Research Output 1986 2019

2019

Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity

Chen, Y. R., Li, Y. H., Hsieh, T. C., Wang, C. M., Cheng, K. C., Wang, L., Lin, T. Y., Cheung, C-H., Wu, C. L. & Chinag, H., 2019 Aug 1, In : Aging Cell. 18, 4, e12989.

Research output: Contribution to journalArticle

Open Access
Alzheimer Disease
Pathology
Diptera
Behavioral Genetics
Amyloid Precursor Protein Secretases

Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli

Tsai, S. L., Chang, Y. C., Sarvagalla, S., Wang, S., Coumar, M. S. & Cheung, C-H., 2019 Aug 1, In : Protein Expression and Purification. 160, p. 73-83 11 p.

Research output: Contribution to journalArticle

Escherichia coli Proteins
Organism Cloning
Recombinant Proteins
Histidine
Proteins
Semaphorin-3A
Memory Disorders
Alzheimer Disease
Animal Models
Proteins

Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila

Shyu, W. H., Lee, W. P., Chiang, M. H., Chang, C. C., Fu, T. F., Chinag, H., Wu, T. & Wu, C. L., 2019 May 1, In : PLoS genetics. 15, 5, p. e1008153

Research output: Contribution to journalArticle

Open Access
Electrical Synapses
Mushroom Bodies
mushroom bodies
mushroom
synapse

Functional effects of let-7g expression in colon cancer metastasis

Chang, C. M., Wong, H. S. C., Huang, C. Y., Hsu, W. L., Maio, Z. F., Chiu, S. J., Tsai, Y. T., Chen, B-K., Wan, Y. J. Y., Wang, J. Y. & Chang, W. C., 2019 Apr 1, In : Cancers. 11, 4, 489.

Research output: Contribution to journalArticle

Open Access
Colonic Neoplasms
Colorectal Neoplasms
Neoplasm Metastasis
Neoplasms
Atlases
Open Access
Colorectal Neoplasms
Neoplasms
Therapeutics
Genome
Mutation
1 Citation (Scopus)

LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P

Tan, B. S., Yang, M. C., Singh, S., Chou, Y. C., Chen, H. Y., Wang, M. Y., Wang, Y-C. & Chen, R. H., 2019 Jul 11, In : Oncogene. 38, 28, p. 5612-5626 15 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Long Noncoding RNA
Breast Neoplasms
Neoplasm Metastasis
Mi-2 Nucleosome Remodeling and Deacetylase Complex
1 Citation (Scopus)

Myostatin Is Associated With Cognitive Decline in an Animal Model of Alzheimer’s Disease

Lin, Y. S., Lin, F. Y. & Hsiao, Y-H., 2019 Mar 1, In : Molecular Neurobiology. 56, 3, p. 1984-1991 8 p.

Research output: Contribution to journalArticle

Myostatin
Muscular Atrophy
Amyloid beta-Protein Precursor
Alzheimer Disease
Animal Models

Protein Glycation by Glyoxal Promotes Amyloid Formation by Islet Amyloid Polypeptide

Hsu, Y. H., Chen, Y-W., Wu, M. H. & Tu, L. H., 2019 Jun 18, In : Biophysical Journal. 116, 12, p. 2304-2313 10 p.

Research output: Contribution to journalArticle

Glyoxal
Islet Amyloid Polypeptide
Amyloid
Type 2 Diabetes Mellitus
Peptide Hormones
1 Citation (Scopus)
Open Access
Oncology
Esophageal Neoplasms
DNA Repair
DNA Damage
Carcinogenesis

Store-Operated Ca2+ entry in tumor progression: From molecular mechanisms to clinical implications

Chen, Y. F., Lin, P-C., Yeh, Y. M., Chen, L. H. & Shen, M-R., 2019 Jul 1, In : Cancers. 11, 7, 899.

Research output: Contribution to journalReview article

Open Access
Neoplasms
Endoplasmic Reticulum
Neoplasm Metastasis
Cellular Microenvironment
Tumor Microenvironment
2 Citations (Scopus)

The distinct role of STIM1 and STIM2 in the regulation of store-operated Ca 2+ entry and cellular function

Chen, Y. F., Chen, L. H. & Shen, M-R., 2019 Jun 1, In : Journal of Cellular Physiology. 234, 6, p. 8727-8739 13 p.

Research output: Contribution to journalArticle

Uterine Cervical Neoplasms
Endoplasmic Reticulum
Sensors
Microtubules
Tissue
Open Access
Social Isolation
Weaning
Aggression
Hypothalamus
Hippocampus
2018

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W., Chang, H., Lin, Y., Lin, Y., Chang, H., Lin, H., Huang, S., Tang, M. & Shen, M., 2018 Dec 1, In : Cell Death Discovery. 4, 1

Research output: Contribution to journalArticle

KATP Channels
Palmitic Acid
Insulin
Glucose
Glyburide

Correction: Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies (FASEB Journal (2018) 32 (1375-1387) DOI: 10.1096/fj.201700199RR)

Ji, X. R., Cheng, K. C., Chen, Y. R., Lin, T. Y., Cheung, C-H., Wu, C. L. & Chinag, H., 2018 Nov 1, In : FASEB Journal. 32, 11, 1 p.

Research output: Contribution to journalComment/debate

Pathology
Taiwan
Medicine
Degradation
Biochemistry

Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies

Ji, X. R., Cheng, K. C., Chen, Y. R., Lin, T. Y., Cheung, C-H., Wu, C. L. & Chinag, H., 2018 Mar 1, In : FASEB Journal. 32, 3, p. 1375-1387 13 p.

Research output: Contribution to journalArticle

Autophagy
Pathology
Proteasome Endopeptidase Complex
Ubiquitin
Alzheimer Disease

Functional engineered mesenchymal stem cells with fibronectin-gold composite coated catheters for vascular tissue regeneration

Chen, Y., Hsieh, S., Yang, Y., Hsu, S., Kung, M., Lin, P., Hsieh, H., Lin, C., Tang, C. & Hung, H., 2018 Apr 1, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 3, p. 699-711

Research output: Contribution to journalArticle

2 Citations (Scopus)
Amino Acid Transport System X-AG
High Fat Diet
Neuroglia
Lactic Acid
Hippocampus
3 Citations (Scopus)

High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice

Tsai, S. F., Wu, H. T., Chen, P., Chen, Y-W., Yu, M., Wang, T. F., Wu, S. Y., Tzeng, S-F. & Kuo, Y-M., 2018 Dec 1, In : Brain Research. 1700, p. 66-77 12 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
High Fat Diet
Neuronal Plasticity
Neuroglia
Hippocampus

High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice.

Tsai, SF., Wu, HT., Chen, PC. & Chen, Y-W., 2018 Jul 13, In : Brain Research. 18, p. 30401 3 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
High Fat Diet
Neuronal Plasticity
Neuroglia
Hippocampus
7 Citations (Scopus)

Impact of social relationships on Alzheimer's memory impairment: Mechanistic studies

Hsiao, Y-H., Chang, C. H. & Gean, P-W., 2018 Jan 11, In : Journal of biomedical science. 25, 1, 3.

Research output: Contribution to journalReview article

Alzheimer Disease
Data storage equipment
Memory Disorders
Loneliness
Social Isolation

Integrative genomic analysis for the functional roles of ITPKC in bone mineral density

Lu, H. F., Wong, H. S. C., Chen, B-K., Liao, H. T., Hsu, Y. W., Ikegawa, S., Cho, E. C., Hung, K. S. & Chang, W. C., 2018 Nov 30, In : Bioscience Reports. 38, 6, BSR20181481.

Research output: Contribution to journalArticle

Bone Density
Minerals
Bone
Genes
Osteoclasts
1 Citation (Scopus)

Mechanism underlying NMDA blockade-induced inhibition of aggression in post-weaning socially isolated mice

Chang, C. H., Su, C. L. & Gean, P-W., 2018 Dec 1, In : Neuropharmacology. 143, p. 95-105 11 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
N-Methylaspartate
Weaning
Aggression
Hippocampus
2 Citations (Scopus)

Mushroom body glycolysis is required for olfactory memory in Drosophila

Wu, C. L., Chang, C. C., Wu, J. K., Chiang, M. H., Yang, C. H. & Chinag, H., 2018 Apr 1, In : Neurobiology of Learning and Memory. 150, p. 13-19 7 p.

Research output: Contribution to journalArticle

Mushroom Bodies
Glycolysis
Drosophila
Pyruvate Kinase
Phosphofructokinases
6 Citations (Scopus)

Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype

Tzeng, H. T., Su, C. C., Chang, C. P., Lai, W. W., Su, W. C. & Wang, Y-C., 2018 Oct 1, In : International Journal of Cancer. 143, 7, p. 1753-1763 11 p.

Research output: Contribution to journalArticle

Exocytosis
Lung Neoplasms
Macrophages
Phenotype
Neoplasms
1 Citation (Scopus)

VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function

Wang, Y., Tzeng, H., Tsai, C., Cheng, H., Lai, W., Liu, H. & Wang, Y., 2018 Nov 1, In : Cancer Letters. 437, p. 79-88

Research output: Contribution to journalArticle

25 Citations (Scopus)

Visualization of Membrane Pore in Live Cells Reveals a Dynamic-Pore Theory Governing Fusion and Endocytosis

Shin, W., Ge, L., Arpino, G., Villarreal, S. A., Hamid, E., Liu, H., Zhao, W. D., Wen, P. J., Chinag, H. & Wu, L. G., 2018 May 3, In : Cell. 173, 4, p. 934-945.e12

Research output: Contribution to journalArticle

Endocytosis
Fusion reactions
Visualization
Constriction
Membranes
1 Citation (Scopus)

XBP1 and PERK Have Distinct Roles in Aβ-Induced Pathology

Cheng, K. C. & Chinag, H., 2018 Sep 1, In : Molecular Neurobiology. 55, 9, p. 7523-7532 10 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Pathology
Learning
Proteasome Endopeptidase Complex
Diptera
2017
7 Citations (Scopus)

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y-J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y-C., 2017 May 15, In : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

Research output: Contribution to journalArticle

decitabine
Wnt Signaling Pathway
Histone Deacetylase Inhibitors
Histone Deacetylases
Non-Small Cell Lung Carcinoma
4 Citations (Scopus)

A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Wu, Y-H., Hong, C. W., Wang, Y-C., Huang, W. J., Yeh, Y. L., Wang, B. J., Wang, Y-J. & Chiu, H. W., 2017 Aug 1, In : Cancer Letters. 400, p. 79-88 10 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Etoposide
DNA Repair
3 Citations (Scopus)
Chemoradiotherapy
DNA Methylation
Biomarkers
Methylation
Therapeutics
4 Citations (Scopus)

CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression

Liao, S. Y., Chiang, C-W., Hsu, C. H., Chen, Y. T., Jen, J., Juan, H. F., Lai, W-W. & Wang, Y-C., 2017 Oct 12, In : Oncogene. 36, 41, p. 5722-5733 12 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Zinc Fingers
Lung Neoplasms
Serine
Phosphorylation
6 Citations (Scopus)
Brain-Derived Neurotrophic Factor
Epigenomics
Histone Deacetylase 2
Alzheimer Disease
Animal Models
3 Citations (Scopus)

Cyclic AMP (cAMP) confers drug resistance against DNA damaging agents via PKAIA in CML cells

Xiao, L. Y. & Kan, W-M., 2017 Jan 1, In : European Journal of Pharmacology. 794, p. 201-208 8 p.

Research output: Contribution to journalArticle

Drug Resistance
Cyclic AMP
DNA
K562 Cells
Cyclic AMP-Dependent Protein Kinases
2 Citations (Scopus)

Differential Ca2+ mobilization and mast cell degranulation by FcεRI- and GPCR-mediated signaling

Chen, Y. C., Chang, Y. C., Chang, H. A., Lin, Y. S., Tsao, C. W., Shen, M-R. & Chiu, W-T., 2017 Nov 1, In : Cell Calcium. 67, p. 31-39 9 p.

Research output: Contribution to journalArticle

Cell Degranulation
Mast Cells
Histamine
Histamine Release
G-Protein-Coupled Receptors
13 Citations (Scopus)

Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis

Tzeng, H. T., Tsai, C. H., Yen, Y-T., Cheng, H-C., Chen, Y. C., Pu, S. W., Wang, Y. S., Shan, Y-S., Tseng, Y-L., Su, W-C., Lai, W-W., Wu, L-W. & Wang, Y-C., 2017 May 1, In : Clinical Cancer Research. 23, 9, p. 2335-2345 11 p.

Research output: Contribution to journalArticle

Thrombospondin 1
Endothelial Cells
Neoplasm Metastasis
Tumor Microenvironment
Exocytosis
13 Citations (Scopus)

Epidermal growth factor-induced ANGPTL4 enhances anoikis resistance and tumour metastasis in head and neck squamous cell carcinoma

Liao, Y. H., Chiang, K. H., Shieh, J. M., Huang, C. R., Shen, C. J., Huang, W. C. & Chen, B-K., 2017 Apr 20, In : Oncogene. 36, 16, p. 2228-2242 15 p.

Research output: Contribution to journalArticle

Anoikis
Epidermal Growth Factor
Neoplasm Metastasis
Matrix Metalloproteinase 1
Neoplasms
1 Citation (Scopus)

Epidermal growth factor–induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin

Hsu, J. Y., Chang, J-Y., Chang, K. Y., Chang, W. C. & Chen, B-K., 2017 Oct 1, In : FASEB Journal. 31, 10, p. 4265-4276 12 p.

Research output: Contribution to journalArticle

Fibronectins
Matrix Metalloproteinases
Up-Regulation
Neoplasm Metastasis
Epidermal Growth Factor
3 Citations (Scopus)

HDAC2 and HDAC5 up-regulations modulate survivin and miR-125a-5p expressions and promote hormone therapy resistance in estrogen receptor positive breast cancer cells

Huang, W. T., Tsai, Y. H., Chen, S. H., Kuo, C. W., Kuo, Y-L., Lee, K-T., Chen, W. C., Wu, P. C., Chuang, C. Y., Cheng, S. M., Lin, C. H., Leung, E. Y., Chang, Y. C. & Cheung, C-H., 2017 Dec 13, In : Frontiers in Pharmacology. 8, DEC, 902.

Research output: Contribution to journalArticle

Estrogen Receptors
Up-Regulation
Hormones
Breast Neoplasms
Tamoxifen
4 Citations (Scopus)

Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer

Kuo, Y. Z., Fang, W. Y., Huang, C-C., Tsai, S-T., Wang, Y-C., Yang, C. L. & Wu, L-W., 2017 Jan 1, In : Oncotarget. 8, 9, p. 15563-15583 21 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Tumor Necrosis Factor-alpha
Hyaluronic Acid
Chemokine CCL2
hyaluronan synthase
5 Citations (Scopus)

Minoxidil is a potential neuroprotective drug for paclitaxel-induced peripheral neuropathy

Chen, Y. F., Chen, L. H., Yeh, Y-M., Wu, P-Y., Chen, Y. F., Chang, L. Y., Chang, J-Y. & Shen, M-R., 2017 Mar 28, In : Scientific reports. 7, 45366.

Research output: Contribution to journalArticle

Minoxidil
Neuroprotective Agents
Peripheral Nervous System Diseases
Paclitaxel
Hair
55 Citations (Scopus)

Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression

Jen, J., Tang, Y. A., Lu, Y. H., Lin, C. C., Lai, W-W. & Wang, Y-C., 2017 Jan 1, In : Molecular cancer. 16, 1, 104.

Research output: Contribution to journalArticle

Long Noncoding RNA
Lung Neoplasms
Neoplasm Metastasis
Cell Movement
Chromatin Immunoprecipitation
7 Citations (Scopus)

Oleate-induced PTX3 promotes head and neck squamous cell carcinoma metastasis through the up-regulation of vimentin

Chan, S-H., Tsai, J. P., Shen, C. J., Liao, Y. H. & Chen, B-K., 2017 Jan 1, In : Oncotarget. 8, 25, p. 41364-41378 15 p.

Research output: Contribution to journalArticle

Vimentin
Oleic Acid
Up-Regulation
Neoplasm Metastasis
Neoplasms
9 Citations (Scopus)

Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin

Shen, C. J., Chan, S-H., Lee, C-T., Huang, W. C., Tsai, J. P. & Chen, B-K., 2017 Feb 1, In : Cancer Letters. 386, p. 110-122 13 p.

Research output: Contribution to journalArticle

Anoikis
Oleic Acid
Fibronectins
Up-Regulation
Neoplasm Metastasis
6 Citations (Scopus)

Oncogenic MCT-1 activation promotes YY1-EGFR-MnSOD signaling and tumor progression

Tseng, H., Chen, Y., Jen, J., Shen, P., Chen, L., Lin, T., Wang, Y-C. & Hsu, H., 2017 Apr 1, In : Oncogenesis. 6, 4, p. e313-e313

Research output: Contribution to journalArticle

2 Citations (Scopus)

p53 modulates the effect of ribosomal protein S6 kinase1 (S6K1) on cisplatin toxicity in chronic myeloid leukemia cells

Xiao, L. Y. & Kan, W-M., 2017 May 1, In : Pharmacological Research. 119, p. 443-462 20 p.

Research output: Contribution to journalArticle

Ribosomal Protein S6
Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cisplatin
S 6