Department of Microbiology and Immunology

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Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis

Huang, W. C., Tsai, C. C., Chen, C. L., Chen, T. Y., Chen, Y. P., Lin, Y. S., Lu, P. J., Lin, C. M., Wang, S. H., Tsao, C. W., Wang, C. Y., Cheng, Y. L., Hsieh, C. Y., Tseng, P. C. & Lin, C. F., 2011 Oct 1, In : FASEB Journal. 25, 10, p. 3661-3673 13 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Glutathione depletion-induced apoptosis of Ha-ras-transformed NIH3T3 cells can be prevented by melatonin

Chuang, J. I., Chang, T. Y. & Liu, H. S., 2003 Mar 6, In : Oncogene. 22, 9, p. 1349-1357 9 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis

Wang, C. Y., Lin, Y. S., Su, W. C., Chen, C. L. & Lin, C. F., 2009 Oct 1, In : Molecular Biology of the Cell. 20, 19, p. 4153-4161 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Glycogen synthase kinase-3 facilitates con a-induced IFN-γ-mediated immune hepatic injury

Tsai, C. C., Huang, W. C., Chen, C. L., Hsieh, C. Y., Lin, Y. S., Chen, S. H., Yang, K. C. & Lin, C. F., 2011 Oct 1, In : Journal of Immunology. 187, 7, p. 3867-3877 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells

Huang, W. C., Lin, Y. S., Wang, C. Y., Tsai, C. C., Tseng, H. C., Chen, C. L., Lu, P. J., Chen, P. S., Qian, L., Hong, J. S. & Lin, C. F., 2009 Sep 1, In : Immunology. 128, 1 PART 2, p. e275-e286

Research output: Contribution to journalArticle

81 Citations (Scopus)

Glycogen synthase kinase-3β facilitates IFN-γ-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2

Tsai, C. C., Kai, J. I., Huang, W. C., Wang, C. Y., Wang, Y., Chen, C. L., Fang, Y. T., Lin, Y. S., Anderson, R., Chen, S. H., Tsao, C. W. & Lin, C. F., 2009 Jul 15, In : Journal of Immunology. 183, 2, p. 856-864 9 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Glycogen synthase kinase-3β inactivation is an intracellular marker and regulator for endotoxemic neutrophilia

Yang, T. T., Chen, C. L., Lin, W-C., Lin, Y-S., Tseng, P. C., Hsieh, C. Y., Chen, Y-H., Huang, W. C., Tsai, C. C., Wang, C. Y., Shieh, C-C. & Lin, C. F., 2013 Feb 1, In : Journal of Molecular Medicine. 91, 2, p. 207-217 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Glycogen synthase kinase-3β mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia

Huang, W. C., Lin, Y. S., Chen, C. L., Wang, C. Y., Chiu, W. H. & Lin, C. F., 2009 May 1, In : Journal of Pharmacology and Experimental Therapeutics. 329, 2, p. 524-531 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Glycosylation regulates the function and membrane localization of KCC4

Weng, T. Y., Chiu, W. T., Liu, H. S., Cheng, H. C., Shen, M. R., Mount, D. B. & Chou, C. Y., 2013 May 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1133-1146 14 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Gold nanoparticles for microfluidics-based biosensing of PCR products by hybridization-induced fluorescence quenching

Li, Y. T., Liu, H-S., Lin, H-P. & Chen, S-H., 2005 Dec 1, In : Electrophoresis. 26, 24, p. 4743-4750 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
22 Citations (Scopus)

Group A streptococcal infection caused by emm1 strains among children in southern Taiwan

Lin, H. C., Wang, S-M., Lin, Y. L., Lin, Y-S., Wu, J. J., Chuang, W-J., Lin, M. T. & Liu, C-C., 2008 Dec 1, In : European Journal of Clinical Microbiology and Infectious Diseases. 27, 12, p. 1253-1256 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Group a Streptococcus induces apoptosis in human epithelial cells

Tsai, P-J., Lin, Y-S., Kuo, C. F., Lei, H. Y. & Wu, J. J., 1999 Sep 1, In : Infection and Immunity. 67, 9, p. 4334-4339 6 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

Cheng, Y. L., Kuo, C. F., Lu, S. L., Hiroko, O., Wu, Y. N., Hsie, C. L., Nod, T., Wu, S. R., Anderson, R., Lin, C. F., Chen, C. L., Wu, J. J. & Lin, Y. S., 2019 Jan 1, In : mBio. 10, 5, e02148-19.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

GSK-3β acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis

Lin, C. F., Chen, C. L., Chiang, C-W., Jan, M. S., Huang, W. C. & Lin, Y-S., 2007 Aug 15, In : Journal of Cell Science. 120, 16, p. 2935-2943 9 p.

Research output: Contribution to journalArticle

110 Citations (Scopus)

Ha-ras(Val12) oncogene increases susceptibility of NIH/3T3 cells to lovastatin

Chang, M. Y., Jan, M. S., Won, S. J. & Liu, H. S., 1998 Jul 9, In : Biochemical and Biophysical Research Communications. 248, 1, p. 62-68 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell

Yeh, H. H., Giri, R., Chang, T. Y., Chou, C. Y., Su, W. C. & Liu, H. S., 2009 Mar 1, In : DNA and Cell Biology. 28, 3, p. 131-139 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Ha-ras overexpression mediated cell apoptosis in the presence of 5-fluorouracil

Tseng, Y. S., Tzeng, C. C., Chiu, A. W. H., Lin, C. H., Won, S. J., Wu, I. C. & Liu, H. S., 2003 Aug 15, In : Experimental Cell Research. 288, 2, p. 403-414 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

Tseng, P. C., Kuo, C. F., Cheng, M. H., Wan, S. W., Lin, C. F., Chang, C. P., Lin, Y. S., Wu, J. J., Huang, C. C. & Chen, C. L., 2019 Sep 18, In : Frontiers in Immunology. 10, 2147.

Research output: Contribution to journalArticle

Open Access

Heparin inhibits dengue-2 virus infection of five human liver cell lines

Lin, Y. L., Lei, H. Y., Lin, Y. S., Yeh, T. M., Chen, S. H. & Liu, H. S., 2002 Oct 1, In : Antiviral Research. 56, 1, p. 93-96 4 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)
9 Citations (Scopus)
48 Citations (Scopus)
11 Citations (Scopus)

Hepatocellular carcinoma–related cyclin D1 is selectively regulated by autophagy degradation system

Wu, S. Y., Lan, S. H., Wu, S. R., Chiu, Y. C., Lin, X. Z., Su, I. J., Tsai, T. F., Yen, C. J., Lu, T. H., Liang, F. W., Li, C. Y., Su, H. J., Su, C. L. & Liu, H. S., 2018 Jul, In : Hepatology. 68, 1, p. 141-154 14 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Herpes simplex virus 1 tegument protein VP22 abrogates cGAS/ STING-mediated antiviral innate immunity

Huang, J., You, H., Su, C., Li, Y., Chen, S. & Zheng, C., 2018 Aug 1, In : Journal of Virology. 92, 15, e00841-18.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Herpes simplex virus type 1 inoculation enhances hippocampal excitability and seizure susceptibility in mice

Wu, H. M., Huang, C. C., Chen, S., Liang, Y. C., Tsai, J. J., Hsieh, C. L. & Hsu, K-S., 2003 Dec, In : European Journal of Neuroscience. 18, 12, p. 3294-3304 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Heterologous protection in pigs induced by a plasmid-cured and crp gene-deleted Salmonella choleraesuis live vaccine

Chu, C. Y., Wang, S. Y., Chen, Z. W., Chien, M. S., Huang, J. P., Chen, J. J., Hong, L. S., Shiau, A. L., Tsai, J. L. & Wu, C. L., 2007 Oct 10, In : Vaccine. 25, 41, p. 7031-7040 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

High case-fatality rate of adults with dengue hemorrhagic fever during an outbreak in non-endemic Taiwan: Risk factors for dengue-infected elders

Liu, C. C., Huang, K. J., Huang, M. C., Lin, J. J., Wang, S. M., Liu, J. J., Tsai, J. J., Huang, J. H., Lin, Y. S., Liu, H. S., Yeh, T. M. & Lei, H. Y., 2008 Jan 1, In : American Journal of Infectious Diseases. 4, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

High expression of vascular endothelial growth factor in EV71-infected patients does not originate from EV71-infected cells

Huang, S. C., Raghavaraju, G. & Liu, H. S., 2010 Sep 1, In : Intervirology. 53, 6, p. 394-401 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection

Kuo, C. F., Luo, Y. H., Lin, H. Y., Huang, K. J., Wu, J. J., Lei, H. Y., Lin, M. T., Chuang, W. J., Liu, C. C., Jin, Y. T. & Lin, Y. S., 2004 May 1, In : Microbial Pathogenesis. 36, 5, p. 273-285 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis

Lee, Y. R., Yeh, S. F., Ruan, X. M., Zhang, H., Hsu, S. D., Huang, H. D., Hsieh, C. C., Lin, Y. S., Yeh, T. M., Liu, H. S. & Gan, D. D., 2017 Feb 23, In : Journal of Ethnopharmacology. 198, p. 109-121 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
42 Citations (Scopus)

Human endothelial cell activation and apoptosis induced by enterovirus 71 infection

Liang, C. C., Sun, M. J., Lei, H. Y., Chen, S., Yu, C-K., Liu, C-C., Wang, J-R. & Yeh, T-M., 2004 Jan 1, In : Journal of Medical Virology. 74, 4, p. 597-603 7 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
28 Citations (Scopus)

Humoral immune responses inhibit the antitumor activities mediated by salmonella enterica serovar choleraesuis

Lee, C. H., Wu, C-L., Chen, S. & Shiau, A-L., 2009 May 1, In : Journal of Immunotherapy. 32, 4, p. 376-388 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Hydroxyurea and splenic irradiation-induced tumour lysis syndrome: A case report and review of the literature

Chen, S. W., Hwang, W. S., Tsao, C. J., Liu, H. S. & Huang, G. C., 2005 Dec 1, In : Journal of Clinical Pharmacy and Therapeutics. 30, 6, p. 623-625 3 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Hypoxia imaging predicts success of hypoxia-induced cytosine deaminase/5-fluorocytosine gene therapy in a murine lung tumor model

Lee, B. F., Lee, C. H., Chiu, N. T., Hsia, C. C., Shen, L. H. & Shiau, A. L., 2012 Apr 1, In : Cancer Gene Therapy. 19, 4, p. 255-262 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Hypoxia-induced cytosine deaminase gene expression for cancer therapy

Lee, C. H., Wu, C-L. & Shiau, A-L., 2007 Jan 1, In : Human Gene Therapy. 18, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Hypoxia promotes nuclear translocation and transcriptional function in the oncogenic tyrosine kinase RON

Chang, H. Y., Liu, H. S., Lai, M. D., Tsai, Y. S., Tzai, T. S., Cheng, H. L. & Chow, N. H., 2014 Aug 15, In : Cancer Research. 74, 16, p. 4549-4562 14 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Identification and nucleotide sequence analysis of an open reading frame involved in high-frequency conversion of turbid to clear plaque mutants of filamentous phage Cf1t

Shieh, G. J., Charng, Y. C., Yang, B. C., Jenn-Tu, Bau, H. J. & Kuo, T. T., 1991 Nov, In : Virology. 185, 1, p. 316-322 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Identification of colorectal cancer recurrence-related microRNAs

Ju, J. A., Huang, Y. C., Lan, S. H., Wang, T. H., Lin, P-C., Lee, J. C., Niu, K. C., Tian, Y. F. & Liu, H-S., 2012 Mar 1, In : Genomic Medicine, Biomarkers, and Health Sciences. 4, 1-2, p. 19-20 2 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Identifying the factors and signal pathways necessary for anchorage-independent growth of Ha-ras oncogene-transformed NIH/3T3 cells

Chang, T. Y., Tsai, W. J., Chou, C. K., Chow, N. H., Leu, T. H. & Liu, H. S., 2003 Jul 25, In : Life Sciences. 73, 10, p. 1265-1274 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

IL-19 induced Th2 cytokines and was up-regulated in asthma patients

Liao, S. C., Cheng, Y. C., Wang, Y. C., Wang, C. W., Yang, S. M., Yu, C. K., Shieh, C. C., Cheng, K. C., Lee, M. F., Chiang, S. R., Shieh, J. M. & Chang, M. S., 2004 Dec 1, In : Journal of Immunology. 173, 11, p. 6712-6718 7 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

IL-24 inhibits the growth of hepatoma cells in vivo

Chen, W. Y., Cheng, Y. T., Lei, H. Y., Chang, C. P., Wang, C. W. & Chang, M. S., 2005 Sep 1, In : Genes and Immunity. 6, 6, p. 493-499 7 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

IL-6 ameliorates acute lung injury in influenza virus infection

Yang, M. L., Wang, C. T., Yang, S. J., Leu, C. H., Chen, S. H., Wu, C. L. & Shiau, A. L., 2017 Mar 6, In : Scientific reports. 7, 43829.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Immune response and protective efficacy of live attenuated Salmonella vaccine expressing antigens of Mycobacterium avium subsp. paratuberculosis against challenge in mice

Chandra, S., Faisal, S. M., Chen, J. W., Chen, T. T., McDonough, S. P., Liu, S., Moreira, M. A. S., Akey, B. L., Chang, C. F. & Chang, Y. F., 2012 Dec 17, In : Vaccine. 31, 1, p. 242-251 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Immune responses to hepatitis B surface antigen in inbred mice.

Lei, H. Y., Yu, C-K. & Ku, L. C., 1988 Feb 1, In : Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association. 87, 2, p. 192-198 7 p.

Research output: Contribution to journalArticle

Immunity to avirulent enterovirus 71 and coxsackie A16 virus protects against enterovirus 71 infection in mice

Wu, T. C., Wang, Y. F., Lee, Y. P., Wang, J. R., Liu, C. C., Wang, S. M., Lei, H. Y., Su, I. J. & Yu, C. K., 2007 Oct 1, In : Journal of Virology. 81, 19, p. 10310-10315 6 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Immunization with a streptococcal multipleepitope recombinant protein protects mice against invasive group A streptococcal infection

Kuo, C. F., Tsao, N., Hsieh, I. C., Lin, Y. S., Wu, J. J. & Hung, Y. T., 2017 Mar, In : PloS one. 12, 3, 0174464.

Research output: Contribution to journalArticle

3 Citations (Scopus)
5 Citations (Scopus)