Research Output

Multiple genetic and epigenetic biomarkers for lung cancer detection in cytologically negative sputum and a nested case-control study for risk assessment

Hsu, H. S., Chen, T. P., Wen, C. K., Hung, C. H., Chen, C. Y., Chen, J. T. & Wang, Y. C., 2007 Dec 1, In : Journal of Pathology. 213, 4, p. 412-419 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Multiple origins of replication in the dihydrofolate reductase amplicons of a methotrexate-resistant Chinese hamster cell line

Ma, C., Leu, T. H. & Hamlin, J. L., 1990, In : Molecular and Cellular Biology. 10, 4, p. 1338-1346 9 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Muscarinic depression of excitatory synaptic transmission mediated by the presynaptic M3 receptors in the rat neostriatum

Hsu, K. S., Huang, C. C. & Gean, P. W., 1995 Sep 8, In : Neuroscience Letters. 197, 2, p. 141-144 4 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Mushroom body glycolysis is required for olfactory memory in Drosophila

Wu, C. L., Chang, C. C., Wu, J. K., Chiang, M. H., Yang, C. H. & Chiang, H. C., 2018 Apr, In : Neurobiology of Learning and Memory. 150, p. 13-19 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila

Lee, W. P., Chiang, M. H., Chang, L. Y., Lee, J. Y., Tsai, Y. L., Chiu, T. H., Chiang, H. C., Fu, T. F., Wu, T. & Wu, C. L., 2020 Aug, In : PLoS genetics. 16, 8, e1008963.

Research output: Contribution to journalArticle

Open Access

Mutation of the PTCH1 gene predicts recurrence of breast cancer

Wang, C. Y., Chang, Y. C., Kuo, Y. L., Lee, K. T., Chen, P. S., Cheung, C. H. A., Chang, C. P., Phan, N. N., Shen, M. R. & Hsu, H. P., 2019 Nov 8, In : Scientific reports. 9, 1, 1 p., 16359.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
3 Citations (Scopus)
23 Citations (Scopus)

Myostatin Is Associated With Cognitive Decline in an Animal Model of Alzheimer’s Disease

Lin, Y. S., Lin, F. Y. & Hsiao, Y. H., 2019 Mar 1, In : Molecular Neurobiology. 56, 3, p. 1984-1991 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
17 Citations (Scopus)

Network-based analysis identifies epigenetic biomarkers of esophageal squamous cell carcinoma progression

Cheng, C. P., Kuo, I. Y., Alakus, H., Frazer, K. A., Harismendy, O., Wang, Y. C. & Tseng, V. S., 2014 May 28, In : Bioinformatics. 30, 21, p. 3054-3061 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Neuroprotective effect of N-acetylcysteine on neuronal apoptosis induced by a synthetic gingerdione compound: Involvement of ERK and p38 phosphorylation

Lin, C. H., Kuo, S. C., Huang, L. J. & Gean, P-W., 2006 Nov 15, In : Journal of Neuroscience Research. 84, 7, p. 1485-1494 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons

Lin, Y. C., Chou, L. C., Chen, S. C., Kuo, S. C., Huang, L. J. & Gean, P. W., 2009 Jun 15, In : Bioorganic and Medicinal Chemistry Letters. 19, 12, p. 3225-3228 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Neuroprotective Effects of Ugonin K on Hydrogen Peroxide-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells

Lin, Y. C., Huang, Y. C., Chen, S. C., Liaw, C. C., Kuo, S. C., Huang, L. J. & Gean, P-W., 2009 May 1, In : Neurochemical Research. 34, 5, p. 923-930 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
15 Citations (Scopus)

Novel 2-step synthetic indole compound 1,1,3-tri(3-indolyl)cyclohexane inhibits cancer cell growth in lung cancer cells and xenograft models

Lee, C. H., Yao, C. F., Huang, S. M., Ko, S., Tan, Y. H., Lee-Chen, G. J. & Wang, Y. C., 2008 Aug 15, In : Cancer. 113, 4, p. 815-825 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Novel lead generation through hypothetical pharmacophore three-dimensional database searching: Discovery of isoflavonoids as nonsteroidal inhibitors of rat 5α-reductase

Chen, G. S., Chang, C. S., Kan, W-M., Chang, C. L., Wang, K. C. & Chern, J. W., 2001 Nov 8, In : Journal of Medicinal Chemistry. 44, 23, p. 3759-3763 5 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Nucleolin regulates c-Jun/Sp1-dependent transcriptional activation of cPLA2α in phorbol ester-treated non-small cell lung cancer A549 cells

Tsou, J. H., Chang, K. Y., Wang, W. C., Tseng, J. T., Su, W. C., Hung, L. Y., Chang, W. C. & Chen, B. K., 2008 Jan, In : Nucleic acids research. 36, 1, p. 217-227 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

O6-methylguanine DNA methyltransferase repairs platinum-DNA adducts following cisplatin treatment and predicts prognoses of nasopharyngeal carcinoma

Chen, S. H., Kuo, C. C., Li, C. F., Cheung, C. H. A., Tsou, T. C., Chiang, H. C., Yang, Y. N., Chang, S. L., Lin, L. C., Pan, H. Y., Chang, K. Y. & Chang, J. Y., 2015 Sep 1, In : International Journal of Cancer. 137, 6, p. 1291-1305 15 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
79 Citations (Scopus)

Oleate-induced PTX3 promotes head and neck squamous cell carcinoma metastasis through the up-regulation of vimentin

Chan, S. H., Tsai, J. P., Shen, C. J., Liao, Y. H. & Chen, B. K., 2017, In : Oncotarget. 8, 25, p. 41364-41378 15 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin

Shen, C. J., Chan, S-H., Lee, C-T., Huang, W. C., Tsai, J. P. & Chen, B-K., 2017 Feb 1, In : Cancer Letters. 386, p. 110-122 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Oleic acid-induced NOX4 is dependent on ANGPTL4 expression to promote human colorectal cancer metastasis

Shen, C. J., Chang, K. Y., Lin, B. W., Lin, W. T., Su, C. M., Tsai, J. P., Liao, Y. H., Hung, L. Y., Chang, W. C. & Chen, B. K., 2020, In : Theranostics. 10, 16, p. 7083-7099 17 p.

Research output: Contribution to journalArticle

Open Access

Oncogenic MCT-1 activation promotes YY1-EGFR-MnSOD signaling and tumor progression

Tseng, H., Chen, Y., Jen, J., Shen, P., Chen, L., Lin, T., Wang, Y-C. & Hsu, H., 2017 Apr 1, In : Oncogenesis. 6, 4, p. e313-e313

Research output: Contribution to journalArticle

12 Citations (Scopus)
5 Citations (Scopus)

Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer

Jen, J., Lin, L. L., Chen, H. T., Liao, S. Y., Lo, F. Y., Tang, Y. A., Su, W. C., Salgia, R., Hsu, C. L., Huang, H. C., Juan, H. F. & Wang, Y. C., 2016 May 5, In : Oncogene. 35, 18, p. 2357-2369 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

One-pot synthesis of ene-lactams via N-debenzylation of keto-containing N-2,4-dimethoxylbenzylamides

Kan, W. M., Cheng, C. L. & Chern, C. Y., 2004 Dec 30, In : Synthetic Communications. 34, 23, p. 4257-4264 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Organization and genesis of dihydrofolate reductase amplicons in the genome of a methotrexate-resistant Chinese hamster ovary cell line

Ma, C., Looney, J. E., Leu, T. H. & Hamlin, J. L., 1988, In : Molecular and Cellular Biology. 8, 6, p. 2316-2327 12 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Origins of replication: timing and chromosomal position

Hamlin, J. L., Vaughn, J. P., Dijkwel, P. A., Leu, T. H. & Ma, C., 1991 Jun, In : Current Opinion in Cell Biology. 3, 3, p. 414-421 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
18 Citations (Scopus)

Overexpression of c-Fos enhances the transcription of human arachidonate 12-lipoxygenase in A431 cells

Chen, B. K. & Chang, W. C., 1999 Aug 11, In : Biochemical and Biophysical Research Communications. 261, 3, p. 848-852 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Overexpression of Ha-ras enhances the transcription of human arachidonate 12-lipoxygenase promoter in A431 cells

Chen, B. K., Liu, Y. W., Yamamoto, S. & Chang, W. C., 1997 Feb 18, In : Biochimica et Biophysica Acta - Lipids and Lipid Metabolism. 1344, 3, p. 270-277 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
64 Citations (Scopus)

Overexpression of p97Eps8 leads to cellular transformatioan: Implication of pleckstrin homology domain in p97Eps8-mediated ERK activation

Maa, M. C., Hsieh, C. Y. & Leu, T. H., 2001 Jan 1, In : Oncogene. 20, 1, p. 106-112 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Overexpression of PAFAH1B1 is associated with tumor metastasis and poor survival in non-small cell lung cancer

Lo, F. Y., Chen, H. T., Cheng, H. C., Hsu, H. S. & Wang, Y. C., 2012 Sep 1, In : Lung Cancer. 77, 3, p. 585-592 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
49 Citations (Scopus)

p53 Codon 72 polymorphism in Taiwanese lung cancer patients: Association with lung cancer susceptibility and prognosis

Wang, Y-C., Chen, C. Y., Chen, S. K., Chang, Y. Y. & Lin, P., 1999 Jan 28, In : Clinical Cancer Research. 5, 1, p. 129-134 6 p.

Research output: Contribution to journalArticle

165 Citations (Scopus)

p53 modulates the effect of ribosomal protein S6 kinase1 (S6K1) on cisplatin toxicity in chronic myeloid leukemia cells

Xiao, L. Y. & Kan, W-M., 2017 May 1, In : Pharmacological Research. 119, p. 443-462 20 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Paired‐pulse depression of the N‐methyl‐D‐aspartate receptor‐mediated synaptic potentials in the amygdala

Huang, CC. C. & Gean, PW. W., 1994 Nov, In : British Journal of Pharmacology. 113, 3, p. 1029-1035 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Pairing of pre- and postsynaptic activities in hippocampal CA1 neurons induces long-term modifications of NMDA receptor-mediated synaptic potential

Lin, J. H., Way, L. J. & Gean, P. W., 1993 Feb 12, In : Brain Research. 603, 1, p. 117-120 4 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Participation of p97Eps8 in Src-mediated Transformation

Leu, T. H., Yeh, H. H., Huang, C. C., Chuang, Y. C., Su, S. L. & Maa, M. C., 2004 Mar 12, In : Journal of Biological Chemistry. 279, 11, p. 9875-9881 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Patients' perceptions and expectations of family participation in the informed consent process of elective surgery in taiwan

Lin, M. L., Kan, W. M. & Chen, C. H., 2012 Jun, In : Asian Nursing Research. 6, 2, p. 55-59 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Pax-2 and N-myc regulate epithelial cell proliferation and apoptosis in a positive autocrine feedback loop

Zhang, S. L., Chen, Y-W., Tran, S., Liu, F., Nestoridi, E., Hébert, M. J. & Ingelfinger, J. R., 2007 Jun 1, In : Pediatric Nephrology. 22, 6, p. 813-824 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Paxillin is a target for somatic mutations in lung cancer: Implications for cell growth and invasion

Jagadeeswaran, R., Surawska, H., Krishnaswamy, S., Janamanchi, V., Mackinnon, A. C., Seiwert, T. Y., Loganathan, S., Kanteti, R., Reichman, T., Nallasura, V., Schwartz, S., Faoro, L., Wang, Y. C., Girard, L., Tretiakova, M. S., Ahmed, S., Zumba, O., Soulii, L., Bindokas, V. P., Szeto, L. L. & 13 others, Gordon, G. J., Bueno, R., Sugarbaker, D., Lingen, M. W., Sattler, M., Krausz, T., Vigneswaran, W., Natarajan, V., Minna, J., Vokes, E. E., Ferguson, M. K., Husain, A. N. & Salgia, R., 2008 Jan 1, In : Cancer Research. 68, 1, p. 132-142 11 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Pentoxifylline stimulates human sperm motility both in vitro and after oral therapy.

Shen, M-R., Chiang, P., Yang, R., Hong, C. & Chen, S., 1991 Jun 1, In : British Journal of Clinical Pharmacology. 31, 6, p. 711-714

Research output: Contribution to journalArticle

47 Citations (Scopus)

Perturbation of platelet adhesion to endothelial cells by plasminogen activation in vitro

Chen, H. I., Wu, Y. I., Hsieh, Y. L., Shi, G. Y., Jiang, M. J., Chang, W. C., Chuang, W. J., Kan, W. M., Tang, M. J. & Jen, C. J., 1997 Aug, In : Thrombosis and Haemostasis. 78, 2, p. 934-938 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Pharamacological characterization of excitaory synaptic potentials in rat basolateral amygdaloid neurons

Gean, P-W. & Chang, FC. C., 1992 Jan 1, In : Synapse. 11, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Phosphorylation of E-cadherin at threonine 790 by protein kinase Cδ reduces β-catenin binding and suppresses the function of E-cadherin

Chen, C. L., Wang, S. H., Chan, P. C., Shen, M. R. & Chen, H. C., 2016 Jan 1, In : Oncotarget. 7, 24, p. 37260-37276 17 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37

Tzeng, H. T., Li, T. H., Tang, Y. A., Tsai, C. H., Lu, P. J. F., Lai, W. W., Chiang, C. W. & Wang, Y. C., 2017, In : Oncotarget. 8, 65, p. 108556-108570 15 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

PI3 kinase signaling is involved in Aβ-induced memory loss in Drosophila

Chiang, H. C., Wang, L., Xie, Z., Yau, A. & Zhong, Y., 2010 Apr 13, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 15, p. 7060-7065 6 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)