Research Output

DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer

Yang, Y. C., Tang, Y. A., Shieh, J. M., Lin, R. K., Hsu, H. S. & Wang, Y. C., 2014 Sep, In : Journal of Thoracic Oncology. 9, 9, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus

Young, C., Gean, P. W., Chiou, L. C. & Shen, Y. Z., 2000 Jul 22, In : Synapse. 37, 2, p. 90-94 5 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Down-regulation of ARNT promotes cancer metastasis by activating the fibronectin/integrin β1/FAK axis

Huang, C. R., Lee, C. T., Chang, K. Y., Chang, W. C., Liu, Y. W., Lee, J. C. & Chen, B. K., 2015, In : Oncotarget. 6, 13, p. 11530-11546 17 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
3 Citations (Scopus)

Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies

Ji, X. R., Cheng, K. C., Chen, Y. R., Lin, T. Y., Cheung, C. H. A., Wu, C. L. & Chiang, H. C., 2018 Mar, In : FASEB Journal. 32, 3, p. 1375-1387 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer

Lin, R. K. & Wang, Y. C., 2014 Aug 19, In : Cell and Bioscience. 4, 1, 46.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer

Lin, R. K., Wu, C. Y., Chang, J. W., Juan, L. J., Hsu, H. S., Chen, C. Y., Lu, Y. Y., Tang, Y. A., Yang, Y. C., Yang, P. C. & Wang, Y. C., 2010 Jul 15, In : Cancer Research. 70, 14, p. 5807-5817 11 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis

Tzeng, H. T., Tsai, C. H., Yen, Y. T., Cheng, H. C., Chen, Y. C., Pu, S. W., Wang, Y. S., Shan, Y. S., Tseng, Y. L., Su, W. C., Lai, W. W., Wu, L. W. & Wang, Y. C., 2017 May 1, In : Clinical Cancer Research. 23, 9, p. 2335-2345 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

E-Cadherin Aptamer-Conjugated Delivery of Doxorubicin for Targeted Inhibition of Prostate Cancer Cells

Chaudhary, R., Roy, K., Kanwar, R. K., Veedu, R. N., Krishnakumar, S., Cheung, C-H., Verma, A. K. & Kanwar, J. R., 2016 Jan 1, In : Australian Journal of Chemistry. 69, 10, p. 1108-1116 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response

Chang, H. Y., Huang, H. C., Huang, T. C., Yang, P. C., Wang, Y. C. & Juan, H. F., 2012 Sep 15, In : Cancer Research. 72, 18, p. 4696-4706 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Effect of hydroxyzine on the transport of etoposide in rat small intestine

Kan, W. M., Liu, Y. T., Hsiao, C. L., Shieh, C. Y., Kuo, J. H., Huang, J. D. & Su, S. F., 2001 Apr 17, In : Anti-Cancer Drugs. 12, 3, p. 267-273 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Effects of Antiepileptic Drugs on Sperm Motility of Normal Controls and Epileptic Patients with Long‐Term Therapy

Chen, SS. S., Shen, MR. R., Chen, TJ. J. & Lai, SL. L., 1992 Jan, In : Epilepsia. 33, 1, p. 149-153 5 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Effects of a workplace multiple cardiovascular disease risks reduction program

Huang, J. J., Lin, H. S., Yen, M., Kan, W. M., Lee, B. O. & Chen, C. H., 2013 Jun, In : Asian Nursing Research. 7, 2, p. 74-82 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle

Lin, H. C., Mao, S. C. & Gean, P. W., 2006 May 1, In : Learning and Memory. 13, 3, p. 316-321 6 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Effects of lithium and haloperidol on human sperm motility in‐vitro

Shen, MR. R., Yang, RC. C. & Chen, SS. S., 1992 Jun, In : Journal of Pharmacy and Pharmacology. 44, 6, p. 534-536 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Effects of phenytoin on the amygdala neurons in vitro

Cheng, L. L., Wang, S. J., Tsai, J. J. & Geana, P. W., 1997 Jan 1, In : Pharmacology. 55, 5, p. 228-234 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Efficient synthesis of 2-(N-Substituted)-2-imidazolines and 2-(N-Substituted)-1,4,5, 6-tetrahydropyrimidines

Kan, W. M., Lin, S. H. & Chern, C. Y., 2005 Nov 10, In : Synthetic Communications. 35, 20, p. 2633-2639 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
72 Citations (Scopus)

Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila

Shyu, W. H., Lee, W. P., Chiang, M. H., Chang, C. C., Fu, T. F., Chiang, H. C., Wu, T. & Wu, C. L., 2019, In : PLoS genetics. 15, 5, e1008153.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Elevated p53 and p21waf1 mRNA expression in blood lymphocytes from lung cancer patients with chemoresistance

Shih, C. M., Chen, K., Wang, Y. C., Lee, P. J. & Wang, Y-C., 2007 Dec 4, In : Cancer Detection and Prevention. 31, 5, p. 366-370 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
15 Citations (Scopus)

Emerging methods for analysis of the cancer methylome

Chang, J. W., Huang, T. H. M. & Wang, Y-C., 2008 Dec 1, In : Pharmacogenomics. 9, 12, p. 1869-1878 10 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Endogenous serotonin inhibits epileptiform activity in rat hippocampal CA1 neurons via 5-hydroxytryptamine(1A) receptor activation

Lu, K. T. & Gean, P. W., 1998 Jun 8, In : Neuroscience. 86, 3, p. 729-737 9 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Enhancement of NMDA receptor-mediated synaptic potential by isoproterenol is blocked by Rp-adenosine 3′,5′-cyclic monophosphothioate

Huang, C. C., Tsai, J. J. & Gean, P. W., 1993 Oct 29, In : Neuroscience Letters. 161, 2, p. 207-210 4 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C. H. A., Chen, L. T. & Chang, J. Y., 2011 Oct 1, In : Cancer Letters. 309, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Enhancement of tyrosyl phosphorylation and protein expression of eps8 by v-Src

Maa, M. C., Lai, J. R., Lin, R. W. & Leu, T. H., 1999 Jul 8, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1450, 3, p. 341-351 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Enhancing cytokine-induced killer cell therapy of multiple myeloma

Liu, C., Suksanpaisan, L., Chen, Y. W., Russell, S. J. & Peng, K. W., 2013 Jun, In : Experimental Hematology. 41, 6, p. 508-517 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
21 Citations (Scopus)

Epidermal growth factor enhances transcription of human arachidonate 12-lipoxygenase in A431 cells

Liu, Y. W., Chen, B. K., Chen, C. J., Arakawa, T., Yoshimoto, T., Yamamoto, S. & Chang, W. C., 1997 Jan 7, In : Biochimica et Biophysica Acta - Lipids and Lipid Metabolism. 1344, 1, p. 38-46 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Epidermal growth factor-induced ANGPTL4 enhances anoikis resistance and tumour metastasis in head and neck squamous cell carcinoma

Liao, Y. H., Chiang, K. H., Shieh, J. M., Huang, C. R., Shen, C. J., Huang, W. C. & Chen, B. K., 2017 Apr 20, In : Oncogene. 36, 16, p. 2228-2242 15 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Epidermal growth factor-induced COX-2 regulates metastasis of head and neck squamous cell carcinoma through upregulation of angiopoietin-like 4

Chiang, K. H., Shieh, J. M., Shen, C. J., Chang, T. W., Wu, P. T., Hsu, J. Y., Tsai, J. P., Chang, W. C. & Chen, B. K., 2020 Jun 1, In : Cancer Science. 111, 6, p. 2004-2015 12 p.

Research output: Contribution to journalArticle

Open Access

Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation

Hsu, J. Y., Chang, K. Y., Chen, S. H., Lee, C. T., Chang, S. T., Cheng, H. C., Chang, W. C. & Chen, B. K., 2015, In : Oncotarget. 6, 3, p. 1723-1739 17 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
3 Citations (Scopus)

Epidermal Growth Factor Protects Squamous Cell Carcinoma against Cisplatin-Induced Cytotoxicity through Increased Interleukin-1β Expression

Ko, S. C., Huang, C. R., Shieh, J. M., Yang, J. H., Chang, W. C. & Chen, B. K., 2013 Feb 1, In : PloS one. 8, 2, e55795.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Epidermal growth factor receptor is a preferred target for treating Amyloid-β-induced memory loss

Wang, L., Chiang, H. C., Wu, W., Liang, B., Xie, Z., Yao, X., Ma, W., Du, S. & Zhong, Y., 2012 Oct 9, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 41, p. 16743-16748 6 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Epigenetic inactivation of the chromosomal stability control genes BRCA1 BRCA2, and XRCC5 in non-small cell lung cancer

Lee, M. N., Tseng, R. C., Hsu, H. S., Chen, J. Y., Tzao, C., Ho, W. L. & Wang, Y. C., 2007 Feb 1, In : Clinical Cancer Research. 13, 3, p. 832-838 7 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression

Su, C. L., Su, C. W., Hsiao, Y. H. & Gean, P. W., 2016 May 1, In : Journal of Psychiatric Research. 76, p. 101-110 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer

Ding, L. Y., Hou, Y. C., Kuo, I. Y., Hsu, T. Y., Tsai, T. C., Chang, H. W., Hsu, W. Y., Tsao, C. C., Tian, C. C., Wang, P. S., Wang, H. C., Lee, C. T., Wang, Y. C., Lin, S. H., Hughes, M. W., Chuang, W. J., Lu, P. J., Shan, Y. S. & Huang, P. H., 2020 Jun 17, In : Clinical Epigenetics. 12, 1, 87.

Research output: Contribution to journalArticle

Open Access

Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type β-catenin nuclear accumulation in lung tumorigenesis

Tseng, R. C., Lin, R. K., Wen, C. K., Tseng, C., Hsu, H. S., Hsu, W. H. & Wang, Y. C., 2008 Jul 24, In : Oncogene. 27, 32, p. 4488-4496 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Epigenetic silencing of CCAAT/enhancer-binding protein δ activity by YY1/polycomb group/DNA methyltransferase complex

Ko, C. Y., Hsu, H. C., Shen, M. R., Chang, W. C. & Wang, J. M., 2008 Nov 7, In : Journal of Biological Chemistry. 283, 45, p. 30919-30932 14 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Epileptiform activity induced by 4-aminopyridine in rat amygdala neurons: the involvement of N-methyl-D-aspartate receptors

Gean, P. W., Chou, S. M. & Chang, F. C., 1990 Aug 10, In : European Journal of Pharmacology. 184, 2-3, p. 213-221 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Epileptiform activity induced by magnesium-free solution in slices of rat amygdala: Antagonism by N-methyl-d-aspartate receptor antagonists

Gean, P. W. & Shinnick-Gallagher, P., 1988 Jun, In : Neuropharmacology. 27, 6, p. 557-562 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
203 Citations (Scopus)

Epithelial-mesenchymal transition in cervical carcinoma

Lee, M. Y. & Shen, M-R., 2012 Feb 9, In : American Journal of Translational Research. 4, 1, p. 1-13 13 p.

Research output: Contribution to journalReview article

93 Citations (Scopus)

Eps8 decreases chemosensitivity and affects survival of cervical cancer patients

Chen, Y. J., Shen, M. R., Chen, Y. J., Maa, M. C. & Leu, T. H., 2008 Oct 15, In : Molecular Cancer Therapeutics. 7, 6, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

EPS8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase

Maa, M. C., Lee, J-C., Chen, Y. J., Chen, Y. J., Lee, Y. C., Wang, S-T., Huang, C. C., Chow, N-H. & Leu, T-H., 2007 Jul 6, In : Journal of Biological Chemistry. 282, 27, p. 19399-19409 11 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages

Chen, Y. J., Hsieh, M. Y., Chang, M. Y., Chen, H. C., Jan, M. S., Maa, M. C. & Leu, T. H., 2012 May 25, In : Journal of Biological Chemistry. 287, 22, p. 18806-18819 14 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages

Chuang, J. P., Kao, C. Y., Lee, J. C., Ling, P., Maa, M. C. & Leu, T. H., 2020 Sep 24, In : Biochemical and Biophysical Research Communications. 530, 3, p. 487-493 7 p.

Research output: Contribution to journalArticle

Open Access

Erratum: Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Cai, Z., Jitkaew, S., Zhao, J., Chinag, H., Choksi, S., Liu, J., Ward, Y., Wu, L. G. & Liu, Z. G., 2014 Feb 1, In : Nature Cell Biology. 16, 2, 1 p.

Research output: Contribution to journalComment/debate

82 Citations (Scopus)