Department of Medical Laboratory Science and Biotechnology

Research Output

2020

Antrodia cinnamomea confers obesity resistance and restores intestinal barrier integrity in leptin-deficient obese mice

Tsai, Y. T., Ruan, J. W., Chang, C. S., Ko, M. L., Chou, H. C., Lin, C. C., Lin, C. M., Huang, C. T., Wei, Y. S., Liao, E. C., Chen, H. Y., Kao, C. Y. & Chan, H. L., 2020 Mar, In : Nutrients. 12, 3, 726.

Research output: Contribution to journalArticle

Open Access

Enhancement of human iPSC-derived cardiomyocyte maturation by chemical conditioning in a 3D environment

Huang, C. Y., Peres Moreno Maia-Joca, R., Ong, C. S., Wilson, I., DiSilvestre, D., Tomaselli, G. F. & Reich, D. H., 2020 Jan, In : Journal of Molecular and Cellular Cardiology. 138, p. 1-11 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Epigenetic silencing of ubiquitin specific protease 4 by snail1 contributes to macrophage-dependent inflammation and therapeutic resistance in lung cancer

Lai, C. Y., Yeh, D. W., Lu, C. H., Liu, Y. L., Chuang, Y. C., Ruan, J. W., Kao, C. Y., Huang, L. R. & Chuang, T. H., 2020 Jan 1, In : Cancers. 12, 1, 148.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Genetic variations on 31 and 450 residues of influenza A nucleoprotein affect viral replication and translation

Hung, S. J., Hsu, Y. M., Huang, S. W., Tsai, H. P., Lee, L. Y. Y., Hurt, A. C., Barr, I. G., Shih, S. R. & Wang, J. R., 2020 Jan 6, In : Journal of biomedical science. 27, 1, 17.

Research output: Contribution to journalArticle

Open Access

Loss of EGR-1 uncouples compensatory responses of pancreatic β cells

Leu, S. Y., Kuo, L. H., Weng, W. T., Lien, I. C., Yang, C. C., Hsieh, T. T., Cheng, Y. N., Chien, P. H., Ho, L. C., Chen, S. H., Shan, Y. S., Chen, Y. W., Tsai, P. J., Sung, J. M. & Tsai, Y. S., 2020 Jan 1, In : Theranostics. 10, 9, p. 4233-4249 17 p.

Research output: Contribution to journalArticle

Open Access

Requirement of cyclin-dependent kinase function for hepatitis B virus cccDNA synthesis as measured by digital PCR

Bao, C. Y., Hung, H. C., Chen, Y. W., Fan, C. Y., Huang, C. J. & Huang, W., 2020 May 1, In : Annals of Hepatology. 19, 3, p. 280-286 7 p.

Research output: Contribution to journalArticle

Open Access

The effect of the chorion on size-dependent acute toxicity and underlying mechanisms of amine-modified silver nanoparticles in zebrafish embryos

Chen, Z. Y., Li, N. J., Cheng, F. Y., Hsueh, J. F., Huang, C. C., Lu, F. I., Fu, T. F., Yan, S. J., Lee, Y. H. & Wang, Y. J., 2020 Apr 2, In : International journal of molecular sciences. 21, 8, 2864.

Research output: Contribution to journalArticle

Open Access

The interaction between carbohydrates and the antimicrobial peptide P-113Tri is involved in the killing of candida albicans

Lin, G. Y., Chang, C. F. & Lan, C. Y., 2020 Feb, In : Microorganisms. 8, 2, 299.

Research output: Contribution to journalArticle

Open Access

Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice

Cheng, Y. Y., Chou, Y. T., Lai, F. J., Jan, M. S., Chang, T. H., Jou, I. M., Chen, P. S., Lo, J. Y., Huang, S. S., Chang, N. S., Liou, Y. T., Hsu, P. C., Cheng, H. C., Lin, Y. S. & Hsu, L. J., 2020 Jan 30, In : Acta Neuropathologica Communications. 8, 1, 6.

Research output: Contribution to journalArticle

Open Access
2019

An Aptamer Based Sandwich Assay for Simultaneous Detection of Multiple Cardiovascular Biomarkers on A Multilayered Integrated Microfluidic System

Sinha, A., Gopinathan, P., Chung, Y. D., Shiesh, S. C. & Lee, G. B., 2019 Jun, 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII. Institute of Electrical and Electronics Engineers Inc., p. 1075-1077 3 p. 8808551. (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

An integrated microfluidic system for on-chip enrichment and quantification of circulating extracellular vesicles from whole blood

Chen, Y. S., Ma, Y. D., Chen, C., Shiesh, S. C. & Lee, G. B., 2019 Oct 7, In : Lab on a Chip. 19, 19, p. 3305-3315 11 p.

Research output: Contribution to journalArticle

An integrated microfluidic system for rapid detection and multiple subtyping of influenza A viruses by using glycan-coated magnetic beads and RT-PCR

Shen, K. M., Sabbavarapu, N. M., Fu, C. Y., Jan, J. T., Wang, J. R., Hung, S. C. & Lee, G. B., 2019 Apr 7, In : Lab on a Chip. 19, 7, p. 1277-1286 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

An integrated microfluidic system with field-effect-transistor sensor arrays for detecting multiple cardiovascular biomarkers from clinical samples

Sinha, A., Tai, T. Y., Li, K. H., Gopinathan, P., Chung, Y. D., Sarangadharan, I., Ma, H. P., Huang, P. C., Shiesh, S-C., Wang, Y. L. & Lee, G. B., 2019 Mar 15, In : Biosensors and Bioelectronics. 129, p. 155-163 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

A novel zebrafish model to emulate lung injury by folate deficiency-induced swim bladder defectiveness and protease/antiprotease expression imbalance

Lee, G. H., Cheng, N. W., Yu, H. H., Tsai, J. N., Liu, T., Wen, Z. H., Chen, B. H. & Fu, T. F., 2019 Dec 1, In : Scientific reports. 9, 1, 12633.

Research output: Contribution to journalArticle

Open Access

An overview of microbiome based strategies on anti-obesity

Chang, C. S., Ruan, J. W. & Kao, C. Y., 2019 Jan 1, In : Kaohsiung Journal of Medical Sciences. 35, 1, p. 7-16 10 p.

Research output: Contribution to journalReview article

Open Access

Application of deep sequencing methods for inferring viral population diversity

Huang, S. W., Hung, S. J. & Wang, J. R., 2019 Apr, In : Journal of Virological Methods. 266, p. 95-102 8 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish

Lee, G. H., Chang, C. L., Chiu, W. T., Hsiao, T. H., Chen, P. Y., Wang, K. C., Kuo, C. H., Chen, B. H., Shi, G. Y., Wu, H. L. & Fu, T. F., 2019 Aug 26, In : Journal of biomedical science. 26, 1, 60.

Research output: Contribution to journalArticle

Open Access

BIRC5/Survivin is a novel ATG12–ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells

Lin, T. Y., Chan, H. H., Chen, S. H., Sarvagalla, S., Chen, P. S., Coumar, M. S., Cheng, S. M., Chang, Y. C., Lin, C. H., Leung, E. & Cheung, C. H. A., 2019 Jan 1, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalReview article

Open Access
3 Citations (Scopus)

Combination of modified NS1 and NS3 as a novel vaccine strategy against dengue virus infection

Kao, Y. S., Yu, C. Y., Huang, H. J., Tien, S. M., Wang, W. Y., Yang, M., Anderson, R., Yeh, T. M., Lin, Y. S. & Wan, S. W., 2019 Oct 1, In : Journal of Immunology. 203, 7, p. 1909-1917 9 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access

Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage

Chao, C. H., Wu, W. C., Lai, Y. C., Tsai, P. J., Perng, G-C., Lin, Y. S. & Yeh, T-M., 2019 Jan 1, In : PLoS pathogens. 15, 4, e1007625.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Design and Demonstration of Tunable Amplified Sensitivity of AlGaN/GaN High Electron Mobility Transistor (HEMT)-Based Biosensors in Human Serum

Tai, T. Y., Sinha, A., Sarangadharan, I., Pulikkathodi, A. K., Wang, S. L., Lee, G. Y., Chyi, J. I., Shiesh, S. C., Lee, G. B. & Wang, Y. L., 2019 May 7, In : Analytical chemistry. 91, 9, p. 5953-5960 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Differential dynamics of hepatic protein expressions with long-term cultivated hepatitis C virus infection

Tsai, P., Lin, T. Y., Cheng, S. L., Sun, H. Y., Chen, S. F. & Young, K. C., 2019 Jan 1, In : Journal of Microbiology, Immunology and Infection.

Research output: Contribution to journalArticle

Open Access

Direct Screening of Glycan Patterns from Human Sera: A Selective Glycoprotein Microarray Strategy

Tu, H. C., Lee, Y. P., Liu, X. Y., Chang, C. F. & Lin, P. C., 2019 Mar 18, In : ACS Applied Bio Materials. 2, 3, p. 1286-1297 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Enterovirus A71: Virulence, antigenicity, and genetic evolution over the years

Huang, S. W., Cheng, D. & Wang, J. R., 2019 Oct 21, In : Journal of biomedical science. 26, 1, 81.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

Enterovirus A71 containing codon-deoptimized VP1 and high-fidelity polymerase as next-generation vaccine candidate

Tsai, Y. H., Huang, S. W., Hsieh, W. S., Cheng, C. K., Chang, C. F., Wang, Y. F. & Wang, J. R., 2019 Jan 1, In : Journal of Virology. 93, 13, e02308-18.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation

Lin, Y. M., Sun, H. Y., Chiu, W. T., Su, H. C., Chien, Y. C., Chang, H. A., Chong, L. W., Chang, H. C., Young, K. C., Bai, C. H. & Tsao, C. W., 2019 Jan 1, In : BioMed research international. 2019, 3102414.

Research output: Contribution to journalArticle

Open Access

Evolutionary and Genomic Insights into Clostridioides difficile Sequence Type 11: a Diverse Zoonotic and Antimicrobial-Resistant Lineage of Global One Health Importance

Knight, D. R., Kullin, B., Androga, G. O., Barbut, F., Eckert, C., Johnson, S., Spigaglia, P., Tateda, K., Tsai, P. J. & Riley, T. V., 2019 Apr 16, In : mBio. 10, 2

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)
Open Access

Glycoproteomic identification of novel plasma biomarkers for oral cancer

Chang, S. C., Lin, W. L., Chang, Y. F., Lee, C. T., Wu, J. S., Hsu, P. H. & Chang, C. F., 2019 Apr, In : Journal of Food and Drug Analysis. 27, 2, p. 483-493 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Group A Streptococcus Subcutaneous Infection-Induced Central Nervous System Inflammation Is Attenuated by Blocking Peripheral TNF

Liu, Y., Wu, P., Kang, C., Tsai, Y., Chou, C., Liang, C., Wu, J. & Tsai, P., 2019, In : Frontiers in Microbiology. 10

Research output: Contribution to journalArticle

Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis

Yen, C. J., Yang, S. T., Chen, R. Y., Huang, W., Chayama, K., Lee, M. H., Yang, S. J., Lai, H. S., Yen, H. Y., Hsiao, Y. W., Wang, J. M., Lin, Y. J. & Hung, L. Y., 2019 Jun 6, In : Journal of biomedical science. 26, 1, 44.

Research output: Contribution to journalArticle

Open Access

Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells

Kuo, P. L., Tseng, J. Y., Chen, H. I., Wu, C. Y., Omar, H. A., Wang, C. Y., Cheng, H. Y., Hsu, C. C., Fu, T. F. & Teng, Y. N., 2019 Mar, In : Biochimie. 158, p. 1-9 9 p.

Research output: Contribution to journalArticle

Improvement of Maturation State of Human Induced Pluripotent Stem Cell-Derived 3D Cardiac Microtissues by Defined Chemical Factors

Huang, C-Y., Joca, R., Ong, C. S., Wilson, I., Teuben, R., Tomaselli, G. F. & Reich, D. H., 2019 Feb, 63 th BPS annual meeting. Baltimore

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Improvement of Maturation State of Human Induced Pluripotent Stem Cell-Derived 3D Cardiac Microtissues by Defined Chemical Factors

Yu Huang, C., Joca, R., Siang Ong, C., Wilson, I., Teuben, R., Tomaselli, G. F. & Reich, D. H., 2019 Feb 1, In : Biophysical Journal. 116, 3, p. 464a-465a

Research output: Contribution to journalArticle

Inhibition of autophagy protects against sepsis by concurrently attenuating the cytokine storm and vascular leakage

Lu, L. H., Chao, C. H. & Yeh, T. M., 2019 Mar, In : Journal of Infection. 78, 3, p. 178-186 9 p.

Research output: Contribution to journalArticle

Mutation of the PTCH1 gene predicts recurrence of breast cancer

Wang, C. Y., Chang, Y. C., Kuo, Y. L., Lee, K. T., Chen, P. S., Cheung, C. H. A., Chang, C. P., Phan, N. N., Shen, M. R. & Hsu, H. P., 2019 Nov 8, In : Scientific reports. 9, 1, 1 p., 16359.

Research output: Contribution to journalArticle

Open Access

New Templated Ostwald Ripening Process of Mesostructured FeOOH for Third-Harmonic Generation Bioimaging

Lee, C. W., Wu, P. C., Hsu, I. L., Liu, T. M., Chong, W. H., Wu, C. H., Hsieh, T. Y., Guo, L. Z., Tsao, Y., Wu, P. T., Yu, J., Tsai, P. J., Huang, H. S., Chuang, Y. C. & Huang, C. C., 2019 May 17, In : Small. 15, 20, 1805086.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Optimization of an enzyme linked DNA aptamer assay for cardiac troponin i detection: Synchronous multiple sample analysis on an integrated microfluidic platform

Gopinathan, P., Sinha, A., Chung, Y. D., Shiesh, S. C. & Lee, G. B., 2019 Aug 21, In : Analyst. 144, 16, p. 4943-4951 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Plasma proteome plus site-specific N-glycoprofiling for hepatobiliary carcinomas

Chang, T. T., Cheng, J. H., Tsai, H. W., Young, K. C., Hsieh, S. Y. & Ho, C. H., 2019 Jul, In : Journal of Pathology: Clinical Research. 5, 3, p. 199-212 14 p.

Research output: Contribution to journalArticle

Open Access

Pyridoxamine supplementation effectively reverses the abnormal phenotypes of zebrafish larvae with PNPO deficiency

Chen, P. Y., Tu, H. C., Schirch, V., Safo, M. K. & Fu, T. F., 2019 Jan 1, In : Frontiers in Pharmacology. 10, SEP, 1086.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Rapid Prototyping of an Open-Surface Microfluidic Platform Using Wettability-Patterned Surfaces Prepared by an Atmospheric-Pressure Plasma Jet

Wu, S. T., Huang, C. Y., Weng, C. C., Chang, C. C., Li, B. R. & Hsu, C. S., 2019 Oct 8, In : ACS Omega. 4, 15, p. 16292-16299 8 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Risk factors of Clostridium difficile-associated diarrhea in hospitalized adults: Vary by hospitalized duration

Hung, Y. P., Lee, J. C., Tsai, B. Y., Wu, J. L., Liu, H. C., Liu, H. C., Lin, H. J., Tsai, P. J. & Ko, W. C., 2019 Jan 1, (Accepted/In press) In : Journal of Microbiology, Immunology and Infection.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer

Chuang, P. K., Hsiao, M., Hsu, T. L., Chang, C. F., Wu, C. Y., Chen, B. R., Huang, H. W., Liao, K. S., Chen, C. C., Chen, C. L., Yang, S. M., Kuo, C. W., Chen, P., Chiu, P. T., Chen, I. J., Lai, J. S., Yu, C. D. T. & Wong, C. H., 2019 Feb 26, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3518-3523 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Simultaneous detection of multiple NT-proBNP clinical samples utilizing an aptamer-based sandwich assay on an integrated microfluidic system

Sinha, A., Gopinathan, P., Chung, Y. D., Shiesh, S. C. & Lee, G. B., 2019 May 7, In : Lab on a Chip. 19, 9, p. 1676-1685 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment

Chou, P. Y., Lai, F. J., Chen, Y. A., Sie, Y. D., Kuo, H. L., Su, W. P., Wu, C. Y., Liu, T. Y., Wen, K. Y., Hsu, L. J., Sze, C. I. & Chang, N. S., 2019 Dec 1, In : Cell Death Discovery. 5, 1, 97.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Supplementation with 5-formyltetrahydrofolate alleviates ultraviolet B-inflicted oxidative damage in folate-deficient zebrafish

Tu, H. C., Lin, M. Y., Lin, C. Y., Hsiao, T. H., Wen, Z. H., Chen, B. H. & Fu, T. F., 2019 Oct 30, In : Ecotoxicology and Environmental Safety. 182, 109380.

Research output: Contribution to journalArticle

TARBP2-enhanced resistance during tamoxifen treatment in breast cancer

Wang, M. Y., Huang, H. Y., Kuo, Y. L., Lo, C., Sun, H. Y., Lyu, Y. J., Chen, B. R., Li, J. N. & Chen, P. S., 2019 Feb, In : Cancers. 11, 2, 210.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma

Lai, H. H., Li, C. W., Hong, C. C., Sun, H. Y., Chiu, C. F., Ou, D. L. & Chen, P. S., 2019 Apr, In : Molecular Oncology. 13, 4, p. 928-945 18 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)