Department of Internal Medicine

Research Output 1987 2019

2019
3 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J-Y. & Liou, J. P., 2019 Jan 15, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
3 Citations (Scopus)

A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan: prevalence, determinants, and impact on quality of life

Chou, W. C., Chen, J. S., Hung, C. Y., Lu, C. H., Shao, Y. Y., Chiou, T. J., Sung, Y. C., Rau, K. M., Yen, C-J., Yeh, S. P., Liu, T. C., Wu, M. F., Lee, M. Y., Yu, M. S., Hwang, W. L., Lai, P. Y., Chang, C. S. & Hsieh, R. K., 2019 Aug 1, In : Supportive Care in Cancer. 27, 8, p. 2857-2867 11 p.

Research output: Contribution to journalArticle

Taiwan
Analgesics
Quality of Life
Neoplasms
Pain
Open Access
Klebsiella pneumoniae
Taiwan
Pseudomonas aeruginosa
Intensive Care Units
Imipenem

A performance guide for major risk factors control in patients with atherosclerotic cardiovascular disease in Taiwan

Li, Y-H., Chen, J. W., Lin, T. H., Wang, Y. C., Wu, C. C., Yeh, H. I., Huang, C. C., Chang, K. C., Wu, C. K., Chen, P-W., Huang, C-W., Chen, Z. C., Chang, W. T., Huang, W. C., Wang, C. Y., Lee, M. Y., Chao, A. C., Fu, W. R., Tsai, L. K., Tang, S. C. & 5 others, Chan, H. L., Yang, Y-C., Wu, Y. W., Hwang, J. J. & Lin, J. L., 2019 Jan 1, In : Journal of the Formosan Medical Association.

Research output: Contribution to journalReview article

Open Access
Taiwan
Cardiovascular Diseases
Cerebrovascular Disorders
Peripheral Arterial Disease
Hypercholesterolemia

A phase 1, open-label, dose-escalation trial of oral TSR-011 in patients with advanced solid tumours and lymphomas

Lin, C. C., Arkenau, H. T., Lu, S., Sachdev, J., de Castro Carpeño, J., Mita, M., Dziadziuszko, R., Su, W-C., Bobilev, D., Hughes, L., Chan, J., Zhang, Z. Y. & Weiss, G. J., 2019 Jul 16, In : British Journal of Cancer. 121, 2, p. 131-138 8 p.

Research output: Contribution to journalArticle

Open Access
Lymphoma
Neoplasms
Safety
Non-Small Cell Lung Carcinoma
Maximum Tolerated Dose

A subanalysis of Taiwanese patients from ODYSSEY South Korea and Taiwan study evaluating the efficacy and safety of alirocumab

Chao, T-H., Hsiao, P. J., Liu, M. E., Wu, C. J., Chiang, F. T., Chen, Z. C., Chen, C. P., Yeh, H. I., Lee, T. H. & Chiang, C. E., 2019 Jan 1, In : Journal of the Chinese Medical Association. 82, 4, p. 265-271 7 p.

Research output: Contribution to journalArticle

Republic of Korea
Taiwan
LDL Cholesterol
Safety
Placebos
Vascular Stiffness
Antiviral Agents
Fibrosis
Chronic Hepatitis C
Blood Pressure
Dengue
Infection
Therapeutics
Anti-Bacterial Agents
Levofloxacin

Bortezomib therapy in a real-world setting in patients with relapsed or refractory multiple myeloma

Huang, S. Y., Chen, T-Y., Kuo, C. Y., Chen, Y. C., Lin, S. F., Chang, M. C., Lv, X., Yang, B. & Chang, C. S., 2019 Jan 14, In : Oncology Reviews. 13, 1, p. 15-22 8 p.

Research output: Contribution to journalReview article

Open Access
Multiple Myeloma
Therapeutics
Bortezomib
Safety
Proteasome Inhibitors

Brain MRI imaging characteristics predict treatment response and outcome in patients with de novo brain metastasis of EGFR-mutated NSCLC

Lin, C. Y., Chang, C-C., Su, P. L., Lin, C-C., Tseng, Y-L., Su, W. C., Yen, Y-T. & Patel, G., 2019 Aug 1, In : Medicine (United States). 98, 33, e16766.

Research output: Contribution to journalArticle

Open Access
Neuroimaging
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Disease-Free Survival
Epidermal Growth Factor Receptor
1 Citation (Scopus)

Changing practice pattern of acute coronary syndromes in Taiwan from 2008 to 2015

Li, Y-H., Chiu, Y. W., Cheng, J. J., Hsieh, I. C., Lo, P. H., Lei, M. H., Ueng, K. C., Chiang, F. T., Sung, S. H., Kuo, J. Y., Chen, C. P., Lai, W. T., Lee, W. L. & Chen, J. H., 2019 Jan 1, In : Acta Cardiologica Sinica. 35, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Acute Coronary Syndrome
Taiwan
Registries
Percutaneous Coronary Intervention
Drug-Eluting Stents
3 Citations (Scopus)

Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity

Chang, K., Lee, N-Y., Ko, W-C., Lin, W. R., Chen, Y. H., Tsai, J. J., Chen, T. C., Lin, C. Y., Chang, Y. T. & Lu, P. L., 2019 Feb 1, In : Journal of Microbiology, Immunology and Infection. 52, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

Endemic Flea-Borne Typhus
Scrub Typhus
Q Fever
Prothrombin Time
Multivariate Analysis

Clinical Benefit of Empiric High-dose Levofloxacin Therapy for Adults With Community-onset Enterobacteriaceae Bacteremia

Lee, C. C., Yang, C-Y., Lee, C. H., Hsieh, C-C., Hong, M-Y., Tang, H. J. & Ko, W-C., 2019 Jan 1, (Accepted/In press) In : Clinical Therapeutics.

Research output: Contribution to journalArticle

Levofloxacin
Enterobacteriaceae
Bacteremia
Mortality
Therapeutics
4 Citations (Scopus)

Clinical manifestations of candidemia caused by uncommon Candida species and antifungal susceptibility of the isolates in a regional hospital in Taiwan, 2007–2014

Liu, W. L., Lai, C. C., Li, M-C., Wu, C. J., Ko, W-C., Hung, Y. L., Tang, H. J. & Hsueh, P. R., 2019 Aug 1, In : Journal of Microbiology, Immunology and Infection. 52, 4, p. 612-619 8 p.

Research output: Contribution to journalArticle

Candidemia
Taiwan
Candida
Azoles
Microbial Sensitivity Tests
Propensity Score
Hepatocellular Carcinoma
Survival
Liver
Liver Neoplasms

Contrast-induced acute kidney injury among patients with chronic kidney disease undergoing imaging studies: A meta-analysis

Lee, Y. C., Hsieh, C. C., Chang, T-T. & Li, C-Y., 2019 Jan 1, In : American Journal of Roentgenology. 213, 4, p. 728-735 8 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Acute Kidney Injury
Meta-Analysis
Contrast Media
Glomerular Filtration Rate
Open Access
Inflammasomes
Clostridium difficile
Adenosine Triphosphate
Medicine
corrigendum

Diabetes-related kidney, eye, and foot disease in Taiwan: An analysis of nationwide data from 2005 to 2014

Lin, K. D., Hsu, C. C., Ou, H-Y., Wang, C. Y., Chin, M. C. & Shin, S. J., 2019 Jan 1, (Accepted/In press) In : Journal of the Formosan Medical Association.

Research output: Contribution to journalArticle

Open Access
Foot Diseases
Eye Diseases
Kidney Diseases
Taiwan
Diabetic Foot

Dialysis therapy: Concept evolution and update

Kuo, Y. T., Lee, C-C. & Sung, J-M., 2019 Apr 1, In : Journal of Internal Medicine of Taiwan. 30, 2, p. 86-95 10 p.

Research output: Contribution to journalReview article

Peritoneal Dialysis
Renal Dialysis
Dialysis
Dialysis Solutions
Quality of Life

Differential Organ-Specific Tumor Response to Immune Checkpoint Inhibitors in Hepatocellular Carcinoma

Lu, L. C., Hsu, C., Shao, Y. Y., Chao, Y., Yen, C-J., Shih, I. L., Hung, Y. P., Chang, C. J., Shen, Y. C., Guo, J. C., Liu, T. H., Hsu, C. H. & Cheng, A. L., 2019 Jan 1, (Accepted/In press) In : Liver Cancer.

Research output: Contribution to journalArticle

Open Access
Hepatocellular Carcinoma
Liver
Neoplasms
Lung
Monoclonal Antibodies
26 Citations (Scopus)
Tenofovir
Lamivudine
HIV Infections
HIV-1
Pharmaceutical Preparations
Open Access
clopidogrel
Percutaneous Coronary Intervention
Acute Coronary Syndrome
Taiwan
Observation

Dynamic Changes of Health Utility in Lung Cancer Patients Receiving Different Treatments: A 7-Year Follow-up

Yang, S-C., Kuo, C. W., Lai, W-W., Lin, C-C., Su, W-C., Chang, S-M. & Wang, J. D., 2019 Jan 1, (Accepted/In press) In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

Open Access
Lung Neoplasms
Health
Quality of Life
Drug Therapy
Therapeutics

Effect of First-line S-1 Plus Oxaliplatin With or Without Ramucirumab Followed by Paclitaxel Plus Ramucirumab on Advanced Gastric Cancer in East Asia: The Phase 2 RAINSTORM Randomized Clinical Trial

Yoshikawa, T., Muro, K., Shitara, K., Oh, D. Y., Kang, Y. K., Chung, H. C., Kudo, T., Chin, K., Kadowaki, S., Hamamoto, Y., Hironaka, S., Yoshida, K., Yen, C-J., Omuro, Y., Bai, L. Y., Maeda, K., Ozeki, A., Yoshikawa, R. & Kitagawa, Y., 2019 Aug 2, In : JAMA network open. 2, 8, p. e198243

Research output: Contribution to journalArticle

Open Access
oxaliplatin
Far East
Paclitaxel
Stomach Neoplasms
Randomized Controlled Trials

Effect of individualized antihypertensive therapy on the blood pressure and left ventricular hypertrophy of hypertensive patients with coronary heart disease

Liu, T. T., Li, Y-H., Yao, S. Y., Wang, C., Wang, M., Liu, J., Shi, Y. J. & Xue, H., 2019 Apr 2, In : Zhonghua yi xue za zhi. 99, 13, p. 977-982 6 p.

Research output: Contribution to journalArticle

Left Ventricular Hypertrophy
Antihypertensive Agents
Coronary Disease
Blood Pressure
Therapeutics

Evaluation Efficacy of Rhenium-188-Loaded Micro-particles for Radiotherapy in a Mouse Model of Hepatocellular Carcinoma

Shih, Y. H., Peng, C. L., Weng, M. F., Chiang, P. F., Luo, T. Y. & Lin, X-Z., 2019 Mar 4, In : Molecular Pharmaceutics. 16, 3, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

Rhenium
Tin
Colloids
Hepatocellular Carcinoma
Radiotherapy

Fully galactosyl-fucosyl-bisected IgG 1 reduces anti-HBV efficacy and liver histological improvement

Ho, C. H., Chen, S-H., Tsai, H-W., Wu, I-C. & Chang, T-T., 2019 Mar 1, In : Antiviral Research. 163, p. 1-10 10 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Immunoglobulin G
Liver
Hepatitis B e Antigens
Acetylglucosamine

Gender differences in inappropriate use of urinary catheters among hospitalized older patients

Hu, F. W., Chang, C-M., Su, P-F., Chen, H. Y. & Chen, C. H., 2019 Mar 4, In : Journal of Women and Aging. 31, 2, p. 165-175 11 p.

Research output: Contribution to journalArticle

Urinary Catheters
gender-specific factors
incidence
Catheters
demographic factors

Generation of a heterozygous p53 R249S mutant human embryonic stem cell line by TALEN-mediated genome editing

Huo, Z., Tu, J., Xu, A., Li, Y., Wang, D., Liu, M., Zhou, R., Zhu, D., Lin, Y., Gingold, J. A., Yen, C-J., Xiao, H. & Zhao, R., 2019 Jan 1, In : Stem Cell Research. 34, 101360.

Research output: Contribution to journalArticle

Open Access
Cell Line
Mutation
Germ Layers
Teratoma
Liver Neoplasms
Open Access
Colorectal Neoplasms
Neoplasms
Therapeutics
Genome
Mutation

H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer

Yeh, Y. C., Kuo, H. Y., Chang, W-L., Yang, H. B., Lu, C-C., Cheng, H-C., Wu, M. S. & Sheu, B-S., 2019 Jan 5, In : Journal of biomedical science. 26, 1, 4.

Research output: Contribution to journalArticle

Pylorus
Polymorphism
Stomach Neoplasms
Amino Acid Sequence
Amino Acids
2 Citations (Scopus)
Open Access
Helicobacter Infections
Helicobacter pylori
Pylorus
Breath Tests
Infection

Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis

Yen, C-J., Yang, S. T., Chen, R. Y., Huang, W-Y., Chayama, K., Lee, M. H., Yang, S. J., Lai, H. S., Yen, H. Y., Hsiao, Y. W., Wang, J-M., Lin, Y-J. & Hung, L-Y., 2019 Jun 6, In : Journal of biomedical science. 26, 1, 44.

Research output: Contribution to journalArticle

Open Access
Proteins
Hepatocellular Carcinoma
Viruses
Hepatitis B virus
Cyclic AMP Response Element-Binding Protein

High smoking prevalence among HIV-positive individuals: A systematic review and meta-analysis

Lindayani, L., Yeh, C. Y., Ko, W-C. & Ko, N-Y., 2019 Jan 1, (Accepted/In press) In : Journal of Substance Use.

Research output: Contribution to journalReview article

Meta-Analysis
smoking
Smoking
HIV
Cross-Sectional Studies

Identification and characterization of permissive cells to dengue virus infection in human hematopoietic stem and progenitor cells

Hsu, A. Y., Ho, T. C., Lai, M. L., Tan, S. S., Chen, T-Y., Lee, M., Chien, Y-W., Chen, Y-P. & Perng, G-C., 2019 Sep 1, In : Transfusion. 59, 9, p. 2938-2951 14 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Hematopoietic Stem Cells
Bone Marrow
Hematopoietic Stem Cell Transplantation

Idiopathic Sclerosing Orbital Inflammation in a Relapsing Polychondritis Patient with Impaired Vision

Wang, C-R., Hsu, S. M., Chen, Y. C., Ho, C. L. & Fang, S. Y., 2019 Sep 1, In : Journal of Clinical Rheumatology. 25, 6, p. E82-E83

Research output: Contribution to journalComment/debate

Relapsing Polychondritis
Eye Manifestations
Inflammation
Exophthalmos
Methylprednisolone

Impact of prior pulmonary tuberculosis in treatment outcomes of HCAP and CAP patients in intensive care units

Lin, F. M., Feng, J. Y., Fang, W. F., Wu, C. L., Yu, C. J., Lin, M. C., Ku, S. C., Chen, C-W., Tu, C. Y. & Yang, K. Y., 2019 Apr 1, In : Journal of Microbiology, Immunology and Infection. 52, 2, p. 320-328 9 p.

Research output: Contribution to journalArticle

Pulmonary Tuberculosis
Intensive Care Units
Pneumonia
Delivery of Health Care
Taiwan
1 Citation (Scopus)

Implementation of a national quality improvement program to enhance hand hygiene in nursing homes in Taiwan

for Infection Control Society of Taiwan, 2019 Apr 1, In : Journal of Microbiology, Immunology and Infection. 52, 2, p. 345-351 7 p.

Research output: Contribution to journalArticle

Hand Hygiene
Quality Improvement
Nursing Homes
Taiwan
Cross Infection
Aplastic Anemia
Databases
Incidence
Population
Survival
Open Access
Clarithromycin
Metronidazole
Helicobacter Infections
Taiwan
Helicobacter pylori

Intravenous Thrombolysis in Acute Ischemic Stroke After Idarucizumab Reversal of Dabigatran Effect: Analysis of the Cases From Taiwan

Fang, C. W., Tsai, Y. T., Chou, P. C., Chen, H. M., Lu, C. M., Tsao, C. R., Chen, C. L., Sun, M. C., Shih, Y. S., Hsieh, C. Y., Chen, L. A., Chen, P. L., Yeh, J. T. & Li, Y-H., 2019 Mar 1, In : Journal of Stroke and Cerebrovascular Diseases. 28, 3, p. 815-820 6 p.

Research output: Contribution to journalArticle

Taiwan
Stroke
Tissue Plasminogen Activator
Cerebral Hemorrhage
National Institutes of Health (U.S.)
1 Citation (Scopus)

Laminin γ2-enriched extracellular vesicles of oral squamous cell carcinoma cells enhance in vitro lymphangiogenesis via integrin α3-dependent uptake by lymphatic endothelial cells

Wang, S. H., Liou, G. G., Liu, S. H., Chang, J. S., Hsiao, J-R., Yen, Y. C., Chen, Y. L., Wu, W. L., Chang, J-Y. & Chen, Y. W., 2019 Jun 1, In : International Journal of Cancer. 144, 11, p. 2795-2810 16 p.

Research output: Contribution to journalArticle

Lymphangiogenesis
Laminin
Integrins
Squamous Cell Carcinoma
Endothelial Cells

Lead Time Bias May Contribute to the Shorter Life Expectancy in Post-colonoscopy Colorectal Cancer

Chen, W-Y., Cheng, H-C., Cheng, W. C., Wang, J-D. & Sheu, B-S., 2019 Sep 15, In : Digestive Diseases and Sciences. 64, 9, p. 2622-2630 9 p.

Research output: Contribution to journalArticle

Colonoscopy
Life Expectancy
Colorectal Neoplasms
Neoplasms
Taiwan

Long-term safety and efficacy of deferasirox in patients with myelodysplastic syndrome, aplastic anemia and other rare anemia in Taiwan

Ko, B. S., Chang, M. C., Chiou, T. J., Chang, T. K., Chen, Y. C., Lin, S. F., Chang, C. S., Lu, Y. C., Yeh, S. P., Chen, T-Y. & Hwang, W. S., 2019 Dec 1, In : Hematology (Amsterdam, Netherlands). 24, 1, p. 247-254 8 p.

Research output: Contribution to journalArticle

Aplastic Anemia
Myelodysplastic Syndromes
Taiwan
Anemia
Safety

Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry

Lin, H. H., Chen, S-J., Shen, M-R., Huang, Y. T., Hsieh, H. P., Lin, S. Y., Lin, C. C., Chang, W. S. W. & Chang, J-Y., 2019 Dec 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 12, 118517.

Research output: Contribution to journalArticle

cathepsin S
Cysteine Proteases
Cell Movement
Neoplasms
protease S
1 Citation (Scopus)

Maintenance avelumab versus continuation of first-line chemotherapy in gastric cancer: JAVELIN Gastric 100 study design

Moehler, M., Ryu, M. H., Dvorkin, M., Lee, K. W., Coşkun, H., Wong, R., Chung, H. C., Poltoratsky, A., Tsuji, A., Yen, C-J., Muntean, A. S., Le Sourd, S., Vaccaro, G. M., Overton, L., Boku, N., Wainberg, Z. A., Patel, M., Sharma, M., Xiong, H., Conti, I. & 2 others, Taieb, J. & Bang, Y. J., 2019 Feb 1, In : Future Oncology. 15, 6, p. 567-577 11 p.

Research output: Contribution to journalArticle

Open Access
Stomach Neoplasms
Esophagogastric Junction
Stomach
oxaliplatin
Maintenance

Male patients on peritoneal dialysis have a higher risk of sleep apnea

Lee, Y. C., Hung, S. Y., Wang, H. K., Lin, C. W., Wang, H. H., Chang, M. Y., Wu, C. F., Sung, J-M., Chiou, Y-Y. & Lin, S-H., 2019 Jan 1, In : Journal of Clinical Sleep Medicine. 15, 7, p. 937-945 9 p.

Research output: Contribution to journalArticle

Sleep Apnea Syndromes
Peritoneal Dialysis
Renal Dialysis
Uremia
Databases
2 Citations (Scopus)

MiR-338-5p promotes metastasis of colorectal cancer by inhibition of phosphatidylinositol 3-kinase, catalytic subunit type 3-mediated autophagy pathway

Chu, C. A., Lee, C-T., Lee, J-C., Wang, Y. W., Huang, C. T., Lan, S. H., Lin, P-C., Lin, P-W., Tian, Y. F., Liu, H-S. & Chow, N-H., 2019 May 1, In : EBioMedicine. 43, p. 270-281 12 p.

Research output: Contribution to journalArticle

Open Access
Class III Phosphatidylinositol 3-Kinases
Autophagy
Tumors
Colorectal Neoplasms
Genes

Multimodal exercise ameliorates exercise responses and body composition in head and neck cancer patients receiving chemotherapy

Yen, C-J., Hung, C-H., Kao, C. L., Tsai, W. M., Chan, S-H., Cheng, H. C., Jheng, W. T., Lu, Y. J. & Tsai, K-L., 2019 Jan 1, In : Supportive Care in Cancer.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Body Composition
Exercise
Drug Therapy
Heart Rate
1 Citation (Scopus)

National bundle care program implementation to reduce ventilator-associated pneumonia in intensive care units in Taiwan

for the Infection Control Society of Taiwan, 2019 Aug 1, In : Journal of Microbiology, Immunology and Infection. 52, 4, p. 592-597 6 p.

Research output: Contribution to journalArticle

Patient Care Bundles
Ventilator-Associated Pneumonia
Taiwan
Intensive Care Units
Mechanical Ventilators