Oct 1, In : Molecular Neurobiology. 55, 10, p. 7743-7757 15 p.

Research output: Contribution to journalArticle

Human Umbilical Vein Endothelial Cells
Ischemia
Brain
Hypoxia
Genes
6 Citations (Scopus)

Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration

Jheng, G. W., Hur, S. S., Chang, C. M., Wu, C. C., Cheng, J. S., Lee, H. H., Chung, B. C., Wang, Y. K., Lin, K. H., del Álamo, J. C., Chien, S. & Tsai, J. W., 2018 Mar 11, In : Biochemical and Biophysical Research Communications. 497, 3, p. 869-875 7 p.

Research output: Contribution to journalArticle

Traction
Cell Movement
Adhesion
Cell adhesion
Fibroblasts
9 Citations (Scopus)

Long-Term Moderate Exercise Rescues Age-Related Decline in Hippocampal Neuronal Complexity and Memory

Tsai, S. F., Ku, N. W., Wang, T. F., Yang, Y. H., Shih, Y. H., Wu, S. Y., Lee, C. W., Yu, M., Yang, T. T. & Kuo, Y. M., 2018 Oct 1, In : Gerontology. 64, 6, p. 551-561 11 p.

Research output: Contribution to journalArticle

Exercise
Neuronal Plasticity
Running
Hippocampus
Long-Term Potentiation
3 Citations (Scopus)

LRWD1 Regulates Microtubule Nucleation and Proper Cell Cycle Progression in the Human Testicular Embryonic Carcinoma Cells

Wang, C-Y., Hong, Y. H., Syu, J. S., Tsai, Y. C., Liu, X. Y., Chen, T. Y., Su, Y. M., Kuo, P-L., Lin, Y. & Teng, Y. N., 2018 Jan 1, In : Journal of Cellular Biochemistry. 119, 1, p. 314-326 13 p.

Research output: Contribution to journalArticle

Microtubules
Cell Cycle
Nucleation
Centrosome
Cells
2 Citations (Scopus)

Midazolam activates caspase, MAPKs and endoplasmic reticulum stress pathways, and inhibits cell cycle and akt pathway, to induce apoptosis in TM3 mouse Leydig progenitor cells

Kang, F. C., Wang, S. C., Chang, M. M., Pan, B. S., Wong, K. L., Cheng, K. S., So, E. C. & Huang, B. M., 2018 Mar 15, In : OncoTargets and Therapy. 11, p. 1475-1490 16 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Leydig Cells
Midazolam
Caspases
Cell Cycle

Midazolam inhibits chondrogenesis via peripheral benzodiazepine receptor in human mesenchymal stem cells

Chen, Y. C., Wu, K. C., Huang, B. M., So, E. C. & Wang, Y. K., 2018 May, In : Journal of Cellular and Molecular Medicine. 22, 5, p. 2896-2907 12 p.

Research output: Contribution to journalArticle

Chondrogenesis
Midazolam
GABA-A Receptors
Mesenchymal Stromal Cells
Osteogenesis
2 Citations (Scopus)

Quantitative evaluation of different far lateral approaches to the cranio-vertebral junction using the microscope and the endoscope: a cadaveric study using a tumor model

Wu, P., Colasanti, R., Lee, J-S., Scerrati, A., Ercan, S., Zhang, J. & Ammirati, M., 2018 Apr 1, In : Acta Neurochirurgica. 160, 4, p. 695-705 11 p.

Research output: Contribution to journalArticle

Endoscopes
Neoplasms
Skull Base
Neuronavigation
Head

Robust and brilliant Raman tags based on core-satellite assemblies for brain tumor cell imaging

Chang, Y. C., Huang, L. C., Sun, W. L., Chuang, S. Y., Lin, T. H., Wu, Y. S., Sze, C-I. & Chen, S-Y., 2018 Jan 1, Biomedical Vibrational Spectroscopy 2018: Advances in Research and Industry. Mahadevan-Jansen, A. & Petrich, W. (eds.). SPIE, 1049006. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10490).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fluorophores
Glioblastoma
Brain Neoplasms
Surgery
Labeling