Research Output

2020

Anti-apoptotic proteins in the autophagic world: An update on functions of XIAP, Survivin, and BRUCE

Cheung, C. H. A., Chang, Y. C., Lin, T. Y., Cheng, S. M. & Leung, E., 2020 Feb 5, In : Journal of biomedical science. 27, 1, 31.

Research output: Contribution to journalReview article

Open Access
Open Access

Epidermal growth factor-induced COX-2 regulates metastasis of head and neck squamous cell carcinoma through upregulation of angiopoietin-like 4

Chiang, K. H., Shieh, J. M., Shen, C. J., Chang, T. W., Wu, P. T., Hsu, J. Y., Tsai, J. P., Chang, W. C. & Chen, B. K., 2020 Jan 1, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Open Access

Relative D3 vitamin deficiency and consequent cognitive impairment in an animal model of Alzheimer's disease: Potential involvement of collapsin response mediator protein-2

Lin, F. Y., Lin, Y. F., Lin, Y. S., Yang, C. M., Wang, C. C. & Hsiao, Y. H., 2020 Mar 1, In : Neuropharmacology. 164, 107910.

Research output: Contribution to journalArticle

1 Citation (Scopus)

ST2 Signaling in the Tumor Microenvironment

Chang, C. P., Hu, M. H., Hsiao, Y. P. & Wang, Y. C., 2020 Jan 1, Advances in Experimental Medicine and Biology. Springer, p. 83-93 11 p. (Advances in Experimental Medicine and Biology; vol. 1240).

Research output: Chapter in Book/Report/Conference proceedingChapter

TIAM2S as a novel regulator for serotonin level enhances brain plasticity and locomotion behavior

Chu, C. H., Chen, J. S., Chuang, P. C., Su, C. H., Chan, Y. L., Yang, Y. J., Chiang, Y. T., Su, Y. Y., Gean, P. W. & Sun, H. S., 2020 Feb 1, In : FASEB Journal. 34, 2, p. 3267-3288 22 p.

Research output: Contribution to journalArticle

Open Access
2019

Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity

Chen, Y. R., Li, Y. H., Hsieh, T. C., Wang, C. M., Cheng, K. C., Wang, L., Lin, T. Y., Cheung, C. H. A., Wu, C. L. & Chiang, H. C., 2019 Aug, In : Aging Cell. 18, 4, e12989.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression

Liao, S. Y., Kuo, I. Y., Chen, Y. T., Liao, P. C., Liu, Y. F., Wu, H. Y., Lai, W. W. & Wang, Y. C., 2019 Oct 10, In : Oncogene. 38, 41, p. 6723-6736 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Association of gout and colorectal cancer in Taiwan: A nationwide population-based cohort study

Chuang, J. P., Lee, J. C., Leu, T. H., Hidajah, A. C., Chang, Y. H. & Li, C. Y., 2019 Oct 1, In : BMJ open. 9, 10, e028892.

Research output: Contribution to journalArticle

Open Access
Open Access

BIRC5/Survivin is a novel ATG12–ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells

Lin, T. Y., Chan, H. H., Chen, S. H., Sarvagalla, S., Chen, P. S., Coumar, M. S., Cheng, S. M., Chang, Y. C., Lin, C. H., Leung, E. & Cheung, C. H. A., 2019 Jan 1, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalReview article

Open Access
3 Citations (Scopus)

Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli

Tsai, S. L., Chang, Y. C., Sarvagalla, S., Wang, S., Coumar, M. S. & Cheung, C. H. A., 2019 Aug, In : Protein Expression and Purification. 160, p. 73-83 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1 Citation (Scopus)
Open Access

Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila

Shyu, W. H., Lee, W. P., Chiang, M. H., Chang, C. C., Fu, T. F., Chiang, H. C., Wu, T. & Wu, C. L., 2019 Jan 1, In : PLoS genetics. 15, 5, e1008153.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Functional effects of let-7g expression in colon cancer metastasis

Chang, C. M., Wong, H. S. C., Huang, C. Y., Hsu, W. L., Maio, Z. F., Chiu, S. J., Tsai, Y. T., Chen, B. K., Wan, Y. J. Y., Wang, J. Y. & Chang, W. C., 2019 Apr, In : Cancers. 11, 4, 489.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
5 Citations (Scopus)

High-CLDN4 ESCC cells harbor stem-like properties and indicate for poor concurrent chemoradiation therapy response in esophageal squamous cell carcinoma

Lin, C. H., Li, H. Y., Liu, Y. P., Kuo, P. F., Wang, W. C., Lin, F. C., Chang, W. L., Sheu, B. S., Wang, Y. C., Hung, W. C., Cheng, H. C., Yao, Y. C., Calkins, M. J., Hsiao, M. & Lu, P. J., 2019 Jan 1, In : Therapeutic Advances in Medical Oncology. 11

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P

Tan, B. S., Yang, M. C., Singh, S., Chou, Y. C., Chen, H. Y., Wang, M. Y., Wang, Y. C. & Chen, R. H., 2019 Jul 11, In : Oncogene. 38, 28, p. 5612-5626 15 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry

Lin, H. H., Chen, S. J., Shen, M. R., Huang, Y. T., Hsieh, H. P., Lin, S. Y., Lin, C. C., Chang, W. S. W. & Chang, J. Y., 2019 Dec, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 12, 118517.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Mutation of the PTCH1 gene predicts recurrence of breast cancer

Wang, C. Y., Chang, Y. C., Kuo, Y. L., Lee, K. T., Chen, P. S., Cheung, C. H. A., Chang, C. P., Phan, N. N., Shen, M. R. & Hsu, H. P., 2019 Nov 8, In : Scientific reports. 9, 1, 1 p., 16359.

Research output: Contribution to journalArticle

Open Access

Myostatin Is Associated With Cognitive Decline in an Animal Model of Alzheimer’s Disease

Lin, Y. S., Lin, F. Y. & Hsiao, Y. H., 2019 Mar 1, In : Molecular Neurobiology. 56, 3, p. 1984-1991 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Protein Glycation by Glyoxal Promotes Amyloid Formation by Islet Amyloid Polypeptide

Hsu, Y. H., Chen, Y. W., Wu, M. H. & Tu, L. H., 2019 Jun 18, In : Biophysical Journal. 116, 12, p. 2304-2313 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
Open Access
2 Citations (Scopus)

Store-Operated Ca2+ entry in tumor progression: From molecular mechanisms to clinical implications

Chen, Y. F., Lin, P. C., Yeh, Y. M., Chen, L. H. & Shen, M. R., 2019 Jul, In : Cancers. 11, 7, 899.

Research output: Contribution to journalReview article

Open Access
7 Citations (Scopus)

The distinct role of STIM1 and STIM2 in the regulation of store-operated Ca2+ entry and cellular function

Chen, Y. F., Chen, L. H. & Shen, M. R., 2019 Jun, In : Journal of Cellular Physiology. 234, 6, p. 8727-8739 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
Open Access
3 Citations (Scopus)
2018

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W., Chang, H., Lin, Y., Lin, Y., Chang, H., Lin, H., Huang, S., Tang, M. & Shen, M., 2018 Dec 1, In : Cell Death Discovery. 4, 1

Research output: Contribution to journalArticle

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W. T., Chang, H. A., Lin, Y. H., Lin, Y. S., Chang, H. T., Lin, H. H., Huang, S. C., Tang, M. J. & Shen, M. R., 2018 Dec 1, In : Cell Death Discovery. 4, 1, 37.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)
2 Citations (Scopus)

Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies

Ji, X. R., Cheng, K. C., Chen, Y. R., Lin, T. Y., Cheung, C. H. A., Wu, C. L. & Chiang, H. C., 2018 Mar, In : FASEB Journal. 32, 3, p. 1375-1387 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Functional engineered mesenchymal stem cells with fibronectin-gold composite coated catheters for vascular tissue regeneration

Chen, Y., Hsieh, S., Yang, Y., Hsu, S., Kung, M., Lin, P., Hsieh, H., Lin, C., Tang, C. & Hung, H., 2018 Apr 1, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 3, p. 699-711

Research output: Contribution to journalArticle

3 Citations (Scopus)

High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice

Tsai, S. F., Wu, H. T., Chen, P. C., Chen, Y. W., Yu, M., Wang, T. F., Wu, S. Y., Tzeng, S. F. & Kuo, Y. M., 2018 Dec 1, In : Brain Research. 1700, p. 66-77 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice.

Tsai, SF., Wu, HT., Chen, PC. & Chen, Y-W., 2018 Jul 13, In : Brain Research. 18, p. 30401 3 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Integrative genomic analysis for the functional roles of ITPKC in bone mineral density

Lu, H. F., Wong, H. S. C., Chen, B. K., Liao, H. T., Hsu, Y. W., Ikegawa, S., Cho, E. C., Hung, K. S. & Chang, W. C., 2018 Nov 30, In : Bioscience Reports. 38, 6, BSR20181481.

Research output: Contribution to journalArticle

Mechanism underlying NMDA blockade-induced inhibition of aggression in post-weaning socially isolated mice

Chang, C. H., Su, C. L. & Gean, P. W., 2018 Dec, In : Neuropharmacology. 143, p. 95-105 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Medical Applications of Collagen and Hyaluronan in Regenerative Medicine

Huang, L. L. H., Chen, Y. H. A., Zhuo, Z. Y., Hsieh, Y. T., Yang, C. L., Chen, W. T., Lin, J. Y., Lin, Y. X., Jiang, J. T., Zhuang, C. H., Wang, Y. C., Nguyendac, H., Lin, K. W. & Liu, W. L., 2018 Jan 1, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 285-306 22 p. (Advances in Experimental Medicine and Biology; vol. 1077).

Research output: Chapter in Book/Report/Conference proceedingChapter

Mushroom body glycolysis is required for olfactory memory in Drosophila

Wu, C. L., Chang, C. C., Wu, J. K., Chiang, M. H., Yang, C. H. & Chiang, H. C., 2018 Apr, In : Neurobiology of Learning and Memory. 150, p. 13-19 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
3 Citations (Scopus)

Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype

Tzeng, H. T., Su, C. C., Chang, C. P., Lai, W. W., Su, W. C. & Wang, Y-C., 2018 Oct 1, In : International Journal of Cancer. 143, 7, p. 1753-1763 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
4 Citations (Scopus)

VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function

Wang, Y., Tzeng, H., Tsai, C., Cheng, H., Lai, W., Liu, H. & Wang, Y., 2018 Nov 1, In : Cancer Letters. 437, p. 79-88

Research output: Contribution to journalArticle

2 Citations (Scopus)

Visualization of Membrane Pore in Live Cells Reveals a Dynamic-Pore Theory Governing Fusion and Endocytosis

Shin, W., Ge, L., Arpino, G., Villarreal, S. A., Hamid, E., Liu, H., Zhao, W. D., Wen, P. J., Chiang, H. C. & Wu, L. G., 2018 May 3, In : Cell. 173, 4, p. 934-945.e12

Research output: Contribution to journalArticle

44 Citations (Scopus)

XBP1 and PERK Have Distinct Roles in Aβ-Induced Pathology

Cheng, K. C. & Chiang, H. C., 2018 Sep 1, In : Molecular Neurobiology. 55, 9, p. 7523-7532 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., 2017 May 15, In : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Wu, Y. H., Hong, C. W., Wang, Y. C., Huang, W. J., Yeh, Y. L., Wang, B. J., Wang, Y. J. & Chiu, H. W., 2017 Aug 1, In : Cancer Letters. 400, p. 79-88 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)