Research Output

Article

Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene

Chen, B-K., Tsai, T. Y., Huang, H-S., Chen, L. C., Chang, W. C., Tsai, S. B. & Chang, W. C., 2002 Apr 6, In : Journal of biomedical science. 9, 2, p. 156-165 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

GABAA receptor endocytosis in the basolateral amygdala is critical to the reinstatement of fear memory measured by fear-potentiated startle

Lin, H. C., Tseng, Y. C., Mao, S. C., Chen, P. S. & Gean, P. W., 2011 Jun 15, In : Journal of Neuroscience. 31, 24, p. 8851-8861 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Gene regulation of human 12(S)-lipoxygenase

Chang, W. C. & Chen, B. K., 2002 Nov 1, In : International Congress Series. 1233, C, p. 329-335 7 p.

Research output: Contribution to journalArticle

Genetic testing in spinocerebellar ataxia in Taiwan: Expansions of trinucleotide repeats in SCA8 and SCA17 are associated with typical Parkinson's disease

Wu, Y. R., Lin, H. Y., Chen, C. M., Gwinn-Hardy, K., Ro, L. S., Wang, Y. C., Li, S. H., Hwang, J. C., Fang, K., Hsieh-Li, H. M., Li, M. L., Tung, L. C., Su, M. T., Lu, K. T. & Lee-Chen, G. J., 2004 Mar 1, In : Clinical Genetics. 65, 3, p. 209-214 6 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer

Tseng, R. C., Chang, J. W., Hsien, F. J., Chang, Y. H., Hsiao, C. F., Chen, J. T., Chen, C. Y., Jou, Y. S. & Wang, Y. C., 2005 Nov 1, In : International Journal of Cancer. 117, 2, p. 241-247 7 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)
Open Access
5 Citations (Scopus)

Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer

Tang, Y. A., Chen, C. H., Sun, H. S., Cheng, C. P., Tseng, V. S., Hsu, H. S., Su, W. C., Lai, W. W. & Wang, Y. C., 2015, In : Nucleic acids research. 43, 3, p. 1593-1608 16 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Glucose regulates amyloid β production via AMPK

Yang, T. T., Shih, Y. S., Chen, Y-W., Kuo, Y-M. & Lee, C. W., 2015 Oct 1, In : Journal of Neural Transmission. 122, 10, p. 1381-1390 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
50 Citations (Scopus)

Glycosylation regulates the function and membrane localization of KCC4

Weng, T. Y., Chiu, W. T., Liu, H. S., Cheng, H. C., Shen, M. R., Mount, D. B. & Chou, C. Y., 2013 May 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1133-1146 14 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer

Tseng, R. C., Chang, J. W., Mao, J. S., Tsai, C. D., Wu, P. C., Lin, C. J., Lu, Y. L., Liao, S. Y., Cheng, H. C., Hsu, H. S. & Wang, Y. C., 2015 Jan 1, In : Oncotarget. 6, 42, p. 44207-44221 15 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

HBP1 promoter methylation augments the oncogenic β-catenin to correlate with prognosis in NSCLC

Tseng, R. C., Huang, W. R., Lin, S. F., Wu, P. C., Hsu, H. S. & Wang, Y. C., 2014 Sep 1, In : Journal of Cellular and Molecular Medicine. 18, 9, p. 1752-1761 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

HDAC2 and HDAC5 up-regulations modulate survivin and miR-125a-5p expressions and promote hormone therapy resistance in estrogen receptor positive breast cancer cells

Huang, W. T., Tsai, Y. H., Chen, S. H., Kuo, C. W., Kuo, Y. L., Lee, K. T., Chen, W. C., Wu, P. C., Chuang, C. Y., Cheng, S. M., Lin, C. H., Leung, E. Y., Chang, Y. C. & Cheung, C. H. A., 2017 Dec 13, In : Frontiers in Pharmacology. 8, DEC, 902.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Hemi-fused structure mediates and controls fusion and fission in live cells

Zhao, W. D., Hamid, E., Shin, W., Wen, P. J., Krystofiak, E. S., Villarreal, S. A., Chiang, H. C., Kachar, B. & Wu, L. G., 2016 Jun 15, In : Nature. 534, 7608, p. 548-552 5 p.

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56 Citations (Scopus)

Hepatitis B virus preS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability

Yen, T. T. C., Yang, A., Chiu, W. T., Li, T. N., Wang, L. H., Wu, Y. H., Wang, H. C., Chen, L., Wang, W. C., Huang, W., Chang, C. W., Chang, M. D. T., Shen, M. R., Su, I. J. & Wang, L. H. C., 2016 Apr 26, In : Oncotarget. 7, 17, p. 23346-23360 15 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Heterogeneous nuclear ribonucleoprotein K modulates angiotensinogen gene expression in kidney cells

Wei, C. C., Zhang, S. L., Chen, Y. W., Guo, D. F., Ingelfinger, J. R., Bomsztyk, K. & Chan, J. S. D., 2006 Sep 1, In : Journal of Biological Chemistry. 281, 35, p. 25344-25355 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

High-CLDN4 ESCC cells harbor stem-like properties and indicate for poor concurrent chemoradiation therapy response in esophageal squamous cell carcinoma

Lin, C. H., Li, H. Y., Liu, Y. P., Kuo, P. F., Wang, W. C., Lin, F. C., Chang, W. L., Sheu, B. S., Wang, Y. C., Hung, W. C., Cheng, H. C., Yao, Y. C., Calkins, M. J., Hsiao, M. & Lu, P. J., 2019, In : Therapeutic Advances in Medical Oncology. 11

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
4 Citations (Scopus)

High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice

Tsai, S. F., Wu, H. T., Chen, P. C., Chen, Y. W., Yu, M., Wang, T. F., Wu, S. Y., Tzeng, S. F. & Kuo, Y. M., 2018 Dec 1, In : Brain Research. 1700, p. 66-77 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice.

Tsai, SF., Wu, HT., Chen, PC. & Chen, Y-W., 2018 Jul 13, In : Brain Research. 18, p. 30401 3 p.

Research output: Contribution to journalArticle

High frequency of deletion mutations in p53 gene from squamous cell lung cancer patients in Taiwan

Wang, Y. C., Chen, C. Y., Chen, S. K., Cherng, S. H., Ho, W. L. & Lee, H., 1998 Jan 15, In : Cancer Research. 58, 2, p. 328-333 6 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

High glucose promotes nascent nephron apoptosis via NF-κB and p53 pathways

Chen, Y-W., Chenier, I., Chang, S. Y., Tran, S., Ingelfinger, J. R. & Zhang, S. L., 2011 Jan 1, In : American Journal of Physiology - Renal Physiology. 300, 1

Research output: Contribution to journalArticle

18 Citations (Scopus)

High prevalence of metabolic disturbances in patients with bipolar disorder in Taiwan

Chang, H. H., Chou, C. H., Chen, P. S., Gean, P. W., Huang, H. C., Lin, C. Y., Yang, Y. K. & Lu, R. B., 2009 Sep 1, In : Journal of Affective Disorders. 117, 1-2, p. 124-129 6 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing

Lee, C. F., Ou, D. S. C., Lee, S. B., Chang, L. H., Lin, R. K., Li, Y. S., Upadhyay, A. K., Cheng, X., Wang, Y. C., Hsu, H. S., Hsiao, M., Wu, C. W. & Juan, L. J., 2010 Aug 2, In : Journal of Clinical Investigation. 120, 8, p. 2920-2930 11 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Human cervical cancer cells use Ca2+ signalling, protein tyrosine phosphorylation and MAP kinase in regulatory volume decrease

Shen, M. R., Chou, C. Y., Browning, J. A., Wilkins, R. J. & Clive Ellory, J., 2001 Dec 1, In : Journal of Physiology. 537, 2, p. 347-362 16 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer

Kuo, Y. Z., Fang, W. Y., Huang, C. C., Tsai, S. T., Wang, Y. C., Yang, C. L. & Wu, L. W., 2017 Jan 1, In : Oncotarget. 8, 9, p. 15563-15583 21 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Hypoxia-inducible factor-1α protects cultured cortical neurons from lipopolysaccharide-induced cell death via regulation of NR1 expression

Yeh, S. H., Hung, J. J., Gean, P. W. & Chang, W., 2008 Dec 24, In : Journal of Neuroscience. 28, 52, p. 14259-14270 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60(src) substrate

Flynn, D. C., Leu, T. H., Reynolds, A. B. & Parsons, J. T., 1993 Jan 1, In : Molecular and Cellular Biology. 13, 12, p. 7892-7900 9 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

IDENTIFICATION OF ADENOSINE RECEPTORS IN HUMAN SPERMATOZOA

Shen, MR. R., Linden, J., Chen, SS. S. & Wu, SN. N., 1993 Aug, In : Clinical and Experimental Pharmacology and Physiology. 20, 7-8, p. 527-534 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Identification of calcineurin as a key signal in the extinction of fear memory

Lin, C. H., Yeh, S. H., Leu, T. H., Chang, W. C., Wang, S. T. & Gean, P. W., 2003 Mar 1, In : Journal of Neuroscience. 23, 5, p. 1574-1579 6 p.

Research output: Contribution to journalArticle

Open Access
136 Citations (Scopus)

Identifying the factors and signal pathways necessary for anchorage-independent growth of Ha-ras oncogene-transformed NIH/3T3 cells

Chang, T. Y., Tsai, W. J., Chou, C. K., Chow, N. H., Leu, T. H. & Liu, H. S., 2003 Jul 25, In : Life Sciences. 73, 10, p. 1265-1274 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness

Hsu, Y. M., Chou, C-Y., Chen, H. H. W., Lee, W. Y., Chen, Y. F., Lin, P. W., Alper, S. L., Ellory, J. C. & Shen, M-R., 2007 Mar 1, In : Journal of Cellular Physiology. 210, 3, p. 626-636 11 p.

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31 Citations (Scopus)
2 Citations (Scopus)

Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples

Wang, Y. C., Lu, Y. P., Tseng, R. C., Lin, R. K., Chang, J. W., Chen, J. T., Shih, C. M. & Chen, C. Y., 2003 Mar, In : Journal of Clinical Investigation. 111, 6, p. 887-895 9 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)
27 Citations (Scopus)

Induction of 12-lipoxygenase expression by phorbol 12-myristate 13-acetate in human epidermoid carcinoma A431 cells

Liaw, Y. W., Liu, Y. W., Chen, B. K. & Chang, W. C., 1998 Jan 5, In : Biochimica et Biophysica Acta - Lipids and Lipid Metabolism. 1389, 1, p. 23-33 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Induction of 12-lipoxygenase expression by transforming growth factor-α in human epidermoid carcinoma A431 cells

Chen, L. C., Chen, B. K., Liu, Y. W. & Chang, W. C., 1999 Jul 16, In : FEBS Letters. 455, 1-2, p. 105-110 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Influence of polymorphism at p53, CYP1A1 and GSTM1 loci on p53 mutation and association of p53 mutation with prognosis in lung cancer

Wang, Y. C., Chen, C. Y., Wang, H. J., Chen, S. K., Chang, Y. Y. & Lin, P., 1999 Jul, In : Chinese Medical Journal (Taipei). 62, 7, p. 395-403 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST

Lu, T. J., Lai, W. Y., Huang, C. Y. F., Hsieh, W. J., Yu, J. S., Hsieh, Y. J., Chang, W. T., Leu, T. H., Chang, W. C., Chuang, W. J., Tang, M. J., Chen, T. Y., Lu, T. L. & Lai, M. D., 2006 Dec 15, In : Journal of Biological Chemistry. 281, 50, p. 38405-38417 13 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death

Liu, W. T., Huang, C. Y., Lu, I. C. & Gean, P. W., 2013 Sep 1, In : Neuro-Oncology. 15, 9, p. 1127-1141 15 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Inhibition of HDAC3- and HDAC6-promoted survivin expression plays an important role in SAHA-induced autophagy and viability reduction in breast cancer cells

Lee, J. Y. C., Kuo, C. W., Tsai, S. L., Cheng, S. M., Chen, S. H., Chan, H. H., Lin, C. H., Lin, K. Y., Li, C. F., Kanwar, J. R., Leung, E. Y., Cheung, C. C. H., Huang, W. J., Wang, Y. C. & Cheung, C. H. A., 2016 Mar 31, In : Frontiers in Pharmacology. 7, MAR, 81.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Inhibition of initiation of simian virus 40 DNA replication during acute response of cells irradiated by ultraviolet light

Wang, Y. C. & Hsu, M. T., 1996, In : Nucleic acids research. 24, 16, p. 3149-3157 9 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones

Wang, S. J., Huang, C. C., Hsu, K-S., Tsai, J. J. & Gean, P-W., 1996 Jan 1, In : NeuroReport. 7, 18, p. 3037-3040 4 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Inhibition of Spontaneous Recovery of Fear by mGluR5 after Prolonged Extinction Training

Mao, S. C., Chang, C. H., Wu, C. C., Orejanera, M. J., Manzoni, O. J. & Gean, P. W., 2013 Mar 21, In : PloS one. 8, 3, e59580.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Inhibition of synaptic transmission and epileptiform activity in central neurones by fluspirilene

Wang, S. J., Lu, K. T. & Gean, P. W., 1997 Apr 1, In : British Journal of Pharmacology. 120, 6, p. 1114-1118 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
70 Citations (Scopus)

Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells

Shen, M. R., Lin, A. C., Hsu, Y. M., Chang, T. J., Tang, M. J., Alper, S. L., Ellory, J. C. & Chou, C. Y., 2004 Sep 17, In : Journal of Biological Chemistry. 279, 38, p. 40017-40025 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)
10 Citations (Scopus)

Integrative genomic analysis for the functional roles of ITPKC in bone mineral density

Lu, H. F., Wong, H. S. C., Chen, B. K., Liao, H. T., Hsu, Y. W., Ikegawa, S., Cho, E. C., Hung, K. S. & Chang, W. C., 2018 Nov 30, In : Bioscience Reports. 38, 6, BSR20181481.

Research output: Contribution to journalArticle