Department of Internal Medicine

Research Output 1987 2020

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Article
2020
Highly Active Antiretroviral Therapy
Obstructive Sleep Apnea
Taiwan
Longitudinal Studies
Cohort Studies
2019
4 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J-Y. & Liou, J. P., 2019 Jan 15, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
Open Access
Propensity Score
hemodialysis
Dialysis
Peritoneal Dialysis
heart failure

Aeromonas isolates from fish and patients in Tainan City, Taiwan: genotypic and phenotypic characteristics

Wu, C. J., Ko, W. C., Lee, N. Y., Su, S. L., Li, C. W., Li, M. C., Chen, Y. W., Su, Y. C., Shu, C. Y., Lin, Y. T. & Chen, P. L., 2019 Nov 1, In : Applied and environmental microbiology. 85, 21, e01360-19.

Research output: Contribution to journalArticle

Aeromonas
Aeromonas caviae
virulence
Taiwan
Virulence

Ambulatory independence is associated with higher incidence of latent tuberculosis infection in long-term care facilities in Taiwan

Lin, S. Y., Chien, J. Y., Chiang, H. T., Lu, M. C., Ko, W. C., Chen, Y. H. & Hsueh, P. R., 2019 Jan 1, (Accepted/In press) In : Journal of Microbiology, Immunology and Infection.

Research output: Contribution to journalArticle

Open Access
Latent Tuberculosis
Long-Term Care
Taiwan
Interferon-gamma Release Tests
Incidence
4 Citations (Scopus)

A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan: prevalence, determinants, and impact on quality of life

Chou, W. C., Chen, J. S., Hung, C. Y., Lu, C. H., Shao, Y. Y., Chiou, T. J., Sung, Y. C., Rau, K. M., Yen, C-J., Yeh, S. P., Liu, T. C., Wu, M. F., Lee, M. Y., Yu, M. S., Hwang, W. L., Lai, P. Y., Chang, C. S. & Hsieh, R. K., 2019 Aug 1, In : Supportive Care in Cancer. 27, 8, p. 2857-2867 11 p.

Research output: Contribution to journalArticle

Taiwan
Analgesics
Quality of Life
Neoplasms
Pain
Open Access
Klebsiella pneumoniae
Taiwan
Pseudomonas aeruginosa
Intensive Care Units
Imipenem

A phase 1, open-label, dose-escalation trial of oral TSR-011 in patients with advanced solid tumours and lymphomas

Lin, C. C., Arkenau, H. T., Lu, S., Sachdev, J., de Castro Carpeño, J., Mita, M., Dziadziuszko, R., Su, W. C., Bobilev, D., Hughes, L., Chan, J., Zhang, Z. Y. & Weiss, G. J., 2019 Jul 16, In : British Journal of Cancer. 121, 2, p. 131-138 8 p.

Research output: Contribution to journalArticle

Open Access
Lymphoma
Neoplasms
Safety
Non-Small Cell Lung Carcinoma
Maximum Tolerated Dose

A subanalysis of Taiwanese patients from ODYSSEY South Korea and Taiwan study evaluating the efficacy and safety of alirocumab

Chao, T. H., Hsiao, P. J., Liu, M. E., Wu, C. J., Chiang, F. T., Chen, Z. C., Chen, C. P., Yeh, H. I., Lee, T. H. & Chiang, C. E., 2019 Jan 1, In : Journal of the Chinese Medical Association. 82, 4, p. 265-271 7 p.

Research output: Contribution to journalArticle

Republic of Korea
Taiwan
LDL Cholesterol
Safety
Placebos
1 Citation (Scopus)
Vascular Stiffness
Antiviral Agents
Fibrosis
Chronic Hepatitis C
Blood Pressure
1 Citation (Scopus)
Dengue
Infection
Therapeutics
Anti-Bacterial Agents
Levofloxacin

Brain MRI imaging characteristics predict treatment response and outcome in patients with de novo brain metastasis of EGFR-mutated NSCLC

Lin, C. Y., Chang, C. C., Su, P. L., Lin, C. C., Tseng, Y. L., Su, W. C., Yen, Y. T. & Patel, G., 2019 Aug 1, In : Medicine (United States). 98, 33, e16766.

Research output: Contribution to journalArticle

Open Access
Neuroimaging
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Disease-Free Survival
Epidermal Growth Factor Receptor
2 Citations (Scopus)

Changing practice pattern of acute coronary syndromes in Taiwan from 2008 to 2015

Li, Y-H., Chiu, Y. W., Cheng, J. J., Hsieh, I. C., Lo, P. H., Lei, M. H., Ueng, K. C., Chiang, F. T., Sung, S. H., Kuo, J. Y., Chen, C. P., Lai, W. T., Lee, W. L. & Chen, J. H., 2019 Jan 1, In : Acta Cardiologica Sinica. 35, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Acute Coronary Syndrome
Taiwan
Registries
Percutaneous Coronary Intervention
Drug-Eluting Stents
4 Citations (Scopus)

Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity

Chang, K., Lee, N. Y., Ko, W. C., Lin, W. R., Chen, Y. H., Tsai, J. J., Chen, T. C., Lin, C. Y., Chang, Y. T. & Lu, P. L., 2019 Feb, In : Journal of Microbiology, Immunology and Infection. 52, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

Endemic Flea-Borne Typhus
Scrub Typhus
Q Fever
Prothrombin Time
Multivariate Analysis

Clinical Benefit of Empiric High-Dose Levofloxacin Therapy for Adults With Community-onset Enterobacteriaceae Bacteremia

Lee, C. C., Yang, C. Y., Lee, C. H., Hsieh, C. C., Hong, M. Y., Tang, H. J. & Ko, W. C., 2019 Oct, In : Clinical Therapeutics. 41, 10, p. 1996-2007 12 p.

Research output: Contribution to journalArticle

Levofloxacin
Enterobacteriaceae
Bacteremia
Mortality
Therapeutics
3 Citations (Scopus)

Clinical manifestations of candidemia caused by uncommon Candida species and antifungal susceptibility of the isolates in a regional hospital in Taiwan, 2007–2014

Liu, W. L., Lai, C. C., Li, M. C., Wu, C. J., Ko, W. C., Hung, Y. L., Tang, H. J. & Hsueh, P. R., 2019 Aug, In : Journal of Microbiology, Immunology and Infection. 52, 4, p. 612-619 8 p.

Research output: Contribution to journalArticle

Candidemia
Taiwan
Candida
Azoles
Microbial Sensitivity Tests
Propensity Score
Hepatocellular Carcinoma
Survival
Liver
Liver Neoplasms

Comprehensive assessment of HER2 alteration in a colorectal cancer cohort: From next-generation sequencing to clinical significance

Yeh, Y. M., Lee, C. H., Chen, S. H., Lee, C. T., Lin, B. W., Lin, S. C., Chan, R. H., Lee, J. C., Shen, M. R. & Lin, P. C., 2019 Jan 1, In : Cancer Management and Research. 11, p. 7867-7875 9 p.

Research output: Contribution to journalArticle

Open Access
Colorectal Neoplasms
oxaliplatin
human ERBB2 protein
Fluorescence In Situ Hybridization
Therapeutics
Open Access
Endoscopic Retrograde Cholangiopancreatography
Tomography
Air
Mortality
Endoscopy
1 Citation (Scopus)

Contrast-induced acute kidney injury among patients with chronic kidney disease undergoing imaging studies: A meta-analysis

Lee, Y. C., Hsieh, C. C., Chang, T. T. & Li, C. Y., 2019 Jan 1, In : American Journal of Roentgenology. 213, 4, p. 728-735 8 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Acute Kidney Injury
Meta-Analysis
Contrast Media
Glomerular Filtration Rate
2 Citations (Scopus)

CPAP promotes angiogenesis and metastasis by enhancing STAT3 activity

Chen, R. Y., Yen, C. J., Liu, Y. W., Guo, C. G., Weng, C. Y., Lai, C. H., Wang, Y. M., Lin, Y. J. & Hung, L. Y., 2019 Jan 1, (Accepted/In press) In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Hepatocellular Carcinoma
Proteins
Interleukin-8
Interleukin-6
Open Access
Cefazolin
Enterobacteriaceae
Bacteremia
Taiwan
Therapeutics

Determining the clinical characteristics and prognostic factors for the outcomes of Japanese encephalitis in adults: A multicenter study from southern Taiwan

Lo, S. H., Tang, H. J., Lee, S. S. J., Lee, J. C., Liu, J. W., Ko, W. C., Chang, K., Lee, C. Y., Chang, Y. T. & Lu, P. L., 2019 Jan 1, (Accepted/In press) In : Journal of Microbiology, Immunology and Infection.

Research output: Contribution to journalArticle

Open Access
Japanese Encephalitis
Taiwan
Multicenter Studies
Glasgow Coma Scale
Viral Encephalitis
2 Citations (Scopus)

Diabetes-related kidney, eye, and foot disease in Taiwan: An analysis of nationwide data from 2005 to 2014

Lin, K. D., Hsu, C. C., Ou, H. Y., Wang, C. Y., Chin, M. C. & Shin, S. J., 2019 Nov, In : Journal of the Formosan Medical Association. 118, p. S103-S110

Research output: Contribution to journalArticle

Open Access
Foot Diseases
Eye Diseases
Kidney Diseases
Taiwan
Diabetic Foot

Differential Organ-Specific Tumor Response to Immune Checkpoint Inhibitors in Hepatocellular Carcinoma

Lu, L. C., Hsu, C., Shao, Y. Y., Chao, Y., Yen, C. J., Shih, I. L., Hung, Y. P., Chang, C. J., Shen, Y. C., Guo, J. C., Liu, T. H., Hsu, C. H. & Cheng, A. L., 2019 Nov 1, In : Liver Cancer. 8, 6, p. 480-490 11 p.

Research output: Contribution to journalArticle

Open Access
Hepatocellular Carcinoma
Liver
Neoplasms
Lung
Monoclonal Antibodies
35 Citations (Scopus)
Tenofovir
Lamivudine
HIV Infections
HIV-1
Pharmaceutical Preparations
1 Citation (Scopus)
Open Access
clopidogrel
Percutaneous Coronary Intervention
Acute Coronary Syndrome
Taiwan
Observation

Dynamic Changes of Health Utility in Lung Cancer Patients Receiving Different Treatments: A 7-Year Follow-up

Yang, S. C., Kuo, C. W., Lai, W. W., Lin, C. C., Su, W. C., Chang, S. M. & Wang, J. D., 2019 Nov, In : Journal of Thoracic Oncology. 14, 11, p. 1892-1900 9 p.

Research output: Contribution to journalArticle

Open Access
Lung Neoplasms
Health
Quality of Life
Drug Therapy
Therapeutics

Effect of First-line S-1 Plus Oxaliplatin With or Without Ramucirumab Followed by Paclitaxel Plus Ramucirumab on Advanced Gastric Cancer in East Asia: The Phase 2 RAINSTORM Randomized Clinical Trial

Yoshikawa, T., Muro, K., Shitara, K., Oh, D. Y., Kang, Y. K., Chung, H. C., Kudo, T., Chin, K., Kadowaki, S., Hamamoto, Y., Hironaka, S., Yoshida, K., Yen, C-J., Omuro, Y., Bai, L. Y., Maeda, K., Ozeki, A., Yoshikawa, R. & Kitagawa, Y., 2019 Aug 2, In : JAMA network open. 2, 8, p. e198243

Research output: Contribution to journalArticle

Open Access
oxaliplatin
Far East
Paclitaxel
Stomach Neoplasms
Randomized Controlled Trials

Effect of individualized antihypertensive therapy on the blood pressure and left ventricular hypertrophy of hypertensive patients with coronary heart disease

Liu, T. T., Li, Y., Yao, S. Y., Wang, C., Wang, M., Liu, J., Shi, Y. J. & Xue, H., 2019 Apr 2, In : Zhonghua yi xue za zhi. 99, 13, p. 977-982 6 p.

Research output: Contribution to journalArticle

Left Ventricular Hypertrophy
Antihypertensive Agents
Coronary Disease
Blood Pressure
Therapeutics

Evaluation Efficacy of Rhenium-188-Loaded Micro-particles for Radiotherapy in a Mouse Model of Hepatocellular Carcinoma

Shih, Y. H., Peng, C. L., Weng, M. F., Chiang, P. F., Luo, T. Y. & Lin, X-Z., 2019 Mar 4, In : Molecular Pharmaceutics. 16, 3, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

Rhenium
Tin
Colloids
Hepatocellular Carcinoma
Radiotherapy

Fully galactosyl-fucosyl-bisected IgG 1 reduces anti-HBV efficacy and liver histological improvement

Ho, C. H., Chen, S-H., Tsai, H-W., Wu, I-C. & Chang, T-T., 2019 Mar 1, In : Antiviral Research. 163, p. 1-10 10 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Immunoglobulin G
Liver
Hepatitis B e Antigens
Acetylglucosamine

Gender differences in inappropriate use of urinary catheters among hospitalized older patients

Hu, F. W., Chang, C-M., Su, P-F., Chen, H. Y. & Chen, C. H., 2019 Mar 4, In : Journal of Women and Aging. 31, 2, p. 165-175 11 p.

Research output: Contribution to journalArticle

Urinary Catheters
gender-specific factors
incidence
Catheters
demographic factors

Generation of a heterozygous p53 R249S mutant human embryonic stem cell line by TALEN-mediated genome editing

Huo, Z., Tu, J., Xu, A., Li, Y., Wang, D., Liu, M., Zhou, R., Zhu, D., Lin, Y., Gingold, J. A., Yen, C-J., Xiao, H. & Zhao, R., 2019 Jan 1, In : Stem Cell Research. 34, 101360.

Research output: Contribution to journalArticle

Open Access
Cell Line
Mutation
Germ Layers
Teratoma
Liver Neoplasms
Open Access
Colorectal Neoplasms
Neoplasms
Therapeutics
Genome
Mutation

H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer

Yeh, Y. C., Kuo, H. Y., Chang, W. L., Yang, H. B., Lu, C. C., Cheng, H. C., Wu, M. S. & Sheu, B. S., 2019 Jan 5, In : Journal of biomedical science. 26, 1, 4.

Research output: Contribution to journalArticle

Pylorus
Polymorphism
Stomach Neoplasms
Amino Acid Sequence
Amino Acids
2 Citations (Scopus)
Open Access
Helicobacter Infections
Helicobacter pylori
Pylorus
Breath Tests
Infection

Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis

Yen, C. J., Yang, S. T., Chen, R. Y., Huang, W., Chayama, K., Lee, M. H., Yang, S. J., Lai, H. S., Yen, H. Y., Hsiao, Y. W., Wang, J. M., Lin, Y. J. & Hung, L. Y., 2019 Jun 6, In : Journal of biomedical science. 26, 1, 44.

Research output: Contribution to journalArticle

Open Access
Proteins
Hepatocellular Carcinoma
Viruses
Hepatitis B virus
Cyclic AMP Response Element-Binding Protein

High-CLDN4 ESCC cells harbor stem-like properties and indicate for poor concurrent chemoradiation therapy response in esophageal squamous cell carcinoma

Lin, C. H., Li, H. Y., Liu, Y. P., Kuo, P. F., Wang, W. C., Lin, F. C., Chang, W. L., Sheu, B. S., Wang, Y. C., Hung, W. C., Cheng, H. C., Yao, Y. C., Calkins, M. J., Hsiao, M. & Lu, P. J., 2019 Jan 1, In : Therapeutic Advances in Medical Oncology. 11

Research output: Contribution to journalArticle

Open Access
Stem Cells
Fursultiamin
Neoplasms
Therapeutics
Neoplastic Stem Cells

Identification and characterization of permissive cells to dengue virus infection in human hematopoietic stem and progenitor cells

Hsu, A. Y., Ho, T. C., Lai, M. L., Tan, S. S., Chen, T. Y., Lee, M., Chien, Y. W., Chen, Y. P. & Perng, G. C., 2019 Sep 1, In : Transfusion. 59, 9, p. 2938-2951 14 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Hematopoietic Stem Cells
Bone Marrow
Hematopoietic Stem Cell Transplantation

Impact of prior pulmonary tuberculosis in treatment outcomes of HCAP and CAP patients in intensive care units

Lin, F. M., Feng, J. Y., Fang, W. F., Wu, C. L., Yu, C. J., Lin, M. C., Ku, S. C., Chen, C-W., Tu, C. Y. & Yang, K. Y., 2019 Apr 1, In : Journal of Microbiology, Immunology and Infection. 52, 2, p. 320-328 9 p.

Research output: Contribution to journalArticle

Pulmonary Tuberculosis
Intensive Care Units
Pneumonia
Delivery of Health Care
Taiwan
2 Citations (Scopus)

Implementation of a national quality improvement program to enhance hand hygiene in nursing homes in Taiwan

for Infection Control Society of Taiwan, 2019 Apr 1, In : Journal of Microbiology, Immunology and Infection. 52, 2, p. 345-351 7 p.

Research output: Contribution to journalArticle

Hand Hygiene
Quality Improvement
Nursing Homes
Taiwan
Cross Infection
Aplastic Anemia
Databases
Incidence
Population
Survival
Open Access
Clarithromycin
Metronidazole
Helicobacter Infections
Taiwan
Helicobacter pylori

Intravenous Thrombolysis in Acute Ischemic Stroke After Idarucizumab Reversal of Dabigatran Effect: Analysis of the Cases From Taiwan

Fang, C. W., Tsai, Y. T., Chou, P. C., Chen, H. M., Lu, C. M., Tsao, C. R., Chen, C. L., Sun, M. C., Shih, Y. S., Hsieh, C. Y., Chen, L. A., Chen, P. L., Yeh, J. T. & Li, Y-H., 2019 Mar 1, In : Journal of Stroke and Cerebrovascular Diseases. 28, 3, p. 815-820 6 p.

Research output: Contribution to journalArticle

Taiwan
Stroke
Tissue Plasminogen Activator
Cerebral Hemorrhage
National Institutes of Health (U.S.)
1 Citation (Scopus)

Laminin γ2-enriched extracellular vesicles of oral squamous cell carcinoma cells enhance in vitro lymphangiogenesis via integrin α3-dependent uptake by lymphatic endothelial cells

Wang, S. H., Liou, G. G., Liu, S. H., Chang, J. S., Hsiao, J-R., Yen, Y. C., Chen, Y. L., Wu, W. L., Chang, J-Y. & Chen, Y. W., 2019 Jun 1, In : International Journal of Cancer. 144, 11, p. 2795-2810 16 p.

Research output: Contribution to journalArticle

Lymphangiogenesis
Laminin
Integrins
Squamous Cell Carcinoma
Endothelial Cells

Lead Time Bias May Contribute to the Shorter Life Expectancy in Post-colonoscopy Colorectal Cancer

Chen, W-Y., Cheng, H-C., Cheng, W. C., Wang, J-D. & Sheu, B-S., 2019 Sep 15, In : Digestive Diseases and Sciences. 64, 9, p. 2622-2630 9 p.

Research output: Contribution to journalArticle

Colonoscopy
Life Expectancy
Colorectal Neoplasms
Neoplasms
Taiwan

Long-term safety and efficacy of deferasirox in patients with myelodysplastic syndrome, aplastic anemia and other rare anemia in Taiwan

Ko, B. S., Chang, M. C., Chiou, T. J., Chang, T. K., Chen, Y. C., Lin, S. F., Chang, C. S., Lu, Y. C., Yeh, S. P., Chen, T. Y. & Hwang, W. S., 2019 Dec 1, In : Hematology (Amsterdam, Netherlands). 24, 1, p. 247-254 8 p.

Research output: Contribution to journalArticle

Aplastic Anemia
Myelodysplastic Syndromes
Taiwan
Anemia
Safety

Low seroprevalence of Zika virus infection among adults in Southern Taiwan

Chien, Y. W., Ho, T. C., Huang, P. W., Ko, N. Y., Ko, W. C. & Perng, G. C., 2019 Oct 23, In : BMC infectious diseases. 19, 1, 884.

Research output: Contribution to journalArticle

Open Access
Seroepidemiologic Studies
Taiwan
Dengue Virus
Immunoglobulin G
Dengue

Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry

Lin, H. H., Chen, S. J., Shen, M. R., Huang, Y. T., Hsieh, H. P., Lin, S. Y., Lin, C. C., Chang, W. S. W. & Chang, J. Y., 2019 Dec, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 12, 118517.

Research output: Contribution to journalArticle

cathepsin S
Cysteine Proteases
Cell Movement
Neoplasms
protease S