Research Output

Article

4(R)- And 4(S)-(5-phenylpentyl)-glutamic Acids Attenuate Excitatory Postsynaptic Potential on Hippocampus without Inhibiting Postsynaptic NMDA and AMPA Receptors

Tyan, S. H., Chang, H., Gean, P. W., Hon, Y. S. & Chang, Y. C., 1996 Jan 1, In : Chinese Journal of Physiology. 39, 2, p. 131-137 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
21 Citations (Scopus)

5′CpG island hypermethylation and aberrant transcript splicing both contribute to the inactivation of the FHIT gene in resected non-small cell lung cancer

Tzao, C., Tsai, H. Y., Chen, J. T., Chen, C. Y. & Wang, Y. C., 2004 Sep, In : European Journal of Cancer. 40, 14, p. 2175-2183 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

5′cytosine-Phospho-Guanine island methylation is responsible for p14ARF inactivation and inversely correlates with p53 overexpression in resected non-small cell lung cancer

Hsu, H. S., Wang, Y. C., Tseng, R. C., Chang, J. W., Chen, J. T., Shih, C. M., Chen, C. Y. & Wang, Y. C., 2004 Jul 15, In : Clinical Cancer Research. 10, 14, p. 4734-4741 8 p.

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33 Citations (Scopus)

A 3D-QSAR study of celebrex-based PDK1 inhibitors using CoMFA method

Wang, W. H., Jena, N. R., Wang, Y. C. & Sun, Y. C., 2009 Jan 1, In : Journal of the Chinese Chemical Society. 56, 1, p. 59-64 6 p.

Research output: Contribution to journalArticle

Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells

Tsou, J. H., Chang, K-C., Chang-Liao, P. Y., Yang, S. T., Lee, C-T., Chen, Y-P., Lee, Y. C., Lin, P-W., Lee, J-C., Shen, M-R., Chuang, C. K., Chang, W. C., Wang, J-M. & Hung, L-Y., 2011 Oct 1, In : Journal of Pathology. 225, 2, p. 243-254 12 p.

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22 Citations (Scopus)

A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF-α therapy

Cheung, C. H. A., Sun, X., Kanwar, J. R., Bai, J. Z., Cheng, L. T. & Krissansen, G. W., 2010 Oct 1, In : Cancer Cell International. 10, 36.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Acetylation of nuclear factor-κB in rat amygdala improves long-term but not short-term retention of fear memory

Yeh, S. H., Lin, C. H. & Gean, P. W., 2004 May 1, In : Molecular Pharmacology. 65, 5, p. 1286-1292 7 p.

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175 Citations (Scopus)

Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane

Wen, P. J., Grenklo, S., Arpino, G., Tan, X., Liao, H. S., Heureaux, J., Peng, S. Y., Chiang, H. C., Hamid, E., Zhao, W. D., Shin, W., Näreoja, T., Evergren, E., Jin, Y., Karlsson, R., Ebert, S. N., Jin, A., Liu, A. P., Shupliakov, O. & Wu, L. G., 2016 Aug 31, In : Nature communications. 7, 12604.

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56 Citations (Scopus)

Actions of isoproterenol on amygdalar neurons in vitro

Huang, C. C., Tsai, J. J. & Gean, P-W., 1994 Jan 1, In : Chinese Journal of Physiology. 37, 2, p. 73-78 6 p.

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11 Citations (Scopus)

Activating protein 1-mediated cyclooxygenase-2 expression is independent of N-terminal phosphorylation of c-Jun

Chen, L. C., Chen, B-K. & Chang, W. C., 2005 Jun 1, In : Molecular Pharmacology. 67, 6, p. 2057-2069 13 p.

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22 Citations (Scopus)

Activation of a mammalian origin of replication by chromosomal rearrangement

Leu, T-H. & Hamlin, J. L., 1992 Jan 1, In : Molecular and Cellular Biology. 12, 6, p. 2804-2812 9 p.

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9 Citations (Scopus)

Activation of group II metabotropic glutamate receptors induces depotentiation in amygdala slices and reduces fear-potentiated startle in rats

Lin, C. H., Lee, C. C., Huang, Y. C., Wang, S. J. & Gean, P. W., 2005 Mar 1, In : Learning and Memory. 12, 2, p. 130-137 8 p.

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37 Citations (Scopus)

Activation of group II metabotropic glutamate receptors induces long-term depression of synaptic transmission in the rat amygdala

Wang, H. C., Lin, S. J., Luo, M. Z. & Gean, P. W., 2000 Dec 15, In : Journal of Neuroscience. 20, 24, p. 9017-9024 8 p.

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51 Citations (Scopus)
17 Citations (Scopus)

Adenosine Stimulates Human Sperm Motility via A2 Receptors

SHEN, MENGRU. R., LINDEN, JOEL., CHIANG, POHUI. H., CHEN, SHUNSHENG. S. & WU, SHENGNAN. N., 1993 Jul, In : Journal of Pharmacy and Pharmacology. 45, 7, p. 650-653 4 p.

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26 Citations (Scopus)
78 Citations (Scopus)

A Fluorogenic Molecule for Probing Islet Amyloid Using Flavonoid as a Scaffold Design

Chen, W. L., Ma, S. T., Chen, Y. W., Chao, Y. C., Chan, A. C., Tu, L. H. & Liu, W. M., 2020 Apr 21, In : Biochemistry. 59, 15, p. 1482-1492 11 p.

Research output: Contribution to journalArticle

Aging and exercise affect hippocampal neurogenesis via different mechanisms

Yang, T. T., Lo, C. P., Tsai, P. S., Wu, S. Y., Wang, T. F., Chen, Y. W., Jiang-Shieh, Y. F. & Kuo, Y. M., 2015 Jul 6, In : PloS one. 10, 7, e0132152.

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16 Citations (Scopus)

Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity

Chen, Y. R., Li, Y. H., Hsieh, T. C., Wang, C. M., Cheng, K. C., Wang, L., Lin, T. Y., Cheung, C. H. A., Wu, C. L. & Chiang, H. C., 2019 Aug, In : Aging Cell. 18, 4, e12989.

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Open Access
2 Citations (Scopus)

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., 2017 May 15, In : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

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11 Citations (Scopus)

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., 2014 Apr 28, In : Cancer Letters. 346, 1, p. 84-93 10 p.

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18 Citations (Scopus)

AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression

Liao, S. Y., Kuo, I. Y., Chen, Y. T., Liao, P. C., Liu, Y. F., Wu, H. Y., Lai, W. W. & Wang, Y. C., 2019 Oct 10, In : Oncogene. 38, 41, p. 6723-6736 14 p.

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2 Citations (Scopus)

Alteration of DNA methyltransferases contributes to 5′CpG methylation and poor prognosis in lung cancer

Lin, R. K., Hsu, H. S., Chang, J. W., Chen, C. Y., Chen, J. T. & Wang, Y. C., 2007 Feb 1, In : Lung Cancer. 55, 2, p. 205-213 9 p.

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172 Citations (Scopus)

Alterations of excitatory transmission in the lateral amygdala during expression and extinction of fear memory

Lin, H. C., Mao, S. C., Su, C. L. & Gean, P. W., 2010 Apr 1, In : International Journal of Neuropsychopharmacology. 13, 3, p. 335-345 11 p.

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24 Citations (Scopus)

Alterations of the p16INK4a gene in resected nonsmall cell lung tumors and exfoliated cells within sputum

Chen, J. T., Chen, Y. C., Wang, Y. C., Tseng, R. C., Chen, C. Y. & Wang, Y-C., 2002 Apr 10, In : International Journal of Cancer. 98, 5, p. 724-731 8 p.

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46 Citations (Scopus)
30 Citations (Scopus)
16 Citations (Scopus)

Amplification of DNA Sequences in Mammalian Cells

Hamlin, J. L., Leu, T. H., Vaughn, J. P., Ma, C. & Dijkwel, P. A., 1991 Jan 1, In : Progress in Nucleic Acid Research and Molecular Biology. 41, C, p. 203-239 37 p.

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39 Citations (Scopus)

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

Lai, C., Xie, C., McCormack, S. G., Chiang, H. C., Michalak, M. K., Lin, X., Chandran, J., Shim, H., Shimoji, M., Cookson, M. R., Huganir, R. L., Rothstein, J. D., Price, D. L., Wong, P. C., Martin, L. J., Zhu, J. J. & Cai, H., 2006 Nov 8, In : Journal of Neuroscience. 26, 45, p. 11798-11806 9 p.

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62 Citations (Scopus)

Analysis of carbamazepine's anticonvulsant actions in hippocampal and amygdaloid slices of the rat

Gean, P. W., Huang, C. C., Kuo, J. R., Lin, J. H., Yi, P. L. & Tsai, J. J., 1993 Jan 1, In : Chinese Journal of Physiology. 36, 4, p. 199-204 6 p.

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5 Citations (Scopus)

Analysis of K-ras gene mutations in lung carcinomas: Correlation with gender, histological subtypes, and clinical outcome

Wang, Y. C., Lee, H. S., Chen, S. K., Yang, S. C. & Chen, C. Y., 1998 Oct 27, In : Journal of Cancer Research and Clinical Oncology. 124, 9, p. 517-522 6 p.

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35 Citations (Scopus)

An E3 ubiquitin ligase: C-Cbl: A new therapeutic target of lung cancer

Lo, F. Y., Tan, Y. H. C., Cheng, H. C., Salgia, R. & Wang, Y. C., 2011 Dec 1, In : Cancer. 117, 23, p. 5344-5350 7 p.

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23 Citations (Scopus)

Angiotensin II type II receptor deficiency accelerates the development of nephropathy in type i diabetes via oxidative stress and ACE2

Chang, S. Y., Chen, Y. W., Chenier, I., Tran, S. L. M. & Zhang, S. L., 2011 Dec 1, In : Experimental Diabetes Research. 2011, 521076.

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35 Citations (Scopus)

An increase in reactive oxygen species by deregulation of ARNT enhances chemotherapeutic drug-induced cancer cell death

Shieh, J. M., Shen, C. J., Chang, W. C., Cheng, H. C., Chan, Y. Y., Huang, W. C., Chang, W. C. & Chen, B. K., 2014 Jun 12, In : PloS one. 9, 6, e99242.

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15 Citations (Scopus)

Anion exchanger isoform 2 operates in parallel with Na+/H+ exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells

Shen, M. R., Wilkins, R. J., Chou, C. Y. & Ellory, J. C., 2002 Feb 13, In : FEBS Letters. 512, 1-3, p. 52-58 7 p.

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16 Citations (Scopus)

Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms

Wang, C. Y., Chen, C. L., Tseng, Y. L., Fang, Y. T., Lin, Y. S., Su, W. C., Chen, C. C., Chang, K. C., Wang, Y. C. & Lin, C. F., 2012 Sep 21, In : Journal of Biological Chemistry. 287, 39, p. 32512-32524 13 p.

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45 Citations (Scopus)
27 Citations (Scopus)

A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer

Tang, Y. A., Wen, W. L., Chang, J. W., Wei, T. T., Tan, Y. H. C., Salunke, S., Chen, C. T., Chen, C. S. & Wang, Y. C., 2010 Nov 1, In : PloS one. 5, 9, p. 1-13 13 p., e12417.

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Open Access
41 Citations (Scopus)

A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Wu, Y. H., Hong, C. W., Wang, Y. C., Huang, W. J., Yeh, Y. L., Wang, B. J., Wang, Y. J. & Chiu, H. W., 2017 Aug 1, In : Cancer Letters. 400, p. 79-88 10 p.

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9 Citations (Scopus)

A novel NMDA receptor antagonist protects against N-methyl-D-aspartate- and glutamate-induced neurotoxicity in the goldfish retina

Tyan, S. H., Sue, T. Y., Hon, Y. S., Gean, P. W. & Chang, Y. C., 1997 Feb 26, In : European Journal of Pharmacology. 321, 2, p. 171-179 9 p.

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6 Citations (Scopus)

A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways

Chen, J. Y., Tang, Y. A., Huang, S. M., Juan, H. F., Wu, L. W., Sun, Y. C., Wang, S. C., Wu, K. W., Balraj, G., Chang, T. T., Li, W. S., Cheng, H. C. & Wang, Y. C., 2011 Jan 15, In : Cancer Research. 71, 2, p. 473-483 11 p.

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72 Citations (Scopus)

Anticonvulsant effects of dizocilpine against picrotoxin-induced seizure activity in vivo and in vitro

Gean, P. W., Lin, J. H., Huang, C. C. & Kuo, J. R., 1993 Jan 1, In : Journal of the Formosan Medical Association. 92, 3, p. 213-219 7 p.

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4 Citations (Scopus)

Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential

Wang, S. C., Lee, T. H., Hsu, C. H., Chang, Y. J., Chang, M. S., Wang, Y-C., Ho, Y. S., Wen, W. C. & Lin, R. K., 2014 Jun 18, In : Journal of Agricultural and Food Chemistry. 62, 24, p. 5625-5635 11 p.

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29 Citations (Scopus)

A polymorphism in the hMLH1 gene (-93G→A) associated with lung cancer susceptibility and prognosis

Shih, C. M., Chen, C. Y., Lee, I. H., Kao, W. T. & Wang, Y. C., 2010 Jan 1, In : International journal of molecular medicine. 25, 1, p. 165-170 6 p.

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14 Citations (Scopus)

A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis

Yen, J. H., Chang, C. M., Hsu, Y. W., Lee, C. H., Wu, M. S., Hwang, D. Y., Chen, B. K., Liao, H. T., Wu, M. T. M. & Chang, W. C., 2014, In : Mediators of Inflammation. 2014, 834831.

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15 Citations (Scopus)
4 Citations (Scopus)

A protein that is highly related to GTPase-activating protein-associated p62 complexes with phospholipase Cγ

Maa, M. C., Leu, T-H., Trandel, B. J., Chang, J. H. & Parsons, S. J., 1994 Aug, In : Molecular and Cellular Biology. 14, 8, p. 5466-5473 8 p.

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38 Citations (Scopus)

A rapid, nongenomic pathway facilitates the synaptic transmission induced by retinoic acid at the developing synapse

Liou, J. C., Ho, S. Y., Shen, M. R., Liao, Y. P., Chiu, W. T. & Kang, K. H., 2005 Oct 15, In : Journal of Cell Science. 118, 20, p. 4721-4730 10 p.

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21 Citations (Scopus)