Department of Microbiology and Immunology

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2013

Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group a streptococcal infection

Lu, S. L., Tsai, C. Y., Luo, Y. H., Kuo, C. F., Lin, W. C., Chang, Y. T., Wu, J. J., Chuang, W. J., Liu, C. C., Chao, L., Chao, J. & Lin, Y. S., 2013 Nov 1, In : Antimicrobial agents and chemotherapy. 57, 11, p. 5366-5372 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Lentiviral small hairpin RNA knockdown of macrophage inflammatory protein-1γ ameliorates experimentally induced osteoarthritis in mice

Shen, P. C., Lu, C. S., Shiau, A. L., Lee, C. H., Jou, I. M. & Hsieh, J. L., 2013 Oct 1, In : Human Gene Therapy. 24, 10, p. 871-882 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Low concentration of arsenic-induced aberrant mitosis in keratinocytes through E2F1 transcriptionally regulated aurora-A

Wu, C. H., Tseng, Y. S., Kao, Y. T., Sheu, H. M. & Liu, H. S., 2013 Mar 1, In : Toxicological Sciences. 132, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Peroxide responsive regulator PerR of group A streptococcus is required for the expression of phage-associated DNase Sda1 under oxidative stress

Wang, C. H., Chiang-Ni, C., Kuo, H. T., Zheng, P. X., Tsou, C. C., Wang, S., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2013 Dec 3, In : PloS one. 8, 12, e81882.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Pilus gene pool variation and the virulence of Corynebacterium diphtheriae clinical isolates during infection of a nematode

Broadway, M. M., Rogers, E. A., Chang, C., Huang, I. H., Dwivedi, P., Yildirim, S., Schmitt, M. P., Das, A. & Ton-That, H., 2013 Aug 7, In : Journal of Bacteriology. 195, 16, p. 3774-3783 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Plasma kallistatin levels in patients with severe community-acquired pneumonia

Lin, W. C., Lu, S. L., Lin, C. F., Chen, C. W., Chao, L., Chao, J. & Lin, Y. S., 2013 Feb 8, In : Critical Care. 17, 1, R27.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Plasma thymosin-α1 level as a potential biomarker in urothelial and renal cell carcinoma

Jou, Y. C., Tsai, Y. S., Hsieh, H. Y., Chen, S. Y., Tsai, H. T., Chen, K. J., Wang, S. T., Shiau, A. L., Wu, C. L. & Tzai, T. S., 2013 Nov 1, In : Urologic Oncology: Seminars and Original Investigations. 31, 8, p. 1806-1811 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Proteomic comparison of historic and recently emerged hypervirulent clostridium difficile strains

Chen, J. W., Scaria, J., Mao, C., Sobral, B., Zhang, S., Lawley, T. & Chang, Y. F., 2013 Mar 11, In : Journal of Proteome Research. 12, 3, p. 1151-1161 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Prothymosin α overexpression contributes to the development of pulmonary emphysema

Su, B. H., Tseng, Y. L., Shieh, G. S., Chen, Y. C., Shiang, Y. C., Wu, P., Li, K. J., Yen, T. H., Shiau, A. L. & Wu, C. L., 2013 Jun 12, In : Nature communications. 4, 1906.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Regulatory role of GSK-3 β on NF-B, nitric oxide, and TNF-α in group A streptococcal infection

Chang, Y. T., Chen, C. L., Lin, C. F., Lu, S. L., Cheng, M. H., Kuo, C. F. & Lin, Y. S., 2013 Apr 2, In : Mediators of Inflammation. 2013, 720689.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Structural insights into the interaction of IL-33 with its receptors

Liu, X., Hammel, M., He, Y., Tainer, J. A., Jeng, U. S., Zhang, L., Wang, S. & Wang, X., 2013 Sep 10, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 37, p. 14918-14923 6 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)
22 Citations (Scopus)

Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation

Chang, C. P., Su, Y. C., Lee, P. H. & Lei, H. Y., 2013 Apr, In : Autophagy. 9, 4, p. 619-621 3 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

TGF-β1 conjugated to gold nanoparticles results in protein conformational changes and attenuates the biological function

Tsai, Y-S., Chen, Y-H., Cheng, P. C., Tsai, H. T., Shiau, A-L., Tzai, T. S. & Wu, C-L., 2013 Jun 24, In : Small. 9, 12, p. 2119-2128 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates

Wang, Y. T., Kuo, P. H., Chiang, C. H., Liang, J. R., Chen, Y. R., Wang, S., Shen, J. C. K. & Yuan, H. S., 2013 Mar 29, In : Journal of Biological Chemistry. 288, 13, p. 9049-9057 9 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation

Chang, C. P., Su, Y. C., Hu, C. W. & Lei, H. Y., 2013 Jan 1, In : Cell Death and Differentiation. 20, 3, p. 515-523 9 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
11 Citations (Scopus)

WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma

Tsai, C. W., Lai, F. J., Sheu, H. M., Lin, Y. S., Chang, T. H., Jan, M. S., Chen, S. M., Hsu, P. C., Huang, T. T., Huang, T. C., Sheen, M. C., Chen, S. T., Chang, W. C., Chang, N. S. & Hsu, L. J., 2013 Sep 1, In : Cell Death and Disease. 4, 9, e792.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2012

Acquisition of an enhanced aggressive phenotype in human lung cancer cells selected by suboptimal doses of cisplatin following cell deattachment and reattachment

Hsieh, J. L., Lu, C. S., Huang, C. L., Shieh, G. S., Su, B. H., Su, Y. C., Lee, C. H., Chang, M. Y., Wu, C. L. & Shiau, A. L., 2012 Aug 1, In : Cancer Letters. 321, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223

Li, Y. T., Chen, S. Y., Wang, C. R., Liu, M. F., Lin, C. C., Jou, I. M., Shiau, A. L. & Wu, C. L., 2012 Oct 1, In : Arthritis and Rheumatism. 64, 10, p. 3240-3245 6 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)
30 Citations (Scopus)

Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms

Wang, C. Y., Chen, C. L., Tseng, Y. L., Fang, Y. T., Lin, Y. S., Su, W. C., Chen, C. C., Chang, K. C., Wang, Y. C. & Lin, C. F., 2012 Sep 21, In : Journal of Biological Chemistry. 287, 39, p. 32512-32524 13 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Catenarin prevents type 1 diabetes in nonobese diabetic mice via inhibition of leukocyte migration involving the MEK6/p38 and MEK7/JNK pathways

Shen, M. Y., Lin, Y. P., Yang, B. C., Jang, Y. S., Chiang, C. K., Mettling, C., Chen, Z. W., Sheu, J. R., Chang, C. L., Lin, Y. L. & Yang, W. C., 2012 Mar 19, In : Evidence-based Complementary and Alternative Medicine. 2012, 982396.

Research output: Contribution to journalArticle

8 Citations (Scopus)

CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells

Ko, C. Y., Chang, L. H., Lee, Y. C., Sterneck, E., Cheng, C. P., Chen, S., Huang, A. M., Tseng, T-C. & Wang, J-M., 2012 Jan 1, In : Neurobiology of Aging. 33, 2, p. 422.e11-422.e25

Research output: Contribution to journalArticle

35 Citations (Scopus)

CD4 T-cell-independent antibody response reduces enterovirus 71 lethality in mice by decreasing tissue viral loads

Wang, L. C., Kao, C. M., Ling, P., Su, I. J., Chang, T. M. & Chen, S. H., 2012 Dec 3, In : Clinical and Developmental Immunology. 2012, 580696.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Cell surface sialylation affects binding of enterovirus 71 to rhabdomyosarcoma and neuroblastoma cells

Su, P. Y., Liu, Y. T., Chang, H. Y., Huang, S. W., Wang, Y. F., Yu, C. K., Wang, J. R. & Chang, C. F., 2012 Aug 3, In : BMC microbiology. 12, 162.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Crystal structure of a human single domain antibody dimer formed through V H-V H non-covalent interactions

Baral, T. N., Chao, S. Y., Li, S., Tanha, J., Arbabi-Ghahroudi, M., Zhang, J. & Wang, S., 2012 Jan 12, In : PloS one. 7, 1, e30149.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Dengue virus nonstructural protein NS1 binds to prothrombin/thrombin and inhibits prothrombin activation

Lin, S. W., Chuang, Y. C., Lin, Y. S., Lei, H. Y., Liu, H. S. & Yeh, T. M., 2012 Mar 1, In : Journal of Infection. 64, 3, p. 325-334 10 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Endothelial cell surface expression of protein disulfide isomerase activates β1 and β3 integrins and facilitates dengue virus infection

Wan, S. W., Lin, C. F., Lu, Y. T., Lei, H. Y., Anderson, R. & Lin, Y. S., 2012 May 1, In : Journal of Cellular Biochemistry. 113, 5, p. 1681-1691 11 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Enterovirus 71 blocks selectively type I interferon production through the 3C viral protein in mice

Lee, Y. P., Wang, Y. F., Wang, J. R., Huang, S. W. & Yu, C. K., 2012 Nov 1, In : Journal of Medical Virology. 84, 11, p. 1779-1789 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Environmental pH changes, but not the LuxS signalling pathway, regulate SpeB expression in M1 group A streptococci

Chiang-Ni, C., Zheng, P. X., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2012 Jan 1, In : Journal of Medical Microbiology. 61, 1, p. 16-22 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Factors affecting herpes simplex virus reactivation from the explanted mouse brain

Yao, H. W., Ling, P., Chen, S. H., Tung, Y. Y. & Chen, S. H., 2012 Nov 10, In : Virology. 433, 1, p. 116-123 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Fas ligand enhances malignant behavior of tumor cells through interaction with met, hepatocyte growth factor receptor, in lipid rafts

Lin, H. C., Lai, P. Y., Lin, Y. P., Huang, J. Y. & Yang, B. C., 2012 Jun 8, In : Journal of Biological Chemistry. 287, 24, p. 20664-20673 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Hypoxia imaging predicts success of hypoxia-induced cytosine deaminase/5-fluorocytosine gene therapy in a murine lung tumor model

Lee, B. F., Lee, C. H., Chiu, N. T., Hsia, C. C., Shen, L. H. & Shiau, A. L., 2012 Apr 1, In : Cancer Gene Therapy. 19, 4, p. 255-262 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification of colorectal cancer recurrence-related microRNAs

Ju, J. A., Huang, Y. C., Lan, S. H., Wang, T. H., Lin, P-C., Lee, J. C., Niu, K. C., Tian, Y. F. & Liu, H-S., 2012 Mar 1, In : Genomic Medicine, Biomarkers, and Health Sciences. 4, 1-2, p. 19-20 2 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Immune response and protective efficacy of live attenuated Salmonella vaccine expressing antigens of Mycobacterium avium subsp. paratuberculosis against challenge in mice

Chandra, S., Faisal, S. M., Chen, J. W., Chen, T. T., McDonough, S. P., Liu, S., Moreira, M. A. S., Akey, B. L., Chang, C. F. & Chang, Y. F., 2012 Dec 17, In : Vaccine. 31, 1, p. 242-251 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Immunogenicity and protective efficacy of the Mycobacterium avium subsp. paratuberculosis attenuated mutants against challenge in a mouse model

Chen, J. W., Faisal, S. M., Chandra, S., McDonough, S. P., Moreira, M. A. S., Scaria, J., Chang, C. F., Bannantine, J. P., Akey, B. & Chang, Y. F., 2012 Apr 19, In : Vaccine. 30, 19, p. 3015-3025 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Impact of the location of CpG methylation within the GSTP1 gene on its specificity as a DNA marker for hepatocellular carcinoma

Jain, S., Chen, S., Chang, K. C., Lin, Y. J., Hu, C. T., Boldbaatar, B., Hamilton, J. P., Lin, S. Y., Chang, T. T., Chen, S. H., Song, W., Meltzer, S. J., Block, T. M. & Su, Y. H., 2012 Apr 20, In : PloS one. 7, 4, e35789.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Inhibiting glycogen synthase kinase-3 decreases 12-O-tetradecanoylphorbol- 13-acetate-induced interferon-γ-mediated skin inflammation

Hsieh, C. Y., Chen, C. L., Tsai, C. C., Huang, W. C., Tseng, P. C., Lin, Y. S., Chen, S. H., Wong, T. W., Choi, P. C. & Lin, C. F., 2012 Oct 1, In : Journal of Pharmacology and Experimental Therapeutics. 343, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Interferon-γ stimulates p11-dependent surface expression of annexin A2 in lung epithelial cells to enhance phagocytosis

Fang, Y. T., Lin, C. F., Wang, C. Y., Anderson, R. & Lin, Y-S., 2012 Jun 1, In : Journal of Cellular Physiology. 227, 6, p. 2775-2787 13 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation

Chuang, Y. C., Su, W. H., Lei, H. Y., Lin, Y. S., Liu, H. S., Chang, C. P. & Yeh, T. M., 2012 May 22, In : PloS one. 7, 5, e37613.

Research output: Contribution to journalArticle

42 Citations (Scopus)

MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells

Feng, Y. H., Wu, C. L., Shiau, A. L., Lee, J. C., Chang, J. G., Lu, P. J., Tung, C. L., Feng, L. Y., Huang, W. T. & Tsao, C. J., 2012 May 1, In : International journal of molecular medicine. 29, 5, p. 920-926 7 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering

Huang, Y. J., Shiau, A. L., Chen, S. Y., Chen, Y. L., Wang, C. R., Tsai, C. Y., Chang, M. Y., Li, Y. T., Leu, C. H. & Wu, C. L., 2012 Jan, In : European Cells and Materials. 23, p. 170-181 12 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement

Huang, S. W., Wang, Y. F., Yu, C. K., Su, I. J. & Wang, J. R., 2012 Jan 5, In : Virology. 422, 1, p. 132-143 12 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Pangenomic study of Corynebacterium diphtheriae that provides insights into the genomic diversity of pathogenic isolates from cases of classical diphtheria, endocarditis, and pneumonia

Trost, E., Blom, J., de Soares, S. C., Huang, I. H., Al-Dilaimi, A., Schröder, J., Jaenicke, S., Dorella, F. A., Rocha, F. S., Miyoshi, A., Azevedo, V., Schneider, M. P., Silva, A., Camello, T. C., Sabbadini, P. S., Santos, C. S., Santos, L. S., Hirata, R. J., Mattos-Guaraldi, A. L., Efstratiou, A. & 3 others, Schmitt, M. P., Ton-That, H. & Tauch, A., 2012 Jun 1, In : Journal of Bacteriology. 194, 12, p. 3199-3215 17 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Phenotypic and transcriptomic response of auxotrophic mycobacterium avium subsp. paratuberculosis leuD mutant under environmental stress

Chen, J. W., Scaria, J. & Chang, Y. F., 2012 Jun 4, In : PloS one. 7, 6, e37884.

Research output: Contribution to journalArticle

12 Citations (Scopus)
51 Citations (Scopus)

Protective role of autophagy in branched polyethylenimine (25K)- and poly(L-lysine) (30-70K)-induced cell death

Lin, C. W., Jan, M. S., Kuo, J. H. S., Hsu, L. J. & Lin, Y. S., 2012 Dec 18, In : European Journal of Pharmaceutical Sciences. 47, 5, p. 865-874 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Significance of migration-related genes (S100A9, MAGED4, C8orf30A, IL-8) in esophageal squamous cell carcinoma

Huang, C. T., Huang, G. C., Wu, P. S., Wu, L. W., Lin, S. H., Lai, W. W., Wang, Y. C. & Liu, H. S., 2012 Mar 1, In : Genomic Medicine, Biomarkers, and Health Sciences. 4, 1-2, p. 16-18 3 p.

Research output: Contribution to journalArticle