Department of Internal Medicine

Research Output 1987 2020

2020
Highly Active Antiretroviral Therapy
Obstructive Sleep Apnea
Taiwan
Longitudinal Studies
Cohort Studies
2019
4 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J-Y. & Liou, J. P., 2019 Jan 15, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
1 Citation (Scopus)

2019 Taiwan Society of Lipids and Atherosclerosis expert consensus statement on statin intolerance

Chien, S. C., Chen, P-S., Huang, Y. H., Tang, S. C., Li, Y-H. & Yeh, H. I., 2019 Oct 1, In : Journal of the Formosan Medical Association. 118, 10, p. 1385-1392 8 p.

Research output: Contribution to journalReview article

Open Access
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Taiwan
Atherosclerosis
Lipids
Liver
Open Access
Propensity Score
hemodialysis
Dialysis
Peritoneal Dialysis
heart failure

Aeromonas isolates from fish and patients in Tainan City, Taiwan: genotypic and phenotypic characteristics

Wu, C. J., Ko, W. C., Lee, N. Y., Su, S. L., Li, C. W., Li, M. C., Chen, Y. W., Su, Y. C., Shu, C. Y., Lin, Y. T. & Chen, P. L., 2019 Nov 1, In : Applied and environmental microbiology. 85, 21, e01360-19.

Research output: Contribution to journalArticle

Aeromonas
Aeromonas caviae
virulence
Taiwan
Virulence

Ambulatory independence is associated with higher incidence of latent tuberculosis infection in long-term care facilities in Taiwan

Lin, S. Y., Chien, J. Y., Chiang, H. T., Lu, M. C., Ko, W. C., Chen, Y. H. & Hsueh, P. R., 2019 Jan 1, (Accepted/In press) In : Journal of Microbiology, Immunology and Infection.

Research output: Contribution to journalArticle

Open Access
Latent Tuberculosis
Long-Term Care
Taiwan
Interferon-gamma Release Tests
Incidence
4 Citations (Scopus)

A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan: prevalence, determinants, and impact on quality of life

Chou, W. C., Chen, J. S., Hung, C. Y., Lu, C. H., Shao, Y. Y., Chiou, T. J., Sung, Y. C., Rau, K. M., Yen, C-J., Yeh, S. P., Liu, T. C., Wu, M. F., Lee, M. Y., Yu, M. S., Hwang, W. L., Lai, P. Y., Chang, C. S. & Hsieh, R. K., 2019 Aug 1, In : Supportive Care in Cancer. 27, 8, p. 2857-2867 11 p.

Research output: Contribution to journalArticle

Taiwan
Analgesics
Quality of Life
Neoplasms
Pain
Open Access
Klebsiella pneumoniae
Taiwan
Pseudomonas aeruginosa
Intensive Care Units
Imipenem

A performance guide for major risk factors control in patients with atherosclerotic cardiovascular disease in Taiwan

Li, Y-H., Chen, J. W., Lin, T. H., Wang, Y. C., Wu, C. C., Yeh, H. I., Huang, C. C., Chang, K. C., Wu, C. K., Chen, P-W., Huang, C-W., Chen, Z. C., Chang, W. T., Huang, W. C., Wang, C. Y., Lee, M. Y., Chao, A. C., Fu, W. R., Tsai, L. K., Tang, S. C. & 5 others, Chan, H. L., Yang, Y-C., Wu, Y. W., Hwang, J. J. & Lin, J. L., 2019 Jan 1, In : Journal of the Formosan Medical Association.

Research output: Contribution to journalReview article

Open Access
Taiwan
Cardiovascular Diseases
Cerebrovascular Disorders
Peripheral Arterial Disease
Hypercholesterolemia

A phase 1, open-label, dose-escalation trial of oral TSR-011 in patients with advanced solid tumours and lymphomas

Lin, C. C., Arkenau, H. T., Lu, S., Sachdev, J., de Castro Carpeño, J., Mita, M., Dziadziuszko, R., Su, W. C., Bobilev, D., Hughes, L., Chan, J., Zhang, Z. Y. & Weiss, G. J., 2019 Jul 16, In : British Journal of Cancer. 121, 2, p. 131-138 8 p.

Research output: Contribution to journalArticle

Open Access
Lymphoma
Neoplasms
Safety
Non-Small Cell Lung Carcinoma
Maximum Tolerated Dose

A subanalysis of Taiwanese patients from ODYSSEY South Korea and Taiwan study evaluating the efficacy and safety of alirocumab

Chao, T-H., Hsiao, P. J., Liu, M. E., Wu, C. J., Chiang, F. T., Chen, Z. C., Chen, C. P., Yeh, H. I., Lee, T. H. & Chiang, C. E., 2019 Jan 1, In : Journal of the Chinese Medical Association. 82, 4, p. 265-271 7 p.

Research output: Contribution to journalArticle

Republic of Korea
Taiwan
LDL Cholesterol
Safety
Placebos
1 Citation (Scopus)
Vascular Stiffness
Antiviral Agents
Fibrosis
Chronic Hepatitis C
Blood Pressure
1 Citation (Scopus)
Dengue
Infection
Therapeutics
Anti-Bacterial Agents
Levofloxacin

Bortezomib therapy in a real-world setting in patients with relapsed or refractory multiple myeloma

Huang, S. Y., Chen, T-Y., Kuo, C. Y., Chen, Y. C., Lin, S. F., Chang, M. C., Lv, X., Yang, B. & Chang, C. S., 2019 Jan 14, In : Oncology Reviews. 13, 1, p. 15-22 8 p.

Research output: Contribution to journalReview article

Open Access
Multiple Myeloma
Therapeutics
Bortezomib
Safety
Proteasome Inhibitors

Brain MRI imaging characteristics predict treatment response and outcome in patients with de novo brain metastasis of EGFR-mutated NSCLC

Lin, C. Y., Chang, C. C., Su, P. L., Lin, C. C., Tseng, Y. L., Su, W. C., Yen, Y. T. & Patel, G., 2019 Aug 1, In : Medicine (United States). 98, 33, e16766.

Research output: Contribution to journalArticle

Open Access
Neuroimaging
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Disease-Free Survival
Epidermal Growth Factor Receptor
2 Citations (Scopus)

Changing practice pattern of acute coronary syndromes in Taiwan from 2008 to 2015

Li, Y-H., Chiu, Y. W., Cheng, J. J., Hsieh, I. C., Lo, P. H., Lei, M. H., Ueng, K. C., Chiang, F. T., Sung, S. H., Kuo, J. Y., Chen, C. P., Lai, W. T., Lee, W. L. & Chen, J. H., 2019 Jan 1, In : Acta Cardiologica Sinica. 35, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Acute Coronary Syndrome
Taiwan
Registries
Percutaneous Coronary Intervention
Drug-Eluting Stents
4 Citations (Scopus)

Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity

Chang, K., Lee, N. Y., Ko, W. C., Lin, W. R., Chen, Y. H., Tsai, J. J., Chen, T. C., Lin, C. Y., Chang, Y. T. & Lu, P. L., 2019 Feb, In : Journal of Microbiology, Immunology and Infection. 52, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

Endemic Flea-Borne Typhus
Scrub Typhus
Q Fever
Prothrombin Time
Multivariate Analysis

Clinical Benefit of Empiric High-Dose Levofloxacin Therapy for Adults With Community-onset Enterobacteriaceae Bacteremia

Lee, C. C., Yang, C. Y., Lee, C. H., Hsieh, C. C., Hong, M. Y., Tang, H. J. & Ko, W. C., 2019 Oct, In : Clinical Therapeutics. 41, 10, p. 1996-2007 12 p.

Research output: Contribution to journalArticle

Levofloxacin
Enterobacteriaceae
Bacteremia
Mortality
Therapeutics
3 Citations (Scopus)

Clinical manifestations of candidemia caused by uncommon Candida species and antifungal susceptibility of the isolates in a regional hospital in Taiwan, 2007–2014

Liu, W. L., Lai, C. C., Li, M. C., Wu, C. J., Ko, W. C., Hung, Y. L., Tang, H. J. & Hsueh, P. R., 2019 Aug, In : Journal of Microbiology, Immunology and Infection. 52, 4, p. 612-619 8 p.

Research output: Contribution to journalArticle

Candidemia
Taiwan
Candida
Azoles
Microbial Sensitivity Tests
Propensity Score
Hepatocellular Carcinoma
Survival
Liver
Liver Neoplasms

Community-acquired adenoviral and pneumococcal pneumonia complicated by pulmonary aspergillosis in an immunocompetent adult

Lee, J. Y., Yang, P. C., Chang, C., Lin, I. T., Ko, W. C. & Cia, C. T., 2019 Oct, In : Journal of Microbiology, Immunology and Infection. 52, 5, p. 838-839 2 p.

Research output: Contribution to journalLetter

Open Access

Comprehensive assessment of HER2 alteration in a colorectal cancer cohort: From next-generation sequencing to clinical significance

Yeh, Y. M., Lee, C. H., Chen, S. H., Lee, C. T., Lin, B. W., Lin, S. C., Chan, R. H., Lee, J. C., Shen, M. R. & Lin, P. C., 2019 Jan 1, In : Cancer Management and Research. 11, p. 7867-7875 9 p.

Research output: Contribution to journalArticle

Open Access
Colorectal Neoplasms
oxaliplatin
human ERBB2 protein
Fluorescence In Situ Hybridization
Therapeutics
Open Access
Endoscopic Retrograde Cholangiopancreatography
Tomography
Air
Mortality
Endoscopy
1 Citation (Scopus)

Contrast-induced acute kidney injury among patients with chronic kidney disease undergoing imaging studies: A meta-analysis

Lee, Y. C., Hsieh, C. C., Chang, T. T. & Li, C. Y., 2019 Jan 1, In : American Journal of Roentgenology. 213, 4, p. 728-735 8 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Acute Kidney Injury
Meta-Analysis
Contrast Media
Glomerular Filtration Rate
Open Access
Inflammasomes
Clostridium difficile
Adenosine Triphosphate
Medicine
corrigendum
2 Citations (Scopus)

CPAP promotes angiogenesis and metastasis by enhancing STAT3 activity

Chen, R. Y., Yen, C. J., Liu, Y. W., Guo, C. G., Weng, C. Y., Lai, C. H., Wang, Y. M., Lin, Y. J. & Hung, L. Y., 2019 Jan 1, (Accepted/In press) In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Hepatocellular Carcinoma
Proteins
Interleukin-8
Interleukin-6
Open Access
Cefazolin
Enterobacteriaceae
Bacteremia
Taiwan
Therapeutics

Determining the clinical characteristics and prognostic factors for the outcomes of Japanese encephalitis in adults: A multicenter study from southern Taiwan

Lo, S. H., Tang, H. J., Lee, S. S. J., Lee, J. C., Liu, J. W., Ko, W. C., Chang, K., Lee, C. Y., Chang, Y. T. & Lu, P. L., 2019 Jan 1, (Accepted/In press) In : Journal of Microbiology, Immunology and Infection.

Research output: Contribution to journalArticle

Open Access
Japanese Encephalitis
Taiwan
Multicenter Studies
Glasgow Coma Scale
Viral Encephalitis
2 Citations (Scopus)

Diabetes-related kidney, eye, and foot disease in Taiwan: An analysis of nationwide data from 2005 to 2014

Lin, K. D., Hsu, C. C., Ou, H. Y., Wang, C. Y., Chin, M. C. & Shin, S. J., 2019 Nov, In : Journal of the Formosan Medical Association. 118, p. S103-S110

Research output: Contribution to journalArticle

Open Access
Foot Diseases
Eye Diseases
Kidney Diseases
Taiwan
Diabetic Foot

Dialysis therapy: Concept evolution and update

Kuo, Y. T., Lee, C-C. & Sung, J-M., 2019 Apr 1, In : Journal of Internal Medicine of Taiwan. 30, 2, p. 86-95 10 p.

Research output: Contribution to journalReview article

Peritoneal Dialysis
Renal Dialysis
Dialysis
Dialysis Solutions
Quality of Life

Differential Organ-Specific Tumor Response to Immune Checkpoint Inhibitors in Hepatocellular Carcinoma

Lu, L. C., Hsu, C., Shao, Y. Y., Chao, Y., Yen, C. J., Shih, I. L., Hung, Y. P., Chang, C. J., Shen, Y. C., Guo, J. C., Liu, T. H., Hsu, C. H. & Cheng, A. L., 2019 Nov 1, In : Liver Cancer. 8, 6, p. 480-490 11 p.

Research output: Contribution to journalArticle

Open Access
Hepatocellular Carcinoma
Liver
Neoplasms
Lung
Monoclonal Antibodies
35 Citations (Scopus)
Tenofovir
Lamivudine
HIV Infections
HIV-1
Pharmaceutical Preparations
1 Citation (Scopus)
Open Access
clopidogrel
Percutaneous Coronary Intervention
Acute Coronary Syndrome
Taiwan
Observation

Dynamic Changes of Health Utility in Lung Cancer Patients Receiving Different Treatments: A 7-Year Follow-up

Yang, S. C., Kuo, C. W., Lai, W. W., Lin, C. C., Su, W. C., Chang, S. M. & Wang, J. D., 2019 Nov, In : Journal of Thoracic Oncology. 14, 11, p. 1892-1900 9 p.

Research output: Contribution to journalArticle

Open Access
Lung Neoplasms
Health
Quality of Life
Drug Therapy
Therapeutics

Effect of First-line S-1 Plus Oxaliplatin With or Without Ramucirumab Followed by Paclitaxel Plus Ramucirumab on Advanced Gastric Cancer in East Asia: The Phase 2 RAINSTORM Randomized Clinical Trial

Yoshikawa, T., Muro, K., Shitara, K., Oh, D. Y., Kang, Y. K., Chung, H. C., Kudo, T., Chin, K., Kadowaki, S., Hamamoto, Y., Hironaka, S., Yoshida, K., Yen, C-J., Omuro, Y., Bai, L. Y., Maeda, K., Ozeki, A., Yoshikawa, R. & Kitagawa, Y., 2019 Aug 2, In : JAMA network open. 2, 8, p. e198243

Research output: Contribution to journalArticle

Open Access
oxaliplatin
Far East
Paclitaxel
Stomach Neoplasms
Randomized Controlled Trials

Effect of individualized antihypertensive therapy on the blood pressure and left ventricular hypertrophy of hypertensive patients with coronary heart disease

Liu, T. T., Li, Y., Yao, S. Y., Wang, C., Wang, M., Liu, J., Shi, Y. J. & Xue, H., 2019 Apr 2, In : Zhonghua yi xue za zhi. 99, 13, p. 977-982 6 p.

Research output: Contribution to journalArticle

Left Ventricular Hypertrophy
Antihypertensive Agents
Coronary Disease
Blood Pressure
Therapeutics

Evaluation Efficacy of Rhenium-188-Loaded Micro-particles for Radiotherapy in a Mouse Model of Hepatocellular Carcinoma

Shih, Y. H., Peng, C. L., Weng, M. F., Chiang, P. F., Luo, T. Y. & Lin, X-Z., 2019 Mar 4, In : Molecular Pharmaceutics. 16, 3, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

Rhenium
Tin
Colloids
Hepatocellular Carcinoma
Radiotherapy

Fecal microbiota transplantation for Clostridium difficile infection in Taiwan: Establishment and implementation

Lin, T. C., Hung, Y. P., Ko, W. C. & Ruan, J. W., 2019 Jan 1, (Accepted/In press) In : Journal of Microbiology, Immunology and Infection.

Research output: Contribution to journalReview article

Open Access
Clostridium Infections
Clostridium difficile
Taiwan
Fecal Microbiota Transplantation
Donor Selection

Fully galactosyl-fucosyl-bisected IgG 1 reduces anti-HBV efficacy and liver histological improvement

Ho, C. H., Chen, S-H., Tsai, H-W., Wu, I-C. & Chang, T-T., 2019 Mar 1, In : Antiviral Research. 163, p. 1-10 10 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Immunoglobulin G
Liver
Hepatitis B e Antigens
Acetylglucosamine

Gender differences in inappropriate use of urinary catheters among hospitalized older patients

Hu, F. W., Chang, C-M., Su, P-F., Chen, H. Y. & Chen, C. H., 2019 Mar 4, In : Journal of Women and Aging. 31, 2, p. 165-175 11 p.

Research output: Contribution to journalArticle

Urinary Catheters
gender-specific factors
incidence
Catheters
demographic factors

Generation of a heterozygous p53 R249S mutant human embryonic stem cell line by TALEN-mediated genome editing

Huo, Z., Tu, J., Xu, A., Li, Y., Wang, D., Liu, M., Zhou, R., Zhu, D., Lin, Y., Gingold, J. A., Yen, C-J., Xiao, H. & Zhao, R., 2019 Jan 1, In : Stem Cell Research. 34, 101360.

Research output: Contribution to journalArticle

Open Access
Cell Line
Mutation
Germ Layers
Teratoma
Liver Neoplasms
Open Access
Colorectal Neoplasms
Neoplasms
Therapeutics
Genome
Mutation

H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer

Yeh, Y. C., Kuo, H. Y., Chang, W. L., Yang, H. B., Lu, C. C., Cheng, H. C., Wu, M. S. & Sheu, B. S., 2019 Jan 5, In : Journal of biomedical science. 26, 1, 4.

Research output: Contribution to journalArticle

Pylorus
Polymorphism
Stomach Neoplasms
Amino Acid Sequence
Amino Acids
2 Citations (Scopus)
Open Access
Helicobacter Infections
Helicobacter pylori
Pylorus
Breath Tests
Infection

Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis

Yen, C. J., Yang, S. T., Chen, R. Y., Huang, W., Chayama, K., Lee, M. H., Yang, S. J., Lai, H. S., Yen, H. Y., Hsiao, Y. W., Wang, J. M., Lin, Y. J. & Hung, L. Y., 2019 Jun 6, In : Journal of biomedical science. 26, 1, 44.

Research output: Contribution to journalArticle

Open Access
Proteins
Hepatocellular Carcinoma
Viruses
Hepatitis B virus
Cyclic AMP Response Element-Binding Protein

High-CLDN4 ESCC cells harbor stem-like properties and indicate for poor concurrent chemoradiation therapy response in esophageal squamous cell carcinoma

Lin, C. H., Li, H. Y., Liu, Y. P., Kuo, P. F., Wang, W. C., Lin, F. C., Chang, W. L., Sheu, B. S., Wang, Y. C., Hung, W. C., Cheng, H. C., Yao, Y. C., Calkins, M. J., Hsiao, M. & Lu, P. J., 2019 Jan 1, In : Therapeutic Advances in Medical Oncology. 11

Research output: Contribution to journalArticle

Open Access
Stem Cells
Fursultiamin
Neoplasms
Therapeutics
Neoplastic Stem Cells

High smoking prevalence among HIV-positive individuals: A systematic review and meta-analysis

Lindayani, L., Yeh, C. Y., Ko, W. C. & Ko, N. Y., 2019 Jan 1, (Accepted/In press) In : Journal of Substance Use.

Research output: Contribution to journalReview article

Meta-Analysis
smoking
Smoking
HIV
Cross-Sectional Studies

Identification and characterization of permissive cells to dengue virus infection in human hematopoietic stem and progenitor cells

Hsu, A. Y., Ho, T. C., Lai, M. L., Tan, S. S., Chen, T. Y., Lee, M., Chien, Y. W., Chen, Y. P. & Perng, G. C., 2019 Sep 1, In : Transfusion. 59, 9, p. 2938-2951 14 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Hematopoietic Stem Cells
Bone Marrow
Hematopoietic Stem Cell Transplantation

Idiopathic Sclerosing Orbital Inflammation in a Relapsing Polychondritis Patient with Impaired Vision

Wang, C. R., Hsu, S. M., Chen, Y. C., Ho, C. L. & Fang, S. Y., 2019 Sep 1, In : Journal of Clinical Rheumatology. 25, 6, p. E82-E83

Research output: Contribution to journalComment/debate

Relapsing Polychondritis
Eye Manifestations
Inflammation
Exophthalmos
Methylprednisolone

Impact of prior pulmonary tuberculosis in treatment outcomes of HCAP and CAP patients in intensive care units

Lin, F. M., Feng, J. Y., Fang, W. F., Wu, C. L., Yu, C. J., Lin, M. C., Ku, S. C., Chen, C-W., Tu, C. Y. & Yang, K. Y., 2019 Apr 1, In : Journal of Microbiology, Immunology and Infection. 52, 2, p. 320-328 9 p.

Research output: Contribution to journalArticle

Pulmonary Tuberculosis
Intensive Care Units
Pneumonia
Delivery of Health Care
Taiwan