Department of Microbiology and Immunology

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Sera of patients with systemic lupus erythematosus cross-neutralizes dengue viruses

Zainal, N., Tan, K. K., Johari, J., Hussein, H., Wan Musa, W. R., Hassan, J., Lin, Y. S. & AbuBakar, S., 2018 Oct, In : Microbiology and Immunology. 62, 10, p. 659-672 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma

Chen, C. L., Wang, S. D., Zeng, Z. Y., Lin, K. J., Kao, S. T., Tani, T., Yu, C. K. & Wang, J. Y., 2006 Jul, In : Journal of Allergy and Clinical Immunology. 118, 1, p. 105-112 8 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Serotonin transporter mRNA expression is decreased by lamivudine and ribavirin and increased by interferon in immune cells

Tsao, C. W., Lin, Y-S., Cheng, J. T., Chang, W. W., Chen, C. L., Wu, S. R., Fan, C. W. & Lo, H. Y., 2006 Feb 1, In : Scandinavian Journal of Immunology. 63, 2, p. 106-115 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor

Chiang, C. Y., Pan, C. C., Chang, H. Y., Lai, M-D., Tzai, T. S., Tsai, Y-S., Ling, P., Liu, H-S., Lee, B-F., Cheng, H-L., Ho, C-L., Chen, S-H. & Chow, N-H., 2015 Dec 15, In : Clinical Cancer Research. 21, 24, p. 5601-5611 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Signaling pathways involved in dengue-2 virus infection induced RANTES overexpression

Lee, Y. R., Lei, H. Y., Chen, S. H., Wang, J. R., Lin, Y. S., Yeh, T. M., Liu, C. C. & Liu, H. S., 2008 Jan 1, In : American Journal of Infectious Diseases. 4, 1, p. 32-40 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Significance of migration-related genes (S100A9, MAGED4, C8orf30A, IL-8) in esophageal squamous cell carcinoma

Huang, C. T., Huang, G. C., Wu, P. S., Wu, L. W., Lin, S. H., Lai, W. W., Wang, Y. C. & Liu, H. S., 2012 Mar 1, In : Genomic Medicine, Biomarkers, and Health Sciences. 4, 1-2, p. 16-18 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Significance of urinary epidermal growth factor and its receptor expression in human bladder cancer

Chow, N. H., Liu, H. S., Lee, E. I. C., Chang, C. J., Chan, S. H., Cheng, H. L., Tzai, T. S. & Lin, J. S. N., 1997 Dec 1, In : Anticancer research. 17, 2B, p. 1293-1296 4 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)
61 Citations (Scopus)

Solution structure and backbone dynamics of streptopain: Insight into diverse substrate specificity

Wang, C. C., Houng, H. C., Chen, C. L., Wang, P. J., Kuo, C. F., Lin, Y. S., Wu, J. J., Lin, M. T., Liu, C. C., Huang, W. & Chuang, W. J., 2009 Apr 17, In : Journal of Biological Chemistry. 284, 16, p. 10957-10967 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

SPAK mediates KCC3-enhanced cervical cancer tumorigenesis

Chiu, M. H., Liu, H. S., Wu, Y. H., Shen, M. R. & Chou, C. Y., 2014 May, In : FEBS Journal. 281, 10, p. 2353-2365 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells

Feng, Y. H., Tsao, C. J., Wu, C-L., Chang, J. G., Lu, P-J., Yeh, K. T., Shieh, G. S., Shiau, A-L. & Lee, J-C., 2010 Sep 1, In : Cancer Science. 101, 9, p. 2033-2038 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Steric recognition of T-cell receptor contact residues is required to map mutant epitopes by immunoinformatical programmes

Hsu, S. C., Chang, C. P., Tsai, C. Y., Hsieh, S. H., Wu-Hsieh, B. A., Lo, Y. S. & Yang, J. M., 2012 Jun 1, In : Immunology. 136, 2, p. 139-152 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Streptococcal pyrogenic exotoxin B antibodies in a mouse model of glomerulonephritis

Luo, Y. H., Kuo, C. F., Huang, K. J., Wu, J. J., Lei, H. Y., Lin, M. T., Chuang, W. J., Liu, C. C., Lin, C. F. & Lin, Y. S., 2007 Sep 1, In : Kidney international. 72, 6, p. 716-724 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Streptococcal pyrogenic exotoxin B causes mitochondria damage to polymorphonuclear cells preventing phagocytosis of Group A streptococcus

Chiang-Ni, C., Wang, C. H., Tsai, P. J., Chuang, W. J., Lin, Y. S., Lin, M. T., Liu, C. C. & Wu, J. J., 2006 Jun 1, In : Medical Microbiology and Immunology. 195, 2, p. 55-63 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Streptococcal pyrogenic exotoxin B cleaves human S-adenosylhomocysteine hydrolase and induces hypermethioninemia

Hsu, J. F., Chuang, W. J., Shiesh, S. C., Lin, Y. S., Liu, C. C., Wang, C. C., Fu, T. N., Tsai, J. H., Tsai, W. L., Huang, Y. J., Hsieh, Y. H., Wu, J. J., Lin, M. T. & Huang, W., 2008 Aug 1, In : Journal of Infectious Diseases. 198, 3, p. 367-374 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Streptococcal pyrogenic exotoxin B cleaves properdin and inhibits complement-mediated opsonophagocytosis

Tsao, N., Tsai, W. H., Lin, Y. S., Chuang, W. J., Wang, C. H. & Kuo, C. F., 2006 Jan 20, In : Biochemical and Biophysical Research Communications. 339, 3, p. 779-784 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Streptococcal pyrogenic exotoxin B-induced apoptosis in A549 cells is mediated by a receptor- and mitochondrion-dependent pathway

Tsai, W. H., Chang, C. W., Chuang, W. J., Lin, Y. S., Wu, J. J., Liu, C. C., Chang, W. T. & Lin, M. T., 2004 Dec, In : Infection and Immunity. 72, 12, p. 7055-7062 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Streptococcal pyrogenic exotoxin B-induced apoptosis in A549 cells is mediated through αvβ3 integrin and Fas

Tsai, W. H., Chang, C. W., Lin, Y. S., Chuang, W. J., Wu, J. J., Liu, C. C., Tsai, P. J. & Lin, M. T., 2008 Apr 1, In : Infection and Immunity. 76, 4, p. 1349-1357 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Streptococcal pyrogenic exotoxin B induces apoptosis and reduces phagocytic activity in U937 cells

Kuo, C. F., Wu, J. J., Tsai, P. J., Kao, F. J., Lei, H. Y., Lin, M. T. & Lin, Y. S., 1999 Jan, In : Infection and Immunity. 67, 1, p. 126-130 5 p.

Research output: Contribution to journalArticle

Open Access
47 Citations (Scopus)

Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage

Chen, C. L., Wu, Y. Y., Lin, C. F., Kuo, C. F., Han, C. L., Wang, S., Chuang, W. J., Chen, C. Y., Wu, J. J., Tsai, P. J., Liu, C. C. & Lin, Y. S., 2016 May 16, In : Scientific reports. 6, 26026.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection

Tsao, N., Kuo, C. F., Cheng, M. H., Lin, W. C., Lin, C. F. & Lin, Y. S., 2019 Dec 1, In : Scientific reports. 9, 1, 5371.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein

Zhang, S., Zhou, P., Wang, P., Li, Y., Jiang, L., Jia, W., Wang, H., Fan, A., Wang, D., Shi, X., Fang, X., Hammel, M., Wang, S., Wang, X. & Zhang, L., 2018 Jul 10, In : Cell Reports. 24, 2, p. 441-452 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Structural determinants of actinomyces sortase srtC2 required for membrane localization and assembly of type 2 fimbriae for interbacterial coaggregation and oral biofilm formation

Wu, C., Mishra, A., Reardon, M. E., Huang, I. H., Counts, S. C., Das, A. & Ton-That, H., 2012 May, In : Journal of Bacteriology. 194, 10, p. 2531-2539 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Structural differences between the Streptococcus agalactiae housekeeping and pilus-specific sortases: SrtA and SrtC1

Khare, B., Krishnan, V., Rajashankar, K. R., I-Hsiu, H., Xin, M., Ton-That, H. & Narayana, S. V., 2011 Sep 6, In : PloS one. 6, 8, e22995.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Structural insights into substrate recognition by Clostridium difficile sortase

Yin, J. C., Fei, C. H., Lo, Y. C., Hsiao, Y. Y., Chang, J. C., Nix, J. C., Chang, Y. Y., Yang, L. W., Huang, I. H. & Wang, S., 2016 Nov 22, In : Frontiers in Cellular and Infection Microbiology. 6, NOV, 160.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Structural insights into the duplex DNA processing of TREX2

Cheng, H. L., Lin, C. T., Huang, K. W., Wang, S., Lin, Y. T., Toh, S. I. & Hsiao, Y. Y., 2018 Jan 1, In : Nucleic acids research. 46, 22, p. 12166-12176 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Structural insights into the interaction of IL-33 with its receptors

Liu, X., Hammel, M., He, Y., Tainer, J. A., Jeng, U. S., Zhang, L., Wang, S. & Wang, X., 2013 Sep 10, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 37, p. 14918-14923 6 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Structure of the Escherichia coli FlhDC complex, a prokaryotic heteromeric regulator of transcription

Wang, S., Fleming, R. T., Westbrook, E. M., Matsumura, P. & McKay, D. B., 2006 Jan 27, In : Journal of Molecular Biology. 355, 4, p. 798-808 11 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)
22 Citations (Scopus)

Suckling mice were used to detect infectious dengue-2 viruses by intracerebral injection of the full-length RNA transcript

Lee, Y. R., Huang, K. J., Lei, H. Y., Chen, S. H., Lin, Y. S., Yeh, T. M. & Liu, H. S., 2005 Mar 1, In : Intervirology. 48, 2-3, p. 161-166 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

SUMO-1 overexpression increases RbAp46 protein stability and suppresses cell growth

Giri, R., Yeh, H. H., Wu, C. H. & Liu, H-S., 2008 Nov 1, In : Anticancer research. 28, 6 A, p. 3749-3756 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene

Chen, S. Y., Shiau, A. L., Li, Y. T., Lin, Y. S., Lee, C. H., Wu, C. L. & Wang, C. R., 2012 Jul 1, In : Gene Therapy. 19, 7, p. 752-760 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Suppression of cytolytic T-cell activity by staphylococcal enterotoxin B-induced suppressor cells: Role of interleukin 2

Lin, Y. S., Patel, M. R., Linna, T. J. & Rogers, T. J., 1986 Nov, In : Cellular Immunology. 103, 1, p. 147-159 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Suppression of natural killer cell activity in mouse spleen lymphocytes by several dopamine receptor antagonists

Won, S. J., Chuang, Y. C., Huang, W. T., Liu, H. S. & Lin, M. T., 1995 Apr 1, In : Experientia. 51, 4, p. 343-348 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Suppression of the reactive oxygen response alleviates experimental autoimmune uveitis in mice

Hsu, S. M., Yang, C. H., Teng, Y. T., Tsai, H. Y., Lin, C. Y., Lin, C. J., Shieh, C. C. & Chen, S. H., 2020 May 1, In : International journal of molecular sciences. 21, 9, 3261.

Research output: Contribution to journalArticle

Open Access

Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice

Yao, H. W., Chen, S. H., Li, C., Tung, Y-Y. & Chen, S., 2012 Aug 1, In : Journal of Virology. 86, 16, p. 8568-8580 13 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Suppression of transcription factor early growth response 1 reduces herpes simplex virus lethality in mice

Chen, S. H., Yao, H. W., Chen, I. T., Shieh, B., Li, C. & Chen, S. H., 2008 Oct 1, In : Journal of Clinical Investigation. 118, 10, p. 3470-3477 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Swimming pool-associated Vittaforma-like microsporidia linked to microsporidial keratoconjunctivitis outbreak, Taiwan

Chen, J. S., Hsu, T. K., Hsu, B. M., Chao, S. C., Huang, T. Y., Ji, D. D., Yang, P. Y. & Huang, I. H., 2019 Jan 1, In : Emerging infectious diseases. 25, 11, p. 2100-2103 4 p.

Research output: Contribution to journalArticle

Open Access

Synergistic anti-herpes effect of TNF-α and IFN-γ in human corneal epithelial cells compared with that in corneal fibroblasts

Chen, S. H., Oakes, J. E. & Lausch, R. N., 1994 Dec, In : Antiviral Research. 25, 3-4, p. 201-213 13 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
33 Citations (Scopus)

Synergistic effects of streptolysin S and streptococcal pyrogenic exotoxin B on the mouse model of group A streptococcal infection

Hung, C. H., Tsao, N., Zeng, Y. F., Lu, S. L., Chiang-Ni, C., Lin, Y-S., Wu, J. J. & Kuo, C. F., 2012 Aug 1, In : Medical Microbiology and Immunology. 201, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
79 Citations (Scopus)

Systemic administration of attenuated Salmonella choleraesuis in combination with cisplatin for cancer therapy

Lee, C. H., Wu, C. L., Tai, Y. S. & Shiau, A. L., 2005 May 1, In : Molecular Therapy. 11, 5, p. 707-716 10 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation

Chang, C. P., Su, Y. C., Lee, P. H. & Lei, H. Y., 2013 Apr, In : Autophagy. 9, 4, p. 619-621 3 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
12 Citations (Scopus)

TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity

Chen, K. R., Chang, C. H., Huang, C. Y., Lin, C. Y., Lin, W. Y., Lo, Y. C., Yang, C. Y., Hsing, E. W., Chen, L. F., Shih, S. R., Shiau, A. L., Lei, H. Y., Tan, T. H. & Ling, P., 2012 Sep 14, In : Journal of Biological Chemistry. 287, 38, p. 32216-32221 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

TBK1-associated Protein in Endolysosomes (TAPE) is an innate immune regulator modulating the TLR3 and TLR4 signaling pathways

Chang, C. H., Lai, L. C., Cheng, H. C., Chen, K. R., Syue, Y. Z., Lu, H. C., Lin, W. Y., Chen, S. H., Huang, H. S., Shiau, A. L., Lei, H. Y., Qin, J. & Ling, P., 2011 Mar 4, In : Journal of Biological Chemistry. 286, 9, p. 7043-7051 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

T cell augments the antitumor activity of tumor-targeting Salmonella

Lee, C. H., Hsieh, J. L., Wu, C. L., Hsu, P. Y. & Shiau, A. L., 2011 May 1, In : Applied Microbiology and Biotechnology. 90, 4, p. 1381-1388 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

TGF-β1 conjugated to gold nanoparticles results in protein conformational changes and attenuates the biological function

Tsai, Y-S., Chen, Y-H., Cheng, P. C., Tsai, H. T., Shiau, A-L., Tzai, T. S. & Wu, C-L., 2013 Jun 24, In : Small. 9, 12, p. 2119-2128 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)