Research Output

2006
9 Citations (Scopus)

Extinction training in conjunction with a partial agonist of the glycine site on the NMDA receptor erases memory trace

Mao, S. C., Hsiao, Y. H. & Gean, P. W., 2006 Aug 30, In : Journal of Neuroscience. 26, 35, p. 8892-8899 8 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Heterogeneous nuclear ribonucleoprotein K modulates angiotensinogen gene expression in kidney cells

Wei, C. C., Zhang, S. L., Chen, Y. W., Guo, D. F., Ingelfinger, J. R., Bomsztyk, K. & Chan, J. S. D., 2006 Sep 1, In : Journal of Biological Chemistry. 281, 35, p. 25344-25355 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST

Lu, T. J., Lai, W. Y., Huang, C. Y. F., Hsieh, W. J., Yu, J. S., Hsieh, Y. J., Chang, W. T., Leu, T. H., Chang, W. C., Chuang, W. J., Tang, M. J., Chen, T. Y., Lu, T. L. & Lai, M. D., 2006 Dec 15, In : Journal of Biological Chemistry. 281, 50, p. 38405-38417 13 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
70 Citations (Scopus)

Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFα secretion in macrophages

Leu, T. H., Charoenfuprasert, S., Yen, C. K., Fan, C. W. & Maa, M. C., 2006 Feb 1, In : Molecular Immunology. 43, 4, p. 308-316 9 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Molecular diagnostic markers for lung cancer in sputum and plasma

Wang, Y. C., Hsu, H. S., Chen, T. P. & Chen, J. T., 2006 Sep, Circulating Nucleic Acids in Plasma and Serum IV. Blackwell Publishing Inc., p. 179-184 6 p. (Annals of the New York Academy of Sciences; vol. 1075).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

46 Citations (Scopus)

Neuroprotective effect of N-acetylcysteine on neuronal apoptosis induced by a synthetic gingerdione compound: Involvement of ERK and p38 phosphorylation

Lin, C. H., Kuo, S. C., Huang, L. J. & Gean, P-W., 2006 Nov 15, In : Journal of Neuroscience Research. 84, 7, p. 1485-1494 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Polymorphisms of p53 and p21 genes in chronic obstructive pulmonary disease

Lee, Y. L., Chen, W., Tsai, W. K., Lee, J. C., Chiou, H. L., Shih, C. M. & Wang, Y-C., 2006 May 1, In : Journal of Laboratory and Clinical Medicine. 147, 5, p. 228-233 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Reactive oxygen species and nuclear factor-kappa B pathway mediate high glucose-induced Pax-2 gene expression in mouse embryonic mesenchymal epithelial cells and kidney explants

Chen, Y. W., Liu, F., Tran, S., Zhu, Y., Hébert, M. J., Ingelfinger, J. R. & Zhang, S. L., 2006 Nov 1, In : Kidney international. 70, 9, p. 1607-1615 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Reduced Acetylated Histone H4 is Associated With Promoter Methylation of the Fragile Histidine Triad Gene in Resected Esophageal Squamous Cell Carcinoma

Tzao, C., Sun, G. H., Tung, H. J., Hsu, H. S., Hsu, W. H., Wang, Y. C., Cheng, Y. L. & Lee, S. C., 2006 Aug, In : Annals of Thoracic Surgery. 82, 2, p. 396-401 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
94 Citations (Scopus)

Src oncogene activates MMP-2 expression via the ERK/Sp1 pathway

Kuo, L., Chang, H. C., Leu, T. H., Maa, M. C. & Hung, W. C., 2006 Jun 1, In : Journal of Cellular Physiology. 207, 3, p. 729-734 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Synaptic expression of glutamate receptor after encoding of fear memory in the rat amygdala

Yeh, S. H., Mao, S. C., Lin, H. C. & Gean, P. W., 2006 Jan, In : Molecular Pharmacology. 69, 1, p. 299-308 10 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

The Role of the Amygdala in the Extinction of Conditioned Fear

Barad, M., Gean, P. W. & Lutz, B., 2006 Aug 15, In : Biological Psychiatry. 60, 4, p. 322-328 7 p.

Research output: Contribution to journalReview article

102 Citations (Scopus)

Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes

Chen, P-S., Peng, G. S., Li, G., Yang, S., Wu, X., Wang, C. C., Wilson, B., Lu, R-B., Gean, P-W., Chuang, D. M. & Hong, J. S., 2006 Dec 1, In : Molecular Psychiatry. 11, 12, p. 1116-1125 10 p.

Research output: Contribution to journalArticle

269 Citations (Scopus)
2007

Alteration of DNA methyltransferases contributes to 5′CpG methylation and poor prognosis in lung cancer

Lin, R. K., Hsu, H. S., Chang, J. W., Chen, C. Y., Chen, J. T. & Wang, Y. C., 2007 Feb 1, In : Lung Cancer. 55, 2, p. 205-213 9 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)
35 Citations (Scopus)

Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma

Hsu, H. S., Chen, T. P., Hung, C. H., Wen, C. K., Lin, R. K., Lee, H. C. & Wang, Y-C., 2007 Nov 1, In : Cancer. 110, 9, p. 2019-2026 8 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)

Elevated p53 and p21waf1 mRNA expression in blood lymphocytes from lung cancer patients with chemoresistance

Shih, C. M., Chen, K., Wang, Y. C., Lee, P. J. & Wang, Y-C., 2007 Dec 4, In : Cancer Detection and Prevention. 31, 5, p. 366-370 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Epigenetic inactivation of the chromosomal stability control genes BRCA1 BRCA2, and XRCC5 in non-small cell lung cancer

Lee, M. N., Tseng, R. C., Hsu, H. S., Chen, J. Y., Tzao, C., Ho, W. L. & Wang, Y. C., 2007 Feb 1, In : Clinical Cancer Research. 13, 3, p. 832-838 7 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

EPS8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase

Maa, M. C., Lee, J-C., Chen, Y. J., Chen, Y. J., Lee, Y. C., Wang, S-T., Huang, C. C., Chow, N-H. & Leu, T-H., 2007 Jul 6, In : Journal of Biological Chemistry. 282, 27, p. 19399-19409 11 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness

Hsu, Y. M., Chou, C-Y., Chen, H. H. W., Lee, W. Y., Chen, Y. F., Lin, P. W., Alper, S. L., Ellory, J. C. & Shen, M-R., 2007 Mar 1, In : Journal of Cellular Physiology. 210, 3, p. 626-636 11 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
27 Citations (Scopus)

KCl cotransporter-3 down-regulates E-cadherin/β-catenin complex to promote epithelial-mesenchymal transition

Hsu, Y. M., Chen, Y. F., Chou, C. Y., Tang, M. J., Chen, J. H., Wilkins, R. J., Clive Ellory, J. & Shen, M. R., 2007 Nov 15, In : Cancer Research. 67, 22, p. 11064-11073 10 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells

Lin, R. K., Hsu, C. H. & Wang, Y-C., 2007 Nov 1, In : Anti-Cancer Drugs. 18, 10, p. 1157-1164 8 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Multiple genetic and epigenetic biomarkers for lung cancer detection in cytologically negative sputum and a nested case-control study for risk assessment

Hsu, H. S., Chen, T. P., Wen, C. K., Hung, C. H., Chen, C. Y., Chen, J. T. & Wang, Y. C., 2007 Dec 1, In : Journal of Pathology. 213, 4, p. 412-419 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Pax-2 and N-myc regulate epithelial cell proliferation and apoptosis in a positive autocrine feedback loop

Zhang, S. L., Chen, Y-W., Tran, S., Liu, F., Nestoridi, E., Hébert, M. J. & Ingelfinger, J. R., 2007 Jun 1, In : Pediatric Nephrology. 22, 6, p. 813-824 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Polymorphism in the hMSH2 gene (gISV12-6T > C) is a prognostic factor in non-small cell lung cancer

Hsu, H. S., Lee, I. H., Hsu, W. H., Kao, W. T. & Wang, Y. C., 2007 Oct 1, In : Lung Cancer. 58, 1, p. 123-130 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

PP2B-mediated dephosphorylation of c-Jun C terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cells

Chen, B. K., Huang, C. C., Chang, W. C., Chen, Y. J., Kikkawa, U., Nakahama, K. I., Morita, I. & Chang, W. C., 2007 Mar 1, In : Molecular Biology of the Cell. 18, 3, p. 1118-1127 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Reactive oxygen species in the presence of high glucose alter ureteric bud morphogenesis

Zhang, S. L., Chen, Y. W., Tran, S., Chenier, I., Hébert, M. J. & Ingelfinger, J. R., 2007 Jul, In : Journal of the American Society of Nephrology. 18, 7, p. 2105-2115 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Role of transcriptional factors Sp1, c-Rel, and c-Jun in LPS-induced C/EBPd gene expression of mouse macrophages

Liu, Y. W., Chen, C. C., Wang, J-M., Chang, W. C., Huang, Y. C., Chung, S. Y., Chen, B-K. & Hung, J-J., 2007 Dec 1, In : Cellular and Molecular Life Sciences. 64, 24, p. 3282-3294 13 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Soft substrate induces apoptosis by the disturbance of Ca2+ homeostasis in renal epithelial LLC-PK1 cells

Chiu, W-T., Wang, Y. H., Tang, M-J. & Shen, M-R., 2007 Aug 1, In : Journal of Cellular Physiology. 212, 2, p. 401-410 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The effect of prostacyclin agonists on the differentiation of phorbol ester treated human erythroleukemia cells

Shen, H. W., Chen, Y. L., Chern, C. Y. & Kan, W. M., 2007 May, In : Prostaglandins and Other Lipid Mediators. 83, 3 SPEC. ISS., p. 231-236 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Transcriptional regulation of brain-derived neurotrophic factor in the amygdala during consolidation of fear memory

Ou, L. C. & Gean, P. W., 2007 Aug 1, In : Molecular Pharmacology. 72, 2, p. 350-358 9 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity

Chen, P. S., Wang, C. C., Bortner, C. D., Peng, G. S., Wu, X., Pang, H., Lu, R. B., Gean, P. W., Chuang, D. M. & Hong, J. S., 2007 Oct 12, In : Neuroscience. 149, 1, p. 203-212 10 p.

Research output: Contribution to journalArticle

182 Citations (Scopus)
2008

A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells

Chen, C. T., Munot, Y. S., Salunke, S. B., Wang, Y-C., Lin, R. K., Lin, C. C., Chen, C. C. & Liu, Y. H., 2008 Feb 22, In : Advanced Functional Materials. 18, 4, p. 527-540 14 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
11 Citations (Scopus)

Augmentation of fear extinction by D-cycloserine is blocked by proteasome inhibitors

Mao, S. C., Lin, H. C. & Gean, P-W., 2008 Dec 1, In : Neuropsychopharmacology. 33, 13, p. 3085-3095 11 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Aβ42 mutants with different aggregation profiles induce distinct pathologies in Drosophila

Iijima, K., Chiang, H. C., Hearn, S. A., Hakker, I., Gatt, A., Shenton, C., Granger, L., Leung, A., Iijima-Ando, K. & Zhong, Y., 2008 Feb 27, In : PloS one. 3, 2, e1703.

Research output: Contribution to journalArticle

114 Citations (Scopus)

Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation

Huang, C. C., Wang, J. M., Kikkawa, U., Mukai, H., Shen, M. R., Morita, I., Chen, B. K. & Chang, W. C., 2008 Apr 10, In : Oncogene. 27, 17, p. 2422-2429 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Chronic cannabinoid administration in vivo compromises extinction of fear memory

Lin, H. C., Mao, S. C., Chen, P-S. & Gean, P-W., 2008 Dec 1, In : Learning and Memory. 15, 12, p. 876-884 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
38 Citations (Scopus)

Conditionally replicating E1B-deleted adenovirus driven by the squamous cell carcinoma antigen 2 promoter for uterine cervical cancer therapy

Hsu, K. F., Wu, C. L., Huang, S. C., Hsieh, J. L., Huang, Y. S., Chen, Y. F., Shen, M. R., Chung, W. J., Chou, C. Y. & Shiau, A. L., 2008 Aug 18, In : Cancer Gene Therapy. 15, 8, p. 526-534 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Cytotoxicity and proteomics analyses of OSU03013 in lung cancer

Tan, Y. H., Lee, K. H., Lin, T., Sun, Y. C., Hsieh-Li, H. M., Juan, H. F. & Wang, Y. C., 2008 Mar 15, In : Clinical Cancer Research. 14, 6, p. 1823-1830 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis

Chen, Y-W., Tran, S., Chenier, I., Chan, J. S. D., Ingelfinger, J. R., Inagami, T. & Zhang, S. L., 2008 Jul 9, In : Pediatric Nephrology. 23, 10, p. 1769-1777 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
72 Citations (Scopus)

Emerging methods for analysis of the cancer methylome

Chang, J. W., Huang, T. H. M. & Wang, Y-C., 2008 Dec 1, In : Pharmacogenomics. 9, 12, p. 1869-1878 10 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type β-catenin nuclear accumulation in lung tumorigenesis

Tseng, R. C., Lin, R. K., Wen, C. K., Tseng, C., Hsu, H. S., Hsu, W. H. & Wang, Y. C., 2008 Jul 24, In : Oncogene. 27, 32, p. 4488-4496 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Epigenetic silencing of CCAAT/enhancer-binding protein δ activity by YY1/polycomb group/DNA methyltransferase complex

Ko, C. Y., Hsu, H. C., Shen, M. R., Chang, W. C. & Wang, J. M., 2008 Nov 7, In : Journal of Biological Chemistry. 283, 45, p. 30919-30932 14 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)