Department of Medical Laboratory Science and Biotechnology

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2020

Epigenetic silencing of ubiquitin specific protease 4 by snail1 contributes to macrophage-dependent inflammation and therapeutic resistance in lung cancer

Lai, C. Y., Yeh, D. W., Lu, C. H., Liu, Y. L., Chuang, Y. C., Ruan, J. W., Kao, C. Y., Huang, L. R. & Chuang, T. H., 2020 Jan 1, In : Cancers. 12, 1, 148.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Requirement of cyclin-dependent kinase function for hepatitis B virus cccDNA synthesis as measured by digital PCR

Bao, C. Y., Hung, H. C., Chen, Y. W., Fan, C. Y., Huang, C. J. & Huang, W., 2020 Jan 1, (Accepted/In press) In : Annals of Hepatology.

Research output: Contribution to journalArticle

Open Access

The interaction between carbohydrates and the antimicrobial peptide P-113Tri is involved in the killing of candida albicans

Lin, G. Y., Chang, C. F. & Lan, C. Y., 2020 Feb, In : Microorganisms. 8, 2, 299.

Research output: Contribution to journalArticle

Open Access

Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice

Cheng, Y. Y., Chou, Y. T., Lai, F. J., Jan, M. S., Chang, T. H., Jou, I. M., Chen, P. S., Lo, J. Y., Huang, S. S., Chang, N. S., Liou, Y. T., Hsu, P. C., Cheng, H. C., Lin, Y. S. & Hsu, L. J., 2020 Jan 30, In : Acta Neuropathologica Communications. 8, 1, 6.

Research output: Contribution to journalArticle

Open Access
2019

An integrated microfluidic system for on-chip enrichment and quantification of circulating extracellular vesicles from whole blood

Chen, Y. S., Ma, Y. D., Chen, C., Shiesh, S. C. & Lee, G. B., 2019 Jan 1, In : Lab on a Chip. 19, 19, p. 3305-3315 11 p.

Research output: Contribution to journalArticle

An integrated microfluidic system for rapid detection and multiple subtyping of influenza A viruses by using glycan-coated magnetic beads and RT-PCR

Shen, K. M., Sabbavarapu, N. M., Fu, C. Y., Jan, J. T., Wang, J. R., Hung, S. C. & Lee, G. B., 2019 Jan 1, In : Lab on a Chip. 19, 7, p. 1277-1286 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

An integrated microfluidic system with field-effect-transistor sensor arrays for detecting multiple cardiovascular biomarkers from clinical samples

Sinha, A., Tai, T. Y., Li, K. H., Gopinathan, P., Chung, Y. D., Sarangadharan, I., Ma, H. P., Huang, P. C., Shiesh, S-C., Wang, Y. L. & Lee, G. B., 2019 Mar 15, In : Biosensors and Bioelectronics. 129, p. 155-163 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A novel zebrafish model to emulate lung injury by folate deficiency-induced swim bladder defectiveness and protease/antiprotease expression imbalance

Lee, G. H., Cheng, N. W., Yu, H. H., Tsai, J. N., Liu, T., Wen, Z. H., Chen, B. H. & Fu, T. F., 2019 Dec 1, In : Scientific reports. 9, 1, 12633.

Research output: Contribution to journalArticle

Open Access

A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish

Lee, G. H., Chang, C. L., Chiu, W. T., Hsiao, T. H., Chen, P. Y., Wang, K. C., Kuo, C. H., Chen, B. H., Shi, G. Y., Wu, H. L. & Fu, T. F., 2019 Aug 26, In : Journal of biomedical science. 26, 1, 60.

Research output: Contribution to journalArticle

Open Access

Combination of modified NS1 and NS3 as a novel vaccine strategy against dengue virus infection

Kao, Y. S., Yu, C. Y., Huang, H. J., Tien, S. M., Wang, W. Y., Yang, M., Anderson, R., Yeh, T. M., Lin, Y. S. & Wan, S. W., 2019 Oct 1, In : Journal of Immunology. 203, 7, p. 1909-1917 9 p.

Research output: Contribution to journalArticle

Open Access

Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage

Chao, C. H., Wu, W. C., Lai, Y. C., Tsai, P. J., Perng, G-C., Lin, Y. S. & Yeh, T-M., 2019 Jan 1, In : PLoS pathogens. 15, 4, e1007625.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Design and Demonstration of Tunable Amplified Sensitivity of AlGaN/GaN High Electron Mobility Transistor (HEMT)-Based Biosensors in Human Serum

Tai, T. Y., Sinha, A., Sarangadharan, I., Pulikkathodi, A. K., Wang, S. L., Lee, G. Y., Chyi, J. I., Shiesh, S. C., Lee, G. B. & Wang, Y. L., 2019 May 7, In : Analytical chemistry. 91, 9, p. 5953-5960 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Differential dynamics of hepatic protein expressions with long-term cultivated hepatitis C virus infection

Tsai, P., Lin, T. Y., Cheng, S. L., Sun, H. Y., Chen, S. F. & Young, K. C., 2019 Jan 1, In : Journal of Microbiology, Immunology and Infection.

Research output: Contribution to journalArticle

Open Access

Direct Screening of Glycan Patterns from Human Sera: A Selective Glycoprotein Microarray Strategy

Tu, H. C., Lee, Y. P., Liu, X. Y., Chang, C. F. & Lin, P. C., 2019 Mar 18, In : ACS Applied Bio Materials. 2, 3, p. 1286-1297 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Enterovirus A71 containing codon-deoptimized VP1 and high-fidelity polymerase as next-generation vaccine candidate

Tsai, Y. H., Huang, S. W., Hsieh, W. S., Cheng, C. K., Chang, C. F., Wang, Y. F. & Wang, J. R., 2019 Jan 1, In : Journal of Virology. 93, 13, e02308-18.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation

Lin, Y. M., Sun, H. Y., Chiu, W. T., Su, H. C., Chien, Y. C., Chang, H. A., Chong, L. W., Chang, H. C., Young, K. C., Bai, C. H. & Tsao, C. W., 2019 Jan 1, In : BioMed research international. 2019, 3102414.

Research output: Contribution to journalArticle

Open Access

Evolutionary and Genomic Insights into Clostridioides difficile Sequence Type 11: a Diverse Zoonotic and Antimicrobial-Resistant Lineage of Global One Health Importance

Knight, D. R., Kullin, B., Androga, G. O., Barbut, F., Eckert, C., Johnson, S., Spigaglia, P., Tateda, K., Tsai, P. J. & Riley, T. V., 2019 Apr 16, In : mBio. 10, 2

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Glycoproteomic identification of novel plasma biomarkers for oral cancer

Chang, S. C., Lin, W. L., Chang, Y. F., Lee, C. T., Wu, J. S., Hsu, P. H. & Chang, C. F., 2019 Apr, In : Journal of Food and Drug Analysis. 27, 2, p. 483-493 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Group A Streptococcus Subcutaneous Infection-Induced Central Nervous System Inflammation Is Attenuated by Blocking Peripheral TNF

Liu, Y., Wu, P., Kang, C., Tsai, Y., Chou, C., Liang, C., Wu, J. & Tsai, P., 2019, In : Frontiers in Microbiology. 10

Research output: Contribution to journalArticle

Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis

Yen, C. J., Yang, S. T., Chen, R. Y., Huang, W., Chayama, K., Lee, M. H., Yang, S. J., Lai, H. S., Yen, H. Y., Hsiao, Y. W., Wang, J. M., Lin, Y. J. & Hung, L. Y., 2019 Jun 6, In : Journal of biomedical science. 26, 1, 44.

Research output: Contribution to journalArticle

Open Access

Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells

Kuo, P. L., Tseng, J. Y., Chen, H. I., Wu, C. Y., Omar, H. A., Wang, C. Y., Cheng, H. Y., Hsu, C. C., Fu, T. F. & Teng, Y. N., 2019 Mar, In : Biochimie. 158, p. 1-9 9 p.

Research output: Contribution to journalArticle

Inhibition of autophagy protects against sepsis by concurrently attenuating the cytokine storm and vascular leakage

Lu, L. H., Chao, C. H. & Yeh, T-M., 2019 Mar 1, In : Journal of Infection. 78, 3, p. 178-186 9 p.

Research output: Contribution to journalArticle

Mutation of the PTCH1 gene predicts recurrence of breast cancer

Wang, C. Y., Chang, Y. C., Kuo, Y. L., Lee, K. T., Chen, P. S., Cheung, C. H. A., Chang, C. P., Phan, N. N., Shen, M. R. & Hsu, H. P., 2019 Nov 8, In : Scientific reports. 9, 1, 1 p., 16359.

Research output: Contribution to journalArticle

Open Access

New Templated Ostwald Ripening Process of Mesostructured FeOOH for Third-Harmonic Generation Bioimaging

Lee, C. W., Wu, P. C., Hsu, I. L., Liu, T. M., Chong, W. H., Wu, C. H., Hsieh, T. Y., Guo, L. Z., Tsao, Y., Wu, P. T., Yu, J., Tsai, P. J., Huang, H. S., Chuang, Y. C. & Huang, C. C., 2019 May 17, In : Small. 15, 20, 1805086.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Optimization of an enzyme linked DNA aptamer assay for cardiac troponin i detection: Synchronous multiple sample analysis on an integrated microfluidic platform

Gopinathan, P., Sinha, A., Chung, Y. D., Shiesh, S. C. & Lee, G. B., 2019 Aug 21, In : Analyst. 144, 16, p. 4943-4951 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Plasma proteome plus site-specific N-glycoprofiling for hepatobiliary carcinomas

Chang, T. T., Cheng, J. H., Tsai, H. W., Young, K. C., Hsieh, S. Y. & Ho, C. H., 2019 Jul, In : Journal of Pathology: Clinical Research. 5, 3, p. 199-212 14 p.

Research output: Contribution to journalArticle

Open Access

Pyridoxamine supplementation effectively reverses the abnormal phenotypes of zebrafish larvae with PNPO deficiency

Chen, P. Y., Tu, H. C., Schirch, V., Safo, M. K. & Fu, T. F., 2019 Jan 1, In : Frontiers in Pharmacology. 10, SEP, 1086.

Research output: Contribution to journalArticle

Open Access

Risk factors of Clostridium difficile-associated diarrhea in hospitalized adults: Vary by hospitalized duration

Hung, Y. P., Lee, J. C., Tsai, B. Y., Wu, J. L., Liu, H. C., Liu, H. C., Lin, H. J., Tsai, P. J. & Ko, W. C., 2019 Jan 1, (Accepted/In press) In : Journal of Microbiology, Immunology and Infection.

Research output: Contribution to journalArticle

Open Access

Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer

Chuang, P. K., Hsiao, M., Hsu, T. L., Chang, C. F., Wu, C. Y., Chen, B. R., Huang, H. W., Liao, K. S., Chen, C. C., Chen, C. L., Yang, S. M., Kuo, C. W., Chen, P., Chiu, P. T., Chen, I. J., Lai, J. S., Yu, C. D. T. & Wong, C. H., 2019 Feb 26, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3518-3523 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Simultaneous detection of multiple NT-proBNP clinical samples utilizing an aptamer-based sandwich assay on an integrated microfluidic system

Sinha, A., Gopinathan, P., Chung, Y. D., Shiesh, S. C. & Lee, G. B., 2019 Jan 1, In : Lab on a Chip. 19, 9, p. 1676-1685 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment

Chou, P. Y., Lai, F. J., Chen, Y. A., Sie, Y. D., Kuo, H. L., Su, W. P., Wu, C. Y., Liu, T. Y., Wen, K. Y., Hsu, L. J., Sze, C. I. & Chang, N. S., 2019 Dec 1, In : Cell Death Discovery. 5, 1, 97.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Supplementation with 5-formyltetrahydrofolate alleviates ultraviolet B-inflicted oxidative damage in folate-deficient zebrafish

Tu, H. C., Lin, M. Y., Lin, C. Y., Hsiao, T. H., Wen, Z. H., Chen, B. H. & Fu, T. F., 2019 Oct 30, In : Ecotoxicology and Environmental Safety. 182, 109380.

Research output: Contribution to journalArticle

TARBP2-enhanced resistance during tamoxifen treatment in breast cancer

Wang, M. Y., Huang, H. Y., Kuo, Y. L., Lo, C., Sun, H. Y., Lyu, Y. J., Chen, B. R., Li, J. N. & Chen, P. S., 2019 Feb, In : Cancers. 11, 2, 210.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma

Lai, H. H., Li, C. W., Hong, C. C., Sun, H. Y., Chiu, C. F., Ou, D. L. & Chen, P. S., 2019 Apr, In : Molecular Oncology. 13, 4, p. 928-945 18 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma

Lai, H., Li, C., Hong, C., Sun, H., Chiu, C., Ou, D. & Chen, P-S., 2019 Jan 18, In : Molecular Oncology.

Research output: Contribution to journalArticle

Targeted delivery of curcumin rescues endoplasmic reticulum-retained mutant Nox2 protein and avoids leukocyte apoptosis

Yen, C. L., Liao, Y. C., Chen, R. F., Huang, Y. F., Chung, W. C., Lo, P. C., Chang, C. F., Wu, P. C., Shieh, D. B., Jiang, S. T. & Shieh, C. C., 2019 Jun 15, In : Journal of Immunology. 202, 12, p. 3394-3403 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access

Vancomycin-Loaded Nanoparticles Enhance Sporicidal and Antibacterial Efficacy for Clostridium difficile Infection

Chen, Y., Li, T., Tsai, B., Chen, L., Lai, Y., Li, M., Tsai, C., Tsai, P. & Shieh, D., 2019 May, In : Frontiers in Microbiology. 10, 1141.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

An automatic method to calculate heart rate from zebrafish larval cardiac videos

Kang, C. P., Tu, H. C., Fu, T. F., Wu, J. M., Chu, P. H. & Chang, D. T. H., 2018 May 9, In : BMC Bioinformatics. 19, 1, 169.

Research output: Contribution to journalArticle

1 Citation (Scopus)

An integrated microfluidic platform to perform uninterrupted SELEX cycles to screen affinity reagents specific to cardiovascular biomarkers

Sinha, A., Gopinathan, P., Chung, Y., Lin, H., Li, K., Ma, H., Huang, P., Shiesh, S. & Lee, G., 2018 Dec 1, In : Biosensors and Bioelectronics. 122, p. 104-112

Research output: Contribution to journalArticle

9 Citations (Scopus)

Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition

Liao, K. F., Chiu, T. L., Huang, S. Y., Hsieh, T. F., Chang, S. F., Ruan, J. W., Chen, S. P., Pang, C. Y. & Chiu, S. C., 2018 Aug 1, In : Cellular Physiology and Biochemistry. 48, 6, p. 2231-2236 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Aptamer-functionalized AlGaN/GaN high-electron-mobility transistor for rapid diagnosis of fibrinogen in human plasma

Tai, T. Y., Sinha, A., Sarangadharan, I., Pulikkathodi, A. K., Wang, S. L., Shiesh, S. C., Lee, G. B. & Wang, Y. L., 2018 Jan 1, In : Sensors and Materials. 30, 10, p. 2321-2331 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Assembled growth of 3D Fe3O4@Au nanoparticles for efficient photothermal ablation and SERS detection of microorganisms

Hong, W., Hsu, I., Huang, S., Lee, C., Ko, H., Tsai, P., Shieh, D. & Huang, C., 2018, In : Journal of Materials Chemistry B. 6, 36, p. 5689-5697

Research output: Contribution to journalArticle

6 Citations (Scopus)

Borneol and Luteolin from Chrysanthemum morifolium Regulate Ubiquitin Signal Degradation

Chang, T., Liou, P., Cheng, P., Chang, H. & Tsai, P., 2018 Aug 8, In : Journal of Agricultural and Food Chemistry. 66, 31, p. 8280-8290

Research output: Contribution to journalArticle

1 Citation (Scopus)

Calcitriol inhibits HCV infection via blockade of activation of PPAR and interference with endoplasmic reticulum-associated degradation

Lin, Y. M., Sun, H. Y., Chiu, W. T., Su, H. C., Chien, Y. C., Chong, L. W., Chang, H. C., Bai, C. H., Young, K. C. & Tsao, C. W., 2018 Feb, In : Viruses. 10, 2, 57.

Research output: Contribution to journalArticle

3 Citations (Scopus)
3 Citations (Scopus)

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

Lee, Y. R., Kuo, S. H., Lin, C. Y., Fu, P. J., Lin, Y. S., Yeh, T. M. & Liu, H. S., 2018 Dec 1, In : Scientific reports. 8, 1, 489.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Detection of adulterated drugs in traditional Chinese medicine and dietary supplements using hydrogen as a carrier gas

Lin, Y. P., Lee, Y. L., Hung, C. Y., Chang, C. F. & Chen, Y., 2018 Oct, In : PloS one. 13, 10, e0205371.

Research output: Contribution to journalArticle

Development of an efficient viral aerosol collector for higher sampling flow rate

Lin, X. T., Hsu, N. Y., Wang, J. R., Chen, N. T., Su, H. J. & Lin, M. Y., 2018 Feb 1, In : Environmental Science and Pollution Research. 25, 4, p. 3884-3893 10 p.

Research output: Contribution to journalArticle