Department of Microbiology and Immunology

Research Output 1984 2020

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2020

Bortezomib induces HSV-1 lethality in mice with neutrophil deficiency

Yao, H. W., Wang, L. C., Tsai, H. Y., Fang, Y. H., Zheng, C., Chen, S. H. & Hsu, S. M., 2020 Jan 1, In : Journal of Leukocyte Biology. 107, 1, p. 105-112 8 p.

Research output: Contribution to journalArticle

Human Herpesvirus 1
Neutrophils
Virus Diseases
Leukocytes
Drug Therapy
2019
1 Citation (Scopus)

Amelioration of experimentally induced arthritis by reducing reactive oxygen species production through the intra-articular injection of water-soluble fullerenol

Kuo, W. S., Weng, C-T., Chen, J. H., Wu, C-L., Shiau, A-L., Hsieh, J. L., So, E. C., Wu, P-T. & Chen, S. Y., 2019 Jun, In : Nanomaterials. 9, 6, 909.

Research output: Contribution to journalArticle

Open Access
Reactive Oxygen Species
Oxygen
Water
Nitric oxide
Cartilage

Anti-inflammatory and antiviral effects of minocycline in enterovirus 71 infections

Liao, Y. T., Wang, S. M. & Chen, S. H., 2019 Oct, In : Biomedicine and Pharmacotherapy. 118, 109271.

Research output: Contribution to journalArticle

Open Access
Enterovirus Infections
Minocycline
Antiviral Agents
Anti-Inflammatory Agents
Enterovirus

Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli

Tsai, S. L., Chang, Y. C., Sarvagalla, S., Wang, S., Coumar, M. S. & Cheung, C. H. A., 2019 Aug, In : Protein Expression and Purification. 160, p. 73-83 11 p.

Research output: Contribution to journalArticle

Escherichia coli Proteins
Organism Cloning
Recombinant Proteins
Histidine
Proteins

Combination of modified NS1 and NS3 as a novel vaccine strategy against dengue virus infection

Kao, Y. S., Yu, C. Y., Huang, H. J., Tien, S. M., Wang, W. Y., Yang, M., Anderson, R., Yeh, T. M., Lin, Y. S. & Wan, S. W., 2019 Oct 1, In : Journal of Immunology. 203, 7, p. 1909-1917 9 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Vaccines
Severe Dengue
Cellular Immunity

Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib

Wu, C. S., Wu, S. Y., Chen, H. C., Chu, C. A., Tang, H. H., Liu, H. S., Hong, Y. R., Huang, C. Y. F., Huang, G. C. & Su, C. L., 2019 Dec, In : Journal of Nutritional Biochemistry. 74, 108227.

Research output: Contribution to journalArticle

Curcumin
HCT116 Cells
Mitogen-Activated Protein Kinase Kinases
Colorectal Neoplasms
Cells

Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking

Kuo, Y. H., Shiau, A. L., Tung, C. L., Su, Y. C., Li, C. F., Su, B. H., Tsao, C. J., Wu, C. L., Feng, Y. H. & Wu, P., 2019 Jun, In : Oncology Letters. 17, 6, p. 5740-5746 7 p.

Research output: Contribution to journalArticle

Open Access
Squamous Cell Carcinoma
Lung Neoplasms
Smoking
Non-Small Cell Lung Carcinoma
Neoplasms

Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling

Ge, J., Remesh, S. G., Hammel, M., Pan, S., Mahan, A. D., Wang, S-Y. & Wang, X., 2019 Aug 6, In : Structure. 27, 8, p. 1296-1307.e5

Research output: Contribution to journalArticle

Interleukin-1 Receptors
Cytokines
Signal Transduction
Ligands

Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

Cheng, Y. L., Kuo, C. F., Lu, S. L., Hiroko, O., Wu, Y. N., Hsie, C. L., Nod, T., Wu, S. R., Anderson, R., Lin, C. F., Chen, C. L., Wu, J. J. & Lin, Y. S., 2019 Jan 1, In : mBio. 10, 5, e02148-19.

Research output: Contribution to journalArticle

Open Access
Streptococcus
Integrins
Reactive Oxygen Species
Endothelial Cells
Phagocytosis

HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

Tseng, P. C., Kuo, C. F., Cheng, M. H., Wan, S. W., Lin, C. F., Chang, C. P., Lin, Y. S., Wu, J. J., Huang, C. C. & Chen, C. L., 2019 Sep 18, In : Frontiers in Immunology. 10, 2147.

Research output: Contribution to journalArticle

Open Access
Toll-Like Receptor 2
Streptococcal Infections
Thioredoxins
Ubiquitin-Protein Ligases
Proteolysis

Implantable microneedles with an immune-boosting function for effective intradermal influenza vaccination

Chen, Y. H., Lai, K. Y., Chiu, Y. H., Wu, Y. W., Shiau, A-L. & Chen, M-C., 2019 Oct 1, In : Acta Biomaterialia. 97, p. 230-238 9 p.

Research output: Contribution to journalArticle

Vaccines
Chitosan
Human Influenza
Vaccination
Influenza Vaccines

Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by the Increase of Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps

Pu, C. M., Chen, Y. C., Chen, Y. C., Lee, T. L., Peng, Y. S., Chen, S. H., Yen, Y. H., Chien, C. L., Hsieh, J. H. & Chen, Y. L., 2019 Jan 1, In : Mediators of Inflammation. 2019, 2343867.

Research output: Contribution to journalArticle

Open Access
Hair Follicle
Reperfusion
Interleukin-6
Stem Cells
Ischemia

Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats

Kuthati, Y., Davuluri, V. N. G., Yang, C. P., Chang, H. C., Chang, C. P. & Wong, C. S., 2019 Jan 1, In : Journal of Pain Research. 12, p. 2473-2485 13 p.

Research output: Contribution to journalArticle

Open Access
Melatonin MT2 Receptor
Neuralgia
Reactive Oxygen Species
Melatonin Receptors
Neuroglia
2 Citations (Scopus)
arsenopyrite
Arsenic
mobilization
arsenic
colonization
3 Citations (Scopus)

MiR-338-5p promotes metastasis of colorectal cancer by inhibition of phosphatidylinositol 3-kinase, catalytic subunit type 3-mediated autophagy pathway

Chu, C. A., Lee, C. T., Lee, J. C., Wang, Y. W., Huang, C. T., Lan, S. H., Lin, P. C., Lin, B. W., Tian, Y. F., Liu, H. S. & Chow, N. H., 2019 May, In : EBioMedicine. 43, p. 270-281 12 p.

Research output: Contribution to journalArticle

Open Access
Class III Phosphatidylinositol 3-Kinases
Autophagy
Tumors
Colorectal Neoplasms
Genes

MST3 is involved in ENaC-mediated hypertension

Lu, T. J., Kan, W. C., Yang, S. S., Jiang, S. T., Wu, S. N., Ling, P., Bao, B. Y., Lin, C. Y., Yang, Z. Y., Weng, Y. P., Chan, C. H. & Lu, T. L., 2019 Jan 1, In : American Journal of Physiology - Renal Physiology. 317, 7, p. F30-F42

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Phosphotransferases
Hypertension
Hypernatremia
Hypokalemia

Mutation of the PTCH1 gene predicts recurrence of breast cancer

Wang, C. Y., Chang, Y. C., Kuo, Y. L., Lee, K. T., Chen, P. S., Cheung, C. H. A., Chang, C. P., Phan, N. N., Shen, M. R. & Hsu, H. P., 2019 Nov 8, In : Scientific reports. 9, 1, 1 p., 16359.

Research output: Contribution to journalArticle

Open Access
Breast Neoplasms
Recurrence
Mutation
Genes
Computational Biology

Oct4 upregulates osteopontin via Egr1 and is associated with poor outcome in human lung cancer

Feng, Y. H., Su, Y. C., Lin, S. F., Lin, P. R., Wu, C. L., Tung, C. L., Li, C. F., Shieh, G. S. & Shiau, A. L., 2019 Aug 9, In : BMC cancer. 19, 1, 791.

Research output: Contribution to journalArticle

Open Access
Osteopontin
Lung Neoplasms
Up-Regulation
Growth
Genes
Open Access
Phosphoric Monoester Hydrolases
Urinary Bladder Neoplasms
Nuclear Localization Signals
Proteins
Ubiquitination

Prothymosin α promotes STAT3 acetylation to induce cystogenesis in Pkd1-deficient mice

Chen, Y. C., Su, Y. C., Shieh, G. S., Su, B. H., Su, W. C., Huang, P. H., Jiang, S. T., Shiau, A. L. & Wu, C. L., 2019 Nov 1, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 13051-13061 11 p.

Research output: Contribution to journalArticle

Acetylation
Polycystic Kidney Diseases
STAT3 Transcription Factor
Kidney
Cysts
1 Citation (Scopus)

Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection

Tsao, N., Kuo, C. F., Cheng, M. H., Lin, W. C., Lin, C. F. & Lin, Y. S., 2019 Dec 1, In : Scientific reports. 9, 1, 5371.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Streptococcus pyogenes
Streptococcus
Macrophages
Infection

Swimming pool-associated Vittaforma-like microsporidia linked to microsporidial keratoconjunctivitis outbreak, Taiwan

Chen, J. S., Hsu, T. K., Hsu, B. M., Chao, S. C., Huang, T. Y., Ji, D. D., Yang, P. Y. & Huang, I. H., 2019 Jan 1, In : Emerging infectious diseases. 25, 11, p. 2100-2103 4 p.

Research output: Contribution to journalArticle

Open Access
Vittaforma
Microsporidia
Swimming Pools
Keratoconjunctivitis
Taiwan
Open Access
Leucine-Responsive Regulatory Protein
Clostridium difficile
Genome
Gram-Positive Bacteria
Virulence Factors
2018
2 Citations (Scopus)

A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli

Kuo, C. J., Wang, S. T., Lin, C. M., Chiu, H. C., Huang, C. R., Lee, D. Y., Chang, G. D., Chou, T. C., Chen, J. W. & Chen, C. S., 2018 Mar 1, In : Cell Death and Disease. 9, 3, 381.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Fumarates
Virulence
Caenorhabditis elegans
Escherichia coli Infections
1 Citation (Scopus)
Open Access
Autophagy
Antioxidant Response Elements
Apoptosis
Drug Therapy
Physiological Stress
1 Citation (Scopus)
Genomics
Plasmids
Clone Cells
Escherichia coli
Cefixime
1 Citation (Scopus)

Correlation of severity of human tick-borne encephalitis virus disease and pathogenicity in mice

Kurhade, C., Schreier, S., Lee, Y. P., Zegenhagen, L., Hjertqvist, M., Dobler, G., Kröger, A. & Överby, A. K., 2018 Sep, In : Emerging infectious diseases. 24, 9, p. 1709-1712 4 p.

Research output: Contribution to journalArticle

Open Access
Tick-Borne Encephalitis Viruses
Tick-Borne Encephalitis
Virus Diseases
Nervous System
Virulence
18 Citations (Scopus)

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

Lee, Y. R., Kuo, S. H., Lin, C. Y., Fu, P. J., Lin, Y. S., Yeh, T. M. & Liu, H. S., 2018 Dec 1, In : Scientific reports. 8, 1, 489.

Research output: Contribution to journalArticle

Virus Activation
Dengue Virus
Endoplasmic Reticulum Stress
Autophagy
Virus Diseases
4 Citations (Scopus)

Dextromethorphan attenuates NADPH oxidase-regulated glycogen synthase kinase 3 and NF-B activation and reduces nitric oxide production in group a streptococcal infection

Chen, C. L., Cheng, M. H., Kuo, C. F., Cheng, Y. L., Li, M. H., Chang, C. P., Wu, J. J., Anderson, R., Wang, S., Tsai, P-J., Liu, C. C. & Linc, Y. S., 2018 Jun, In : Antimicrobial agents and chemotherapy. 62, 6, e02045-17.

Research output: Contribution to journalArticle

Dextromethorphan
Glycogen Synthase Kinase 3
Streptococcal Infections
NADPH Oxidase
Streptococcus
4 Citations (Scopus)

Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression

Su, Y. C., Feng, Y. H., Wu, H. T., Huang, Y. S., Tung, C. L., Wu, P., Chang, C. J., Shiau, A. L. & Wu, C. L., 2018 Dec 1, In : Scientific reports. 8, 1, 6586.

Research output: Contribution to journalArticle

Liver Neoplasms
Hepatocellular Carcinoma
Neoplasms
Fatty Acids
Monounsaturated Fatty Acids
1 Citation (Scopus)

Estrogen and mechanical loading-related regulation of estrogen receptor-β and apoptosis in tendinopathy

Hsieh, J. L., Jou, I. M., Wu, C. L., Wu, P. T., Shiau, A. L., Chong, H. E., Lo, Y. T., Shen, P. C. & Chen, S. Y., 2018 Oct, In : PloS one. 13, 10, e0204603.

Research output: Contribution to journalArticle

Tendinopathy
Estrogen Receptors
estrogens
Tendons
Estrogens

Flt3 ligand treatment reduces enterovirus A71 lethality in mice with enhanced B cell responses

Lin, Y. W., Wang, L. C., Lee, C. K. & Chen, S. H., 2018 Dec 1, In : Scientific reports. 8, 1, 12184.

Research output: Contribution to journalArticle

Enterovirus
B-Lymphocytes
Enterovirus Infections
Viral Load
Therapeutics
3 Citations (Scopus)

Genetic relationships among multidrug-resistant salmonella enterica serovar typhimurium strains from humans and animals

Hong, Y. P., Wang, Y. W., Huang, I. H., Liao, Y. C., Kuo, H. C., Liu, Y. Y., Tu, Y. H., Chen, B. H., Liao, Y. S. & Chiou, C. S., 2018 May, In : Antimicrobial agents and chemotherapy. 62, 5, e00213.

Research output: Contribution to journalArticle

Azithromycin
Salmonella enterica
Salmonella
Cefoxitin
Trimethoprim
16 Citations (Scopus)

Hepatocellular carcinoma–related cyclin D1 is selectively regulated by autophagy degradation system

Wu, S. Y., Lan, S. H., Wu, S-R., Chiu, Y. C., Lin, X-Z., Su, I. J., Tsai, T. F., Yen, C-J., Lu, T-H., Liang, F. W., Li, C-Y., Su, H-J., Su, C. L. & Liu, H-S., 2018 Jul 1, In : Hepatology. 68, 1, p. 141-154 14 p.

Research output: Contribution to journalArticle

Cyclin D1
Autophagy
Hepatocellular Carcinoma
Neoplasms
Carcinogenesis
17 Citations (Scopus)

Herpes simplex virus 1 tegument protein VP22 abrogates cGAS/ STING-mediated antiviral innate immunity

Huang, J., You, H., Su, C., Li, Y., Chen, S. & Zheng, C., 2018 Aug 1, In : Journal of Virology. 92, 15, e00841-18.

Research output: Contribution to journalArticle

GMP synthase (glutamine-hydrolyzing)
cyclic GMP
Human herpesvirus 1
interferons
Innate Immunity
2 Citations (Scopus)

In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking

Chang, C., Amer, B. R., Osipiuk, J., McConnell, S. A., Huang, I. H., Hsieh, V., Fu, J., Nguyen, H. H., Muroski, J., Flores, E., Loo, R. R. O., Loo, J. A., Putkey, J. A., Joachimiak, A., Das, A., Clubb, R. T. & Ton-That, H., 2018 Jun 12, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 24, p. E5477-E5486

Research output: Contribution to journalArticle

Fimbriae Proteins
Polymerization
Protein Subunits
Ligation
Enzymes
10 Citations (Scopus)

Lauric acid is an inhibitor of Clostridium difficile growth in vitro and reduces inflammation in a mouse infection model

Yang, H. T., Chen, J. W., Rathod, J., Jiang, Y. Z., Tsai, P. J., Hung, Y. P., Ko, W. C., Paredes-Sabja, D. & Huang, I. H., 2018 Jan 17, In : Frontiers in Microbiology. 8, JAN, 2635.

Research output: Contribution to journalArticle

lauric acid
Clostridium difficile
Inflammation
Clostridium Infections
Growth
7 Citations (Scopus)
Macrophage Migration-Inhibitory Factors
Glycocalyx
Dengue
Metalloproteases
Proteins
4 Citations (Scopus)

Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy

Lai, Y. C., Chuang, Y. C., Chang, C. P., Lin, Y. S., Perng, G. C., Wu, H. C., Hsieh, S. L. & Yeh, T. M., 2018 Jul, In : Antiviral Research. 155, p. 28-38 11 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Dengue Virus
Minocycline
Autophagy
Virus Replication
1 Citation (Scopus)

MST3 (mammalian Ste20-like protein kinase 3), a novel gene involved in ion homeostasis and renal regulation of blood pressure in spontaneous hypertensive rats

Lu, T. J., Chan, C. H., Ling, P., Chao, Y. M., Bao, B. Y., Chiang, C. Y., Lee, T. H., Weng, Y. P., Kan, W. C. & Lu, T. L., 2018 Dec 1, In : International Urology and Nephrology. 50, 12, p. 2299-2307 9 p.

Research output: Contribution to journalArticle

Protein Kinases
Homeostasis
Ions
Blood Pressure
Hypertension
1 Citation (Scopus)

NAD-glycohydrolase depletes intracellular NAD+ and inhibits acidification of autophagosomes to enhance multiplication of group A Streptococcus in endothelial cells

Hsieh, C. L., Huang, H. M., Hsieh, S. Y., Zheng, P. X., Lin, Y. S., Chiang-Ni, C., Tsai, P. J., Wang, S. Y., Liu, C. C. & Wu, J. J., 2018 Aug 3, In : Frontiers in Microbiology. 9, AUG, 1733.

Research output: Contribution to journalArticle

NAD+ Nucleosidase
Streptococcus
NAD
Endothelial Cells
Vacuoles
4 Citations (Scopus)

Photodynamic inactivation of methicillin-resistant Staphylococcus aureus by indocyanine green and near infrared light

Wong, T-W., Wu, E. C., Ko, W-C., Lee, C. C., Hor, L. I. & Huang, I-H., 2018 Mar 1, In : Dermatologica Sinica. 36, 1, p. 8-15 8 p.

Research output: Contribution to journalArticle

Indocyanine Green
Methicillin-Resistant Staphylococcus aureus
Light
Photochemotherapy
Singlet Oxygen
28 Citations (Scopus)

PM2.5-induced oxidative stress increases intercellular adhesion molecule-1 expression in lung epithelial cells through the IL-6/AKT/STAT3/NF-ΚB-dependent pathway

Liu, C. W., Lee, T. L., Chen, Y. C., Liang, C. J., Wang, S. H., Lue, J. H., Tsai, J. S., Lee, S. W., Chen, S. H., Yang, Y. F., Chuang, T. Y. & Chen, Y. L., 2018 Jan 12, In : Particle and Fibre Toxicology. 15, 1, 4.

Research output: Contribution to journalArticle

Oxidative stress
Particulate Matter
Intercellular Adhesion Molecule-1
Interleukin-6
Oxidative Stress

Sera of patients with systemic lupus erythematosus cross-neutralizes dengue viruses

Zainal, N., Tan, K. K., Johari, J., Hussein, H., Wan Musa, W. R., Hassan, J., Lin, Y. S. & AbuBakar, S., 2018 Oct, In : Microbiology and Immunology. 62, 10, p. 659-672 14 p.

Research output: Contribution to journalArticle

Dengue Virus
Systemic Lupus Erythematosus
Serum
Dengue
Immunoglobulin G
9 Citations (Scopus)

Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein

Zhang, S., Zhou, P., Wang, P., Li, Y., Jiang, L., Jia, W., Wang, H., Fan, A., Wang, D., Shi, X., Fang, X., Hammel, M., Wang, S., Wang, X. & Zhang, L., 2018 Jul 10, In : Cell Reports. 24, 2, p. 441-452 12 p.

Research output: Contribution to journalArticle

Functional analysis
Neutralizing Antibodies
Structural analysis
Epitopes
Glycoproteins

Structural insights into the duplex DNA processing of TREX2

Cheng, H. L., Lin, C. T., Huang, K. W., Wang, S., Lin, Y. T., Toh, S. I. & Hsiao, Y. Y., 2018 Jan 1, In : Nucleic acids research. 46, 22, p. 12166-12176 11 p.

Research output: Contribution to journalArticle

Open Access
Exonucleases
DNA
Skin
Genomic Instability
Psoriasis
3 Citations (Scopus)

Toll-like receptor 3 is involved in detection of enterovirus a71 infection and targeted by viral 2a protease

Chen, K. R., Yu, C. K., Kung, S. H., Chen, S. H., Chang, C. F., Ho, T. C., Lee, Y. P., Chang, H. C., Huang, L. Y., Lo, S. Y., Chang, J. C. & Ling, P., 2018 Dec, In : Viruses. 10, 12, 689.

Research output: Contribution to journalArticle

Toll-Like Receptor 3
Enterovirus Infections
Peptide Hydrolases
Antiviral Agents
Enterovirus
1 Citation (Scopus)

VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function

Wang, Y., Tzeng, H., Tsai, C., Cheng, H., Lai, W., Liu, H. & Wang, Y., 2018 Nov 1, In : Cancer Letters. 437, p. 79-88

Research output: Contribution to journalArticle

2017
27 Citations (Scopus)

Adipose-Derived Stem Cells Protect Skin Flaps against Ischemia/Reperfusion Injury via IL-6 Expression

Pu, C. M., Liu, C. W., Liang, C. J., Yen, Y. H., Chen, S. H., Jiang-Shieh, Y. F., Chien, C. L., Chen, Y. C. & Chen, Y. L., 2017 Jun, In : Journal of Investigative Dermatology. 137, 6, p. 1353-1362 10 p.

Research output: Contribution to journalArticle

Stem cells
Reperfusion Injury
Interleukin-6
Stem Cells
Flaps
10 Citations (Scopus)

Antibodies Against Modified NS1 Wing Domain Peptide Protect Against Dengue Virus Infection

Lai, Y. C., Chuang, Y. C., Liu, C. C., Ho, T. S., Lin, Y. S., Anderson, R. & Yeh, T. M., 2017 Dec 1, In : Scientific reports. 7, 1, 6975.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Antibodies
Proteins
Dengue