Department of Microbiology and Immunology

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2018

Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein

Zhang, S., Zhou, P., Wang, P., Li, Y., Jiang, L., Jia, W., Wang, H., Fan, A., Wang, D., Shi, X., Fang, X., Hammel, M., Wang, S., Wang, X. & Zhang, L., 2018 Jul 10, In : Cell Reports. 24, 2, p. 441-452 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Structural insights into the duplex DNA processing of TREX2

Cheng, H. L., Lin, C. T., Huang, K. W., Wang, S., Lin, Y. T., Toh, S. I. & Hsiao, Y. Y., 2018 Jan 1, In : Nucleic acids research. 46, 22, p. 12166-12176 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Toll-like receptor 3 is involved in detection of enterovirus a71 infection and targeted by viral 2a protease

Chen, K. R., Yu, C. K., Kung, S. H., Chen, S. H., Chang, C. F., Ho, T. C., Lee, Y. P., Chang, H. C., Huang, L. Y., Lo, S. Y., Chang, J. C. & Ling, P., 2018 Dec, In : Viruses. 10, 12, 689.

Research output: Contribution to journalArticle

4 Citations (Scopus)

VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function

Wang, Y., Tzeng, H., Tsai, C., Cheng, H., Lai, W., Liu, H. & Wang, Y., 2018 Nov 1, In : Cancer Letters. 437, p. 79-88

Research output: Contribution to journalArticle

2 Citations (Scopus)
2019

Amelioration of experimentally induced arthritis by reducing reactive oxygen species production through the intra-articular injection of water-soluble fullerenol

Kuo, W. S., Weng, C-T., Chen, J. H., Wu, C-L., Shiau, A-L., Hsieh, J. L., So, E. C., Wu, P-T. & Chen, S. Y., 2019 Jun, In : Nanomaterials. 9, 6, 909.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Anti-inflammatory and antiviral effects of minocycline in enterovirus 71 infections

Liao, Y. T., Wang, S. M. & Chen, S. H., 2019 Oct, In : Biomedicine and Pharmacotherapy. 118, 109271.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli

Tsai, S. L., Chang, Y. C., Sarvagalla, S., Wang, S., Coumar, M. S. & Cheung, C. H. A., 2019 Aug, In : Protein Expression and Purification. 160, p. 73-83 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Combination of modified NS1 and NS3 as a novel vaccine strategy against dengue virus infection

Kao, Y. S., Yu, C. Y., Huang, H. J., Tien, S. M., Wang, W. Y., Yang, M., Anderson, R., Yeh, T. M., Lin, Y. S. & Wan, S. W., 2019 Oct 1, In : Journal of Immunology. 203, 7, p. 1909-1917 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Conditional deletion of CC2D1A reduces hippocampal synaptic plasticity and impairs cognitive function through RAC1 hyperactivation

Yang, C. Y., Yu, T. H., Wen, W. L., Ling, P. & Hsu, K. S., 2019 Jun 19, In : Journal of Neuroscience. 39, 25, p. 4959-4975 17 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib

Wu, C. S., Wu, S. Y., Chen, H. C., Chu, C. A., Tang, H. H., Liu, H. S., Hong, Y. R., Huang, C. Y. F., Huang, G. C. & Su, C. L., 2019 Dec, In : Journal of Nutritional Biochemistry. 74, 108227.

Research output: Contribution to journalArticle

Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking

Kuo, Y. H., Shiau, A. L., Tung, C. L., Su, Y. C., Li, C. F., Su, B. H., Tsao, C. J., Wu, C. L., Feng, Y. H. & Wu, P., 2019 Jun, In : Oncology Letters. 17, 6, p. 5740-5746 7 p.

Research output: Contribution to journalArticle

Open Access

Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling

Ge, J., Remesh, S. G., Hammel, M., Pan, S., Mahan, A. D., Wang, S. & Wang, X., 2019 Aug 6, In : Structure. 27, 8, p. 1296-1307.e5

Research output: Contribution to journalArticle

Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

Cheng, Y. L., Kuo, C. F., Lu, S. L., Hiroko, O., Wu, Y. N., Hsie, C. L., Nod, T., Wu, S. R., Anderson, R., Lin, C. F., Chen, C. L., Wu, J. J. & Lin, Y. S., 2019 Jan 1, In : mBio. 10, 5, e02148-19.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

Tseng, P. C., Kuo, C. F., Cheng, M. H., Wan, S. W., Lin, C. F., Chang, C. P., Lin, Y. S., Wu, J. J., Huang, C. C. & Chen, C. L., 2019 Sep 18, In : Frontiers in Immunology. 10, 2147.

Research output: Contribution to journalArticle

Open Access

Implantable microneedles with an immune-boosting function for effective intradermal influenza vaccination

Chen, Y. H., Lai, K. Y., Chiu, Y. H., Wu, Y. W., Shiau, A-L. & Chen, M-C., 2019 Oct 1, In : Acta Biomaterialia. 97, p. 230-238 9 p.

Research output: Contribution to journalArticle

Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by the Increase of Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps

Pu, C. M., Chen, Y. C., Chen, Y. C., Lee, T. L., Peng, Y. S., Chen, S. H., Yen, Y. H., Chien, C. L., Hsieh, J. H. & Chen, Y. L., 2019 Jan 1, In : Mediators of Inflammation. 2019, 2343867.

Research output: Contribution to journalArticle

Open Access

Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats

Kuthati, Y., Davuluri, V. N. G., Yang, C. P., Chang, H. C., Chang, C. P. & Wong, C. S., 2019 Jan 1, In : Journal of Pain Research. 12, p. 2473-2485 13 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
4 Citations (Scopus)

MiR-338-5p promotes metastasis of colorectal cancer by inhibition of phosphatidylinositol 3-kinase, catalytic subunit type 3-mediated autophagy pathway

Chu, C. A., Lee, C. T., Lee, J. C., Wang, Y. W., Huang, C. T., Lan, S. H., Lin, P. C., Lin, B. W., Tian, Y. F., Liu, H. S. & Chow, N. H., 2019 May, In : EBioMedicine. 43, p. 270-281 12 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

MST3 is involved in ENaC-mediated hypertension

Lu, T. J., Kan, W. C., Yang, S. S., Jiang, S. T., Wu, S. N., Ling, P., Bao, B. Y., Lin, C. Y., Yang, Z. Y., Weng, Y. P., Chan, C. H. & Lu, T. L., 2019 Jan 1, In : American Journal of Physiology - Renal Physiology. 317, 1, p. F30-F42

Research output: Contribution to journalArticle

Mutation of the PTCH1 gene predicts recurrence of breast cancer

Wang, C. Y., Chang, Y. C., Kuo, Y. L., Lee, K. T., Chen, P. S., Cheung, C. H. A., Chang, C. P., Phan, N. N., Shen, M. R. & Hsu, H. P., 2019 Nov 8, In : Scientific reports. 9, 1, 1 p., 16359.

Research output: Contribution to journalArticle

Open Access

Oct4 upregulates osteopontin via Egr1 and is associated with poor outcome in human lung cancer

Feng, Y. H., Su, Y. C., Lin, S. F., Lin, P. R., Wu, C. L., Tung, C. L., Li, C. F., Shieh, G. S. & Shiau, A. L., 2019 Aug 9, In : BMC cancer. 19, 1, 791.

Research output: Contribution to journalArticle

Open Access
Open Access
2 Citations (Scopus)

Prothymosin α promotes STAT3 acetylation to induce cystogenesis in Pkd1-deficient mice

Chen, Y. C., Su, Y. C., Shieh, G. S., Su, B. H., Su, W. C., Huang, P. H., Jiang, S. T., Shiau, A. L. & Wu, C. L., 2019 Nov 1, In : FASEB Journal. 33, 11, p. 13051-13061 11 p.

Research output: Contribution to journalArticle

Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection

Tsao, N., Kuo, C. F., Cheng, M. H., Lin, W. C., Lin, C. F. & Lin, Y. S., 2019 Dec 1, In : Scientific reports. 9, 1, 5371.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Swimming pool-associated Vittaforma-like microsporidia linked to microsporidial keratoconjunctivitis outbreak, Taiwan

Chen, J. S., Hsu, T. K., Hsu, B. M., Chao, S. C., Huang, T. Y., Ji, D. D., Yang, P. Y. & Huang, I. H., 2019 Jan 1, In : Emerging infectious diseases. 25, 11, p. 2100-2103 4 p.

Research output: Contribution to journalArticle

Open Access
Open Access
2020

Bortezomib induces HSV-1 lethality in mice with neutrophil deficiency

Yao, H. W., Wang, L. C., Tsai, H. Y., Fang, Y. H., Zheng, C., Chen, S. H. & Hsu, S. M., 2020 Jan 1, In : Journal of Leukocyte Biology. 107, 1, p. 105-112 8 p.

Research output: Contribution to journalArticle

Functional analysis of Clostridium difficile sortase B reveals key residues for catalytic activity and substrate specificity

Kang, C. Y., Huang, I. H., Chou, C. C., Wu, T. Y., Chang, J. C., Hsiao, Y. Y., Cheng, C. H., Tsai, W. J., Hsu, K. C. & Wang, S., 2020 Mar 13, In : Journal of Biological Chemistry. 295, 11, p. 3734-3745 12 p.

Research output: Contribution to journalArticle

Loss of EGR-1 uncouples compensatory responses of pancreatic β cells

Leu, S. Y., Kuo, L. H., Weng, W. T., Lien, I. C., Yang, C. C., Hsieh, T. T., Cheng, Y. N., Chien, P. H., Ho, L. C., Chen, S. H., Shan, Y. S., Chen, Y. W., Tsai, P. J., Sung, J. M. & Tsai, Y. S., 2020 Jan 1, In : Theranostics. 10, 9, p. 4233-4249 17 p.

Research output: Contribution to journalArticle

Open Access

Nicotinamide Increases Intracellular NAD+ Content to Enhance Autophagy-Mediated Group A Streptococcal Clearance in Endothelial Cells

Hsieh, C. L., Hsieh, S. Y., Huang, H. M., Lu, S. L., Omori, H., Zheng, P. X., Ho, Y. N., Cheng, Y. L., Lin, Y. S., Chiang-Ni, C., Tsai, P. J., Wang, S. Y., Liu, C. C., Noda, T. & Wu, J. J., 2020 Feb 11, In : Frontiers in Microbiology. 11, 117.

Research output: Contribution to journalArticle

Open Access

Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer

Lu, C. S., Shiau, A. L., Su, B. H., Hsu, T. S., Wang, C. T., Su, Y. C., Tsai, M. S., Feng, Y. H., Tseng, Y. L., Yen, Y. T., Wu, C. L. & Shieh, G. S., 2020 Jun 1, In : Journal of hematology & oncology. 13, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Suppression of the reactive oxygen response alleviates experimental autoimmune uveitis in mice

Hsu, S. M., Yang, C. H., Teng, Y. T., Tsai, H. Y., Lin, C. Y., Lin, C. J., Shieh, C. C. & Chen, S. H., 2020 May 1, In : International journal of molecular sciences. 21, 9, 3261.

Research output: Contribution to journalArticle

Open Access

UvrY is required for the full virulence of Aeromonas dhakensis

Chen, Y. W., Yeh, W. H., Tang, H. J., Chen, J. W., Shu, H. Y., Su, Y. C., Wang, S. T., Kuo, C. J., Chuang, Y. C., Chen, C. C., Ko, W. C., Chen, C. S. & Chen, P. L., 2020 Jan 1, In : Virulence. 11, 1, p. 502-520 19 p.

Research output: Contribution to journalArticle

Open Access

Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice

Cheng, Y. Y., Chou, Y. T., Lai, F. J., Jan, M. S., Chang, T. H., Jou, I. M., Chen, P. S., Lo, J. Y., Huang, S. S., Chang, N. S., Liou, Y. T., Hsu, P. C., Cheng, H. C., Lin, Y. S. & Hsu, L. J., 2020 Jan 30, In : Acta Neuropathologica Communications. 8, 1, 6.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)