Department of Microbiology and Immunology

Research Output 1984 2019

2019

Amelioration of experimentally induced arthritis by reducing reactive oxygen species production through the intra-articular injection of water-soluble fullerenol

Kuo, W. S., Weng, C-T., Chen, J. H., Wu, C-L., Shiau, A-L., Hsieh, J. L., So, E. C., Wu, P-T. & Chen, S. Y., 2019 Jun 1, In : Nanomaterials. 9, 6, 909.

Research output: Contribution to journalArticle

Open Access
Reactive Oxygen Species
Oxygen
Water
Nitric oxide
Cartilage

Degradative autophagy selectively regulates CCND1 (cyclin D1) and MIR224, two oncogenic factors involved in hepatocellular carcinoma tumorigenesis

Wu, S. Y., Lan, S. H. & Liu, H-S., 2019 Apr 3, In : Autophagy. 15, 4, p. 729-730 2 p.

Research output: Contribution to journalComment/debate

Cyclin D1
Autophagy
Hepatocellular Carcinoma
Carcinogenesis
Cell Cycle

Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking

Kuo, Y. H., Shiau, A-L., Tung, C. L., Su, Y. C., Li, C. F., Su, B. H., Tsao, C. J., Wu, C-L., Feng, Y. H. & Wu, P., 2019 Jun 1, In : Oncology Letters. 17, 6, p. 5740-5746 7 p.

Research output: Contribution to journalArticle

Open Access
Squamous Cell Carcinoma
Lung Neoplasms
Smoking
Non-Small Cell Lung Carcinoma
Neoplasms

Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling

Ge, J., Remesh, S. G., Hammel, M., Pan, S., Mahan, A. D., Wang, S-Y. & Wang, X., 2019 Aug 6, In : Structure. 27, 8, p. 1296-1307.e5

Research output: Contribution to journalArticle

Interleukin-1 Receptors
Cytokines
Signal Transduction
Ligands

Implantable microneedles with an immune-boosting function for effective intradermal influenza vaccination

Chen, Y. H., Lai, K. Y., Chiu, Y. H., Wu, Y. W., Shiau, A-L. & Chen, M-C., 2019 Jan 1, In : Acta Biomaterialia.

Research output: Contribution to journalArticle

Vaccines
Chitosan
Human Influenza
Vaccination
Influenza Vaccines
1 Citation (Scopus)
arsenopyrite
Arsenic
mobilization
arsenic
colonization
1 Citation (Scopus)

MiR-338-5p promotes metastasis of colorectal cancer by inhibition of phosphatidylinositol 3-kinase, catalytic subunit type 3-mediated autophagy pathway

Chu, C. A., Lee, C-T., Lee, J-C., Wang, Y. W., Huang, C. T., Lan, S. H., Lin, P-C., Lin, P-W., Tian, Y. F., Liu, H-S. & Chow, N-H., 2019 May 1, In : EBioMedicine. 43, p. 270-281 12 p.

Research output: Contribution to journalArticle

Open Access
Class III Phosphatidylinositol 3-Kinases
Autophagy
Tumors
Colorectal Neoplasms
Genes

MST3 is involved in ENaC-mediated hypertension

Lu, T. J., Kan, W. C., Yang, S. S., Jiang, S. T., Wu, S. N., Ling, P., Bao, B. Y., Lin, C. Y., Yang, Z. Y., Weng, Y. P., Chan, C. H. & Lu, T. L., 2019 Jan 1, In : American Journal of Physiology - Renal Physiology. 317, 7, p. F30-F42

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Phosphotransferases
Hypertension
Hypernatremia
Hypokalemia
Open Access
Phosphoric Monoester Hydrolases
Urinary Bladder Neoplasms
Nuclear Localization Signals
Proteins
Ubiquitination

Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection

Tsao, N., Kuo, C. F., Cheng, M. H., Lin, W. C., Lin, C. F. & Lin, Y-S., 2019 Dec 1, In : Scientific reports. 9, 1, 5371.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Streptococcus pyogenes
Streptococcus
Macrophages
Infection
2018

A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli

Kuo, C. J., Wang, S. T., Lin, C. M., Chiu, H. C., Huang, C. R., Lee, D. Y., Chang, G. D., Chou, T. C., Chen, J-W. & Chen, C-S., 2018 Mar 1, In : Cell Death and Disease. 9, 3, 381.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Fumarates
Virulence
Caenorhabditis elegans
Escherichia coli Infections
Genomics
Plasmids
Clone Cells
Escherichia coli
Cefixime
11 Citations (Scopus)

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

Lee, Y. R., Kuo, S. H., Lin, C. Y., Fu, P. J., Lin, Y-S., Yeh, T-M. & Liu, H-S., 2018 Dec 1, In : Scientific reports. 8, 1, 489.

Research output: Contribution to journalArticle

Virus Activation
Dengue Virus
Endoplasmic Reticulum Stress
Autophagy
Virus Diseases
1 Citation (Scopus)

Dextromethorphan attenuates NADPH oxidase-regulated glycogen synthase kinase 3 and NF-B activation and reduces nitric oxide production in group a streptococcal infection

Chen, C. L., Cheng, M. H., Kuo, C. F., Cheng, Y. L., Li, M. H., Chang, C. P., Wu, J. J., Anderson, R., Wang, S., Tsai, P-J., Liu, C. C. & Linc, Y. S., 2018 Jun 1, In : Antimicrobial Agents and Chemotherapy. 62, 6, e02045-17.

Research output: Contribution to journalArticle

Dextromethorphan
Glycogen Synthase Kinase 3
Streptococcal Infections
NADPH Oxidase
Streptococcus
2 Citations (Scopus)

Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression

Su, Y. C., Feng, Y. H., Wu, H. T., Huang, Y. S., Tung, C. L., Wu, P., Chang, C-J., Shiau, A-L. & Wu, C-L., 2018 Dec 1, In : Scientific reports. 8, 1, 6586.

Research output: Contribution to journalArticle

Liver Neoplasms
Hepatocellular Carcinoma
Neoplasms
Fatty Acids
Monounsaturated Fatty Acids

Estrogen and mechanical loading-related regulation of estrogen receptor-β and apoptosis in tendinopathy

Hsieh, J. L., Jou, I. M., Wu, C-L., Wu, P-T., Shiau, A-L., Chong, H. E., Lo, Y. T., Shen, P. C. & Chen, S. Y., 2018 Oct 1, In : PloS one. 13, 10, e0204603.

Research output: Contribution to journalArticle

Tendinopathy
Estrogen Receptors
estrogens
Tendons
Estrogens

Flt3 ligand treatment reduces enterovirus A71 lethality in mice with enhanced B cell responses

Lin, Y. W., Wang, L. C., Lee, C. K. & Chen, S., 2018 Dec 1, In : Scientific reports. 8, 1, 12184.

Research output: Contribution to journalArticle

Enterovirus
B-Lymphocytes
Enterovirus Infections
Viral Load
Therapeutics
3 Citations (Scopus)

Genetic relationships among multidrug-resistant salmonella enterica serovar typhimurium strains from humans and animals

Hong, Y. P., Wang, Y. W., Huang, I-H., Liao, Y. C., Kuo, H. C., Liu, Y. Y., Tu, Y. H., Chen, B. H., Liao, Y. S. & Chiou, C. S., 2018 May 1, In : Antimicrobial Agents and Chemotherapy. 62, 5, e00213.

Research output: Contribution to journalArticle

Azithromycin
Salmonella enterica
Salmonella
Cefoxitin
Trimethoprim
9 Citations (Scopus)

Hepatocellular carcinoma–related cyclin D1 is selectively regulated by autophagy degradation system

Wu, S. Y., Lan, S. H., Wu, S-R., Chiu, Y. C., Lin, X-Z., Su, I. J., Tsai, T. F., Yen, C-J., Lu, T-H., Liang, F. W., Li, C-Y., Su, H-J., Su, C. L. & Liu, H-S., 2018 Jul 1, In : Hepatology. 68, 1, p. 141-154 14 p.

Research output: Contribution to journalArticle

Cyclin D1
Autophagy
Hepatocellular Carcinoma
Neoplasms
Carcinogenesis
11 Citations (Scopus)

Herpes simplex virus 1 tegument protein VP22 abrogates cGAS/ STING-mediated antiviral innate immunity

Huang, J., You, H., Su, C., Li, Y., Chen, S. & Zheng, C., 2018 Aug 1, In : Journal of Virology. 92, 15, e00841-18.

Research output: Contribution to journalArticle

GMP synthase (glutamine-hydrolyzing)
cyclic GMP
Human herpesvirus 1
interferons
Innate Immunity
2 Citations (Scopus)

In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking

Chang, C., Amer, B. R., Osipiuk, J., McConnell, S. A., Huang, I-H., Hsieh, V., Fu, J., Nguyen, H. H., Muroski, J., Flores, E., Loo, R. R. O., Loo, J. A., Putkey, J. A., Joachimiak, A., Das, A., Clubb, R. T. & Ton-That, H., 2018 Jun 12, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 24, p. E5477-E5486

Research output: Contribution to journalArticle

Fimbriae Proteins
Polymerization
Protein Subunits
Ligation
Enzymes
4 Citations (Scopus)

Lauric acid is an inhibitor of Clostridium difficile growth in vitro and reduces inflammation in a mouse infection model

Yang, H. T., Chen, J-W., Rathod, J., Jiang, Y. Z., Tsai, P-J., Hung, Y. P., Ko, W-C., Paredes-Sabja, D. & Huang, I-H., 2018 Jan 17, In : Frontiers in Microbiology. 8, JAN, 2635.

Research output: Contribution to journalArticle

lauric acid
Clostridium difficile
Inflammation
Clostridium Infections
Growth
3 Citations (Scopus)

Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability

Chen, H. R., Chao, C. H., Liu, C-C., Ho, T-S., Tsai, H. P., Perng, G-C., Lin, Y-S., Wang, J-R. & Yeh, T-M., 2018 Apr 1, In : PLoS pathogens. 14, 4, e1007033.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Glycocalyx
Dengue
Metalloproteases
Proteins
3 Citations (Scopus)

Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy

Lai, Y. C., Chuang, Y. C., Chang, C-P., Lin, Y-S., Perng, G-C., Wu, H. C., Hsieh, S. L. & Yeh, T-M., 2018 Jul 1, In : Antiviral Research. 155, p. 28-38 11 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Dengue Virus
Minocycline
Autophagy
Virus Replication
1 Citation (Scopus)

MST3 (mammalian Ste20-like protein kinase 3), a novel gene involved in ion homeostasis and renal regulation of blood pressure in spontaneous hypertensive rats

Lu, T. J., Chan, C. H., Ling, P., Chao, Y. M., Bao, B. Y., Chiang, C. Y., Lee, T. H., Weng, Y. P., Kan, W. C. & Lu, T. L., 2018 Dec 1, In : International Urology and Nephrology. 50, 12, p. 2299-2307 9 p.

Research output: Contribution to journalArticle

Protein Kinases
Homeostasis
Ions
Blood Pressure
Hypertension

NAD-glycohydrolase depletes intracellular NAD+ and inhibits acidification of autophagosomes to enhance multiplication of group A Streptococcus in endothelial cells

Hsieh, C. L., Huang, H. M., Hsieh, S. Y., Zheng, P. X., Lin, Y-S., Chiang-Ni, C., Tsai, P-J., Wang, S-Y., Liu, C-C. & Wu, J. J., 2018 Aug 3, In : Frontiers in Microbiology. 9, AUG, 1733.

Research output: Contribution to journalArticle

NAD+ Nucleosidase
Streptococcus
NAD
Endothelial Cells
Vacuoles
2 Citations (Scopus)

Photodynamic inactivation of methicillin-resistant Staphylococcus aureus by indocyanine green and near infrared light

Wong, T-W., Wu, E. C., Ko, W-C., Lee, C. C., Hor, L. I. & Huang, I-H., 2018 Mar 1, In : Dermatologica Sinica. 36, 1, p. 8-15 8 p.

Research output: Contribution to journalArticle

Indocyanine Green
Methicillin-Resistant Staphylococcus aureus
Light
Photochemotherapy
Singlet Oxygen
20 Citations (Scopus)

PM2.5-induced oxidative stress increases intercellular adhesion molecule-1 expression in lung epithelial cells through the IL-6/AKT/STAT3/NF-ΚB-dependent pathway

Liu, C. W., Lee, T. L., Chen, Y. C., Liang, C. J., Wang, S. H., Lue, J. H., Tsai, J. S., Lee, S. W., Chen, S., Yang, Y. F., Chuang, T. Y. & Chen, Y. L., 2018 Jan 12, In : Particle and Fibre Toxicology. 15, 1, 4.

Research output: Contribution to journalArticle

Oxidative stress
Particulate Matter
Intercellular Adhesion Molecule-1
Interleukin-6
Oxidative Stress

Sera of patients with systemic lupus erythematosus cross-neutralizes dengue viruses

Zainal, N., Tan, K. K., Johari, J., Hussein, H., Wan Musa, W. R., Hassan, J., Lin, Y-S. & AbuBakar, S., 2018 Oct 1, In : Microbiology and Immunology. 62, 10, p. 659-672 14 p.

Research output: Contribution to journalArticle

Dengue Virus
Systemic Lupus Erythematosus
Serum
Dengue
Immunoglobulin G
7 Citations (Scopus)

Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein

Zhang, S., Zhou, P., Wang, P., Li, Y., Jiang, L., Jia, W., Wang, H., Fan, A., Wang, D., Shi, X., Fang, X., Hammel, M., Wang, S-Y., Wang, X. & Zhang, L., 2018 Jul 10, In : Cell Reports. 24, 2, p. 441-452 12 p.

Research output: Contribution to journalArticle

Functional analysis
Neutralizing Antibodies
Structural analysis
Epitopes
Glycoproteins

Structural insights into the duplex DNA processing of TREX2

Cheng, H. L., Lin, C. T., Huang, K. W., Wang, S-Y., Lin, Y. T., Toh, S. I. & Hsiao, Y. Y., 2018 Jan 1, In : Nucleic acids research. 46, 22, p. 12166-12176 11 p.

Research output: Contribution to journalArticle

Open Access
Exonucleases
DNA
Skin
Genomic Instability
Psoriasis

The monocyte-macrophage-mast cell axis in dengue pathogenesis

Wan, S. W., Wu-Hsieh, B. A., Lin, Y-S., Chen, W. Y., Huang, Y. & Anderson, R., 2018 Nov 8, In : Journal of biomedical science. 25, 1, 77.

Research output: Contribution to journalReview article

Dengue Virus
Dengue
Macrophages
Viruses
Mast Cells

Toll-like receptor 3 is involved in detection of enterovirus a71 infection and targeted by viral 2a protease

Chen, K. R., Yu, C-K., Kung, S. H., Chen, S., Chang, C-F., Ho, T. C., Lee, Y. P., Chang, H. C., Huang, L. Y., Lo, S. Y., Chang, J. C. & Ling, P., 2018 Dec 1, In : Viruses. 10, 12, 689.

Research output: Contribution to journalArticle

Toll-Like Receptor 3
Enterovirus Infections
Peptide Hydrolases
Antiviral Agents
Enterovirus

VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function

Wang, Y., Tzeng, H., Tsai, C., Cheng, H., Lai, W., Liu, H. & Wang, Y., 2018 Nov 1, In : Cancer Letters. 437, p. 79-88

Research output: Contribution to journalArticle

2017
21 Citations (Scopus)

Adipose-Derived Stem Cells Protect Skin Flaps against Ischemia/Reperfusion Injury via IL-6 Expression

Pu, C. M., Liu, C. W., Liang, C. J., Yen, Y. H., Chen, S., Jiang-Shieh, Y. F., Chien, C. L., Chen, Y. C. & Chen, Y. L., 2017 Jun 1, In : Journal of Investigative Dermatology. 137, 6, p. 1353-1362 10 p.

Research output: Contribution to journalArticle

Stem cells
Reperfusion Injury
Interleukin-6
Stem Cells
Flaps
7 Citations (Scopus)

Antibodies Against Modified NS1 Wing Domain Peptide Protect Against Dengue Virus Infection

Lai, Y. C., Chuang, Y. C., Liu, C-C., Ho, T-S., Lin, Y-S., Anderson, R. & Yeh, T-M., 2017 Dec 1, In : Scientific reports. 7, 1, 6975.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Antibodies
Proteins
Dengue
5 Citations (Scopus)

Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation

Chu, Y. T., Wan, S. W., Chang, Y. C., Lee, C. K., Wu-Hsieh, B. A., Anderson, R. & Lin, Y-S., 2017 May 1, In : Laboratory Investigation. 97, 5, p. 602-614 13 p.

Research output: Contribution to journalArticle

Dengue Virus
Mast Cells
Severe Dengue
Antibodies
Proteins
12 Citations (Scopus)

AR-12 suppresses dengue virus replication by down-regulation of PI3K/AKT and GRP78

Chen, H. H., Chen, C. C., Lin, Y-S., Chang, P. C., Lu, Z. Y., Lin, C. F., Chen, C. L. & Chang, C-P., 2017 Jun 1, In : Antiviral Research. 142, p. 158-168 11 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Replication
Phosphatidylinositol 3-Kinases
Down-Regulation
Virus Diseases
1 Citation (Scopus)

Arsenic treatment increase Aurora-A overexpression through E2F1 activation in bladder cells

Kao, Y. T., Wu, C. H., Wu, S. Y., Lan, S. H., Liu, H-S. & Tseng, Y. S., 2017 Apr 18, In : BMC cancer. 17, 1, 277.

Research output: Contribution to journalArticle

Arsenic
Urinary Bladder
Cell Proliferation
Centrosome
Carcinogenesis
11 Citations (Scopus)

Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer

Lu, C. S., Shieh, G. S., Wang, C. T., Su, B. H., Su, Y. C., Chen, Y. C., Su, W-C., Wu, P., Yang, W-H., Shiau, A-L. & Wu, C-L., 2017 Jan 1, In : Oncotarget. 8, 19, p. 30844-30858 15 p.

Research output: Contribution to journalArticle

Drug Resistance
Urinary Bladder Neoplasms
Cisplatin
Recurrence
Neoplasms
6 Citations (Scopus)
Brain-Derived Neurotrophic Factor
Epigenomics
Histone Deacetylase 2
Alzheimer Disease
Animal Models
Ribotyping
Clostridium difficile
Taiwan
Prophages
Genome
7 Citations (Scopus)

Dengue virus infection increases microglial cell migration

Jhan, M. K., Tsai, T. T., Chen, C. L., Tsai, C. C., Cheng, Y. L., Lee, Y. C., Ko, C. Y., Lin, Y-S., Chang, C-P., Lin, L. T. & Lin, C. F., 2017 Jan 1, In : Scientific reports. 7, 1, 91.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Cell Movement
Clathrin
Viral RNA
3 Citations (Scopus)

Endothelial cells are intrinsically defective in xenophagy of Streptococcus pyogenes

Lu, S. L., Kawabata, T., Cheng, Y. L., Omori, H., Hamasaki, M., Kusaba, T., Iwamoto, R., Arimoto, H., Noda, T., Lin, Y-S. & Yoshimori, T., 2017 Jul 1, In : PLoS pathogens. 13, 7, e1006444.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Streptococcus
Endothelial Cells
Ubiquitin
Autophagy
14 Citations (Scopus)

Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-γ-stimulated lung epithelial cells

Chen, Y. D., Fang, Y. T., Cheng, Y. L., Lin, C. F., Hsu, L-J., Wang, S-Y., Anderson, R., Chang, C-P. & Lin, Y-S., 2017 Dec 1, In : Scientific reports. 7, 1, 5676.

Research output: Contribution to journalArticle

Annexin A2
Annexins
Epithelial Cells
Lung
Multivesicular Bodies
4 Citations (Scopus)

Galectin-3 inhibits galectin-8/parkin- mediated ubiquitination of group A streptococcus

Cheng, Y. L., Wu, Y. W., Kuo, C. F., Lu, S. L., Liu, F. T., Anderson, R., Lin, C. F., Liu, Y. L., Wang, W. Y., Chen, Y. D., Zheng, P. X., Wu, J. J. & Lin, Y-S., 2017 Jul 1, In : mBio. 8, 4, e00899-17.

Research output: Contribution to journalArticle

Galectins
Galectin 3
Ubiquitination
Streptococcus
Endothelial Cells
4 Citations (Scopus)

Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis

Lee, Y. R., Yeh, S. F., Ruan, X. M., Zhang, H., Hsu, S. D., Huang, H. D., Hsieh, C. C., Lin, Y-S., Yeh, T-M., Liu, H-S. & Gan, D. D., 2017 Feb 23, In : Journal of Ethnopharmacology. 198, p. 109-121 13 p.

Research output: Contribution to journalArticle

Lonicera
Dengue Virus
Virus Replication
MicroRNAs
High-Throughput Nucleotide Sequencing
12 Citations (Scopus)

IL-6 ameliorates acute lung injury in influenza virus infection

Yang, M. L., Wang, C. T., Yang, S. J., Leu, C. H., Chen, S., Wu, C-L. & Shiau, A-L., 2017 Mar 6, In : Scientific reports. 7, 43829.

Research output: Contribution to journalArticle

Acute Lung Injury
Virus Diseases
Orthomyxoviridae
Interleukin-6
Lung
2 Citations (Scopus)

Immunization with a streptococcal multipleepitope recombinant protein protects mice against invasive group A streptococcal infection

Kuo, C. F., Tsao, N., Hsieh, I. C., Lin, Y-S., Wu, J. J. & Hung, Y. T., 2017 Mar 1, In : PLoS ONE. 12, 3, 0174464.

Research output: Contribution to journalArticle

Immunization
Streptococcal Infections
Recombinant Proteins
recombinant proteins
immunization
4 Citations (Scopus)
Clostridium difficile
Immunization
Clostridium Infections
Vaccines
Chitosan