Department of Medical Laboratory Science and Biotechnology

Research Output 1987 2019

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2019

An integrated microfluidic system for on-chip enrichment and quantification of circulating extracellular vesicles from whole blood

Chen, Y. S., Ma, Y. D., Chen, C., Shiesh, S. C. & Lee, G. B., 2019 Jan 1, In : Lab on a Chip. 19, 19, p. 3305-3315 11 p.

Research output: Contribution to journalArticle

Microfluidics
Blood
Plasmas
RNA
Lab-On-A-Chip Devices
1 Citation (Scopus)

An integrated microfluidic system for rapid detection and multiple subtyping of influenza A viruses by using glycan-coated magnetic beads and RT-PCR

Shen, K. M., Sabbavarapu, N. M., Fu, C. Y., Jan, J. T., Wang, J. R., Hung, S. C. & Lee, G. B., 2019 Jan 1, In : Lab on a Chip. 19, 7, p. 1277-1286 10 p.

Research output: Contribution to journalArticle

Microfluidics
Polymerase chain reaction
Influenza A virus
Transcription
Viruses
2 Citations (Scopus)

An integrated microfluidic system with field-effect-transistor sensor arrays for detecting multiple cardiovascular biomarkers from clinical samples

Sinha, A., Tai, T. Y., Li, K. H., Gopinathan, P., Chung, Y. D., Sarangadharan, I., Ma, H. P., Huang, P. C., Shiesh, S-C., Wang, Y. L. & Lee, G. B., 2019 Mar 15, In : Biosensors and Bioelectronics. 129, p. 155-163 9 p.

Research output: Contribution to journalArticle

Microfluidics
Sensor arrays
Biomarkers
Field effect transistors
Cardiovascular Diseases

A novel zebrafish model to emulate lung injury by folate deficiency-induced swim bladder defectiveness and protease/antiprotease expression imbalance

Lee, G-H., Cheng, N. W., Yu, H. H., Tsai, J. N., Liu, T., Wen, Z. H., Chen, B. H. & Fu, T-F., 2019 Dec 1, In : Scientific reports. 9, 1, 12633.

Research output: Contribution to journalArticle

Open Access
Lung Injury
Zebrafish
Protease Inhibitors
Folic Acid
Urinary Bladder

A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish

Lee, G. H., Chang, C. L., Chiu, W. T., Hsiao, T. H., Chen, P. Y., Wang, K. C., Kuo, C. H., Chen, B. H., Shi, G. Y., Wu, H. L. & Fu, T. F., 2019 Aug 26, In : Journal of biomedical science. 26, 1, 60.

Research output: Contribution to journalArticle

Open Access
Thrombomodulin
Germ Layers
Blastomeres
Organogenesis
Zebrafish

Combination of modified NS1 and NS3 as a novel vaccine strategy against dengue virus infection

Kao, Y. S., Yu, C. Y., Huang, H. J., Tien, S. M., Wang, W. Y., Yang, M., Anderson, R., Yeh, T. M., Lin, Y. S. & Wan, S. W., 2019 Oct 1, In : Journal of Immunology. 203, 7, p. 1909-1917 9 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Vaccines
Severe Dengue
Cellular Immunity
3 Citations (Scopus)

Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage

Chao, C. H., Wu, W. C., Lai, Y. C., Tsai, P. J., Perng, G-C., Lin, Y. S. & Yeh, T-M., 2019 Jan 1, In : PLoS pathogens. 15, 4, e1007625.

Research output: Contribution to journalArticle

Open Access
Dengue Virus
Toll-Like Receptor 4
Thrombocytopenia
Blood Platelets
Hemorrhage
3 Citations (Scopus)

Design and Demonstration of Tunable Amplified Sensitivity of AlGaN/GaN High Electron Mobility Transistor (HEMT)-Based Biosensors in Human Serum

Tai, T. Y., Sinha, A., Sarangadharan, I., Pulikkathodi, A. K., Wang, S. L., Lee, G. Y., Chyi, J. I., Shiesh, S-C., Lee, G. B. & Wang, Y. L., 2019 May 7, In : Analytical chemistry. 91, 9, p. 5953-5960 8 p.

Research output: Contribution to journalArticle

High electron mobility transistors
Biosensors
Demonstrations
Sensors
Proteins

Differential dynamics of hepatic protein expressions with long-term cultivated hepatitis C virus infection

Tsai, P., Lin, T. Y., Cheng, S. L., Sun, H. Y., Chen, S. F. & Young, K-C., 2019 Jan 1, In : Journal of Microbiology, Immunology and Infection.

Research output: Contribution to journalArticle

Open Access
Virus Diseases
Hepacivirus
Liver
Proteins
Proteomics
2 Citations (Scopus)

Enterovirus A71 containing codon-deoptimized VP1 and high-fidelity polymerase as next-generation vaccine candidate

Tsai, Y. H., Huang, S. W., Hsieh, W. S., Cheng, C. K., Chang, C-F., Wang, Y. F. & Wang, J-R., 2019 Jan 1, In : Journal of Virology. 93, 13, e02308-18.

Research output: Contribution to journalArticle

Enterovirus
codons
Codon
Vaccines
vaccines

Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation

Lin, Y. M., Sun, H. Y., Chiu, W-T., Su, H. C., Chien, Y. C., Chang, H. A., Chong, L. W., Chang, H. C., Young, K-C., Bai, C. H. & Tsao, C. W., 2019 Jan 1, In : BioMed research international. 2019, 3102414.

Research output: Contribution to journalArticle

Open Access
Hepatitis C
Viruses
Hepacivirus
Insulin Resistance
Insulin
3 Citations (Scopus)

Evolutionary and Genomic Insights into Clostridioides difficile Sequence Type 11: a Diverse Zoonotic and Antimicrobial-Resistant Lineage of Global One Health Importance

Knight, D. R., Kullin, B., Androga, G. O., Barbut, F., Eckert, C., Johnson, S., Spigaglia, P., Tateda, K., Tsai, P. J. & Riley, T. V., 2019 Apr 16, In : mBio. 10, 2

Research output: Contribution to journalArticle

Open Access
Clostridium difficile
Zoonoses
Clostridium Infections
Genome
Ribotyping
1 Citation (Scopus)

Glycoproteomic identification of novel plasma biomarkers for oral cancer

Chang, S. C., Lin, W. L., Chang, Y. F., Lee, C. T., Wu, J. S., Hsu, P. H. & Chang, C. F., 2019 Apr, In : Journal of Food and Drug Analysis. 27, 2, p. 483-493 11 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
biomarkers
Biomarkers
glycoproteins
Glycoproteins

Group A Streptococcus Subcutaneous Infection-Induced Central Nervous System Inflammation Is Attenuated by Blocking Peripheral TNF

Liu, Y., Wu, P., Kang, C., Tsai, Y., Chou, C., Liang, C., Wu, J. & Tsai, P., 2019, In : Frontiers in Microbiology. 10

Research output: Contribution to journalArticle

Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis

Yen, C. J., Yang, S. T., Chen, R. Y., Huang, W., Chayama, K., Lee, M. H., Yang, S. J., Lai, H. S., Yen, H. Y., Hsiao, Y. W., Wang, J. M., Lin, Y. J. & Hung, L. Y., 2019 Jun 6, In : Journal of biomedical science. 26, 1, 44.

Research output: Contribution to journalArticle

Open Access
Proteins
Hepatocellular Carcinoma
Viruses
Hepatitis B virus
Cyclic AMP Response Element-Binding Protein

Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells

Kuo, P-L., Tseng, J. Y., Chen, H. I., Wu, C. Y., Omar, H. A., Wang, C-Y., Cheng, H. Y., Hsu, C. C., Fu, T-F. & Teng, Y. N., 2019 Mar 1, In : Biochimie. 158, p. 1-9 9 p.

Research output: Contribution to journalArticle

Androgen Receptors
Estrogen Receptors
Genes
Dihydrotestosterone
Genetic Promoter Regions

Inhibition of autophagy protects against sepsis by concurrently attenuating the cytokine storm and vascular leakage

Lu, L. H., Chao, C. H. & Yeh, T-M., 2019 Mar 1, In : Journal of Infection. 78, 3, p. 178-186 9 p.

Research output: Contribution to journalArticle

Autophagy
Blood Vessels
Sepsis
Cytokines
Lipopolysaccharides

Mutation of the PTCH1 gene predicts recurrence of breast cancer

Wang, C. Y., Chang, Y. C., Kuo, Y. L., Lee, K. T., Chen, P. S., Cheung, C. H. A., Chang, C. P., Phan, N. N., Shen, M. R. & Hsu, H. P., 2019 Nov 8, In : Scientific reports. 9, 1, 1 p., 16359.

Research output: Contribution to journalArticle

Open Access
Breast Neoplasms
Recurrence
Mutation
Genes
Computational Biology
1 Citation (Scopus)

New Templated Ostwald Ripening Process of Mesostructured FeOOH for Third-Harmonic Generation Bioimaging

Lee, C. W., Wu, P. C., Hsu, I. L., Liu, T. M., Chong, W. H., Wu, C. H., Hsieh, T. Y., Guo, L. Z., Tsao, Y., Wu, P. T., Yu, J., Tsai, P. J., Huang, H. S., Chuang, Y. C. & Huang, C. C., 2019 May 17, In : Small. 15, 20, 1805086.

Research output: Contribution to journalArticle

Nanotubes
Ostwald ripening
Harmonic generation
Nanorods
Iron oxides
2 Citations (Scopus)

Optimization of an enzyme linked DNA aptamer assay for cardiac troponin i detection: Synchronous multiple sample analysis on an integrated microfluidic platform

Gopinathan, P., Sinha, A., Chung, Y. D., Shiesh, S-C. & Lee, G. B., 2019 Aug 21, In : Analyst. 144, 16, p. 4943-4951 9 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Troponin
Troponin I
Microfluidics
Assays

Plasma proteome plus site-specific N-glycoprofiling for hepatobiliary carcinomas

Chang, T-T., Cheng, J. H., Tsai, H-W., Young, K-C., Hsieh, S-Y. & Ho, C. H., 2019 Jul 1, In : Journal of Pathology: Clinical Research. 5, 3, p. 199-212 14 p.

Research output: Contribution to journalArticle

Open Access
Proteome
Complement C3
Carcinoma
Hepatocellular Carcinoma
Cholangiocarcinoma

Pyridoxamine supplementation effectively reverses the abnormal phenotypes of zebrafish larvae with PNPO deficiency

Chen, P. Y., Tu, H. C., Schirch, V., Safo, M. K. & Fu, T. F., 2019 Jan 1, In : Frontiers in Pharmacology. 10, SEP, 1086.

Research output: Contribution to journalArticle

Open Access
Pyridoxamine
Pyridoxal Phosphate
Zebrafish
Larva
Brain Diseases

Risk factors of Clostridium difficile-associated diarrhea in hospitalized adults: Vary by hospitalized duration

Hung, Y. P., Lee, J. C., Tsai, B. Y., Wu, J. L., Liu, H. C., Liu, H. C., Lin, H. J., Tsai, P. J. & Ko, W. C., 2019 Jan 1, (Accepted/In press) In : Journal of Microbiology, Immunology and Infection.

Research output: Contribution to journalArticle

Open Access
Clostridium difficile
Diarrhea
Odds Ratio
Confidence Intervals
Length of Stay
1 Citation (Scopus)

Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer

Chuang, P. K., Hsiao, M., Hsu, T. L., Chang, C. F., Wu, C. Y., Chen, B. R., Huang, H. W., Liao, K. S., Chen, C. C., Chen, C. L., Yang, S. M., Kuo, C. W., Chen, P., Chiu, P. T., Chen, I. J., Lai, J. S., Yu, C. D. T. & Wong, C. H., 2019 Feb 26, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3518-3523 6 p.

Research output: Contribution to journalArticle

Galactosyltransferases
Glycosphingolipids
Receptor-Interacting Protein Serine-Threonine Kinases
Protein Kinases
Breast Neoplasms
1 Citation (Scopus)

Simultaneous detection of multiple NT-proBNP clinical samples utilizing an aptamer-based sandwich assay on an integrated microfluidic system

Sinha, A., Gopinathan, P., Chung, Y. D., Shiesh, S-C. & Lee, G. B., 2019 Jan 1, In : Lab on a Chip. 19, 9, p. 1676-1685 10 p.

Research output: Contribution to journalArticle

Microfluidics
Assays
Heart Failure
Brain Natriuretic Peptide
Biomarkers
3 Citations (Scopus)

Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment

Chou, P. Y., Lai, F. J., Chen, Y. A., Sie, Y. D., Kuo, H. L., Su, W. P., Wu, C. Y., Liu, T. Y., Wen, K. Y., Hsu, L-J., Sze, C-I. & Chang, N-S., 2019 Dec 1, In : Cell Death Discovery. 5, 1, 97.

Research output: Contribution to journalArticle

Open Access
Neoplasms
Cellular Microenvironment
Hyaluronoglucosaminidase
Growth
Neoplasm Metastasis

Supplementation with 5-formyltetrahydrofolate alleviates ultraviolet B-inflicted oxidative damage in folate-deficient zebrafish

Tu, H. C., Lin, M. Y., Lin, C. Y., Hsiao, T. H., Wen, Z. H., Chen, B. H. & Fu, T-F., 2019 Oct 30, In : Ecotoxicology and Environmental Safety. 182, 109380.

Research output: Contribution to journalArticle

Leucovorin
Zebrafish
Folic Acid
Oxidative stress
Acids
1 Citation (Scopus)

TARBP2-enhanced resistance during tamoxifen treatment in breast cancer

Wang, M. Y., Huang, H. Y., Kuo, Y. L., Lo, C., Sun, H. Y., Lyu, Y. J., Chen, B. R., Li, J. N. & Chen, P. S., 2019 Feb, In : Cancers. 11, 2, 210.

Research output: Contribution to journalArticle

Open Access
RNA-Binding Proteins
Tamoxifen
HIV-1
Breast Neoplasms
Neurofibromin 2
1 Citation (Scopus)

TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma

Lai, H. H., Li, C. W., Hong, C. C., Sun, H. Y., Chiu, C. F., Ou, D. L. & Chen, P. S., 2019 Apr 1, In : Molecular Oncology. 13, 4, p. 928-945 18 p.

Research output: Contribution to journalArticle

Open Access
RNA-Binding Proteins
Response Elements
Transcriptional Activation
Hepatocellular Carcinoma
Neoplastic Stem Cells

TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma

Lai, H., Li, C., Hong, C., Sun, H., Chiu, C., Ou, D. & Chen, P-S., 2019 Jan 18, In : Molecular Oncology.

Research output: Contribution to journalArticle

Targeted delivery of curcumin rescues endoplasmic reticulum-retained mutant Nox2 protein and avoids leukocyte apoptosis

Yen, C. L., Liao, Y. C., Chen, R. F., Huang, Y. F., Chung, W. C., Lo, P. C., Chang, C. F., Wu, P. C., Shieh, D. B., Jiang, S. T. & Shieh, C. C., 2019 Jun 15, In : Journal of Immunology. 202, 12, p. 3394-3403 10 p.

Research output: Contribution to journalArticle

Curcumin
Mutant Proteins
Endoplasmic Reticulum
Leukocytes
Apoptosis
Open Access
Leucine-Responsive Regulatory Protein
Clostridium difficile
Genome
Gram-Positive Bacteria
Virulence Factors
1 Citation (Scopus)

Vancomycin-Loaded Nanoparticles Enhance Sporicidal and Antibacterial Efficacy for Clostridium difficile Infection

Chen, Y., Li, T., Tsai, B., Chen, L., Lai, Y., Li, M., Tsai, C., Tsai, P. & Shieh, D., 2019 May, In : Frontiers in Microbiology. 10, 1141.

Research output: Contribution to journalArticle

2018
1 Citation (Scopus)

An automatic method to calculate heart rate from zebrafish larval cardiac videos

Kang, C. P., Tu, H. C., Fu, T. F., Wu, J. M., Chu, P. H. & Chang, D. T. H., 2018 May 9, In : BMC Bioinformatics. 19, 1, 169.

Research output: Contribution to journalArticle

Heart Rate
Zebrafish
Cardiac
Calculate
Video Recording
9 Citations (Scopus)

An integrated microfluidic platform to perform uninterrupted SELEX cycles to screen affinity reagents specific to cardiovascular biomarkers

Sinha, A., Gopinathan, P., Chung, Y., Lin, H., Li, K., Ma, H., Huang, P., Shiesh, S. & Lee, G., 2018 Dec 1, In : Biosensors and Bioelectronics. 122, p. 104-112

Research output: Contribution to journalArticle

2 Citations (Scopus)

Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition

Liao, K. F., Chiu, T. L., Huang, S. Y., Hsieh, T. F., Chang, S. F., Ruan, J-W., Chen, S. P., Pang, C. Y. & Chiu, S. C., 2018 Aug 1, In : Cellular Physiology and Biochemistry. 48, 6, p. 2231-2236 6 p.

Research output: Contribution to journalArticle

Angelica sinensis
Stomach Neoplasms
Neoplasms
Heterografts
RNA Sequence Analysis
1 Citation (Scopus)

Aptamer-functionalized AlGaN/GaN high-electron-mobility transistor for rapid diagnosis of fibrinogen in human plasma

Tai, T. Y., Sinha, A., Sarangadharan, I., Pulikkathodi, A. K., Wang, S. L., Shiesh, S-C., Lee, G. B. & Wang, Y. L., 2018 Jan 1, In : Sensors and Materials. 30, 10, p. 2321-2331 11 p.

Research output: Contribution to journalArticle

Plasma (human)
fibrinogen
High electron mobility transistors
high electron mobility transistors
bioinstrumentation
5 Citations (Scopus)

Assembled growth of 3D Fe3O4@Au nanoparticles for efficient photothermal ablation and SERS detection of microorganisms

Hong, W., Hsu, I., Huang, S., Lee, C., Ko, H., Tsai, P., Shieh, D. & Huang, C., 2018, In : Journal of Materials Chemistry B. 6, 36, p. 5689-5697

Research output: Contribution to journalArticle

1 Citation (Scopus)

Borneol and Luteolin from Chrysanthemum morifolium Regulate Ubiquitin Signal Degradation

Chang, T., Liou, P., Cheng, P., Chang, H. & Tsai, P., 2018 Aug 8, In : Journal of Agricultural and Food Chemistry. 66, 31, p. 8280-8290

Research output: Contribution to journalArticle

3 Citations (Scopus)

Calcitriol inhibits HCV infection via blockade of activation of PPAR and interference with endoplasmic reticulum-associated degradation

Lin, Y. M., Sun, H. Y., Chiu, W-T., Su, H. C., Chien, Y. C., Chong, L. W., Chang, H. C., Bai, C. H., Young, K-C. & Tsao, C. W., 2018 Feb 1, In : Viruses. 10, 2, 57.

Research output: Contribution to journalArticle

Endoplasmic Reticulum-Associated Degradation
Peroxisome Proliferator-Activated Receptors
Calcitriol
Virus Diseases
Hepacivirus
3 Citations (Scopus)
Paramyxoviridae Infections
Taiwan
Croup
Viruses
Hoarseness
17 Citations (Scopus)

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

Lee, Y. R., Kuo, S. H., Lin, C. Y., Fu, P. J., Lin, Y. S., Yeh, T. M. & Liu, H. S., 2018 Dec 1, In : Scientific reports. 8, 1, 489.

Research output: Contribution to journalArticle

Virus Activation
Dengue Virus
Endoplasmic Reticulum Stress
Autophagy
Virus Diseases

Detection of adulterated drugs in traditional Chinese medicine and dietary supplements using hydrogen as a carrier gas

Lin, Y. P., Lee, Y. L., Hung, C. Y., Chang, C-F. & Chen, Y., 2018 Oct 1, In : PloS one. 13, 10, e0205371.

Research output: Contribution to journalArticle

Dietary supplements
Chinese Traditional Medicine
Dietary Supplements
hydrogen
Medicine

Development of an efficient viral aerosol collector for higher sampling flow rate

Lin, X. T., Hsu, N. Y., Wang, J-R., Chen, N. T., Su, H-J. & Lin, M-Y., 2018 Feb 1, In : Environmental Science and Pollution Research. 25, 4, p. 3884-3893 10 p.

Research output: Contribution to journalArticle

Dust collectors
Aerosols
Flow rate
aerosol
Sampling
4 Citations (Scopus)

Dextromethorphan attenuates NADPH oxidase-regulated glycogen synthase kinase 3 and NF-B activation and reduces nitric oxide production in group a streptococcal infection

Chen, C. L., Cheng, M. H., Kuo, C. F., Cheng, Y. L., Li, M. H., Chang, C. P., Wu, J. J., Anderson, R., Wang, S., Tsai, P-J., Liu, C. C. & Linc, Y. S., 2018 Jun, In : Antimicrobial agents and chemotherapy. 62, 6, e02045-17.

Research output: Contribution to journalArticle

Dextromethorphan
Glycogen Synthase Kinase 3
Streptococcal Infections
NADPH Oxidase
Streptococcus
10 Citations (Scopus)

Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses

Chang, J. H., Cheng, C. W., Yang, Y. C., Chen, W. S., Hung, W. Y., Chow, J. M., Chen, P. S., Hsiao, M., Lee, W. J. & Chien, M. H., 2018 Aug 22, In : Journal of Experimental and Clinical Cancer Research. 37, 1, 199.

Research output: Contribution to journalArticle

Dipeptidyl Peptidase 4
Apigenin
Gastropoda
Epidermal Growth Factor Receptor
Lung Neoplasms

Dual mechanism of DICER downregulation facilitates cancer metastasis

Lai, H. & Chen, P., 2018 Sep 3, In : Molecular and Cellular Oncology. 5, 5, p. e1472056

Research output: Contribution to journalArticle

6 Citations (Scopus)
Lipoproteins
Antiviral Agents
Triglycerides
Apolipoproteins B
Lipids

Glycan-binding preferences and genetic evolution of human seasonal influenza A (H3N2) viruses during 1999-2007 in Taiwan

Wang, Y. F., Chang, C. F., Tsai, H. P., Chi, C. Y., Su, I. J. & Wang, J. R., 2018 May, In : PloS one. 13, 5, e0196727.

Research output: Contribution to journalArticle

H3N2 Subtype Influenza A Virus
Molecular Evolution
Influenza A virus
Taiwan
Viruses

Ground glass hepatocytes provide targets for therapy or prevention of hepatitis B virus-related hepatocellular carcinoma

Chang, H., Tsai, H., Teng, C., Hui-ching Wang, L., Huang, W. & Su, I., 2018 Mar 1, In : AIMS Medical Science. 5, 2, p. 90-101

Research output: Contribution to journalArticle