Research Output

TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1

Huang, P. H., Lu, P. J., Ding, L. Y., Chu, P. C., Hsu, W. Y., Chen, C. S., Tsao, C. C., Chen, B. H., Lee, C. T., Shan, Y. S. & Chen, C. S., 2017 Apr 20, In : Oncogene. 36, 16, p. 2202-2214 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The Amygdala Excitatory/Inhibitory Balance in a Valproate-Induced Rat Autism Model

Lin, H. C., Gean, P. W., Wang, C. C., Chan, Y. H. & Chen, P. S., 2013 Jan 29, In : PloS one. 8, 1, e55248.

Research output: Contribution to journalArticle

48 Citations (Scopus)

The beneficial effects of leptin on REM sleep deprivation-induced cognitive deficits in mice

Chang, H. F., Su, C. L., Chang, C. H., Chen, Y. W. & Gean, P. W., 2013 Jun, In : Learning and Memory. 20, 6, p. 328-335 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
7 Citations (Scopus)
16 Citations (Scopus)

The database of chromosome imbalance regions and genes resided in lung cancer from Asian and Caucasian identified by array-comparative genomic hybridization

Lo, F. Y., Chang, J. W., Chang, I. S., Chen, Y. J., Hsu, H. S., Huang, S. F. K., Tsai, F. Y., Jiang, S. S., Kanteti, R., Nandi, S., Salgia, R. & Wang, Y. C., 2012 Jun 12, In : BMC cancer. 12, 235.

Research output: Contribution to journalArticle

26 Citations (Scopus)
17 Citations (Scopus)

The distinct role of STIM1 and STIM2 in the regulation of store-operated Ca2+ entry and cellular function

Chen, Y. F., Chen, L. H. & Shen, M. R., 2019 Jun, In : Journal of Cellular Physiology. 234, 6, p. 8727-8739 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The effect of mefloquine and volume-regulated anion channel inhibitors on induced transport in Plasmodium falciparum-infected human red blood cells

Staines, H. M., Dee, B. C., Shen, M. R. & Ellory, J. C., 2004 May, In : Blood Cells, Molecules, and Diseases. 32, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The effect of prostacyclin agonists on the differentiation of phorbol ester treated human erythroleukemia cells

Shen, H. W., Chen, Y. L., Chern, C. Y. & Kan, W. M., 2007 May, In : Prostaglandins and Other Lipid Mediators. 83, 3 SPEC. ISS., p. 231-236 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The emerging role of KCl cotransport in tumor biology

Chen, Y. F., Chou, C. Y., Clive Ellory, J. & Shen, M. R., 2010 Oct 8, In : American Journal of Translational Research. 2, 4, p. 345-355 11 p.

Research output: Contribution to journalReview article

21 Citations (Scopus)
38 Citations (Scopus)

The ER Ca2+ sensor STIM1 regulates actomyosin contractility of migratory cells

Chen, Y. T., Chen, Y. F., Chiu, W. T., Wang, Y. K., Chang, H. C. & Shen, M. R., 2013 Mar 1, In : Journal of Cell Science. 126, 5, p. 1260-1267 8 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The inducible nitric-oxide synthase (iNOS)/Src axis mediates toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to interferon- β synthesis in macrophages

Hsieh, M. Y., Chang, M. Y., Chen, Y. J., Li, Y. K., Chuang, T. H., Yu, G. Y., Cheung, C. H. A., Chen, H. C., Maa, M. C. & Leu, T. H., 2014 Mar 30, In : Journal of Biological Chemistry. 289, 13, p. 9208-9220 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
6 Citations (Scopus)

The iNOS/Src/FAK axis contributes to lithium chloride-mediated macrophage migration

Chen, H. C., Chien, W. C., Chang, M. Y., Hsieh, M. Y., Lai, M. D., Maa, M. C. & Leu, T. H., 2015 May 1, In : Nitric Oxide - Biology and Chemistry. 47, p. 58-64 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The iNOS/Src/FAK axis is critical in Toll-like receptor-mediated cell motility in macrophages

Maa, M. C., Chang, M. Y., Li, J., Li, Y. Y., Hsieh, M. Y., Yang, C. J., Chen, Y. J., Li, Y., Chen, H. C., Cheng, W. E., Hsieh, C. Y., Cheng, C. W. & Leu, T. H., 2011 Jan 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 1, p. 136-147 12 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation

Liu, P. S., Jong, T. H., Maa, M. C. & Leu, T-H., 2010 Jul 8, In : Oncogene. 29, 27, p. 3977-3989 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
23 Citations (Scopus)

The involvement of metabotropic glutamate receptors in long-term depression of N-methyl-d-aspartate receptor-mediated synaptic potential in the rat hippocampus

Yi, P. L., Chang, F. C., Tsai, J. J., Hung, C. R. & Gean, P. W., 1995 Feb 13, In : Neuroscience Letters. 185, 3, p. 207-210 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The involvement of PTEN in sleep deprivation-induced memory impairment in rats

Su, C. L., Chen, C. H., Lu, H. Y. & Gean, P-W., 2004 Nov 1, In : Molecular Pharmacology. 66, 5, p. 1340-1348 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The KCI cotransporter isoform KCC3 can play an important role in cell growth regulation

Shen, M. R., Chou, C. Y., Hsu, K. F., Liu, H. S., Dunham, P. B., Holtzman, E. J. & Ellory, J. C., 2001 Dec 4, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 25, p. 14714-14719 6 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Thematic series: Transcriptional regulation and disease

Wang, Y. C., 2014 Jun 20, In : Cell and Bioscience. 4, 1, 42.

Research output: Contribution to journalEditorial

The molecular mechanisms for the antitumorigenic effect of curcumin

Leu, T-H. & Maa, M. C., 2002 Jun 27, In : Current Medicinal Chemistry - Anti-Cancer Agents. 2, 3, p. 357-370 14 p.

Research output: Contribution to journalReview article

145 Citations (Scopus)

The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse

Huang, S. M., Hsu, P. C., Chen, M. Y., Li, W. S., More, S. V., Lu, K. T. & Wang, Y-C., 2012 Aug 1, In : International Journal of Cancer. 131, 3, p. 722-732 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism

Wei, W. C., Akerman, C. J., Newey, S. E., Pan, J., Clinch, N. W. V., Jacob, Y., Shen, M. R., Wilkins, R. J. & Ellory, J. C., 2011 Nov, In : Journal of Physiology. 589, 22, p. 5349-5359 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis

Lin, C. H., Chen, P. S., Kuo, S. C., Huang, L. J., Gean, P. W. & Chiu, T. H., 2012 Mar 1, In : Food and Chemical Toxicology. 50, 3-4, p. 1073-1081 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The role of prefrontal cortex CB1 receptors in the modulation of fear memory

Lin, H. C., Mao, S. C., Su, C. L. & Gean, P. W., 2009 Jan 1, In : Cerebral Cortex. 19, 1, p. 165-175 11 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

The Role of the Amygdala in the Extinction of Conditioned Fear

Barad, M., Gean, P. W. & Lutz, B., 2006 Aug 15, In : Biological Psychiatry. 60, 4, p. 322-328 7 p.

Research output: Contribution to journalReview article

105 Citations (Scopus)

The role of valproate in metabolic disturbances in bipolar disorder patients

Chang, H. H., Yang, Y. K., Gean, P. W., Huang, H. C., Chen, P. S. & Lu, R. B., 2010 Aug 1, In : Journal of Affective Disorders. 124, 3, p. 319-323 5 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory

Lin, C. H., Yeh, S. H., Lu, H. Y. & Gean, P. W., 2003 Sep 10, In : Journal of Neuroscience. 23, 23, p. 8310-8317 8 p.

Research output: Contribution to journalArticle

Open Access
211 Citations (Scopus)

The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells

Chang, Y. C., Kondapuram, S. K., Yang, T. H., Syed, S. B., Cheng, S. M., Lin, T. Y., Lin, Y. C., Coumar, M. S., Chang, J. Y., Leung, E. & Cheung, C. H. A., 2020 Aug 15, In : Toxicology and Applied Pharmacology. 401, 115080.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The SNARE proteins SNAP25 and synaptobrevin are involved in endocytosis at hippocampal synapses

Zhang, Z., Wang, D., Sun, T., Xu, J., Chiang, H. C., Shin, W. & Wu, L. G., 2013 May 22, In : Journal of Neuroscience. 33, 21, p. 9169-9175 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

The STIM1-Orai1 pathway of store-operated Ca2+ entry controls the checkpoint in cell cycle G1/S transition

Chen, Y. W., Chen, Y. F., Chen, Y. T., Chiu, W. T. & Shen, M. R., 2016 Feb 26, In : Scientific reports. 26, 6, 22142.

Research output: Contribution to journalArticle

33 Citations (Scopus)

The store-operated Ca2+ entry-mediated signaling is important for cancer spread

Chen, Y. F., Hsu, K. F. & Shen, M. R., 2016 Jun 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1863, 6, p. 1427-1435 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients

Lin, R. K., Hsieh, Y. S., Lin, P., Hsu, H. S., Chen, C. Y., Tang, Y. A., Lee, C. F. & Wang, Y. C., 2010 Feb 1, In : Journal of Clinical Investigation. 120, 2, p. 521-532 12 p.

Research output: Contribution to journalArticle

147 Citations (Scopus)

The transient potassium current, the A-current, is involved in spike frequency adaptation in rat amygdala neurons

Gean, P. W. & Shinnick-Gallagher, P., 1989 Feb 20, In : Brain Research. 480, 1-2, p. 160-169 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
Open Access
8 Citations (Scopus)

Three-dimensional power Doppler imaging of early-stage cervical cancer

Hsu, K. F., Su, J. M., Huang, S. C., Cheng, Y. M., Kang, C. Y., Shen, M. R., Chang, F. M. & Chou, C. Y., 2004 Nov 1, In : Ultrasound in Obstetrics and Gynecology. 24, 6, p. 664-671 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Thromboxane A2 agonist modulation of excitatory synaptic transmission in the rat hippocampal slice

Hsu, K. S. & Kan, W. M., 1996 Jan 1, In : British Journal of Pharmacology. 118, 8, p. 2220-2227 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

TIAM2S as a novel regulator for serotonin level enhances brain plasticity and locomotion behavior

Chu, C. H., Chen, J. S., Chuang, P. C., Su, C. H., Chan, Y. L., Yang, Y. J., Chiang, Y. T., Su, Y. Y., Gean, P. W. & Sun, H. S., 2020 Feb 1, In : FASEB Journal. 34, 2, p. 3267-3288 22 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7

Lai, C. Y., Liu, Y. L., Yu, G. Y., Maa, M. C., Leu, T. H., Xu, C., Luo, Y., Xiang, R. & Chuang, T. H., 2014 Sep 29, In : Vaccine. 32, 43, p. 5593-5599 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

TNF up-regulates Pentraxin3 expression in human airway smooth muscle cells via JNK and ERK1/2 MAPK pathways

Zhang, J., Koussih, L., Shan, L., Halayko, A. J., Chen, B. K. & Gounni, A. S., 2015 Dec 7, In : Allergy, Asthma and Clinical Immunology. 11, 1, 37.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Topical ophthalmic formulation of trichostatin A and SurR9-C84A for quick recovery post-alkali burn of corneal haze

Roy, K., Cheung, C. H. A., Kanwar, R. K., Sandhir, R. & Kanwar, J. R., 2017 May 5, In : Frontiers in Pharmacology. 8, MAY, 223.

Research output: Contribution to journalArticle

1 Citation (Scopus)

TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients

Wang, H. C., Yeh, T. L., Chang, H. H., Gean, P. W., Chi, M. H., Yang, Y. K., Lu, R. B. & Chen, P. S., 2011 Feb 1, In : Psychopharmacology. 213, 4, p. 773-779 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Transcriptional regulation of brain-derived neurotrophic factor in the amygdala during consolidation of fear memory

Ou, L. C. & Gean, P. W., 2007 Aug 1, In : Molecular Pharmacology. 72, 2, p. 350-358 9 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Transcription factor Sp1 functions as an anchor protein in gene transcription of human 12(S)-lipoxygenase

Chang, W. C. & Chen, B. K., 2005 Dec 9, In : Biochemical and Biophysical Research Communications. 338, 1, p. 117-121 5 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)

Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway

Yeh, S. H., Yang, W. B., Gean, P. W., Hsu, C. Y., Tseng, J. T., Su, T. P., Chang, W. C. & Hung, J. J., 2011 Jul, In : Nucleic acids research. 39, 13, p. 5412-5423 12 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Translational up-regulation of Aurora-A in EGFR-overexpressed cancer

Lai, C. H., Tseng, J. T., Lee, Y. C., Chen, Y. J., Lee, J. C., Lin, B. W., Huang, T. C., Liu, Y. W., Leu, T. H., Liu, Y. W., Chen, Y. P., Chang, W. C. & Hung, L. Y., 2010 Jun, In : Journal of Cellular and Molecular Medicine. 14, 6 B, p. 1520-1531 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Treat cancers by targeting survivin: Just a dream or future reality?

Coumar, M. S., Tsai, F. Y., Kanwar, J. R., Sarvagalla, S. & Cheung, C. H. A., 2013 Nov 1, In : Cancer Treatment Reviews. 39, 7, p. 802-811 10 p.

Research output: Contribution to journalReview article

109 Citations (Scopus)