Department of Medical Laboratory Science and Biotechnology

Research output

Research output per year 1987 2005 2006 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

• 876 Article
• 49 Review article
• 35 Conference contribution
• 27 Patent
• 30 More
  • 15 Comment/debate
  • 7 Letter
  • 5 Chapter
  • 2 Short survey
  • 1 Book

Research output per year

Research output per year

Search results

• 2024

  A pilot study on the detection of microsatellite instability using long mononucleotide repeats in solid tumors

  Liu, T., Ho, C. L., Chen, Y. J., Chen, P. J., Chen, W. L., Lee, C. T., Chow, N. H., Huang, W. & Chen, Y. L., 2024 Sept, In: Oncology Letters. 28, 3, 445.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Benign polymorphisms in the BRCA genes with linkage disequilibrium is associated with cancer characteristics

  Lee, K. T., Chen, D. P., Loh, Z. J., Chung, W. P., Wang, C. Y., Chen, P. S., Cheung, C. H. A., Chang, C. P. & Hsu, H. P., 2024 Dec, In: Cancer Science. 115, 12, p. 3973-3985 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Characterization of integrated hepatitis B virus DNA harboring pre-S mutations in hepatocellular carcinoma patients with ground glass hepatocytes

  Su, Y. P., Lin, S. Y., Su, I. J., Kao, Y. L., Shen, S. C., Earl, J. P., Ehrlich, G. D., Chen, C. Y., Huang, W., Su, Y. H. & Tsai, H. W., 2024 Jan, In: Journal of Medical Virology. 96, 1, e29348.

  Research output: Contribution to journal › Article › peer-review

  • Hepatitis B virus 100%
  • Glass 99%
  • Hepatocellular Carcinoma 83%
  • Mutation 57%
  • DNA 57%

• Detection of toxigenic M1_UK lineage group A Streptococcus clones in Taiwan

  Chiang-Ni, C., Hsu, C. Y., Yeh, Y. H., Chi, C. Y., Wang, S., Tsai, P. J. & Chiu, C. H., 2024 Apr, In: Journal of Microbiology, Immunology and Infection. 57, 2, p. 269-277 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Scarlet Fever 100%
  • Streptococcus 65%
  • Clone Cells 50%
  • Pharynx 32%
  • North America 17%
  5 Citations (Scopus)

• Distinct protective effects of a novel Akkermansia sp. BCRC 18949 against DSS-Induced colitis in mice

  Huang, C. H., Huang, C. T., Tsai, H. Y., Liao, Y. C., Lin, C. M., Chen, P. C., Liou, J. S., Hsu, C. L., Chiu, S. H., Chen, C. C., Hsieh, S. Y., Zou, H. B., Hsu, C. C., Chen, P. S., Kao, C. Y. & Ruan, J. W., 2024 Apr, In: Journal of Functional Foods. 115, 106110.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • colitis 100%
  • Colitis 73%
  • protective effect 68%
  • mice 41%
  • food grades 29%
  2 Citations (Scopus)

• Disturbed intracellular folate homeostasis impairs autophagic flux and increases hepatocytic lipid accumulation

  Chi, W. Y., Lee, G. H., Tang, M. J., Chen, B. H., Lin, W. L. & Fu, T. F., 2024 Dec, In: BMC Biology. 22, 1, 146.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Enhancement of NETosis by ACE2-cross-reactive anti-SARS-CoV-2 RBD antibodies in patients with COVID-19

  Hsieh, K. H., Chao, C. H., Cheng, Y. L., Lai, Y. C., Chuang, Y. C., Wang, J. R., Chang, S. Y., Hung, Y. P., Chen, Y. M. A., Liu, W. L., Chuang, W. J. & Yeh, T. M., 2024 Dec, In: Journal of biomedical science. 31, 1, 39.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • angiotensin converting enzyme 2 100%
  • SARS Virus 99%
  • Phosphotransferase Inhibitor 84%
  • Antibodies 37%
  • Protein 27%
  1 Citation (Scopus)

• Focused ion beam-fabricated nanorod substrate for label-free surface-enhanced Raman spectroscopy and enabling dual virus detection

  Lee, H., Liao, J. D., Tsai, H-P., Wang, H. & Sitjar, J., 2024 Oct 1, In: Talanta. 278, 126466.

  Research output: Contribution to journal › Article › peer-review

• Haemolysin Ahh1 secreted from Aeromonas dhakensis activates the NLRP3 inflammasome in macrophages and mediates severe soft tissue infection

  Su, Y. C., Wang, C. C., Chen, Y. W., Wang, S. T., Shu, C. Y., Tsai, P. J., Ko, W. C., Chen, C. S. & Chen, P. L., 2024 Feb 15, In: International Immunopharmacology. 128, 111478.

  Research output: Contribution to journal › Article › peer-review

  • Aeromonas 100%
  • Hemolysin Proteins 90%
  • Soft Tissue Infections 85%
  • Inflammasomes 84%
  • Interleukin-1 69%
  3 Citations (Scopus)

• Intestinal dual-specificity phosphatase 6 regulates the cold-induced gut microbiota remodeling to promote white adipose browning

  Chen, P. C., Tsai, T. P., Liao, Y. C., Liao, Y. C., Cheng, H. W., Weng, Y. H., Lin, C. M., Kao, C. Y., Tai, C. C. & Ruan, J. W., 2024 Dec, In: npj Biofilms and Microbiomes. 10, 1, 22.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dual Specificity Phosphatase 6 100%
  • Cold Temperature 50%
  • Microbiota 24%
  • White Adipose Tissue 15%
  • Non-alcoholic Fatty Liver Disease 6%

• Label-free SERS method with size-matched selectivity for analytes of varying sizes

  Lee, H., Liao, J. D., Tsai, H. P., Chen, C. H., Sitjar, J., Fu, W. E. & Lin, F. H., 2024 Jan, In: Surfaces and Interfaces. 44, 103821.

  Research output: Contribution to journal › Article › peer-review

  • Gold nanoparticles 100%
  • Raman spectroscopy 84%
  • Surface Enhanced Raman Spectroscopy 70%
  • selectivity 59%
  • Labels 53%
  5 Citations (Scopus)

• Phage transcriptional regulator X (PtrX)-mediated augmentation of toxin production and virulence in Clostridioides difficile strain R20291

  Gong, J. J., Huang, I. H., Su, M. S. W., Xie, S. X., Liu, W. Y., Huang, C. R., Hung, YP. P., Wu, S. R., Tsai, PJ. J., Ko, WC. C. & Chen, J. W., 2024 Mar, In: Microbiological Research. 280, 127576.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bacteriophages 100%
  • Virulence 88%
  • Gene Expression 60%
  • Biofilms 49%
  • Bacterial Spores 41%

• Phosphorylation of TG-interacting factor 1 at carboxyl-terminal sites in response to insulin regulates adipocyte differentiation

  Chang, Y. H., Tseng, Y. H., Wang, J. M., Tsai, Y. S., Liu, X. L. & Huang, H. S., 2024 Apr, In: FEBS Letters. 598, 8, p. 945-955 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Insulin Derivative 100%
  • Adipocytes 93%
  • Phosphorylation 67%
  • Insulin 66%
  • U0126 62%

• Simultaneous detection of SARS-CoV-2 and influenza A/B viruses on an electromagnetically-driven, integrated microfluidic system

  Chiu, C. H., Wang, C. H., Lin, Y. J., Tang, C. C., Peng, W. J., Huang, W. Y., Shan, Y. S., Tsai, H. P. & Lee, G. B., 2024 Jul, In: Sensors and Actuators B: Chemical. 410, 135647.

  Research output: Contribution to journal › Article › peer-review

  • influenza 100%
  • viruses 77%
  • Viruses 76%
  • Microfluidics 69%
  • Genes 62%
  1 Citation (Scopus)

• SnoRNA U50A mediates everolimus resistance in breast cancer through mTOR downregulation

  Li, J. N., Loh, Z. J., Chen, H. W., Lee, I. Y., Tsai, J. H. & Chen, P. S., 2024 Oct, In: Translational Oncology. 48, 102062.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• TG-interacting factor 1 regulates mitotic clonal expansion during adipocyte differentiation

  Chang, Y. H., Tseng, Y. H., Wang, J. M., Tsai, Y. S. & Huang, H. S., 2024 Jun, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 5, 159492.

  Research output: Contribution to journal › Article › peer-review

  • Doxycycline 100%
  • Adipocytes 82%
  • Obesity 60%
  • CCAAT-Enhancer-Binding Proteins 60%
  • oil red O 58%

• The molecular epidemiology of a dengue virus outbreak in Taiwan: population wide versus infrapopulation mutation analysis

  Tsai, Y. Y., Cheng, D., Huang, S. W., Hung, S. J., Wang, Y. F., Lin, Y. J., Tsai, H. P., Chu, J. J. H. & Wang, J. R., 2024 Jun, In: PLoS neglected tropical diseases. 18, 6, e0012268.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Using a 3D Silicon Micro-Channel Device and Raman Spectroscopy for the Analysis of Whole Blood and Abnormal Blood

  Chiang, C. C., Huang, S. J., Immanuel, P. N., Lan, J. H., Lo, F. Y. & Young, K. C., 2024 Jan, In: Micromachines. 15, 1, 21.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Raman spectroscopy 100%
  • Blood 69%
  • Silicon 58%
  • Hemoglobin 45%
  • Biomarkers 26%
  1 Citation (Scopus)

• VP1 codon deoptimization and high-fidelity substitutions in 3D polymerase as potential vaccine strategies for eliciting immune responses against enterovirus A71

  Hsieh, W. S., Chao, C. H., Shen, C. Y., Cheng, D., Huang, S. W., Wang, Y. F., Chen, C. C., Chen, S. H., Hsu, L. J. & Wang, J. R., 2024 Jan, In: Journal of Virology. 98, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Enterovirus 100%
  • Codon 78%
  • codons 75%
  • vaccines 68%
  • immune response 65%
• 2023

  Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: Low prevalence and novel mutations

  Kuo, J. Y., Yeh, C. S., Wang, S. M., Chen, S. H., Wang, J. R., Chen, T. Y. & Tsai, H. P., 2023 Aug, In: Journal of Medical Virology. 95, 8, e28985.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acyclovir 100%
  • Human Herpesvirus 1 91%
  • Immunocompromised Host 88%
  • Mutation 46%
  • Genes 16%
  5 Citations (Scopus)

• Age and prior vaccination determine the antibody level in children with primary SARS-CoV-2 Omicron infection

  Taiwan Pediatric Infectious Disease Alliance (TPIDA), 2023 Dec, In: Journal of Microbiology, Immunology and Infection. 56, 6, p. 1187-1197 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Vaccination 62%
  • Neutralizing Antibodies 46%
  • Coronavirus Infections 44%
  3 Citations (Scopus)

• Antagonizing apolipoprotein J chaperone promotes proteasomal degradation of mTOR and relieves hepatic lipid deposition

  Duan, S., Qin, N., Pi, J., Sun, P., Gao, Y., Liu, L., Li, Z., Li, Y., Shi, L., Gao, Q., Qiu, Y., Tang, S., Wang, C. H., Chen, T. Y., Wang, S. T., Young, K. C. & Sun, H. Y., 2023 Oct, In: Hepatology. 78, 4, p. 1182-1199 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Clusterin 100%
  • TOR Serine-Threonine Kinases 79%
  • Lipids 46%
  • Liver 36%
  • Ubiquitin 23%
  1 Citation (Scopus)

• Antigenic mapping of enterovirus A71 from Taiwan and Southeast Asia

  Cheng, D., Huang, S. W., Tsai, Y. H., Lien, Y. Y. & Wang, J. R., 2023 Apr, In: Antiviral Research. 212, 105569.

  Research output: Contribution to journal › Article › peer-review

  • Southeastern Asia 100%
  • Enterovirus 91%
  • Genotype 42%
  • Viruses 39%
  • Reverse Genetics 39%

• Antiviral and immunoregulatory effects of curcumin on coxsackievirus B3-infected hepatitis

  Lin, Y. J., Wang, L. C., Tsai, H. P., Chi, C. Y., Chang, C. P., Chen, S. H. & Wang, S. M., 2023 Oct 15, In: Virus Research. 336, 199203.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Enterovirus 100%
  • Curcumin 98%
  • Hepatitis 82%
  • Antiviral Agents 74%
  • Liver 29%

• Association of Single Nucleotide Polymorphisms in Nucleotide-Binding Domain Leucine-Rich Repeat Protein 1 with Clostridioides difficile Colonization or Infection

  Tsai, B. Y., Tsai, P. J., Lee, C. C., Chiu, C. W., Lai, Y. H., Lee, J. C., Ko, W. C. & Hung, Y. P., 2023, In: Infection and Drug Resistance. 16, p. 413-421 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • NLR Proteins 100%
  • Single Nucleotide Polymorphism 57%
  • Infections 32%
  • Odds Ratio 29%
  • Genotype 27%

• CDCP1 (CUB domain containing protein 1) is a potential urine-based biomarker in the diagnosis of low-grade urothelial carcinoma

  Liu, C. L., Tsai, H. W., Peng, S. L., Chang, C. P., Chang, Y. H. & Huang, H. S., 2023 Mar, In: PloS one. 18, 3 March, e0281873.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Domains 100%
  • Urine 70%
  • Carcinoma 65%
  • Biomarkers 64%
  • Tissue Array Analysis 15%
  1 Citation (Scopus)

• Characteristics of rectal chlamydia among men who have sex with men in southern Taiwan, 2020–2022: An emerging threat of rectal lymphogranuloma venereum L2b

  Tsai, C. S., Chen, P. L., Lee, N. Y., Tsai, H. P., Huang, S. H., Chen, S. Y., Tang, Y. W., Lin, Y. C., Tsai, P. F., Mao, L. W., Su, S. L., Wang, J. L. & Ko, W. C., 2023 Apr, In: Journal of Microbiology, Immunology and Infection. 56, 2, p. 408-415 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lymphogranuloma Venereum 100%
  • Chlamydia 74%
  • Sexual Partners 57%
  • Proctitis 35%
  • Gonorrhea 30%
  8 Citations (Scopus)

• Clinical implications of PNA-sequencing as a complementary test for EGFR mutation analysis in human lung cancer

  Chen, Y. L., Lin, C. C., Yu, Y. T., Chen, W. L., Yang, S. C., Huang, W., Su, W. C., Chow, N. H. & Ho, C. L., 2023, In: Oncology Letters. 26, 6, 539.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peptide Nucleic Acids 100%
  • Lung Neoplasms 53%
  • Mutation 37%
  • ErbB Receptors 25%
  • Protein-Tyrosine Kinases 24%

• Detection of live SARS-CoV-2 virus and its variants by specially designed SERS-active substrates and spectroscopic analyses

  Sitjar, J., Liao, J. D., Lee, H., Tsai, H. P., Wang, J. R., Chen, C. H., Wang, H. & Liu, B. H., 2023 May 22, In: Analytica Chimica Acta. 1256, 341151.

  Research output: Contribution to journal › Article › peer-review

  • severe acute respiratory syndrome 100%
  • SARS Virus 96%
  • Raman Spectrum Analysis 85%
  • Raman spectroscopy 73%
  • Surface Enhanced Raman Spectroscopy 72%
  7 Citations (Scopus)

• Establishment of quantitative and recovery method for detection of dengue virus in wastewater with noncognate spike control

  Chen, K. W., Chen, T. Y., Wang, S. T., Hou, T. Y., Wang, S. W. & Young, K. C., 2023 Apr, In: Journal of Virological Methods. 314, 114687.

  Research output: Contribution to journal › Article › peer-review

  • Waste Water 100%
  • Dengue Virus 91%
  • Wastewater-Based Epidemiological Monitoring 43%
  • Virion 31%
  • Flocculation 16%
  5 Citations (Scopus)

• Experimental study on construction vibration during different phases of diaphragm wall-supported deep excavation and its influence on indoor sensitive receivers

  Ko, Y. Y., Lai, L. Y., Lee, G. H., Wang, Y. F., Jao, S. W. & Fu, T. F., 2023 Sept, In: JVC/Journal of Vibration and Control. 29, 17-18, p. 3925-3941 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Diaphragms 100%
  • Excavation 93%
  • Demolition 39%
  • Pavements 28%
  • Bandwidth 9%
  3 Citations (Scopus)

• High concordance rate of capillary electrophoresis workflow for microsatellite instability analysis and mismatch repair (MMR) immunostaining in colorectal carcinoma

  Huang, W., Ho, C. L., Lee, C. T., Chen, W. L., Yang, S. C., Chow, N. H. & Chen, Y. L., 2023 Apr, In: PloS one. 18, 4 April, e0284227.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Capillary Electrophoresis 100%
  • Colorectal Neoplasms 60%
  • Gels 20%
  • Immunotherapy 11%
  • Fluorescence 10%
  1 Citation (Scopus)

• Highly-specific aptamer targeting SARS-CoV-2 S1 protein screened on an automatic integrated microfluidic system for COVID-19 diagnosis

  Wu, H. B., Wang, C. H., Chung, Y. D., Shan, Y. S., Lin, Y. J., Tsai, H. P. & Lee, G. B., 2023 Sept 15, In: Analytica Chimica Acta. 1274, 341531.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • severe acute respiratory syndrome 100%
  • SARS Virus 96%
  • Coronavirus 82%
  • Microfluidics 78%
  • targeting 64%
  10 Citations (Scopus)

• Inguinal Fat Compensates Whole Body Metabolic Functionality in Partially Lipodystrophic Mice with Reduced PPARγ Expression

  Chang, C. S., Yu, S. S., Ho, L. C., Chao, S. H., Chou, T. Y., Shao, A. N., Kao, L. Z., Chang, C. Y., Chen, Y. H., Wu, M. S., Tsai, P. J., Maeda, N. & Tsai, Y. S., 2023 Feb, In: International journal of molecular sciences. 24, 4, 3904.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peroxisome Proliferator-Activated Receptors 100%
  • fats 58%
  • Oils and fats 56%
  • mice 51%
  • Groin 49%

• Interdependence of glycemic and lipid modulation in cured chronic hepatitis C patients by direct-acting antiviral agents

  Cheng, P. N., Sun, H. Y., Feng, I. C., Chiu, Y. C., Wang, S. T., Tan, D. C., Chiu, H. C., Chien, S. C. & Young, K. C., 2023 Feb, In: Journal of Microbiology, Immunology and Infection. 56, 1, p. 20-30 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chronic Hepatitis C 100%
  • Antiviral Agents 81%
  • Lipids 62%
  • Triglycerides 51%
  • Cholesterol 46%
  1 Citation (Scopus)

• Long-term DEHP/MEHP exposure promotes colorectal cancer stemness associated with glycosylation alterations

  Shih, P. C., Chen, H. P., Hsu, C. C., Lin, C. H., Ko, C. Y., Hsueh, C. W., Huang, C. Y., Chu, T. H., Wu, C. C., Ho, Y. C., Nguyen, N. U. N., Huang, S. C., Fang, C. C., Tzou, S. J., Wu, Y. J., Chen, T. Y., Chang, C. F. & Lee, Y. K., 2023 Jun 15, In: Environmental Pollution. 327, 121476.

  Research output: Contribution to journal › Article › peer-review

  • Glycosylation 100%
  • mono-(2-ethylhexyl)phthalate 91%
  • phthalate 66%
  • Phthalate 63%
  • Cells 55%
  8 Citations (Scopus)

• Loss of fragile WWOX gene leads to senescence escape and genome instability

  Cheng, H. C., Huang, P. H., Lai, F. J., Jan, M. S., Chen, Y. L., Chen, S. Y., Chen, W. L., Hsu, C. K., Huang, W. & Hsu, L. J., 2023 Nov, In: Cellular and Molecular Life Sciences. 80, 11, 338.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genomic Instability 100%
  • Fibroblasts 67%
  • Knockout Mice 66%
  • Cellular Senescence 59%
  • DNA Damage 47%
  2 Citations (Scopus)

• Negative regulation of type I interferon signaling by integrin-linked kinase permits dengue virus replication

  Kao, Y. S., Wang, L. C., Chang, P. C., Lin, H. M., Lin, Y. S., Yu, C. Y., Chen, C. C., Lin, C. F., Yeh, T. M., Wan, S. W., Wang, J. R., Ho, T. S., Chu, C. C., Zhang, B. C. & Chang, C. P., 2023 Mar, In: PLoS pathogens. 19, 3 March, e1011241.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • integrin-linked kinase 100%
  • Dengue virus 87%
  • integrins 82%
  • Interferon Type I 78%
  • Dengue Virus 77%
  3 Citations (Scopus)

• Novel antibacterial activity of silver nanoparticles combined with pterostilbene against Staphylococcus aureus via induction of apoptosis-like cell death and downregulation of ribosomal gene expression

  Shih, Y. H., Pranata, R., Chen, Y. C., Liao, M. Y., Cheng, Y. H., Chen, Y. Y., Lai, Y. H., Tsai, P. J. & Chen, R. J., 2023 Jun 13, In: Environmental Science: Nano. 10, 8, p. 2115-2131 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Pterostilbene 100%
  • Staphylococcus aureus 91%
  • Cell death 84%
  • Silver nanoparticles 82%
  • apoptosis 77%
  5 Citations (Scopus)

• Novel metal peroxide nanoboxes restrain Clostridioides difficile infection beyond the bactericidal and sporicidal activity

  Yang, L. X., Lai, Y. H., Cheung, C. I., Ye, Z., Huang, T. C., Wang, Y. C., Chin, Y. C., Chia, Z. C., Chen, Y. J., Li, M. J., Tseng, H. Y., Tsai, Y. T., Zhang, Z. B., Chen, K. H., Tsai, B. Y., Shieh, D. B., Lee, N. Y., Tsai, P. J. & Huang, C. C., 2023 Nov, In: Bioengineering and Translational Medicine. 8, 6, e10593.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peroxides 100%
  • Peroxide 67%
  • Metals 65%
  • Bacteria 42%
  • Spores 37%
  1 Citation (Scopus)

• Novel Software for High-level Virological Testing: Self-Designed Immersive Virtual Reality Training Approach

  Tsai, H. P., Lin, C. W., Lin, Y. J., Yeh, C. S. & Shan, Y. S., 2023, In: Journal of medical Internet research. 25, e44538.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Virtual Reality 100%
  • Software 62%
  • Students 35%
  • Learning 27%
  • Teaching 11%
  2 Citations (Scopus)

• NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance

  Chen, T., Xu, Z. G., Luo, J., Manne, R. K., Wang, Z., Hsu, C. C., Pan, B. S., Cai, Z., Tsai, P. J., Tsai, Y. S., Chen, Z. Z., Li, H. Y. & Lin, H. K., 2023 Oct 3, In: Cell Metabolism. 35, 10, p. 1782-1798.e8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunotherapy 100%
  • Carcinogenesis 86%
  • Glucose 71%
  • Oncogene Proteins 15%
  • Methyltransferases 15%
  49 Citations (Scopus)

• Optogenetically engineered Ca²⁺ oscillation-mediated DRP1 activation promotes mitochondrial fission and cell death

  Lai, Y. S., Chang, C. C., Chen, Y. Y., Nguyen, T. M. H., Xu, J., Chen, Y. C., Chang, Y. F., Wang, C. Y., Chen, P. S., Lin, S. C., Peng, I. C., Tsai, S. J. & Chiu, W. T., 2023, In: Journal of Cell Science. 136, 12, jcs260819.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitochondrial Dynamics 100%
  • Cell Death 59%
  • Lighting 42%
  • Mitochondrial Proteins 29%
  • Mitochondria 21%
  3 Citations (Scopus)

• Phosphate burden induces vascular calcification through a NLRP3-caspase-1-mediated pyroptotic pathway

  Ho, L. C., Chen, Y. H., Wu, T. Y., Kao, L. Z., Hung, S. Y., Liou, H. H., Chen, P. C., Tsai, P. J., Lin, H. K., Lee, Y. C., Wang, H. H. & Tsai, Y. S., 2023 Nov 1, In: Life Sciences. 332, 122123.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vascular Calcification 100%
  • Osteogenic 97%
  • Western Blotting 97%
  • Caspase 1 94%
  • Inorganic Phosphate 90%
  5 Citations (Scopus)

• Pre-existing humoral immunity and CD4⁺ T cell response correlate with cross-reactivity against SARS-CoV-2 Omicron subvariants after heterologous prime-boost vaccination

  Shen, C. F., Fu, Y. C., Ho, T. S., Chen, P. L., Lee, N. Y., Tsai, B. Y., Tsai, P. J., Ko, W. C., Liu, C. C., Cheng, C. M. & Shieh, C. C., 2023 Jun, In: Clinical Immunology. 251, 109342.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Humoral Immunity 70%
  • Neutralizing Antibodies 67%
  • Vaccination 54%
  • T-Lymphocytes 41%
  4 Citations (Scopus)

• Propagation and immunological characterization of coxsackievirus A10 in a serum-free HEK293A cell culture system

  Lien, S. C., Shen, Y. S., Lin, H. Y., Wu, S. R., Fang, C. Y., Chen, C. H., Chen, Y. A., Chong, P. C. S., Huang, M. H., Chow, Y. H., Wang, J. R., Wu, S. C. & Liu, C. C., 2023 May, In: Virus Research. 329, 199101.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • antineoplaston A10 100%
  • Enterovirus 93%
  • Cell Culture Techniques 62%
  • Serum 37%
  • Hand, Foot and Mouth Disease 19%
  2 Citations (Scopus)

• Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents

  Cheng, P. N., Sun, H. Y., Feng, I. C., Wang, S. T., Chiu, Y. C., Chiu, H. C., Chien, S. C. & Young, K. C., 2023 Mar, In: Journal of Virus Eradication. 9, 1, 100318.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sustained Virologic Response 100%
  • Chronic Hepatitis C 76%
  • contagious disease 71%
  • Antiviral Agents 62%
  • oxidized low density lipoprotein 61%
  1 Citation (Scopus)

• RNA Interference Approach Is a Good Strategy against SARS-CoV-2

  Lee, Y. R., Tsai, H. P., Yeh, C. S., Fang, C. Y., Chan, M. W. Y., Wu, T. Y. & Shen, C. H., 2023 Jan, In: Viruses. 15, 1, 100.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • RNA Interference 65%
  • Vaccines 33%
  • RNA Replicase 30%
  • Mutation Rate 23%
  5 Citations (Scopus)

• RopB-regulated SpeB cysteine protease degrades extracellular vesicles-associated streptolysin O and bacterial proteins from group A Streptococcus

  Chiang-Ni, C., Chiang, C. Y., Chen, Y. W., Shi, Y. A., Chao, Y. T., Wang, S., Tsai, P. J. & Chiu, C. H., 2023, In: Virulence. 14, 1, 2249784.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • streptolysin 100%
  • streptolysin O 96%
  • pyroptosis 81%
  • bacterial proteins 78%
  • Cysteine Proteases 78%
  3 Citations (Scopus)

• Structural basis underlying the synergism of NADase and SLO during group A Streptococcus infection

  Tsai, W. J., Lai, Y. H., Shi, Y. A., Hammel, M., Duff, A. P., Whitten, A. E., Wilde, K. L., Wu, C. M., Knott, R., Jeng, U. S., Kang, C. Y., Hsu, C. Y., Wu, J. L., Tsai, P. J., Chiang-Ni, C., Wu, J. J., Lin, Y. S., Liu, C. C., Senda, T. & Wang, S., 2023 Jan 31, In: Communications Biology. 6, 1, 124.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • NAD+ Nucleosidase 100%
  • streptolysin 93%
  • streptolysin O 89%
  • synergism 65%
  • glycosidases 64%
  3 Citations (Scopus)