Research Output

2020

A Fluorogenic Molecule for Probing Islet Amyloid Using Flavonoid as a Scaffold Design

Chen, W. L., Ma, S. T., Chen, Y. W., Chao, Y. C., Chan, A. C., Tu, L. H. & Liu, W. M., 2020 Apr 21, In : Biochemistry. 59, 15, p. 1482-1492 11 p.

Research output: Contribution to journalArticle

Anti-apoptotic proteins in the autophagic world: An update on functions of XIAP, Survivin, and BRUCE

Cheung, C. H. A., Chang, Y. C., Lin, T. Y., Cheng, S. M. & Leung, E., 2020 Feb 5, In : Journal of biomedical science. 27, 1, 31.

Research output: Contribution to journalReview article

Open Access
Open Access

BIRC5/Survivin is a novel ATG12–ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells

Lin, T. Y., Chan, H. H., Chen, S. H., Sarvagalla, S., Chen, P. S., Coumar, M. S., Cheng, S. M., Chang, Y. C., Lin, C. H., Leung, E. & Cheung, C. H. A., 2020 Jul 2, In : Autophagy. 16, 7, p. 1296-1313 18 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Epidermal growth factor-induced COX-2 regulates metastasis of head and neck squamous cell carcinoma through upregulation of angiopoietin-like 4

Chiang, K. H., Shieh, J. M., Shen, C. J., Chang, T. W., Wu, P. T., Hsu, J. Y., Tsai, J. P., Chang, W. C. & Chen, B. K., 2020 Jun 1, In : Cancer Science. 111, 6, p. 2004-2015 12 p.

Research output: Contribution to journalArticle

Open Access

Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer

Ding, L. Y., Hou, Y. C., Kuo, I. Y., Hsu, T. Y., Tsai, T. C., Chang, H. W., Hsu, W. Y., Tsao, C. C., Tian, C. C., Wang, P. S., Wang, H. C., Lee, C. T., Wang, Y. C., Lin, S. H., Hughes, M. W., Chuang, W. J., Lu, P. J., Shan, Y. S. & Huang, P. H., 2020 Jun 17, In : Clinical Epigenetics. 12, 1, 87.

Research output: Contribution to journalArticle

Open Access

EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages

Chuang, J. P., Kao, C. Y., Lee, J. C., Ling, P., Maa, M. C. & Leu, T. H., 2020, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Open Access

MicroRNA-206 Regulates Stress-Provoked Aggressive Behaviors in Post-weaning Social Isolation Mice

Chang, C. H., Kuek, E. J. W., Su, C. L. & Gean, P. W., 2020 Jun 5, In : Molecular Therapy - Nucleic Acids. 20, p. 812-822 11 p.

Research output: Contribution to journalArticle

Open Access

Oleic acid-induced NOX4 is dependent on ANGPTL4 expression to promote human colorectal cancer metastasis

Shen, C. J., Chang, K. Y., Lin, B. W., Lin, W. T., Su, C. M., Tsai, J. P., Liao, Y. H., Hung, L. Y., Chang, W. C. & Chen, B. K., 2020, In : Theranostics. 10, 16, p. 7083-7099 17 p.

Research output: Contribution to journalArticle

Open Access

Relative D3 vitamin deficiency and consequent cognitive impairment in an animal model of Alzheimer's disease: Potential involvement of collapsin response mediator protein-2

Lin, F. Y., Lin, Y. F., Lin, Y. S., Yang, C. M., Wang, C. C. & Hsiao, Y. H., 2020 Mar 1, In : Neuropharmacology. 164, 107910.

Research output: Contribution to journalArticle

1 Citation (Scopus)

ST2 Signaling in the Tumor Microenvironment

Chang, C. P., Hu, M. H., Hsiao, Y. P. & Wang, Y. C., 2020 Jan 1, Advances in Experimental Medicine and Biology. Springer, p. 83-93 11 p. (Advances in Experimental Medicine and Biology; vol. 1240).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access

Targeting interleukin-20 alleviates paclitaxel-induced peripheral neuropathy

Chen, L. H., Yeh, Y. M., Chen, Y. F., Hsu, Y. H., Wang, H. H., Lin, P. C., Chang, L. Y., Lin, C. C. K., Chang, M. S. & Shen, M. R., 2020 Jun 1, In : Pain. 161, 6, p. 1237-1254 18 p.

Research output: Contribution to journalArticle

The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells

Chang, Y. C., Kondapuram, S. K., Yang, T. H., Syed, S. B., Cheng, S. M., Lin, T. Y., Lin, Y. C., Coumar, M. S., Chang, J. Y., Leung, E. & Cheung, C. H. A., 2020 Aug 15, In : Toxicology and Applied Pharmacology. 401, 115080.

Research output: Contribution to journalArticle

TIAM2S as a novel regulator for serotonin level enhances brain plasticity and locomotion behavior

Chu, C. H., Chen, J. S., Chuang, P. C., Su, C. H., Chan, Y. L., Yang, Y. J., Chiang, Y. T., Su, Y. Y., Gean, P. W. & Sun, H. S., 2020 Feb 1, In : FASEB Journal. 34, 2, p. 3267-3288 22 p.

Research output: Contribution to journalArticle

Open Access
2019

Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity

Chen, Y. R., Li, Y. H., Hsieh, T. C., Wang, C. M., Cheng, K. C., Wang, L., Lin, T. Y., Cheung, C. H. A., Wu, C. L. & Chiang, H. C., 2019 Aug, In : Aging Cell. 18, 4, e12989.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression

Liao, S. Y., Kuo, I. Y., Chen, Y. T., Liao, P. C., Liu, Y. F., Wu, H. Y., Lai, W. W. & Wang, Y. C., 2019 Oct 10, In : Oncogene. 38, 41, p. 6723-6736 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Association of gout and colorectal cancer in Taiwan: A nationwide population-based cohort study

Chuang, J. P., Lee, J. C., Leu, T. H., Hidajah, A. C., Chang, Y. H. & Li, C. Y., 2019 Oct 1, In : BMJ open. 9, 10, e028892.

Research output: Contribution to journalArticle

Open Access
Open Access

Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli

Tsai, S. L., Chang, Y. C., Sarvagalla, S., Wang, S., Coumar, M. S. & Cheung, C. H. A., 2019 Aug, In : Protein Expression and Purification. 160, p. 73-83 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
1 Citation (Scopus)
Open Access

Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila

Shyu, W. H., Lee, W. P., Chiang, M. H., Chang, C. C., Fu, T. F., Chiang, H. C., Wu, T. & Wu, C. L., 2019, In : PLoS genetics. 15, 5, e1008153.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Functional effects of let-7g expression in colon cancer metastasis

Chang, C. M., Wong, H. S. C., Huang, C. Y., Hsu, W. L., Maio, Z. F., Chiu, S. J., Tsai, Y. T., Chen, B. K., Wan, Y. J. Y., Wang, J. Y. & Chang, W. C., 2019 Apr, In : Cancers. 11, 4, 489.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
5 Citations (Scopus)

High-CLDN4 ESCC cells harbor stem-like properties and indicate for poor concurrent chemoradiation therapy response in esophageal squamous cell carcinoma

Lin, C. H., Li, H. Y., Liu, Y. P., Kuo, P. F., Wang, W. C., Lin, F. C., Chang, W. L., Sheu, B. S., Wang, Y. C., Hung, W. C., Cheng, H. C., Yao, Y. C., Calkins, M. J., Hsiao, M. & Lu, P. J., 2019, In : Therapeutic Advances in Medical Oncology. 11

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P

Tan, B. S., Yang, M. C., Singh, S., Chou, Y. C., Chen, H. Y., Wang, M. Y., Wang, Y. C. & Chen, R. H., 2019 Jul 11, In : Oncogene. 38, 28, p. 5612-5626 15 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry

Lin, H. H., Chen, S. J., Shen, M. R., Huang, Y. T., Hsieh, H. P., Lin, S. Y., Lin, C. C., Chang, W. S. W. & Chang, J. Y., 2019 Dec, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 12, 118517.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Mutation of the PTCH1 gene predicts recurrence of breast cancer

Wang, C. Y., Chang, Y. C., Kuo, Y. L., Lee, K. T., Chen, P. S., Cheung, C. H. A., Chang, C. P., Phan, N. N., Shen, M. R. & Hsu, H. P., 2019 Nov 8, In : Scientific reports. 9, 1, 1 p., 16359.

Research output: Contribution to journalArticle

Open Access

Myostatin Is Associated With Cognitive Decline in an Animal Model of Alzheimer’s Disease

Lin, Y. S., Lin, F. Y. & Hsiao, Y. H., 2019 Mar 1, In : Molecular Neurobiology. 56, 3, p. 1984-1991 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Protein Glycation by Glyoxal Promotes Amyloid Formation by Islet Amyloid Polypeptide

Hsu, Y. H., Chen, Y. W., Wu, M. H. & Tu, L. H., 2019 Jun 18, In : Biophysical Journal. 116, 12, p. 2304-2313 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
Open Access
2 Citations (Scopus)

Store-Operated Ca2+ entry in tumor progression: From molecular mechanisms to clinical implications

Chen, Y. F., Lin, P. C., Yeh, Y. M., Chen, L. H. & Shen, M. R., 2019 Jul, In : Cancers. 11, 7, 899.

Research output: Contribution to journalReview article

Open Access
8 Citations (Scopus)

The distinct role of STIM1 and STIM2 in the regulation of store-operated Ca2+ entry and cellular function

Chen, Y. F., Chen, L. H. & Shen, M. R., 2019 Jun, In : Journal of Cellular Physiology. 234, 6, p. 8727-8739 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
Open Access
3 Citations (Scopus)
2018

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W. T., Chang, H. A., Lin, Y. H., Lin, Y. S., Chang, H. T., Lin, H. H., Huang, S. C., Tang, M. J. & Shen, M. R., 2018 Dec 1, In : Cell Death Discovery. 4, 1, 37.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W., Chang, H., Lin, Y., Lin, Y., Chang, H., Lin, H., Huang, S., Tang, M. & Shen, M., 2018 Dec 1, In : Cell Death Discovery. 4, 1

Research output: Contribution to journalArticle

3 Citations (Scopus)

Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies

Ji, X. R., Cheng, K. C., Chen, Y. R., Lin, T. Y., Cheung, C. H. A., Wu, C. L. & Chiang, H. C., 2018 Mar, In : FASEB Journal. 32, 3, p. 1375-1387 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Functional engineered mesenchymal stem cells with fibronectin-gold composite coated catheters for vascular tissue regeneration

Chen, Y., Hsieh, S., Yang, Y., Hsu, S., Kung, M., Lin, P., Hsieh, H., Lin, C., Tang, C. & Hung, H., 2018 Apr 1, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 3, p. 699-711

Research output: Contribution to journalArticle

4 Citations (Scopus)

High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice

Tsai, S. F., Wu, H. T., Chen, P. C., Chen, Y. W., Yu, M., Wang, T. F., Wu, S. Y., Tzeng, S. F. & Kuo, Y. M., 2018 Dec 1, In : Brain Research. 1700, p. 66-77 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice.

Tsai, SF., Wu, HT., Chen, PC. & Chen, Y-W., 2018 Jul 13, In : Brain Research. 18, p. 30401 3 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Integrative genomic analysis for the functional roles of ITPKC in bone mineral density

Lu, H. F., Wong, H. S. C., Chen, B. K., Liao, H. T., Hsu, Y. W., Ikegawa, S., Cho, E. C., Hung, K. S. & Chang, W. C., 2018 Nov 30, In : Bioscience Reports. 38, 6, BSR20181481.

Research output: Contribution to journalArticle

Mechanism underlying NMDA blockade-induced inhibition of aggression in post-weaning socially isolated mice

Chang, C. H., Su, C. L. & Gean, P. W., 2018 Dec, In : Neuropharmacology. 143, p. 95-105 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Medical Applications of Collagen and Hyaluronan in Regenerative Medicine

Huang, L. L. H., Chen, Y. H. A., Zhuo, Z. Y., Hsieh, Y. T., Yang, C. L., Chen, W. T., Lin, J. Y., Lin, Y. X., Jiang, J. T., Zhuang, C. H., Wang, Y. C., Nguyendac, H., Lin, K. W. & Liu, W. L., 2018 Jan 1, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 285-306 22 p. (Advances in Experimental Medicine and Biology; vol. 1077).

Research output: Chapter in Book/Report/Conference proceedingChapter

Mushroom body glycolysis is required for olfactory memory in Drosophila

Wu, C. L., Chang, C. C., Wu, J. K., Chiang, M. H., Yang, C. H. & Chiang, H. C., 2018 Apr, In : Neurobiology of Learning and Memory. 150, p. 13-19 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)