Research Output

2014

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., 2014 Apr 28, In : Cancer Letters. 346, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

An increase in reactive oxygen species by deregulation of ARNT enhances chemotherapeutic drug-induced cancer cell death

Shieh, J. M., Shen, C. J., Chang, W. C., Cheng, H. C., Chan, Y. Y., Huang, W. C., Chang, W. C. & Chen, B. K., 2014 Jun 12, In : PloS one. 9, 6, e99242.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential

Wang, S. C., Lee, T. H., Hsu, C. H., Chang, Y. J., Chang, M. S., Wang, Y-C., Ho, Y. S., Wen, W. C. & Lin, R. K., 2014 Jun 18, In : Journal of Agricultural and Food Chemistry. 62, 24, p. 5625-5635 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis

Yen, J. H., Chang, C. M., Hsu, Y. W., Lee, C. H., Wu, M. S., Hwang, D. Y., Chen, B. K., Liao, H. T., Wu, M. T. M. & Chang, W. C., 2014, In : Mediators of Inflammation. 2014, 834831.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Aurora kinase inhibitor patents and agents in clinical testing: An update (2011-2013)

Cheung, C. H. A., Sarvagalla, S., Lee, J. Y. C., Huang, Y. C. & Coumar, M. S., 2014 Sep, In : Expert Opinion on Therapeutic Patents. 24, 9, p. 1021-1038 18 p.

Research output: Contribution to journalReview article

38 Citations (Scopus)

DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer

Yang, Y. C., Tang, Y. A., Shieh, J. M., Lin, R. K., Hsu, H. S. & Wang, Y. C., 2014 Sep, In : Journal of Thoracic Oncology. 9, 9, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer

Lin, R. K. & Wang, Y. C., 2014 Aug 19, In : Cell and Bioscience. 4, 1, 46.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Erratum: Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Cai, Z., Jitkaew, S., Zhao, J., Chinag, H., Choksi, S., Liu, J., Ward, Y., Wu, L. G. & Liu, Z. G., 2014 Feb 1, In : Nature Cell Biology. 16, 2, 1 p.

Research output: Contribution to journalComment/debate

82 Citations (Scopus)

Exocytosis and endocytosis: Modes, functions, and coupling mechanisms*

Wu, L. G., Hamid, E., Shin, W. & Chiang, H. C., 2014 Feb 1, In : Annual Review of Physiology. 76, p. 301-331 31 p.

Research output: Contribution to journalReview article

169 Citations (Scopus)

HBP1 promoter methylation augments the oncogenic β-catenin to correlate with prognosis in NSCLC

Tseng, R. C., Huang, W. R., Lin, S. F., Wu, P. C., Hsu, H. S. & Wang, Y. C., 2014 Sep 1, In : Journal of Cellular and Molecular Medicine. 18, 9, p. 1752-1761 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Low SOX17 expression is a prognostic factor and drives transcriptional dysregulation and esophageal cancer progression

Kuo, I. Y., Wu, C. C., Chang, J. M., Huang, Y. L., Lin, C. H., Yan, J. J., Sheu, B. S., Lu, P. J., Chang, W. L., Lai, W. W. & Wang, Y. C., 2014 Aug 1, In : International Journal of Cancer. 135, 3, p. 563-573 11 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

MJ-66 induces malignant glioma cells G2/M phase arrest and mitotic catastrophe through regulation of cyclin B1/Cdk1 complex

Liu, W. T., Chen, C., Lu, I. C., Kuo, S. C., Lee, K. H., Chen, T. L., Song, T. S., Lu, Y. L., Gean, P. W. & Hour, M. J., 2014 Aug 19, In : Neuropharmacology. 86, p. 219-227 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Network-based analysis identifies epigenetic biomarkers of esophageal squamous cell carcinoma progression

Cheng, C. P., Kuo, I. Y., Alakus, H., Frazer, K. A., Harismendy, O., Wang, Y. C. & Tseng, V. S., 2014 May 28, In : Bioinformatics. 30, 21, p. 3054-3061 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Pin1 positively affects tumorigenesis of esophageal squamous cell carcinoma and correlates with poor survival of patients

Lin, F. C., Lee, Y. C., Goan, Y. G., Tsai, C. H., Yao, Y. C., Cheng, H. C., Lai, W. W., Wang, Y. C., Sheu, B. S. & Lu, P. J., 2014 Aug 27, In : Journal of biomedical science. 21, 1, 21.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Cai, Z., Jitkaew, S., Zhao, J., Chiang, H. C., Choksi, S., Liu, J., Ward, Y., Wu, L. G. & Liu, Z. G., 2014 Jan 1, In : Nature Cell Biology. 16, 1, p. 55-65 11 p.

Research output: Contribution to journalArticle

457 Citations (Scopus)

Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles

Chiang, H. C., Shin, W., Zhao, W. D., Hamid, E., Sheng, J., Baydyuk, M., Wen, P. J., Jin, A., Momboisse, F. & Wu, L. G., 2014 Feb 24, In : Nature communications. 5, 4356.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Prognostic CpG methylation biomarkers identified by methylation array in esophageal squamous cell carcinoma patients

Kuo, I. Y., Chang, J. M., Jiang, S. S., Chen, C. H., Chang, I. S., Sheu, B. S., Lu, P. J., Chang, W. L., Lai, W. W. & Wang, Y. C., 2014 May 30, In : International Journal of Medical Sciences. 11, 8, p. 779-787 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Roles of testosterone and amygdaloid LTP induction in determining sex differences in fear memory magnitude

Chen, L. S., Tzeng, W. Y., Chuang, J. Y., Cherng, C. G., Gean, P. W. & Yu, L., 2014 Aug, In : Hormones and Behavior. 66, 3, p. 498-508 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis

Tsai, C. H., Cheng, H. C., Wang, Y. S., Lin, P., Jen, J., Kuo, I. Y., Chang, Y. H., Liao, P. C., Chen, R. H., Yuan, W. C., Hsu, H. S., Yang, M. H., Hsu, M. T., Wu, C. Y. & Wang, Y. C., 2014 Sep 3, In : Nature communications. 5, 4804.

Research output: Contribution to journalArticle

24 Citations (Scopus)
61 Citations (Scopus)

SPAK mediates KCC3-enhanced cervical cancer tumorigenesis

Chiu, M. H., Liu, H. S., Wu, Y. H., Shen, M. R. & Chou, C. Y., 2014 May, In : FEBS Journal. 281, 10, p. 2353-2365 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Stimulating ERK/PI3K/NFκB signaling pathways upon activation of mGluR2/3 restores OGD-induced impairment in glutamate clearance in astrocytes

Lin, C. H., You, J. R., Wei, K. C. & Gean, P. W., 2014 Jan 1, In : European Journal of Neuroscience. 39, 1, p. 83-96 14 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The inducible nitric-oxide synthase (iNOS)/Src axis mediates toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to interferon- β synthesis in macrophages

Hsieh, M. Y., Chang, M. Y., Chen, Y. J., Li, Y. K., Chuang, T. H., Yu, G. Y., Cheung, C. H. A., Chen, H. C., Maa, M. C. & Leu, T. H., 2014 Mar 30, In : Journal of Biological Chemistry. 289, 13, p. 9208-9220 13 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Thematic series: Transcriptional regulation and disease

Wang, Y. C., 2014 Jun 20, In : Cell and Bioscience. 4, 1, 42.

Research output: Contribution to journalEditorial

TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7

Lai, C. Y., Liu, Y. L., Yu, G. Y., Maa, M. C., Leu, T. H., Xu, C., Luo, Y., Xiang, R. & Chuang, T. H., 2014 Sep 29, In : Vaccine. 32, 43, p. 5593-5599 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2013
21 Citations (Scopus)
16 Citations (Scopus)

A Synthetic Podophyllotoxin Derivative Exerts Anti-Cancer Effects by Inducing Mitotic Arrest and Pro-Apoptotic ER Stress in Lung Cancer Preclinical Models

Chen, J. Y., Tang, Y. A., Li, W. S., Chiou, Y. C., Shieh, J. M. & Wang, Y. C., 2013 Apr 30, In : PloS one. 8, 4, e62082.

Research output: Contribution to journalArticle

11 Citations (Scopus)
38 Citations (Scopus)

Correction: Inhibition of spontaneous recovery of fear by mGlur5 after prolonged extinction training (PLoS ONE (2013) 8, 3 (e59580) DOI: 10.1371/journal.pone.0059580)

Mao, S. C., Chang, C. H., Wu, C. C., Orejanera, M. J., Manzoni, O. J. & Gean, P. W., 2013 Jun 27, In : PloS one. 8, 6

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Effects of a workplace multiple cardiovascular disease risks reduction program

Huang, J. J., Lin, H. S., Yen, M-F., Kan, W-M., Lee, B. O. & Chen, C. H., 2013 Jan 1, In : Asian Nursing Research. 7, 2, p. 74-82 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Enhancing cytokine-induced killer cell therapy of multiple myeloma

Liu, C., Suksanpaisan, L., Chen, Y. W., Russell, S. J. & Peng, K. W., 2013 Jun 1, In : Experimental Hematology. 41, 6, p. 508-517 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Epidermal Growth Factor Protects Squamous Cell Carcinoma against Cisplatin-Induced Cytotoxicity through Increased Interleukin-1β Expression

Ko, S. C., Huang, C. R., Shieh, J. M., Yang, J. H., Chang, W. C. & Chen, B. K., 2013 Feb 1, In : PloS one. 8, 2, e55795.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Expression of aryl hydrocarbon receptor nuclear translocator enhances cisplatin resistance by upregulating MDR1 expression in cancer cells

Chan, Y. Y., Kalpana, S., Chang, W. C., Chang, W. C. & Chen, B. K., 2013 Oct 1, In : Molecular Pharmacology. 84, 4, p. 591-602 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Glycosylation regulates the function and membrane localization of KCC4

Weng, T. Y., Chiu, W. T., Liu, H. S., Cheng, H. C., Shen, M. R., Mount, D. B. & Chou, C. Y., 2013 May 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1133-1146 14 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death

Liu, W. T., Huang, C. Y., Lu, I. C. & Gean, P. W., 2013 Sep 1, In : Neuro-Oncology. 15, 9, p. 1127-1141 15 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Inhibition of Spontaneous Recovery of Fear by mGluR5 after Prolonged Extinction Training

Mao, S. C., Chang, C. H., Wu, C. C., Orejanera, M. J., Manzoni, O. J. & Gean, P. W., 2013 Mar 21, In : PloS one. 8, 3, e59580.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Involvement of extracellular signal regulated kinases in traumatic brain injury-induced depression in rodents

Kuo, J. R., Cheng, Y. H., Chen, Y. S., Chio, C. C. & Gean, P. W., 2013 Jul 15, In : Journal of Neurotrauma. 30, 14, p. 1223-1231 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Involvement of STIM1 and Orai1 in EGF-mediated cell growth in retinal pigment epithelial cells

Yang, I. H., Tsai, Y. T., Chiu, S. J., Liu, L. T., Lee, H. H., Hou, M. F., Hsu, W. L., Chen, B. K. & Chang, W. C., 2013 Jun 27, In : Journal of biomedical science. 20, 1, 41.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Lack of association of C-Met-N375S sequence variant with lung cancer susceptibility and prognosis

Shieh, J. M., Tang, Y. A., Yang, T. H., Chen, C. Y., Hsu, H. S., Tan, Y. H. C., Salgia, R. & Wang, Y. C., 2013 Jun 28, In : International Journal of Medical Sciences. 10, 8, p. 988-994 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors

Chen, Y. T., Chen, Y. F., Chiu, W. T., Liu, K. Y., Liu, Y. L., Chang, J. Y., Chang, H. C. & Shen, M. R., 2013 Jul 15, In : Cancer Research. 73, 14, p. 4500-4509 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
11 Citations (Scopus)

Most vesicles in a central nerve terminal participate in recycling

Xue, L., Sheng, J., Wu, X. S., Wu, W., Luo, F., Shin, W., Chiang, H. C. & Wu, L. G., 2013 May 15, In : Journal of Neuroscience. 33, 20, p. 8820-8826 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Remodeling of calcium signaling in tumor progression

Chen, Y. F., Chen, Y. T., Chiu, W. T. & Shen, M. R., 2013 Apr 19, In : Journal of biomedical science. 20, 1, 23.

Research output: Contribution to journalReview article

112 Citations (Scopus)

SNARE Proteins Synaptobrevin, SNAP-25, and Syntaxin Are Involved in Rapid and Slow Endocytosis at Synapses

Xu, J., Luo, F., Zhang, Z., Xue, L., Wu, X. S., Chinag, H., Shin, W. & Wu, L. G., 2013 May 30, In : Cell Reports. 3, 5, p. 1414-1421 8 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo

Chiu, H. W., Yeh, Y. L., Wang, Y. C., Huang, W. J., Chen, Y. A., Chiou, Y. S., Ho, S. Y., Lin, P. & Wang, Y. J., 2013 Oct 10, In : PloS one. 8, 10, e76340.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Survivin - biology and potential as a therapeutic target in oncology

Antonio Cheung, C. H., Huang, C. C., Tsai, F. Y., Lee, J. Y. C., Cheng, S. M., Chang, Y. C., Huang, Y. C., Chen, S. H. & Chang, J. Y., 2013 Oct 28, In : OncoTargets and Therapy. 6, p. 1453-1462 10 p.

Research output: Contribution to journalReview article

93 Citations (Scopus)

The Amygdala Excitatory/Inhibitory Balance in a Valproate-Induced Rat Autism Model

Lin, H. C., Gean, P. W., Wang, C. C., Chan, Y. H. & Chen, P. S., 2013 Jan 29, In : PloS one. 8, 1, e55248.

Research output: Contribution to journalArticle

45 Citations (Scopus)

The beneficial effects of leptin on REM sleep deprivation-induced cognitive deficits in mice

Chang, H. F., Su, C. L., Chang, C. H., Chen, Y. W. & Gean, P. W., 2013 Jun 1, In : Learning and Memory. 20, 6, p. 328-335 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
16 Citations (Scopus)