Research Output

2002

Loss of heterozygosity at loci of candidate tumor suppressor genes in microdissected primary non-small cell lung cancer

Ho, W. L., Chang, J. W., Tseng, R. C., Chen, J. T., Chen, C. Y., Jou, Y. S. & Wang, Y. C., 2002 Dec 1, In : Cancer Detection and Prevention. 26, 5, p. 343-349 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Myosin light chain kinase modulates hypotonicity-induced Ca2+ entry and Cl- channel activity in human cervical cancer cells

Shen, M-R., Furla, P., Chou, C-Y. & Ellory, C. J., 2002 May 22, In : Pflugers Archiv European Journal of Physiology. 444, 1-2, p. 276-285 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
18 Citations (Scopus)

The molecular mechanisms for the antitumorigenic effect of curcumin

Leu, T-H. & Maa, M. C., 2002 Jun 27, In : Current Medicinal Chemistry - Anti-Cancer Agents. 2, 3, p. 357-370 14 p.

Research output: Contribution to journalReview article

145 Citations (Scopus)

Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397

Leu, T. H. & Maa, M. C., 2002 Jan 1, In : Oncogene. 21, 46, p. 6992-7000 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2003

Damage formation and repair efficiency in the p53 gene of cell lines and blood lymphocytes assayed by multiplex long quantitative polymerase chain reaction

Wang, Y. C., Lee, P. J., Shih, C. M., Chen, H. Y., Lee, C. C., Chang, Y. Y., Hsu, Y. T., Liang, Y. J., Wang, L. Y., Han, W. H. & Wang, Y. C., 2003 Aug 15, In : Analytical Biochemistry. 319, 2, p. 206-215 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity

Leu, T. H., Su, S. L., Chuang, Y. C. & Maa, M. C., 2003 Dec 15, In : Biochemical Pharmacology. 66, 12, p. 2323-2331 9 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein β and δ in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages

Liu, Y. W., Tseng, H. P., Chen, L. C., Chen, B. K. & Chang, W. C., 2003 Jul 15, In : Journal of Immunology. 171, 2, p. 821-828 8 p.

Research output: Contribution to journalArticle

Open Access
90 Citations (Scopus)

Functional implication of the interaction between egf receptor and C-SRC

Leu, T-H. & Maa, M. C., 2003, In : Frontiers in Bioscience. 8, SUPPL.

Research output: Contribution to journalReview article

60 Citations (Scopus)

Identification of calcineurin as a key signal in the extinction of fear memory

Lin, C. H., Yeh, S. H., Leu, T. H., Chang, W. C., Wang, S. T. & Gean, P. W., 2003 Mar 1, In : Journal of Neuroscience. 23, 5, p. 1574-1579 6 p.

Research output: Contribution to journalArticle

Open Access
136 Citations (Scopus)

Identifying the factors and signal pathways necessary for anchorage-independent growth of Ha-ras oncogene-transformed NIH/3T3 cells

Chang, T. Y., Tsai, W. J., Chou, C. K., Chow, N. H., Leu, T. H. & Liu, H. S., 2003 Jul 25, In : Life Sciences. 73, 10, p. 1265-1274 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples

Wang, Y. C., Lu, Y. P., Tseng, R. C., Lin, R. K., Chang, J. W., Chen, J. T., Shih, C. M. & Chen, C. Y., 2003 Mar, In : Journal of Clinical Investigation. 111, 6, p. 887-895 9 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)

Involvement of a calcineurin cascade in amygdala depotentiation and quenching of fear memory

Lin, C. H., Lee, C. C. & Gean, P-W., 2003 Jan 1, In : Molecular Pharmacology. 63, 1, p. 44-52 9 p.

Research output: Contribution to journalArticle

125 Citations (Scopus)

KCl cotransport is an important modulator of human cervical cancer growth and invasion

Shen, M. R., Chou, C. Y., Hsu, K. F., Hsu, Y. M., Chiu, W. T., Tang, M. J., Alper, S. L. & Ellory, J. C., 2003 Oct 10, In : Journal of Biological Chemistry. 278, 41, p. 39941-39950 10 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Mediation of Amphetamine-Induced Long-Term Depression of Synaptic Transmission by CB1 Cannabinoid Receptors in the Rat Amygdala

Huang, Y. C., Wang, S. J., Chiou, L. C. & Gean, P. W., 2003 Nov 12, In : Journal of Neuroscience. 23, 32, p. 10311-10320 10 p.

Research output: Contribution to journalArticle

Open Access
59 Citations (Scopus)

Molecular and functional identification of the Na + /H + exchange isoforms NHE1 and NHE3 in isolated bovine articular chondrocytes

Tattersall, A. L., Meredith, D., Furla, P., Shen, M-R., Ellory, J. C. & Wilkins, R. J., 2003 Jan 1, In : Cellular Physiology and Biochemistry. 13, 4, p. 215-222 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Selective N-debenzylation of amides with p-TsOH

Chern, C. Y., Huang, Y. P. & Kan, W. M., 2003 Jan 27, In : Tetrahedron Letters. 44, 5, p. 1039-1041 3 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
17 Citations (Scopus)

Synthesis of 4-Aza-3-oxo-androstane-17β-carboxylic Acid, a Key Intermediate for the Preparation of Potent 5α-Reductase Inhibitors

Kan, W-M., Yek, Y. L., Wang, Y. H. & Chern, C. Y., 2003 Jun 1, In : Chinese Pharmaceutical Journal. 55, 3, p. 213-219 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory

Lin, C. H., Yeh, S. H., Lu, H. Y. & Gean, P. W., 2003 Sep 10, In : Journal of Neuroscience. 23, 23, p. 8310-8317 8 p.

Research output: Contribution to journalArticle

Open Access
208 Citations (Scopus)
2004

5′CpG island hypermethylation and aberrant transcript splicing both contribute to the inactivation of the FHIT gene in resected non-small cell lung cancer

Tzao, C., Tsai, H. Y., Chen, J. T., Chen, C. Y. & Wang, Y. C., 2004 Sep, In : European Journal of Cancer. 40, 14, p. 2175-2183 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

5′cytosine-Phospho-Guanine island methylation is responsible for p14ARF inactivation and inversely correlates with p53 overexpression in resected non-small cell lung cancer

Hsu, H. S., Wang, Y. C., Tseng, R. C., Chang, J. W., Chen, J. T., Shih, C. M., Chen, C. Y. & Wang, Y. C., 2004 Jul 15, In : Clinical Cancer Research. 10, 14, p. 4734-4741 8 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Acetylation of nuclear factor-κB in rat amygdala improves long-term but not short-term retention of fear memory

Yeh, S. H., Lin, C. H. & Gean, P. W., 2004 May 1, In : Molecular Pharmacology. 65, 5, p. 1286-1292 7 p.

Research output: Contribution to journalArticle

175 Citations (Scopus)
41 Citations (Scopus)

Genetic testing in spinocerebellar ataxia in Taiwan: Expansions of trinucleotide repeats in SCA8 and SCA17 are associated with typical Parkinson's disease

Wu, Y. R., Lin, H. Y., Chen, C. M., Gwinn-Hardy, K., Ro, L. S., Wang, Y. C., Li, S. H., Hwang, J. C., Fang, K., Hsieh-Li, H. M., Li, M. L., Tung, L. C., Su, M. T., Lu, K. T. & Lee-Chen, G. J., 2004 Mar 1, In : Clinical Genetics. 65, 3, p. 209-214 6 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells

Shen, M. R., Lin, A. C., Hsu, Y. M., Chang, T. J., Tang, M. J., Alper, S. L., Ellory, J. C. & Chou, C. Y., 2004 Sep 17, In : Journal of Biological Chemistry. 279, 38, p. 40017-40025 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

One-pot synthesis of ene-lactams via N-debenzylation of keto-containing N-2,4-dimethoxylbenzylamides

Kan, W. M., Cheng, C. L. & Chern, C. Y., 2004 Dec 30, In : Synthetic Communications. 34, 23, p. 4257-4264 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Participation of p97Eps8 in Src-mediated Transformation

Leu, T. H., Yeh, H. H., Huang, C. C., Chuang, Y. C., Su, S. L. & Maa, M. C., 2004 Mar 12, In : Journal of Biological Chemistry. 279, 11, p. 9875-9881 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Synergistic effects of dopamine and Zn 2+ on the induction of PC12 cell death and dopamine depletion in the striatum: Possible implication in the pathogenesis of Parkinson's disease

Lo, H. S., Chinag, H., Lin, A. M. Y., Chiang, H. Y., Chu, Y. C. & Kao, L. S., 2004 Oct 1, In : Neurobiology of Disease. 17, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

The effect of mefloquine and volume-regulated anion channel inhibitors on induced transport in Plasmodium falciparum-infected human red blood cells

Staines, H. M., Dee, B. C., Shen, M. R. & Ellory, J. C., 2004 May 1, In : Blood Cells, Molecules, and Diseases. 32, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The involvement of PTEN in sleep deprivation-induced memory impairment in rats

Su, C. L., Chen, C. H., Lu, H. Y. & Gean, P-W., 2004 Nov 1, In : Molecular Pharmacology. 66, 5, p. 1340-1348 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Three-dimensional power Doppler imaging of early-stage cervical cancer

Hsu, K. F., Su, J. M., Huang, S. C., Cheng, Y. M., Kang, C. Y., Shen, M. R., Chang, F. M. & Chou, C. Y., 2004 Nov 1, In : Ultrasound in Obstetrics and Gynecology. 24, 6, p. 664-671 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2005

Activating protein 1-mediated cyclooxygenase-2 expression is independent of N-terminal phosphorylation of c-Jun

Chen, L. C., Chen, B-K. & Chang, W. C., 2005 Jun 1, In : Molecular Pharmacology. 67, 6, p. 2057-2069 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Activation of group II metabotropic glutamate receptors induces depotentiation in amygdala slices and reduces fear-potentiated startle in rats

Lin, C. H., Lee, C. C., Huang, Y. C., Wang, S. J. & Gean, P. W., 2005 Mar 1, In : Learning and Memory. 12, 2, p. 130-137 8 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

A rapid, nongenomic pathway facilitates the synaptic transmission induced by retinoic acid at the developing synapse

Liou, J. C., Ho, S. Y., Shen, M. R., Liao, Y. P., Chiu, W. T. & Kang, K. H., 2005 Oct 15, In : Journal of Cell Science. 118, 20, p. 4721-4730 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions

Laird, F. M., Cai, H., Savonenko, A. V., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H. C., Xu, G., Koliatsos, V. E., Borchelt, D. R., Price, D. L., Lee, H. K. & Wong, P. C., 2005 Dec 14, In : Journal of Neuroscience. 25, 50, p. 11693-11709 17 p.

Research output: Contribution to journalArticle

400 Citations (Scopus)

Butyrate regulates the expression of c-Src and focal adhesion kinase and inhibits cell invasion of human colon cancer cells

Lee, J. C., Maa, M. C., Yu, H. S., Wang, J. H., Yen, C. K., Wang, S. T., Chen, Y. J., Liu, Y., Jin, Y. T. & Leu, T. H., 2005 Aug 1, In : Molecular Carcinogenesis. 43, 4, p. 207-214 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Design and synthesis of 3-aryl-5-alicylic-[1,2,4]-oxadiazoles as novel platelet aggregation inhibitors

Chern, C. Y., Chen, S. J. & Kan, W. M., 2005 Jan 1, In : Journal of the Chinese Chemical Society. 52, 2, p. 331-338 8 p.

Research output: Contribution to journalArticle

Efficient synthesis of 2-(N-Substituted)-2-imidazolines and 2-(N-Substituted)-1,4,5, 6-tetrahydropyrimidines

Kan, W. M., Lin, S. H. & Chern, C. Y., 2005 Nov 10, In : Synthetic Communications. 35, 20, p. 2633-2639 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer

Tseng, R. C., Chang, J. W., Hsien, F. J., Chang, Y. H., Hsiao, C. F., Chen, J. T., Chen, C. Y., Jou, Y. S. & Wang, Y. C., 2005 Nov 1, In : International Journal of Cancer. 117, 2, p. 241-247 7 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

Cai, H., Lin, X., Xie, C., Laird, F. M., Lai, C., Wen, H., Chiang, H. C., Shim, H., Farah, M. H., Hoke, A., Price, D. L. & Wong, P. C., 2005 Aug 17, In : Journal of Neuroscience. 25, 33, p. 7567-7574 8 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Promoter hypermethylation is the predominant mechanism in hMLH1 and hMSH2 deregulation and is a poor prognostic factor in nonsmoking lung cancer

Hsu, H. S., Wen, C. K., Tang, Y. A., Lin, R. K., Li, W. Y., Hsu, W. H. & Wang, Y. C., 2005 Aug 1, In : Clinical Cancer Research. 11, 15, p. 5410-5416 7 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma

Tzao, C., Hsu, H. S., Sun, G. H., Lai, H. L., Wang, Y. C., Tung, H. J., Yu, C. P., Cheng, Y. L. & Lee, S. C., 2005 Nov, In : Journal of Thoracic and Cardiovascular Surgery. 130, 5, p. 1371.e1-1371.e8

Research output: Contribution to journalArticle

34 Citations (Scopus)

Transcription factor Sp1 functions as an anchor protein in gene transcription of human 12(S)-lipoxygenase

Chang, W. C. & Chen, B. K., 2005 Dec 9, In : Biochemical and Biophysical Research Communications. 338, 1, p. 117-121 5 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)

Wild-type p53 overexpression and its correlation with MDM2 and p14ARF alterations: An alternative pathway to non-small-cell lung cancer

Wang, Y. C., Lin, R. K., Tan, Y. H., Chen, J. T., Chen, C. Y. & Wang, Y. C., 2005 Jan 1, In : Journal of Clinical Oncology. 23, 1, p. 154-164 11 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3

Lu, T. J., Huang, C. Y. F., Yuan, C. J., Lee, Y. C., Leu, T. H., Chang, W. C., Lu, T. L., Jeng, W. Y. & Lai, M. D., 2005 Jun 1, In : Journal of Inorganic Biochemistry. 99, 6, p. 1306-1313 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2006
78 Citations (Scopus)

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

Lai, C., Xie, C., McCormack, S. G., Chiang, H. C., Michalak, M. K., Lin, X., Chandran, J., Shim, H., Shimoji, M., Cookson, M. R., Huganir, R. L., Rothstein, J. D., Price, D. L., Wong, P. C., Martin, L. J., Zhu, J. J. & Cai, H., 2006 Nov 8, In : Journal of Neuroscience. 26, 45, p. 11798-11806 9 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Direct interaction of C/EBPδ and Sp1 at the GC-enriched promoter region synergizes the IL-10 gene transcription in mouse macrophage

Chiang, B. T., Liu, Y. W., Chen, B. K., Wang, J. M. & Chang, W. C., 2006 Sep, In : Journal of biomedical science. 13, 5, p. 621-635 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle

Lin, H. C., Mao, S. C. & Gean, P. W., 2006 May 1, In : Learning and Memory. 13, 3, p. 316-321 6 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)