Research Output

Selective N-debenzylation of amides with p-TsOH

Chern, C. Y., Huang, Y. P. & Kan, W. M., 2003 Jan 27, In : Tetrahedron Letters. 44, 5, p. 1039-1041 3 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Selective serotonin reuptake inhibitor, fluoxetine, impairs E-cadherin-mediated cell adhesion and alters calcium homeostasis in pancreatic beta cells

Chang, H. Y., Chen, S. L., Shen, M. R., Kung, M. L., Chuang, L. M. & Chen, Y. W., 2017 Dec 1, In : Scientific reports. 7, 1, 3515.

Research output: Contribution to journalArticle

6 Citations (Scopus)
95 Citations (Scopus)

Significance of migration-related genes (S100A9, MAGED4, C8orf30A, IL-8) in esophageal squamous cell carcinoma

Huang, C. T., Huang, G. C., Wu, P. S., Wu, L. W., Lin, S. H., Lai, W. W., Wang, Y. C. & Liu, H. S., 2012 Mar 1, In : Genomic Medicine, Biomarkers, and Health Sciences. 4, 1-2, p. 16-18 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Silver decorated copper oxide (Ag@CuO) nanocomposite enhances ROS-mediated bacterial architecture collapse

Kung, M., Tai, M., Lin, P., Wu, D., Wu, W., Yeh, B., Hung, H., Kuo, C., Chen, Y., Hsieh, S. & Hsieh, S., 2017 Jul 1, In : Colloids and Surfaces B: Biointerfaces. 155, p. 399-407

Research output: Contribution to journalArticle

Site-directed mutagenesis of cysteinyl and serine residues of human thromboxane A2 receptor in insect cells

Chiang, N., Kan, W. M. & Tai, H. H., 1996 Oct 1, In : Archives of Biochemistry and Biophysics. 334, 1, p. 9-17 9 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

SLIT2 attenuation during lung cancer progression deregulates β-catenin and E-cadherin and associates with poor prognosis

Tseng, R. C., Lee, S. H., Hsu, H. S., Chen, B. H., Tsai, W. C., Tzao, C. & Wang, Y-C., 2010 Jan 15, In : Cancer Research. 70, 2, p. 543-551 9 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis

Tsai, C. H., Cheng, H. C., Wang, Y. S., Lin, P., Jen, J., Kuo, I. Y., Chang, Y. H., Liao, P. C., Chen, R. H., Yuan, W. C., Hsu, H. S., Yang, M. H., Hsu, M. T., Wu, C. Y. & Wang, Y. C., 2014 Sep 3, In : Nature communications. 5, 4804.

Research output: Contribution to journalArticle

24 Citations (Scopus)

SNARE Proteins Synaptobrevin, SNAP-25, and Syntaxin Are Involved in Rapid and Slow Endocytosis at Synapses

Xu, J., Luo, F., Zhang, Z., Xue, L., Wu, X. S., Chiang, H. C., Shin, W. & Wu, L. G., 2013 May 30, In : Cell Reports. 3, 5, p. 1414-1421 8 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
62 Citations (Scopus)

Social isolation-induced increase in NMDA receptors in the hippocampus exacerbates emotional dysregulation in mice

Chang, C. H., Hsiao, Y. H., Chen, Y. W., Yu, Y. J. & Gean, P. W., 2015 Apr 1, In : Hippocampus. 25, 4, p. 474-485 12 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Soft substrate induces apoptosis by the disturbance of Ca2+ homeostasis in renal epithelial LLC-PK1 cells

Chiu, W-T., Wang, Y. H., Tang, M-J. & Shen, M-R., 2007 Aug 1, In : Journal of Cellular Physiology. 212, 2, p. 401-410 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
30 Citations (Scopus)

Sonic hedgehog signaling regulates amygdalar neurogenesis and extinction of fear memory

Hung, H. C., Hsiao, Y. H. & Gean, P. W., 2015 Oct, In : European Neuropsychopharmacology. 25, 10, p. 1723-1732 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
Open Access
3 Citations (Scopus)

SPAK mediates KCC3-enhanced cervical cancer tumorigenesis

Chiu, M. H., Liu, H. S., Wu, Y. H., Shen, M. R. & Chou, C. Y., 2014 May, In : FEBS Journal. 281, 10, p. 2353-2365 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Spontaneous epileptiform activity and alteration of GABA- and of NMDA-mediated neurotransmission in amygdala neurons kindled in vivo

Gean, P. W., Shinnick-Gallagher, P. & Anderson, A. C., 1989 Aug 7, In : Brain Research. 494, 1, p. 177-181 5 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Src is required for migration, phagocytosis, and interferon beta production in Toll-like receptor-engaged macrophages

Maa, M. C. & Leu, T. H., 2016 Sep, In : BioMedicine (Netherlands). 6, 3, p. 5-9 5 p., e65.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Src oncogene activates MMP-2 expression via the ERK/Sp1 pathway

Kuo, L., Chang, H. C., Leu, T. H., Maa, M. C. & Hung, W. C., 2006 Jun 1, In : Journal of Cellular Physiology. 207, 3, p. 729-734 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

ST2 Signaling in the Tumor Microenvironment

Chang, C. P., Hu, M. H., Hsiao, Y. P. & Wang, Y. C., 2020 Jan 1, Advances in Experimental Medicine and Biology. Springer, p. 83-93 11 p. (Advances in Experimental Medicine and Biology; vol. 1240).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Stable association of pp60(src) and pp59(fyn) with the focal adhesion- associated protein tyrosine kinase, pp125(FAK)

Cobb, B. S., Schaller, M. D., Leu, T. H. & Parsons, J. T., 1994, In : Molecular and Cellular Biology. 14, 1, p. 147-155 9 p.

Research output: Contribution to journalArticle

473 Citations (Scopus)

STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion

Chen, Y-W., Chen, Y. F., Chiu, W. T., Chen, H. C. & Shen, M. R., 2017 Dec 1, In : Scientific reports. 7, 1, 11523.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Stimulating ERK/PI3K/NFκB signaling pathways upon activation of mGluR2/3 restores OGD-induced impairment in glutamate clearance in astrocytes

Lin, C. H., You, J. R., Wei, K. C. & Gean, P. W., 2014 Jan 1, In : European Journal of Neuroscience. 39, 1, p. 83-96 14 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Store-Operated Ca2+ entry in tumor progression: From molecular mechanisms to clinical implications

Chen, Y. F., Lin, P. C., Yeh, Y. M., Chen, L. H. & Shen, M. R., 2019 Jul, In : Cancers. 11, 7, 899.

Research output: Contribution to journalReview article

Open Access
11 Citations (Scopus)
17 Citations (Scopus)

Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo

Chiu, H. W., Yeh, Y. L., Wang, Y. C., Huang, W. J., Chen, Y. A., Chiou, Y. S., Ho, S. Y., Lin, P. & Wang, Y. J., 2013 Oct 10, In : PloS one. 8, 10, e76340.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Sumoylation of Specificity Protein 1 Augments Its Degradation by Changing the Localization and Increasing the Specificity Protein 1 Proteolytic Process

Wang, Y. T., Chuang, J. Y., Shen, M. R., Yang, W. B., Chang, W. C. & Hung, J. J., 2008 Jul 25, In : Journal of Molecular Biology. 380, 5, p. 869-885 17 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Suppression of 4-aminopyridine-induced paroxysmal depolarizing shift in rat amygdaloid neurons by diltiazem

Gean, P. W. & Chou, S. M., 1991 Sep 27, In : Brain Research. 560, 1-2, p. 306-310 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Survivin - biology and potential as a therapeutic target in oncology

Antonio Cheung, C. H., Huang, C. C., Tsai, F. Y., Lee, J. Y. C., Cheng, S. M., Chang, Y. C., Huang, Y. C., Chen, S. H. & Chang, J. Y., 2013, In : OncoTargets and Therapy. 6, p. 1453-1462 10 p.

Research output: Contribution to journalReview article

98 Citations (Scopus)

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

Cheung, C. H. A., Chen, H. H., Kuo, C. C., Chang, C. Y., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 Jul 3, In : Molecular cancer. 8, 43.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Sustained enhancement of NMDA receptor-mediated synaptic potential by isoproterenol in rat amygdalar slices

Gean, P. W., Huang, C. C., Lin, J. H. & Tsai, J. J., 1992 Oct 30, In : Brain Research. 594, 2, p. 331-334 4 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
30 Citations (Scopus)

Synaptic expression of glutamate receptor after encoding of fear memory in the rat amygdala

Yeh, S. H., Mao, S. C., Lin, H. C. & Gean, P. W., 2006 Jan, In : Molecular Pharmacology. 69, 1, p. 299-308 10 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Synergistic effects of dopamine and Zn 2+ on the induction of PC12 cell death and dopamine depletion in the striatum: Possible implication in the pathogenesis of Parkinson's disease

Lo, H. S., Chinag, H., Lin, A. M. Y., Chiang, H. Y., Chu, Y. C. & Kao, L. S., 2004 Oct 1, In : Neurobiology of Disease. 17, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Synergistic inhibition of tumor growth by combination treatment with drugs against different subpopulations of glioblastoma cells

Chang, C. H., Liu, W. T., Hung, H. C., Gean, C. Y., Tsai, H. M., Su, C. L. & Gean, P. W., 2017 Dec 29, In : BMC cancer. 17, 1, 905.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Synthesis and Biological Evaluation of ortho-Aryl N-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors

Huang, W. J., Wang, Y. C., Chao, S. W., Yang, C. Y., Chen, L. C., Lin, M. H., Hou, W. C., Chen, M. Y., Lee, T. L., Yang, P. & Chang, C. I., 2012 Oct 1, In : ChemMedChem. 7, 10, p. 1815-1824 10 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Synthesis of 1-(2-Carboxyethylbenzyl)-2-benzenesulfonamidobicyclo[2.2.1]heptane: A Novel Potent Thromboxane Antagonist

Kan, W. M., Chern, C. Y. & Su, S. F., 1998 Jan 1, In : Journal of the Chinese Chemical Society. 45, 6, p. 711-712 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis of 2-[4-(imidazolin-2-ylideneamino)benzyl]-Indan-1-ones as novel potent prostacyclin antagonists

Chern, C. Y., Yek, Y. L., Chen, Y. L. & Kan, W. M., 2008 Jan 1, In : Journal of the Chinese Chemical Society. 55, 4, p. 846-853 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis of 4-Aza-3-oxo-androstane-17β-carboxylic Acid, a Key Intermediate for the Preparation of Potent 5α-Reductase Inhibitors

Kan, W-M., Yek, Y. L., Wang, Y. H. & Chern, C. Y., 2003 Jun 1, In : Chinese Pharmaceutical Journal. 55, 3, p. 213-219 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1 Citation (Scopus)

Synthesis of steroid intermediates via alkylation of dianion derived from acetoacetic ester

Wang, K. C., Liang, C. H., Kan, W-M. & Lee, S. S., 1994 Jan 1, In : Bioorganic and Medicinal Chemistry. 2, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
Open Access

Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway

Chen, K. L., Chang, W. S. W., Cheung, C. H. A., Lin, C. C., Huang, C. C., Yang, Y. N., Kuo, C. P., Kuo, C. C., Chang, Y. H., Liu, K. J., Wu, C. M. & Chang, J. Y., 2012 Apr 1, In : Cancer Letters. 317, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistant cancers

Chi, J. Y., Hsiao, Y. W., Li, C. F., Lo, Y. C., Lin, Z. Y., Hong, J. Y., Liu, Y. M., Han, X., Wang, S. M., Chen, B. K., Tsai, K. K. & Wang, J. M., 2015, In : Oncotarget. 6, 27, p. 23987-24001 15 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
37 Citations (Scopus)

Targeting interleukin-20 alleviates paclitaxel-induced peripheral neuropathy

Chen, L. H., Yeh, Y. M., Chen, Y. F., Hsu, Y. H., Wang, H. H., Lin, P. C., Chang, L. Y., Lin, C. C. K., Chang, M. S. & Shen, M. R., 2020 Jun 1, In : Pain. 161, 6, p. 1237-1254 18 p.

Research output: Contribution to journalArticle

Tetrahydro-9-aminoacridine presynaptically inhibits glutamatergic transmission in the rat amygdala

Wang, S. J., Huang, C. C. & Gean, P. W., 1995, In : Brain Research Bulletin. 37, 3, p. 325-327 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

TGF-beta1 increases cell rigidity by enhancing expression of smooth muscle actin: Keloid-derived fibroblasts as a model for cellular mechanics

Lee, C. H., Hong, C. H., Chen, Y. T., Chen, Y. C. & Shen, M-R., 2012 Sep 1, In : Journal of Dermatological Science. 67, 3, p. 173-180 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)