Department of Internal Medicine

Research Output 1987 2020

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Article
2020
Respiratory Tract Infections
Klebsiella pneumoniae
Carbapenems
Escherichia coli
Pseudomonas aeruginosa
Open Access
Endoscopic Retrograde Cholangiopancreatography
Tomography
Air
Mortality
Endoscopy

Discovery of a role of the novel hepatokine, hepassocin, in obesity

Huang, R. L., Li, C. H., Du, Y. F., Cheng, K. P., Lin, C. H., Hu, C. Y., Wu, J. S., Chang, C. J., Wu, H. T. & Ou, H. Y., 2020 Jan 1, In : BioFactors. 46, 1, p. 100-105 6 p.

Research output: Contribution to journalArticle

Obesity
Insulin
Blood pressure
Biomarkers
Public health

Final Overall Survival and Other Efficacy and Safety Results From ASCEND-3: Phase II Study of Ceritinib in ALKi-Naive Patients With ALK-Rearranged NSCLC

Nishio, M., Felip, E., Orlov, S., Park, K., Yu, C. J., Tsai, C. M., Cobo, M., McKeage, M., Su, W. C., Mok, T., Scagliotti, G. V., Spigel, D. R., Viraswami-Appanna, K., Chen, Z., Passos, V. Q. & Shaw, A. T., 2020 Jan 1, (Accepted/In press) In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

Open Access
Safety
Survival
Disease-Free Survival
Research Personnel
Confidence Intervals

Fluoroquinolone resistance in Haemophilus influenzae from nursing home residents in Taiwan: correlation of MICs and mutations in QRDRs

Chang, C. M., Shih, H. I., Wu, C. J., Lauderdale, T. L., Lee, N. Y., Lee, C. C., Chen, Y. C., Huang, C. C. & Ko, W. C., 2020 Jan 1, (Accepted/In press) In : Journal of Applied Microbiology.

Research output: Contribution to journalArticle

Fluoroquinolones
Haemophilus influenzae
Nursing Homes
Taiwan
Mutation
1 Citation (Scopus)

Functional Status in Older Intensive Care Unit Survivors

Tang, H. J., Tang, H. Y., Chang, C. M., Su, P. F. & Chen, C. H., 2020 Jan 1, In : Clinical Nursing Research. 29, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

Geriatrics
Intensive Care Units
Survivors
APACHE
Delirium
Open Access
Hepatitis B e Antigens
Chronic Hepatitis B
Single Nucleotide Polymorphism
Genes
Antiviral Agents

Impact of disease-specific care certification on clinical outcome and healthcare performance of myocardial infarction in Taiwan

Liao, H. H., Wang, P. C., Yeh, E. H., Lin, C. J. & Chao, T. H., 2020 Feb 1, In : Journal of the Chinese Medical Association : JCMA. 83, 2, p. 156-163 8 p.

Research output: Contribution to journalArticle

Open Access
Certification
Taiwan
Myocardial Infarction
Delivery of Health Care
Hospital Mortality
Highly Active Antiretroviral Therapy
Obstructive Sleep Apnea
Taiwan
Longitudinal Studies
Cohort Studies

Phase 4 study in patients from Asia with gastroesophageal reflux disease treated with dexlansoprazole

Wu, J. C. Y., Sheu, B. S., Wu, M. S., Lee, Y. C. & Choi, M. G., 2020 Jan 1, In : Journal of Neurogastroenterology and Motility. 26, 1, p. 85-95 11 p.

Research output: Contribution to journalArticle

Open Access
Dexlansoprazole
Esophagitis
Gastroesophageal Reflux
Heartburn
Acids
2 Citations (Scopus)

Phase III, randomised, double-blind, multicentre study to evaluate the efficacy and safety of vonoprazan compared with lansoprazole in Asian patients with erosive oesophagitis

Xiao, Y., Zhang, S., Dai, N., Fei, G., Goh, K. L., Chun, H. J., Sheu, B. S., Chong, C. F., Funao, N., Zhou, W. & Chen, M., 2020 Feb 1, In : Gut. 69, 2, p. 224-230 7 p.

Research output: Contribution to journalArticle

Open Access
Lansoprazole
Esophagitis
Double-Blind Method
Multicenter Studies
Safety

Reduced economic burden of AIDS-defining illnesses associated with adherence to antiretroviral therapy

Toh, H. S., Yang, C. T., Yang, K. L., Ku, H. C., Liao, C. T., Kuo, S., Tang, H. J., Ko, W. C., Ou, H. T. & Ko, N. Y., 2020 Feb, In : International Journal of Infectious Diseases. 91, p. 44-49 6 p.

Research output: Contribution to journalArticle

Open Access
Acquired Immunodeficiency Syndrome
Economics
Costs and Cost Analysis
Medication Adherence
Cytomegalovirus
2019
5 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J-Y. & Liou, J. P., 2019 Jan 15, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
Open Access
Propensity Score
hemodialysis
Dialysis
Peritoneal Dialysis
heart failure

Aeromonas isolates from fish and patients in Tainan City, Taiwan: genotypic and phenotypic characteristics

Wu, C. J., Ko, W. C., Lee, N. Y., Su, S. L., Li, C. W., Li, M. C., Chen, Y. W., Su, Y. C., Shu, C. Y., Lin, Y. T. & Chen, P. L., 2019 Nov 1, In : Applied and environmental microbiology. 85, 21, e01360-19.

Research output: Contribution to journalArticle

Aeromonas
Aeromonas caviae
virulence
Taiwan
Virulence

Ambulatory independence is associated with higher incidence of latent tuberculosis infection in long-term care facilities in Taiwan

Lin, S. Y., Chien, J. Y., Chiang, H. T., Lu, M. C., Ko, W. C., Chen, Y. H. & Hsueh, P. R., 2019 Jan 1, (Accepted/In press) In : Journal of Microbiology, Immunology and Infection.

Research output: Contribution to journalArticle

Open Access
Latent Tuberculosis
Long-Term Care
Taiwan
Interferon-gamma Release Tests
Incidence
4 Citations (Scopus)

A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan: prevalence, determinants, and impact on quality of life

Chou, W. C., Chen, J. S., Hung, C. Y., Lu, C. H., Shao, Y. Y., Chiou, T. J., Sung, Y. C., Rau, K. M., Yen, C-J., Yeh, S. P., Liu, T. C., Wu, M. F., Lee, M. Y., Yu, M. S., Hwang, W. L., Lai, P. Y., Chang, C. S. & Hsieh, R. K., 2019 Aug 1, In : Supportive Care in Cancer. 27, 8, p. 2857-2867 11 p.

Research output: Contribution to journalArticle

Taiwan
Analgesics
Quality of Life
Neoplasms
Pain

Angioimmunoblastic T-cell lymphoma in Taiwan reveals worse progression-free survival for RHOA G17V mutated subtype

Hsu, Y. T., Wang, Y. C., Chen, R. Y., Hung, L. Y., Li, S. S., Yen, C. C., Chen, T. Y., Medeiros, L. J. & Chang, K. C., 2019 Jan 1, (Accepted/In press) In : Leukemia and Lymphoma.

Research output: Contribution to journalArticle

T-Cell Lymphoma
Taiwan
Disease-Free Survival
Mutation
High-Throughput Nucleotide Sequencing
2 Citations (Scopus)
Open Access
Klebsiella pneumoniae
Taiwan
Pseudomonas aeruginosa
Intensive Care Units
Imipenem

A phase 1, open-label, dose-escalation trial of oral TSR-011 in patients with advanced solid tumours and lymphomas

Lin, C. C., Arkenau, H. T., Lu, S., Sachdev, J., de Castro Carpeño, J., Mita, M., Dziadziuszko, R., Su, W. C., Bobilev, D., Hughes, L., Chan, J., Zhang, Z. Y. & Weiss, G. J., 2019 Jul 16, In : British Journal of Cancer. 121, 2, p. 131-138 8 p.

Research output: Contribution to journalArticle

Open Access
Lymphoma
Neoplasms
Safety
Non-Small Cell Lung Carcinoma
Maximum Tolerated Dose

Application of transthoracic echocardiography in patients receiving intermediate- or high-risk noncardiac surgery

Chang, H. Y., Chang, W. T. & Liu, Y. W., 2019 Apr, In : PloS one. 14, 4, e0215854.

Research output: Contribution to journalArticle

Open Access
Echocardiography
echocardiography
Surgery
surgery
Mitral Valve Insufficiency
1 Citation (Scopus)

A subanalysis of Taiwanese patients from ODYSSEY South Korea and Taiwan study evaluating the efficacy and safety of alirocumab

Chao, T. H., Hsiao, P. J., Liu, M. E., Wu, C. J., Chiang, F. T., Chen, Z. C., Chen, C. P., Yeh, H. I., Lee, T. H. & Chiang, C. E., 2019 Jan 1, In : Journal of the Chinese Medical Association. 82, 4, p. 265-271 7 p.

Research output: Contribution to journalArticle

Republic of Korea
Taiwan
LDL Cholesterol
Safety
Placebos
1 Citation (Scopus)
Vascular Stiffness
Antiviral Agents
Fibrosis
Chronic Hepatitis C
Blood Pressure
Open Access
Bacteremia
Survival
Mortality
Anti-Bacterial Agents
Hospital Emergency Service
1 Citation (Scopus)
Dengue
Infection
Therapeutics
Anti-Bacterial Agents
Levofloxacin
Open Access
Neuroimaging
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Disease-Free Survival
Epidermal Growth Factor Receptor
4 Citations (Scopus)

Changing practice pattern of acute coronary syndromes in Taiwan from 2008 to 2015

Li, Y. H., Chiu, Y. W., Cheng, J. J., Hsieh, I. C., Lo, P. H., Lei, M. H., Ueng, K. C., Chiang, F. T., Sung, S. H., Kuo, J. Y., Chen, C. P., Lai, W. T., Lee, W. L. & Chen, J. H., 2019 Jan 1, In : Acta Cardiologica Sinica. 35, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Acute Coronary Syndrome
Taiwan
Registries
Percutaneous Coronary Intervention
Drug-Eluting Stents
4 Citations (Scopus)

Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity

Chang, K., Lee, N. Y., Ko, W. C., Lin, W. R., Chen, Y. H., Tsai, J. J., Chen, T. C., Lin, C. Y., Chang, Y. T. & Lu, P. L., 2019 Feb, In : Journal of Microbiology, Immunology and Infection. 52, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

Endemic Flea-Borne Typhus
Scrub Typhus
Q Fever
Prothrombin Time
Multivariate Analysis

Clinical Benefit of Empiric High-Dose Levofloxacin Therapy for Adults With Community-onset Enterobacteriaceae Bacteremia

Lee, C. C., Yang, C. Y., Lee, C. H., Hsieh, C. C., Hong, M. Y., Tang, H. J. & Ko, W. C., 2019 Oct, In : Clinical Therapeutics. 41, 10, p. 1996-2007 12 p.

Research output: Contribution to journalArticle

Levofloxacin
Enterobacteriaceae
Bacteremia
Mortality
Therapeutics
3 Citations (Scopus)

Clinical manifestations of candidemia caused by uncommon Candida species and antifungal susceptibility of the isolates in a regional hospital in Taiwan, 2007–2014

Liu, W. L., Lai, C. C., Li, M. C., Wu, C. J., Ko, W. C., Hung, Y. L., Tang, H. J. & Hsueh, P. R., 2019 Aug, In : Journal of Microbiology, Immunology and Infection. 52, 4, p. 612-619 8 p.

Research output: Contribution to journalArticle

Candidemia
Taiwan
Candida
Azoles
Microbial Sensitivity Tests
Propensity Score
Hepatocellular Carcinoma
Survival
Liver
Liver Neoplasms
1 Citation (Scopus)

Contrast-induced acute kidney injury among patients with chronic kidney disease undergoing imaging studies: A meta-analysis

Lee, Y. C., Hsieh, C. C., Chang, T. T. & Li, C. Y., 2019 Jan 1, In : American Journal of Roentgenology. 213, 4, p. 728-735 8 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Acute Kidney Injury
Meta-Analysis
Contrast Media
Glomerular Filtration Rate
2 Citations (Scopus)

CPAP promotes angiogenesis and metastasis by enhancing STAT3 activity

Chen, R. Y., Yen, C. J., Liu, Y. W., Guo, C. G., Weng, C. Y., Lai, C. H., Wang, Y. M., Lin, Y. J. & Hung, L. Y., 2019 Jan 1, (Accepted/In press) In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Hepatocellular Carcinoma
Proteins
Interleukin-8
Interleukin-6
Open Access
Cefazolin
Enterobacteriaceae
Bacteremia
Taiwan
Therapeutics

Determining the clinical characteristics and prognostic factors for the outcomes of Japanese encephalitis in adults: A multicenter study from southern Taiwan

Lo, S. H., Tang, H. J., Lee, S. S. J., Lee, J. C., Liu, J. W., Ko, W. C., Chang, K., Lee, C. Y., Chang, Y. T. & Lu, P. L., 2019 Dec, In : Journal of Microbiology, Immunology and Infection. 52, 6, p. 893-901 9 p.

Research output: Contribution to journalArticle

Open Access
Japanese Encephalitis
Taiwan
Multicenter Studies
Glasgow Coma Scale
Viral Encephalitis
3 Citations (Scopus)

Diabetes-related kidney, eye, and foot disease in Taiwan: An analysis of nationwide data from 2005 to 2014

Lin, K. D., Hsu, C. C., Ou, H. Y., Wang, C. Y., Chin, M. C. & Shin, S. J., 2019 Nov, In : Journal of the Formosan Medical Association. 118, p. S103-S110

Research output: Contribution to journalArticle

Open Access
Foot Diseases
Eye Diseases
Kidney Diseases
Taiwan
Diabetic Foot
50 Citations (Scopus)
Tenofovir
Lamivudine
HIV Infections
HIV-1
Pharmaceutical Preparations
1 Citation (Scopus)
Open Access
clopidogrel
Percutaneous Coronary Intervention
Acute Coronary Syndrome
Taiwan
Observation
1 Citation (Scopus)
Open Access
Lung Neoplasms
Health
Quality of Life
Drug Therapy
Therapeutics

Effect of First-line S-1 Plus Oxaliplatin With or Without Ramucirumab Followed by Paclitaxel Plus Ramucirumab on Advanced Gastric Cancer in East Asia: The Phase 2 RAINSTORM Randomized Clinical Trial

Yoshikawa, T., Muro, K., Shitara, K., Oh, D. Y., Kang, Y. K., Chung, H. C., Kudo, T., Chin, K., Kadowaki, S., Hamamoto, Y., Hironaka, S., Yoshida, K., Yen, C. J., Omuro, Y., Bai, L. Y., Maeda, K., Ozeki, A., Yoshikawa, R. & Kitagawa, Y., 2019 Aug 2, In : JAMA network open. 2, 8, p. e198243

Research output: Contribution to journalArticle

Open Access
oxaliplatin
Far East
Paclitaxel
Stomach Neoplasms
Randomized Controlled Trials

Effect of individualized antihypertensive therapy on the blood pressure and left ventricular hypertrophy of hypertensive patients with coronary heart disease

Liu, T. T., Li, Y., Yao, S. Y., Wang, C., Wang, M., Liu, J., Shi, Y. J. & Xue, H., 2019 Apr 2, In : Zhonghua yi xue za zhi. 99, 13, p. 977-982 6 p.

Research output: Contribution to journalArticle

Left Ventricular Hypertrophy
Antihypertensive Agents
Coronary Disease
Blood Pressure
Therapeutics

Evaluation Efficacy of Rhenium-188-Loaded Micro-particles for Radiotherapy in a Mouse Model of Hepatocellular Carcinoma

Shih, Y. H., Peng, C. L., Weng, M. F., Chiang, P. F., Luo, T. Y. & Lin, X. Z., 2019 Mar 4, In : Molecular Pharmaceutics. 16, 3, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

Rhenium
Tin
Colloids
Hepatocellular Carcinoma
Radiotherapy
Hepatitis B virus
Immunoglobulin G
Liver
Hepatitis B e Antigens
Acetylglucosamine
1 Citation (Scopus)

Gender differences in inappropriate use of urinary catheters among hospitalized older patients

Hu, F. W., Chang, C-M., Su, P-F., Chen, H. Y. & Chen, C. H., 2019 Mar 4, In : Journal of Women and Aging. 31, 2, p. 165-175 11 p.

Research output: Contribution to journalArticle

Urinary Catheters
gender-specific factors
incidence
Catheters
demographic factors

Generation of a heterozygous p53 R249S mutant human embryonic stem cell line by TALEN-mediated genome editing

Huo, Z., Tu, J., Xu, A., Li, Y., Wang, D., Liu, M., Zhou, R., Zhu, D., Lin, Y., Gingold, J. A., Yen, C. J., Xiao, H. & Zhao, R., 2019 Jan, In : Stem Cell Research. 34, 101360.

Research output: Contribution to journalArticle

Open Access
Cell Line
Mutation
Germ Layers
Teratoma
Liver Neoplasms

H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer

Yeh, Y. C., Kuo, H. Y., Chang, W. L., Yang, H. B., Lu, C. C., Cheng, H. C., Wu, M. S. & Sheu, B. S., 2019 Jan 5, In : Journal of biomedical science. 26, 1, 4.

Research output: Contribution to journalArticle

Pylorus
Polymorphism
Stomach Neoplasms
Amino Acid Sequence
Amino Acids
2 Citations (Scopus)
Open Access
Helicobacter Infections
Helicobacter pylori
Pylorus
Breath Tests
Infection
Open Access
HIV Seroprevalence
Immunization Programs
Hepatitis B
Taiwan
Hepatitis B virus

Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis

Yen, C. J., Yang, S. T., Chen, R. Y., Huang, W., Chayama, K., Lee, M. H., Yang, S. J., Lai, H. S., Yen, H. Y., Hsiao, Y. W., Wang, J. M., Lin, Y. J. & Hung, L. Y., 2019 Jun 6, In : Journal of biomedical science. 26, 1, 44.

Research output: Contribution to journalArticle

Open Access
Proteins
Hepatocellular Carcinoma
Viruses
Hepatitis B virus
Cyclic AMP Response Element-Binding Protein

High blood pressure induced by the rivastigmine patch as an uncommon side effect

Huang, C. C., Chang, C. M. & Tu, H. N., 2019 Jan 1, In : International Journal of Gerontology. 13, 4, p. 363-364 2 p.

Research output: Contribution to journalArticle

Rivastigmine
Hypertension
Dementia
Alzheimer Disease
Cholinesterase Inhibitors