Research Output

2012

Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells

Wang, J. Y., Chen, B. K., Wang, Y. S., Tsai, Y. T., Chen, W. C., Chang, W. C., Hou, M. F., Wu, Y. C. & Chang, W. C., 2012 Jan 1, In : Cellular Signalling. 24, 1, p. 162-169 8 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

K+-Cl- cotransport mediates the bactericidal activity of neutrophils by regulating NADPH oxidase activation

Sun, Y. T., Shieh, C. C., Delpire, E. & Shen, M. R., 2012 Jul 1, In : Journal of Physiology. 590, 14, p. 3231-3243 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer

Tang, Y. A., Lin, R. K., Tsai, Y. T., Hsu, H. S., Yang, Y. C., Chen, C. Y. & Wang, Y. C., 2012 Aug 15, In : Clinical Cancer Research. 18, 16, p. 4325-4333 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models

Shieh, J. M., Wei, T. T., Tang, Y. A., Huang, S. M., Wen, W. L., Chen, M. Y., Cheng, H. C., Salunke, S. B., Chen, C. S., Lin, P., Chen, C. T. & Wang, Y. C., 2012 Jan 18, In : PloS one. 7, 1, e30240.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Modulating the interaction of CXCR4 and CXCL12 by low-molecular-weight heparin inhibits hepatic metastasis of colon cancer

Ma, L., Qiao, H., He, C., Yang, Q., Cheung, C. H. A., Kanwar, J. R. & Sun, X., 2012 Apr 1, In : Investigational New Drugs. 30, 2, p. 508-517 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Overexpression of PAFAH1B1 is associated with tumor metastasis and poor survival in non-small cell lung cancer

Lo, F. Y., Chen, H. T., Cheng, H. C., Hsu, H. S. & Wang, Y. C., 2012 Sep 1, In : Lung Cancer. 77, 3, p. 585-592 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Patients' perceptions and expectations of family participation in the informed consent process of elective surgery in taiwan

Lin, M. L., Kan, W. M. & Chen, C. H., 2012 Jun, In : Asian Nursing Research. 6, 2, p. 55-59 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Significance of migration-related genes (S100A9, MAGED4, C8orf30A, IL-8) in esophageal squamous cell carcinoma

Huang, C. T., Huang, G. C., Wu, P. S., Wu, L. W., Lin, S. H., Lai, W. W., Wang, Y. C. & Liu, H. S., 2012 Mar 1, In : Genomic Medicine, Biomarkers, and Health Sciences. 4, 1-2, p. 16-18 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis and Biological Evaluation of ortho-Aryl N-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors

Huang, W. J., Wang, Y. C., Chao, S. W., Yang, C. Y., Chen, L. C., Lin, M. H., Hou, W. C., Chen, M. Y., Lee, T. L., Yang, P. & Chang, C. I., 2012 Oct 1, In : ChemMedChem. 7, 10, p. 1815-1824 10 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway

Chen, K. L., Chang, W. S. W., Cheung, C. H. A., Lin, C. C., Huang, C. C., Yang, Y. N., Kuo, C. P., Kuo, C. C., Chang, Y. H., Liu, K. J., Wu, C. M. & Chang, J. Y., 2012 Apr 1, In : Cancer Letters. 317, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

TGF-beta1 increases cell rigidity by enhancing expression of smooth muscle actin: Keloid-derived fibroblasts as a model for cellular mechanics

Lee, C. H., Hong, C. H., Chen, Y. T., Chen, Y. C. & Shen, M-R., 2012 Sep 1, In : Journal of Dermatological Science. 67, 3, p. 173-180 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

The database of chromosome imbalance regions and genes resided in lung cancer from Asian and Caucasian identified by array-comparative genomic hybridization

Lo, F. Y., Chang, J. W., Chang, I. S., Chen, Y. J., Hsu, H. S., Huang, S. F. K., Tsai, F. Y., Jiang, S. S., Kanteti, R., Nandi, S., Salgia, R. & Wang, Y. C., 2012 Jun 12, In : BMC cancer. 12, 235.

Research output: Contribution to journalArticle

25 Citations (Scopus)

The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse

Huang, S. M., Hsu, P. C., Chen, M. Y., Li, W. S., More, S. V., Lu, K. T. & Wang, Y-C., 2012 Aug 1, In : International Journal of Cancer. 131, 3, p. 722-732 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis

Lin, C. H., Chen, P. S., Kuo, S. C., Huang, L. J., Gean, P. W. & Chiu, T. H., 2012 Mar 1, In : Food and Chemical Toxicology. 50, 3-4, p. 1073-1081 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
51 Citations (Scopus)

Valproic acid mediates the synaptic excitatory/inhibitory balance through astrocytes - A preliminary study

Wang, C. C., Chen, P. S., Hsu, C. W., Wu, S. J., Lin, C. T. & Gean, P. W., 2012 Apr 27, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 37, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2013
21 Citations (Scopus)
16 Citations (Scopus)

A Synthetic Podophyllotoxin Derivative Exerts Anti-Cancer Effects by Inducing Mitotic Arrest and Pro-Apoptotic ER Stress in Lung Cancer Preclinical Models

Chen, J. Y., Tang, Y. A., Li, W. S., Chiou, Y. C., Shieh, J. M. & Wang, Y. C., 2013 Apr 30, In : PloS one. 8, 4, e62082.

Research output: Contribution to journalArticle

11 Citations (Scopus)
38 Citations (Scopus)

Correction: Inhibition of spontaneous recovery of fear by mGlur5 after prolonged extinction training (PLoS ONE (2013) 8, 3 (e59580) DOI: 10.1371/journal.pone.0059580)

Mao, S. C., Chang, C. H., Wu, C. C., Orejanera, M. J., Manzoni, O. J. & Gean, P. W., 2013 Jun 27, In : PloS one. 8, 6

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Effects of a workplace multiple cardiovascular disease risks reduction program

Huang, J. J., Lin, H. S., Yen, M., Kan, W. M., Lee, B. O. & Chen, C. H., 2013 Jun, In : Asian Nursing Research. 7, 2, p. 74-82 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Enhancing cytokine-induced killer cell therapy of multiple myeloma

Liu, C., Suksanpaisan, L., Chen, Y. W., Russell, S. J. & Peng, K. W., 2013 Jun 1, In : Experimental Hematology. 41, 6, p. 508-517 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Epidermal Growth Factor Protects Squamous Cell Carcinoma against Cisplatin-Induced Cytotoxicity through Increased Interleukin-1β Expression

Ko, S. C., Huang, C. R., Shieh, J. M., Yang, J. H., Chang, W. C. & Chen, B. K., 2013 Feb 1, In : PloS one. 8, 2, e55795.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Expression of aryl hydrocarbon receptor nuclear translocator enhances cisplatin resistance by upregulating MDR1 expression in cancer cells

Chan, Y. Y., Kalpana, S., Chang, W. C., Chang, W. C. & Chen, B. K., 2013 Oct 1, In : Molecular Pharmacology. 84, 4, p. 591-602 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Glycosylation regulates the function and membrane localization of KCC4

Weng, T. Y., Chiu, W. T., Liu, H. S., Cheng, H. C., Shen, M. R., Mount, D. B. & Chou, C. Y., 2013 May 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1133-1146 14 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death

Liu, W. T., Huang, C. Y., Lu, I. C. & Gean, P. W., 2013 Sep 1, In : Neuro-Oncology. 15, 9, p. 1127-1141 15 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Inhibition of Spontaneous Recovery of Fear by mGluR5 after Prolonged Extinction Training

Mao, S. C., Chang, C. H., Wu, C. C., Orejanera, M. J., Manzoni, O. J. & Gean, P. W., 2013 Mar 21, In : PloS one. 8, 3, e59580.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Involvement of extracellular signal regulated kinases in traumatic brain injury-induced depression in rodents

Kuo, J. R., Cheng, Y. H., Chen, Y. S., Chio, C. C. & Gean, P. W., 2013 Jul 15, In : Journal of Neurotrauma. 30, 14, p. 1223-1231 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Involvement of STIM1 and Orai1 in EGF-mediated cell growth in retinal pigment epithelial cells

Yang, I. H., Tsai, Y. T., Chiu, S. J., Liu, L. T., Lee, H. H., Hou, M. F., Hsu, W. L., Chen, B. K. & Chang, W. C., 2013 Jun 27, In : Journal of biomedical science. 20, 1, 41.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Lack of association of C-Met-N375S sequence variant with lung cancer susceptibility and prognosis

Shieh, J. M., Tang, Y. A., Yang, T. H., Chen, C. Y., Hsu, H. S., Tan, Y. H. C., Salgia, R. & Wang, Y. C., 2013, In : International Journal of Medical Sciences. 10, 8, p. 988-994 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors

Chen, Y. T., Chen, Y. F., Chiu, W. T., Liu, K. Y., Liu, Y. L., Chang, J. Y., Chang, H. C. & Shen, M. R., 2013 Jul 15, In : Cancer Research. 73, 14, p. 4500-4509 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
11 Citations (Scopus)

Most vesicles in a central nerve terminal participate in recycling

Xue, L., Sheng, J., Wu, X. S., Wu, W., Luo, F., Shin, W., Chiang, H. C. & Wu, L. G., 2013 May 15, In : Journal of Neuroscience. 33, 20, p. 8820-8826 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Remodeling of calcium signaling in tumor progression

Chen, Y. F., Chen, Y. T., Chiu, W. T. & Shen, M. R., 2013 Apr 19, In : Journal of biomedical science. 20, 1, 23.

Research output: Contribution to journalReview article

112 Citations (Scopus)

SNARE Proteins Synaptobrevin, SNAP-25, and Syntaxin Are Involved in Rapid and Slow Endocytosis at Synapses

Xu, J., Luo, F., Zhang, Z., Xue, L., Wu, X. S., Chinag, H., Shin, W. & Wu, L. G., 2013 May 30, In : Cell Reports. 3, 5, p. 1414-1421 8 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo

Chiu, H. W., Yeh, Y. L., Wang, Y. C., Huang, W. J., Chen, Y. A., Chiou, Y. S., Ho, S. Y., Lin, P. & Wang, Y. J., 2013 Oct 10, In : PloS one. 8, 10, e76340.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Survivin - biology and potential as a therapeutic target in oncology

Antonio Cheung, C. H., Huang, C. C., Tsai, F. Y., Lee, J. Y. C., Cheng, S. M., Chang, Y. C., Huang, Y. C., Chen, S. H. & Chang, J. Y., 2013 Oct 28, In : OncoTargets and Therapy. 6, p. 1453-1462 10 p.

Research output: Contribution to journalReview article

93 Citations (Scopus)

The Amygdala Excitatory/Inhibitory Balance in a Valproate-Induced Rat Autism Model

Lin, H. C., Gean, P. W., Wang, C. C., Chan, Y. H. & Chen, P. S., 2013 Jan 29, In : PloS one. 8, 1, e55248.

Research output: Contribution to journalArticle

45 Citations (Scopus)

The beneficial effects of leptin on REM sleep deprivation-induced cognitive deficits in mice

Chang, H. F., Su, C. L., Chang, C. H., Chen, Y. W. & Gean, P. W., 2013 Jun, In : Learning and Memory. 20, 6, p. 328-335 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
16 Citations (Scopus)

The ER Ca2+ sensor STIM1 regulates actomyosin contractility of migratory cells

Chen, Y. T., Chen, Y. F., Chiu, W. T., Wang, Y. K., Chang, H. C. & Shen, M. R., 2013 Mar 1, In : Journal of Cell Science. 126, 5, p. 1260-1267 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

The SNARE proteins SNAP25 and synaptobrevin are involved in endocytosis at hippocampal synapses

Zhang, Z., Wang, D., Sun, T., Xu, J., Chiang, H. C., Shin, W. & Wu, L. G., 2013 May 22, In : Journal of Neuroscience. 33, 21, p. 9169-9175 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Treat cancers by targeting survivin: Just a dream or future reality?

Coumar, M. S., Tsai, F. Y., Kanwar, J. R., Sarvagalla, S. & Cheung, C. H. A., 2013 Nov 1, In : Cancer Treatment Reviews. 39, 7, p. 802-811 10 p.

Research output: Contribution to journalReview article

105 Citations (Scopus)
2014
17 Citations (Scopus)

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., 2014 Apr 28, In : Cancer Letters. 346, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

An increase in reactive oxygen species by deregulation of ARNT enhances chemotherapeutic drug-induced cancer cell death

Shieh, J. M., Shen, C. J., Chang, W. C., Cheng, H. C., Chan, Y. Y., Huang, W. C., Chang, W. C. & Chen, B. K., 2014 Jun 12, In : PloS one. 9, 6, e99242.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential

Wang, S. C., Lee, T. H., Hsu, C. H., Chang, Y. J., Chang, M. S., Wang, Y-C., Ho, Y. S., Wen, W. C. & Lin, R. K., 2014 Jun 18, In : Journal of Agricultural and Food Chemistry. 62, 24, p. 5625-5635 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis

Yen, J. H., Chang, C. M., Hsu, Y. W., Lee, C. H., Wu, M. S., Hwang, D. Y., Chen, B. K., Liao, H. T., Wu, M. T. M. & Chang, W. C., 2014, In : Mediators of Inflammation. 2014, 834831.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Aurora kinase inhibitor patents and agents in clinical testing: An update (2011-2013)

Cheung, C. H. A., Sarvagalla, S., Lee, J. Y. C., Huang, Y. C. & Coumar, M. S., 2014 Sep, In : Expert Opinion on Therapeutic Patents. 24, 9, p. 1021-1038 18 p.

Research output: Contribution to journalReview article

38 Citations (Scopus)