Research Output

2008
201 Citations (Scopus)

Eps8 decreases chemosensitivity and affects survival of cervical cancer patients

Chen, Y. J., Shen, M. R., Chen, Y. J., Maa, M. C. & Leu, T. H., 2008 Oct 15, In : Molecular Cancer Therapeutics. 7, 6, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
50 Citations (Scopus)

Hypoxia-inducible factor-1α protects cultured cortical neurons from lipopolysaccharide-induced cell death via regulation of NR1 expression

Yeh, S. H., Hung, J. J., Gean, P. W. & Chang, W., 2008 Dec 24, In : Journal of Neuroscience. 28, 52, p. 14259-14270 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Low substratum rigidity of collagen gel promotes ERK phosphorylation via lipid raft to augment cell migration

Wei, W. C., Hsu, Y. C., Chiu, W. T., Wang, C. Z., Wu, C. M., Wang, Y. K., Shen, M. R. & Tang, M. J., 2008 Mar 1, In : Journal of Cellular Biochemistry. 103, 4, p. 1111-1124 14 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Maternal diabetes modulates renal morphogenesis in offspring

Tran, S., Chen, Y. W., Chenier, I., Chan, J. S. D., Quaggin, S., Hébert, M. J., Ingelfinger, J. R. & Zhang, S. L., 2008 May 1, In : Journal of the American Society of Nephrology. 19, 5, p. 943-952 10 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Mechanosensing machinery for cells under low substratum rigidity

Wei, W. C., Lin, H. H., Shen, M. R. & Tang, M. J., 2008 Dec 1, In : American Journal of Physiology - Cell Physiology. 295, 6, p. C1579-C1589

Research output: Contribution to journalArticle

47 Citations (Scopus)
21 Citations (Scopus)
16 Citations (Scopus)

Novel 2-step synthetic indole compound 1,1,3-tri(3-indolyl)cyclohexane inhibits cancer cell growth in lung cancer cells and xenograft models

Lee, C. H., Yao, C. F., Huang, S. M., Ko, S., Tan, Y. H., Lee-Chen, G. J. & Wang, Y. C., 2008 Aug 15, In : Cancer. 113, 4, p. 815-825 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Nucleolin regulates c-Jun/Sp1-dependent transcriptional activation of cPLA2α in phorbol ester-treated non-small cell lung cancer A549 cells

Tsou, J. H., Chang, K. Y., Wang, W. C., Tseng, J. T., Su, W. C., Hung, L. Y., Chang, W. C. & Chen, B. K., 2008 Jan 1, In : Nucleic acids research. 36, 1, p. 217-227 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
64 Citations (Scopus)

Paxillin is a target for somatic mutations in lung cancer: Implications for cell growth and invasion

Jagadeeswaran, R., Surawska, H., Krishnaswamy, S., Janamanchi, V., Mackinnon, A. C., Seiwert, T. Y., Loganathan, S., Kanteti, R., Reichman, T., Nallasura, V., Schwartz, S., Faoro, L., Wang, Y. C., Girard, L., Tretiakova, M. S., Ahmed, S., Zumba, O., Soulii, L., Bindokas, V. P., Szeto, L. L. & 13 others, Gordon, G. J., Bueno, R., Sugarbaker, D., Lingen, M. W., Sattler, M., Krausz, T., Vigneswaran, W., Natarajan, V., Minna, J., Vokes, E. E., Ferguson, M. K., Husain, A. N. & Salgia, R., 2008 Jan 1, In : Cancer Research. 68, 1, p. 132-142 11 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

Reduced membranous β-catenin protein expression is associated with metastasis and poor prognosis in squamous cell carcinoma of the esophagus

Hsu, P. K., Li, A. F. Y., Wang, Y. C., Hsieh, C. C., Huang, M. H., Hsu, W. H. & Hsu, H. S., 2008 May 1, In : Journal of Thoracic and Cardiovascular Surgery. 135, 5, p. 1029-1035 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Requirement of inducible nitric-oxide synthase in lipopolysaccharide- mediated Src induction and macrophage migration

Maa, M. C., Miao, Y. C., Chen, Y. J., Lin, C. H., Chih, J. Y., Yi, L. Y., Li, J., Chen, P. R., Tang, C. H., Lei, H. Y. & Leu, T-H., 2008 Nov 14, In : Journal of Biological Chemistry. 283, 46, p. 31408-31416 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
30 Citations (Scopus)

Sumoylation of Specificity Protein 1 Augments Its Degradation by Changing the Localization and Increasing the Specificity Protein 1 Proteolytic Process

Wang, Y. T., Chuang, J. Y., Shen, M. R., Yang, W. B., Chang, W. C. & Hung, J. J., 2008 Jul 25, In : Journal of Molecular Biology. 380, 5, p. 869-885 17 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Synthesis of 2-[4-(imidazolin-2-ylideneamino)benzyl]-Indan-1-ones as novel potent prostacyclin antagonists

Chern, C. Y., Yek, Y. L., Chen, Y. L. & Kan, W. M., 2008 Jan 1, In : Journal of the Chinese Chemical Society. 55, 4, p. 846-853 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2009

A 3D-QSAR study of celebrex-based PDK1 inhibitors using CoMFA method

Wang, W. H., Jena, N. R., Wang, Y. C. & Sun, Y. C., 2009 Jan 1, In : Journal of the Chinese Chemical Society. 56, 1, p. 59-64 6 p.

Research output: Contribution to journalArticle

Advances in Aurora kinase inhibitor patents

Coumar, M. S., Cheung, C-H., Chang, J-Y. & Hsieh, H. P., 2009 Mar 1, In : Expert Opinion on Therapeutic Patents. 19, 3, p. 321-356 36 p.

Research output: Contribution to journalReview article

22 Citations (Scopus)

Augmentation of fear extinction by infusion of glycine transporter blockers into the amygdala

Mao, S. C., Lin, H. C. & Gean, P. W., 2009 Aug, In : Molecular Pharmacology. 76, 2, p. 369-378 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Aurora kinase inhibitors in preclinical and clinical testing

Cheung, C. H. A., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 Apr 1, In : Expert Opinion on Investigational Drugs. 18, 4, p. 379-398 20 p.

Research output: Contribution to journalReview article

83 Citations (Scopus)

Block of γ-Aminobutyric Acid-A Receptor Insertion in the Amygdala Impairs Extinction of Conditioned Fear

Lin, H. C., Mao, S. C. & Gean, P. W., 2009 Oct 1, In : Biological Psychiatry. 66, 7, p. 665-673 9 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients

Tseng, R. C., Lee, C. C., Hsu, H. S., Tzao, C. & Wang, Y. C., 2009 Aug, In : Neoplasia. 11, 8, p. 763-770 8 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Distinctive roles of different β-amyloid 42 aggregates in modulation of synaptic functions

Chiang, H. C., Iijima, K., Hakker, I. & Zhong, Y., 2009 Jun 1, In : FASEB Journal. 23, 6, p. 1969-1977 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
21 Citations (Scopus)

Ethnic differences and functional analysis of MET mutations in lung cancer

Krishnaswamy, S., Kanteti, R., Duke-Cohan, J. S., Loganathan, S., Liu, W., Ma, P. C., Sattler, M., Singleton, P. A., Ramnath, N., Innocenti, F., Nicolae, D. L., Ouyang, Z., Liang, J., Minna, J., Kozloff, M. F., Ferguson, M. K., Natarajan, V., Wang, Y. C., Garcia, J. G. N., Vokes, E. E. & 1 others, Salgia, R., 2009 Sep 15, In : Clinical Cancer Research. 15, 18, p. 5714-5723 10 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)

Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer

Wu, C. Y., Tseng, R. C., Hsu, H. S., Wang, Y. C. & Hsu, M. T., 2009 Mar 1, In : Lung Cancer. 63, 3, p. 360-367 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

High prevalence of metabolic disturbances in patients with bipolar disorder in Taiwan

Chang, H. H., Chou, C. H., Chen, P. S., Gean, P. W., Huang, H. C., Lin, C. Y., Yang, Y. K. & Lu, R. B., 2009 Sep 1, In : Journal of Affective Disorders. 117, 1-2, p. 124-129 6 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
54 Citations (Scopus)

Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes: A multiple genotype-phenotype study

Tseng, R. C., Hsieh, F. J., Shih, C. M., Hsu, H. S., Chen, C. Y. & Wang, Y-C., 2009 Jul 1, In : Cancer. 115, 13, p. 2939-2948 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion

Chen, Y. F., Chou, C. Y., Wilkins, R. J., Ellory, J. C., Mount, D. B. & Shen, M. R., 2009 Nov 15, In : Cancer Research. 69, 22, p. 8585-8593 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons

Lin, Y. C., Chou, L. C., Chen, S. C., Kuo, S. C., Huang, L. J. & Gean, P. W., 2009 Jun 15, In : Bioorganic and Medicinal Chemistry Letters. 19, 12, p. 3225-3228 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Neuroprotective Effects of Ugonin K on Hydrogen Peroxide-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells

Lin, Y. C., Huang, Y. C., Chen, S. C., Liaw, C. C., Kuo, S. C., Huang, L. J. & Gean, P-W., 2009 May 1, In : Neurochemical Research. 34, 5, p. 923-930 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Reduced axin protein expression is associated with a poor prognosis in patients with squamous cell carcinoma of esophagus

Li, A. F. Y., Hsu, P. K., Tzao, C., Wang, Y-C., Hung, I. C., Huang, M. H. & Hsu, H. S., 2009 Sep 1, In : Annals of Surgical Oncology. 16, 9, p. 2486-2493 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

Cheung, C. H. A., Chen, H. H., Kuo, C. C., Chang, C. Y., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 Jul 3, In : Molecular cancer. 8, 43.

Research output: Contribution to journalArticle

56 Citations (Scopus)

The role of prefrontal cortex CB1 receptors in the modulation of fear memory

Lin, H. C., Mao, S. C., Su, C. L. & Gean, P. W., 2009 Jan 1, In : Cerebral Cortex. 19, 1, p. 165-175 11 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)
2010

A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF-α therapy

Cheung, C. H. A., Sun, X., Kanwar, J. R., Bai, J. Z., Cheng, L. T. & Krissansen, G. W., 2010 Oct 1, In : Cancer Cell International. 10, 36.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Alterations of excitatory transmission in the lateral amygdala during expression and extinction of fear memory

Lin, H. C., Mao, S. C., Su, C. L. & Gean, P. W., 2010 Apr 1, In : International Journal of Neuropsychopharmacology. 13, 3, p. 335-345 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer

Tang, Y. A., Wen, W. L., Chang, J. W., Wei, T. T., Tan, Y. H. C., Salunke, S., Chen, C. T., Chen, C. S. & Wang, Y. C., 2010, In : PloS one. 5, 9, p. 1-13 13 p., e12417.

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)

A polymorphism in the hMLH1 gene (-93G→A) associated with lung cancer susceptibility and prognosis

Shih, C. M., Chen, C. Y., Lee, I. H., Kao, W. T. & Wang, Y. C., 2010 Jan 1, In : International journal of molecular medicine. 25, 1, p. 165-170 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
37 Citations (Scopus)

Butyrate reduced lipopolysaccharide-mediated macrophage migration by suppression of Src enhancement and focal adhesion kinase activity

Maa, M. C., Chang, M. Y., Hsieh, M. Y., Chen, Y. J., Yang, C. J., Chen, Z. C., Li, Y. K., Yen, C. K., Wu, R. R. & Leu, T-H., 2010 Dec 1, In : Journal of Nutritional Biochemistry. 21, 12, p. 1186-1192 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
19 Citations (Scopus)

Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes

Cheung, C. H. A., Wu, S. Y., Lee, T. R., Chang, C. Y., Wu, J. S., Hsieh, H. P. & Chang, J. Y., 2010 Nov 1, In : PloS one. 5, 9, p. 1-11 11 p., e12564.

Research output: Contribution to journalArticle

30 Citations (Scopus)

CBL is frequently altered in lung cancers: Its relationship to mutations in met and EGFR tyrosine kinases

Tan, Y. H. C., Krishnaswamy, S., Nandi, S., Kanteti, R., Vora, S., Onel, K., Hasina, R., Lo, F. Y., El-Hashani, E., Cervantes, G., Robinson, M., Kales, S. C., Lipkowitz, S., Karrison, T., Sattler, M., Vokes, E. E., Wang, Y. C. & Salgia, R., 2010 Jan 29, In : PloS one. 5, 1, e8972.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells

Hsieh, C. C., Kuo, Y. H., Kuo, C. C., Chen, L. T., Cheung, C. H. A., Chao, T. Y., Lin, C. H., Pan, W. Y., Chang, C. Y., Chien, S. C., Chen, T. W., Lung, C. C. & Chang, J. Y., 2010 May 1, In : Biochemical Pharmacology. 79, 9, p. 1261-1271 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Correction: A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF-α therapy

Cheung, C. H. A., Sun, X., Kanwar, J. R., Bai, J. Z., Cheng, L. & Krissansen, G. W., 2010 Oct 28, In : Cancer Cell International. 10, 43.

Research output: Contribution to journalComment/debate

10 Citations (Scopus)

Deficiency of electroneutral K+-Cl- cotransporter 3 causes a disruption in impulse propagation along peripheral nerves

Sun, Y-T., Lin, T-S., Tzeng, S-F., Delpire, E. & Shen, M-R., 2010 Oct 1, In : GLIA. 58, 13, p. 1544-1552 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Distinct epigenetic domains separated by a CTCF bound insulator between the tandem genes, BLU and RASSF1A

Chang, J. W., Hsu, H. S., Ni, H. J., Chuang, C. T., Hsiung, C. H., Huang, T. H. & Wang, Y. C., 2010, In : PloS one. 5, 9, p. 1-13 13 p., e12847.

Research output: Contribution to journalArticle

10 Citations (Scopus)