Research Output

2013
16 Citations (Scopus)

The ER Ca2+ sensor STIM1 regulates actomyosin contractility of migratory cells

Chen, Y. T., Chen, Y. F., Chiu, W. T., Wang, Y. K., Chang, H. C. & Shen, M. R., 2013 Mar 1, In : Journal of Cell Science. 126, 5, p. 1260-1267 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

The SNARE proteins SNAP25 and synaptobrevin are involved in endocytosis at hippocampal synapses

Zhang, Z., Wang, D., Sun, T., Xu, J., Chiang, H. C., Shin, W. & Wu, L. G., 2013 May 22, In : Journal of Neuroscience. 33, 21, p. 9169-9175 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Treat cancers by targeting survivin: Just a dream or future reality?

Coumar, M. S., Tsai, F. Y., Kanwar, J. R., Sarvagalla, S. & Cheung, C. H. A., 2013 Nov 1, In : Cancer Treatment Reviews. 39, 7, p. 802-811 10 p.

Research output: Contribution to journalReview article

105 Citations (Scopus)
2012
30 Citations (Scopus)

Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms

Wang, C. Y., Chen, C. L., Tseng, Y. L., Fang, Y. T., Lin, Y. S., Su, W. C., Chen, C. C., Chang, K. C., Wang, Y. C. & Lin, C. F., 2012 Sep 21, In : Journal of Biological Chemistry. 287, 39, p. 32512-32524 13 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Cancer epigenomics

Chang, J. W. & Wang, Y-C., 2012 Jan 1, Systems Biology: Applications in Cancer-Related Research. World Scientific Publishing Co., p. 129-159 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Cancer targeted nanoparticles specifically induce apoptosis in cancer cells and spare normal cells

Kanwar, J. R., Kanwar, R. K., Mahidhara, G. & Cheung, C. H. A., 2012 Feb 16, In : Australian Journal of Chemistry. 65, 1, p. 5-14 10 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Catalase prevents maternal diabetes-induced perinatal programming via the Nrf2-HO-1 defense system

Chang, S. Y., Chen, Y. W., Zhao, X. P., Chenier, I., Tran, S., Sauvé, A., Ingelfinger, J. R. & Zhang, S. L., 2012 Oct 1, In : Diabetes. 61, 10, p. 2565-2574 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response

Chang, H. Y., Huang, H. C., Huang, T. C., Yang, P. C., Wang, Y. C. & Juan, H. F., 2012 Sep 15, In : Cancer Research. 72, 18, p. 4696-4706 11 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Epidermal growth factor receptor is a preferred target for treating Amyloid-β-induced memory loss

Wang, L., Chiang, H. C., Wu, W., Liang, B., Xie, Z., Yao, X., Ma, W., Du, S. & Zhong, Y., 2012 Oct 9, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 41, p. 16743-16748 6 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Epithelial-mesenchymal transition in cervical carcinoma

Lee, M. Y. & Shen, M-R., 2012 Feb 9, In : American Journal of Translational Research. 4, 1, p. 1-13 13 p.

Research output: Contribution to journalReview article

92 Citations (Scopus)

Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages

Chen, Y. J., Hsieh, M. Y., Chang, M. Y., Chen, H. C., Jan, M. S., Maa, M. C. & Leu, T. H., 2012 May 25, In : Journal of Biological Chemistry. 287, 22, p. 18806-18819 14 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Expression of Eps8 correlates with poor survival in oral squamous cell carcinoma

Chu, P. Y., Liou, J. H., Lin, Y. M., Chen, C. J., Chen, M. K., Lin, S. H., Yeh, C. M., Wang, H. K., Maa, M. C., Leu, T. H., Chang, N. W., Hsu, N. C. & Yeh, K. T., 2012 Dec 1, In : Asia-Pacific Journal of Clinical Oncology. 8, 4, p. e77-e81

Research output: Contribution to journalArticle

10 Citations (Scopus)

Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells

Wang, J. Y., Chen, B. K., Wang, Y. S., Tsai, Y. T., Chen, W. C., Chang, W. C., Hou, M. F., Wu, Y. C. & Chang, W. C., 2012 Jan 1, In : Cellular Signalling. 24, 1, p. 162-169 8 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

K+-Cl- cotransport mediates the bactericidal activity of neutrophils by regulating NADPH oxidase activation

Sun, Y. T., Shieh, C. C., Delpire, E. & Shen, M. R., 2012 Jul 1, In : Journal of Physiology. 590, 14, p. 3231-3243 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer

Tang, Y. A., Lin, R. K., Tsai, Y. T., Hsu, H. S., Yang, Y. C., Chen, C. Y. & Wang, Y. C., 2012 Aug 15, In : Clinical Cancer Research. 18, 16, p. 4325-4333 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models

Shieh, J. M., Wei, T. T., Tang, Y. A., Huang, S. M., Wen, W. L., Chen, M. Y., Cheng, H. C., Salunke, S. B., Chen, C. S., Lin, P., Chen, C. T. & Wang, Y. C., 2012 Jan 18, In : PloS one. 7, 1, e30240.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Modulating the interaction of CXCR4 and CXCL12 by low-molecular-weight heparin inhibits hepatic metastasis of colon cancer

Ma, L., Qiao, H., He, C., Yang, Q., Cheung, C. H. A., Kanwar, J. R. & Sun, X., 2012 Apr 1, In : Investigational New Drugs. 30, 2, p. 508-517 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Overexpression of PAFAH1B1 is associated with tumor metastasis and poor survival in non-small cell lung cancer

Lo, F. Y., Chen, H. T., Cheng, H. C., Hsu, H. S. & Wang, Y. C., 2012 Sep 1, In : Lung Cancer. 77, 3, p. 585-592 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Patients' perceptions and expectations of family participation in the informed consent process of elective surgery in taiwan

Lin, M. L., Kan, W. M. & Chen, C. H., 2012 Jun, In : Asian Nursing Research. 6, 2, p. 55-59 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Significance of migration-related genes (S100A9, MAGED4, C8orf30A, IL-8) in esophageal squamous cell carcinoma

Huang, C. T., Huang, G. C., Wu, P. S., Wu, L. W., Lin, S. H., Lai, W. W., Wang, Y. C. & Liu, H. S., 2012 Mar 1, In : Genomic Medicine, Biomarkers, and Health Sciences. 4, 1-2, p. 16-18 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis and Biological Evaluation of ortho-Aryl N-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors

Huang, W. J., Wang, Y. C., Chao, S. W., Yang, C. Y., Chen, L. C., Lin, M. H., Hou, W. C., Chen, M. Y., Lee, T. L., Yang, P. & Chang, C. I., 2012 Oct 1, In : ChemMedChem. 7, 10, p. 1815-1824 10 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway

Chen, K. L., Chang, W. S. W., Cheung, C. H. A., Lin, C. C., Huang, C. C., Yang, Y. N., Kuo, C. P., Kuo, C. C., Chang, Y. H., Liu, K. J., Wu, C. M. & Chang, J. Y., 2012 Apr 1, In : Cancer Letters. 317, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

TGF-beta1 increases cell rigidity by enhancing expression of smooth muscle actin: Keloid-derived fibroblasts as a model for cellular mechanics

Lee, C. H., Hong, C. H., Chen, Y. T., Chen, Y. C. & Shen, M-R., 2012 Sep 1, In : Journal of Dermatological Science. 67, 3, p. 173-180 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

The database of chromosome imbalance regions and genes resided in lung cancer from Asian and Caucasian identified by array-comparative genomic hybridization

Lo, F. Y., Chang, J. W., Chang, I. S., Chen, Y. J., Hsu, H. S., Huang, S. F. K., Tsai, F. Y., Jiang, S. S., Kanteti, R., Nandi, S., Salgia, R. & Wang, Y. C., 2012 Jun 12, In : BMC cancer. 12, 235.

Research output: Contribution to journalArticle

25 Citations (Scopus)

The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse

Huang, S. M., Hsu, P. C., Chen, M. Y., Li, W. S., More, S. V., Lu, K. T. & Wang, Y-C., 2012 Aug 1, In : International Journal of Cancer. 131, 3, p. 722-732 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis

Lin, C. H., Chen, P. S., Kuo, S. C., Huang, L. J., Gean, P. W. & Chiu, T. H., 2012 Mar 1, In : Food and Chemical Toxicology. 50, 3-4, p. 1073-1081 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
51 Citations (Scopus)

Valproic acid mediates the synaptic excitatory/inhibitory balance through astrocytes - A preliminary study

Wang, C. C., Chen, P. S., Hsu, C. W., Wu, S. J., Lin, C. T. & Gean, P. W., 2012 Apr 27, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 37, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2011

Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells

Tsou, J. H., Chang, K-C., Chang-Liao, P. Y., Yang, S. T., Lee, C-T., Chen, Y-P., Lee, Y. C., Lin, P-W., Lee, J-C., Shen, M-R., Chuang, C. K., Chang, W. C., Wang, J-M. & Hung, L-Y., 2011 Oct 1, In : Journal of Pathology. 225, 2, p. 243-254 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Activation of Toll-like receptors induces macrophage migration via the iNOS/Src/FAK pathway

Maa, M. C. & Leu, T-H., 2011 Dec 1, In : BioMedicine (Netherlands). 1, 1, p. 11-15 5 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

An E3 ubiquitin ligase: C-Cbl: A new therapeutic target of lung cancer

Lo, F. Y., Tan, Y. H. C., Cheng, H. C., Salgia, R. & Wang, Y. C., 2011 Dec 1, In : Cancer. 117, 23, p. 5344-5350 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Angiotensin II type II receptor deficiency accelerates the development of nephropathy in type i diabetes via oxidative stress and ACE2

Chang, S. Y., Chen, Y. W., Chenier, I., Tran, S. L. M. & Zhang, S. L., 2011 Dec 1, In : Experimental Diabetes Research. 2011, 521076.

Research output: Contribution to journalArticle

35 Citations (Scopus)

A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways

Chen, J. Y., Tang, Y. A., Huang, S. M., Juan, H. F., Wu, L. W., Sun, Y. C., Wang, S. C., Wu, K. W., Balraj, G., Chang, T. T., Li, W. S., Cheng, H. C. & Wang, Y. C., 2011 Jan 15, In : Cancer Research. 71, 2, p. 473-483 11 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

ATM/ATR and SMAD3 pathways contribute to 3-indole-induced G1 arrest in cancer cells and xenograft models

Huang, S. M., Lu, K. T. & Wang, Y. I. C., 2011 Jan 1, In : Anticancer research. 31, 1, p. 203-208 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
7 Citations (Scopus)

Aurora kinase inhibitor patents and agents in clinical testing: An update (2009 - 10)

Cheung, C. H. A., Coumar, M. S., Chang, J. Y. & Hsieh, H. P., 2011 Jun 1, In : Expert Opinion on Therapeutic Patents. 21, 6, p. 857-884 28 p.

Research output: Contribution to journalReview article

34 Citations (Scopus)

BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Cheung, C. H. A., Lin, W. H., HsuJohn, J. T. A., Hour, T. C., Yeh, T. K., Ko, S., Lien, T. W., Coumar, M. S., Liu, J. F., Lai, W. Y., Shiao, H. Y., Lee, T. R., Hsieh, H. P. & Chang, J. Y., 2011 Aug 24, In : PloS one. 6, 8, e23485.

Research output: Contribution to journalArticle

14 Citations (Scopus)
215 Citations (Scopus)

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C. H. A., Chen, L. T. & Chang, J. Y., 2011 Oct 1, In : Cancer Letters. 309, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Functional EGFR germline polymorphisms may confer risk for EGFR somatic mutations in non-small cell lung cancer, with a predominant effect on exon 19 microdeletions

Liu, W., He, L., Ramírez, J., Krishnaswamy, S., Kanteti, R., Wang, Y. C., Salgia, R. & Ratain, M. J., 2011 Apr 1, In : Cancer Research. 71, 7, p. 2423-2427 5 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

GABAA receptor endocytosis in the basolateral amygdala is critical to the reinstatement of fear memory measured by fear-potentiated startle

Lin, H. C., Tseng, Y. C., Mao, S. C., Chen, P. S. & Gean, P. W., 2011 Jun 15, In : Journal of Neuroscience. 31, 24, p. 8851-8861 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

High glucose promotes nascent nephron apoptosis via NF-κB and p53 pathways

Chen, Y-W., Chenier, I., Chang, S. Y., Tran, S., Ingelfinger, J. R. & Zhang, S. L., 2011 Jan 1, In : American Journal of Physiology - Renal Physiology. 300, 1

Research output: Contribution to journalArticle

18 Citations (Scopus)

Investigations of survivin: The past, present and future

Cheung, C. H. A., Cheng, L. T., Chang, K. Y., Chen, H. H. & Chang, J. Y., 2011 Jan 1, In : Frontiers in Bioscience. 16, 3, p. 952-961 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Mechanisms underlying Benzyl alcohol cytotoxicity (triamcinolone acetonide preservative) in human retinal pigment epithelial cells

Chang, Y-S., Lin, C. F., Wu, C-L., Kuo, P. Y., Wu, F. S., Shieh, C-C., Gean, P-W., Chen, S. T., Chen, M. S., Wu, W. C., Tai, M. H. & Tseng, S. H., 2011 Jun 1, In : Investigative Ophthalmology and Visual Science. 52, 7, p. 4214-4222 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Minocycline inhibits the growth of glioma by inducing autophagy

Liu, W. T., Lin, C. H., Hsiao, M. & Gean, P. W., 2011 Feb, In : Autophagy. 7, 2, p. 166-175 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Selective inhibition of early-but not late-expressed HIF-1α is neuroprotective in rats after focal ischemic brain damage

Yeh, S. H., Ou, L. C., Gean, P-W., Hung, J-J. & Chang, W. C., 2011 May 1, In : Brain Pathology. 21, 3, p. 249-262 14 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

The iNOS/Src/FAK axis is critical in Toll-like receptor-mediated cell motility in macrophages

Maa, M. C., Chang, M. Y., Li, J., Li, Y. Y., Hsieh, M. Y., Yang, C. J., Chen, Y. J., Li, Y., Chen, H. C., Cheng, W. E., Hsieh, C. Y., Cheng, C. W. & Leu, T. H., 2011 Jan 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 1, p. 136-147 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
22 Citations (Scopus)