Research Output

2011

TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients

Wang, H. C., Yeh, T. L., Chang, H. H., Gean, P. W., Chi, M. H., Yang, Y. K., Lu, R. B. & Chen, P. S., 2011 Feb 1, In : Psychopharmacology. 213, 4, p. 773-779 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway

Yeh, S. H., Yang, W. B., Gean, P. W., Hsu, C. Y., Tseng, J. T., Su, T. P., Chang, W. C. & Hung, J. J., 2011 Jul 1, In : Nucleic acids research. 39, 13, p. 5412-5423 12 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2010

A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF-α therapy

Cheung, C. H. A., Sun, X., Kanwar, J. R., Bai, J. Z., Cheng, L. T. & Krissansen, G. W., 2010 Oct 1, In : Cancer Cell International. 10, 36.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Alterations of excitatory transmission in the lateral amygdala during expression and extinction of fear memory

Lin, H. C., Mao, S. C., Su, C. L. & Gean, P. W., 2010 Apr 1, In : International Journal of Neuropsychopharmacology. 13, 3, p. 335-345 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer

Tang, Y. A., Wen, W. L., Chang, J. W., Wei, T. T., Tan, Y. H. C., Salunke, S., Chen, C. T., Chen, C. S. & Wang, Y. C., 2010 Nov 1, In : PloS one. 5, 9, p. 1-13 13 p., e12417.

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)

A polymorphism in the hMLH1 gene (-93G→A) associated with lung cancer susceptibility and prognosis

Shih, C. M., Chen, C. Y., Lee, I. H., Kao, W. T. & Wang, Y. C., 2010 Jan 1, In : International journal of molecular medicine. 25, 1, p. 165-170 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
37 Citations (Scopus)

Butyrate reduced lipopolysaccharide-mediated macrophage migration by suppression of Src enhancement and focal adhesion kinase activity

Maa, M. C., Chang, M. Y., Hsieh, M. Y., Chen, Y. J., Yang, C. J., Chen, Z. C., Li, Y. K., Yen, C. K., Wu, R. R. & Leu, T-H., 2010 Dec 1, In : Journal of Nutritional Biochemistry. 21, 12, p. 1186-1192 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
19 Citations (Scopus)

Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes

Cheung, C. H. A., Wu, S. Y., Lee, T. R., Chang, C. Y., Wu, J. S., Hsieh, H. P. & Chang, J. Y., 2010 Nov 1, In : PloS one. 5, 9, p. 1-11 11 p., e12564.

Research output: Contribution to journalArticle

30 Citations (Scopus)

CBL is frequently altered in lung cancers: Its relationship to mutations in met and EGFR tyrosine kinases

Tan, Y. H. C., Krishnaswamy, S., Nandi, S., Kanteti, R., Vora, S., Onel, K., Hasina, R., Lo, F. Y., El-Hashani, E., Cervantes, G., Robinson, M., Kales, S. C., Lipkowitz, S., Karrison, T., Sattler, M., Vokes, E. E., Wang, Y. C. & Salgia, R., 2010 Jan 29, In : PloS one. 5, 1, e8972.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells

Hsieh, C. C., Kuo, Y. H., Kuo, C. C., Chen, L. T., Cheung, C-H., Chao, T. Y., Lin, C. H., Pan, W. Y., Chang, C. Y., Chien, S. C., Chen, T. W., Lung, C. C. & Chang, J-Y., 2010 May 1, In : Biochemical Pharmacology. 79, 9, p. 1261-1271 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Correction: A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF-α therapy

Cheung, C. H. A., Sun, X., Kanwar, J. R., Bai, J. Z., Cheng, L. & Krissansen, G. W., 2010 Oct 28, In : Cancer Cell International. 10, 43.

Research output: Contribution to journalComment/debate

10 Citations (Scopus)

Deficiency of electroneutral K+-Cl- cotransporter 3 causes a disruption in impulse propagation along peripheral nerves

Sun, Y-T., Lin, T-S., Tzeng, S-F., Delpire, E. & Shen, M-R., 2010 Oct 1, In : GLIA. 58, 13, p. 1544-1552 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Distinct epigenetic domains separated by a CTCF bound insulator between the tandem genes, BLU and RASSF1A

Chang, J. W., Hsu, H. S., Ni, H. J., Chuang, C. T., Hsiung, C. H., Huang, T. H. & Wang, Y. C., 2010 Oct 29, In : PloS one. 5, 9, p. 1-13 13 p., e12847.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer

Lin, R. K., Wu, C. Y., Chang, J. W., Juan, L. J., Hsu, H. S., Chen, C. Y., Lu, Y. Y., Tang, Y. A., Yang, Y. C., Yang, P. C. & Wang, Y. C., 2010 Jul 15, In : Cancer Research. 70, 14, p. 5807-5817 11 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing

Lee, C. F., Ou, D. S. C., Lee, S. B., Chang, L. H., Lin, R. K., Li, Y. S., Upadhyay, A. K., Cheng, X., Wang, Y. C., Hsu, H. S., Hsiao, M., Wu, C. W. & Juan, L. J., 2010 Aug 2, In : Journal of Clinical Investigation. 120, 8, p. 2920-2930 11 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Involvement of aryl hydrocarbon receptor nuclear translocato in EGF-induced c-Jun/Sp1-mediated gene expression

Huang, W. C., Chen, S. T., Chang, W. C., Chang, K. Y., Chang, W. C. & Chen, B-K., 2010 Oct 1, In : Cellular and Molecular Life Sciences. 67, 20, p. 3523-3533 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Late expression of brain-derived neurotrophic factor in the amygdala is required for persistence of fear memory

Ou, L. C., Yeh, S. H. & Gean, P. W., 2010 Mar 1, In : Neurobiology of Learning and Memory. 93, 3, p. 372-382 11 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Maternal diabetes programs hypertension and kidney injury in offspring

Chen, Y-W., Chenier, I., Tran, S., Scotcher, M., Chang, S. Y. & Zhang, S. L., 2010 Jul 1, In : Pediatric Nephrology. 25, 7, p. 1319-1329 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

PI3 kinase signaling is involved in Aβ-induced memory loss in Drosophila

Chiang, H. C., Wang, L., Xie, Z., Yau, A. & Zhong, Y., 2010 Apr 13, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 15, p. 7060-7065 6 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Proliferative and protective effects of SurR9-C84A on differentiated neural cells

Baratchi, S., Kanwar, R. K., Cheung, C. H. A. & Kanwar, J. R., 2010 Oct 1, In : Journal of Neuroimmunology. 227, 1-2, p. 120-132 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Recent advances in anti-survivin treatments for cancer

Kanwar, R. K., Cheung, C-H., Chang, J-Y. & Kanwar, J. R., 2010 Jun 18, In : Current Medicinal Chemistry. 17, 15, p. 1509-1515 7 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

SLIT2 attenuation during lung cancer progression deregulates β-catenin and E-cadherin and associates with poor prognosis

Tseng, R. C., Lee, S. H., Hsu, H. S., Chen, B. H., Tsai, W. C., Tzao, C. & Wang, Y-C., 2010 Jan 15, In : Cancer Research. 70, 2, p. 543-551 9 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)
36 Citations (Scopus)

The emerging role of KCl cotransport in tumor biology

Chen, Y. F., Chou, C. Y., Clive Ellory, J. & Shen, M. R., 2010 Oct 8, In : American Journal of Translational Research. 2, 4, p. 345-355 11 p.

Research output: Contribution to journalReview article

20 Citations (Scopus)

The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation

Liu, P. S., Jong, T. H., Maa, M. C. & Leu, T-H., 2010 Jul 8, In : Oncogene. 29, 27, p. 3977-3989 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The role of valproate in metabolic disturbances in bipolar disorder patients

Chang, H. H., Yang, Y. K., Gean, P. W., Huang, H. C., Chen, P. S. & Lu, R. B., 2010 Aug 1, In : Journal of Affective Disorders. 124, 3, p. 319-323 5 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients

Lin, R. K., Hsieh, Y. S., Lin, P., Hsu, H. S., Chen, C. Y., Tang, Y. A., Lee, C. F. & Wang, Y. C., 2010 Feb 1, In : Journal of Clinical Investigation. 120, 2, p. 521-532 12 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

Translational up-regulation of Aurora-A in EGFR-overexpressed cancer

Lai, C. H., Tseng, J. T., Lee, Y. C., Chen, Y. J., Lee, J. C., Lin, B. W., Huang, T. C., Liu, Y. W., Leu, T. H., Liu, Y. W., Chen, Y. P., Chang, W. C. & Hung, L. Y., 2010 Jun 1, In : Journal of Cellular and Molecular Medicine. 14, 6 B, p. 1520-1531 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer

Lin, L. F., Chuang, C. H., Li, C. F., Liao, C. C., Cheng, C. P., Cheng, T. L., Shen, M. R., Tseng, J. T., Chang, W., Lee, W. H. & Wang, J. M., 2010 Jan 1, In : Cancer Research. 70, 1, p. 192-201 10 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2009

A 3D-QSAR study of celebrex-based PDK1 inhibitors using CoMFA method

Wang, W. H., Jena, N. R., Wang, Y. C. & Sun, Y. C., 2009 Jan 1, In : Journal of the Chinese Chemical Society. 56, 1, p. 59-64 6 p.

Research output: Contribution to journalArticle

Advances in Aurora kinase inhibitor patents

Coumar, M. S., Cheung, C-H., Chang, J-Y. & Hsieh, H. P., 2009 Mar 1, In : Expert Opinion on Therapeutic Patents. 19, 3, p. 321-356 36 p.

Research output: Contribution to journalReview article

22 Citations (Scopus)

Augmentation of fear extinction by infusion of glycine transporter blockers into the amygdala

Mao, S. C., Lin, H. C. & Gean, P-W., 2009 Aug 1, In : Molecular Pharmacology. 76, 2, p. 369-378 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Aurora kinase inhibitors in preclinical and clinical testing

Cheung, C. H. A., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 Apr 1, In : Expert Opinion on Investigational Drugs. 18, 4, p. 379-398 20 p.

Research output: Contribution to journalReview article

83 Citations (Scopus)

Block of γ-Aminobutyric Acid-A Receptor Insertion in the Amygdala Impairs Extinction of Conditioned Fear

Lin, H. C., Mao, S. C. & Gean, P. W., 2009 Oct 1, In : Biological Psychiatry. 66, 7, p. 665-673 9 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients

Tseng, R. C., Lee, C. C., Hsu, H. S., Tzao, C. & Wang, Y. C., 2009 Aug, In : Neoplasia. 11, 8, p. 763-770 8 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Distinctive roles of different β-amyloid 42 aggregates in modulation of synaptic functions

Chiang, H. C., Iijima, K., Hakker, I. & Zhong, Y., 2009 Jun 1, In : FASEB Journal. 23, 6, p. 1969-1977 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
21 Citations (Scopus)

Ethnic differences and functional analysis of MET mutations in lung cancer

Krishnaswamy, S., Kanteti, R., Duke-Cohan, J. S., Loganathan, S., Liu, W., Ma, P. C., Sattler, M., Singleton, P. A., Ramnath, N., Innocenti, F., Nicolae, D. L., Ouyang, Z., Liang, J., Minna, J., Kozloff, M. F., Ferguson, M. K., Natarajan, V., Wang, Y. C., Garcia, J. G. N., Vokes, E. E. & 1 others, Salgia, R., 2009 Sep 15, In : Clinical Cancer Research. 15, 18, p. 5714-5723 10 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)

Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer

Wu, C. Y., Tseng, R. C., Hsu, H. S., Wang, Y. C. & Hsu, M. T., 2009 Mar 1, In : Lung Cancer. 63, 3, p. 360-367 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

High prevalence of metabolic disturbances in patients with bipolar disorder in Taiwan

Chang, H. H., Chou, C. H., Chen, P. S., Gean, P. W., Huang, H. C., Lin, C. Y., Yang, Y. K. & Lu, R. B., 2009 Sep 1, In : Journal of Affective Disorders. 117, 1-2, p. 124-129 6 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
54 Citations (Scopus)

Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes: A multiple genotype-phenotype study

Tseng, R. C., Hsieh, F. J., Shih, C. M., Hsu, H. S., Chen, C. Y. & Wang, Y-C., 2009 Jul 1, In : Cancer. 115, 13, p. 2939-2948 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion

Chen, Y. F., Chou, C. Y., Wilkins, R. J., Ellory, J. C., Mount, D. B. & Shen, M. R., 2009 Nov 15, In : Cancer Research. 69, 22, p. 8585-8593 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons

Lin, Y. C., Chou, L. C., Chen, S. C., Kuo, S. C., Huang, L. J. & Gean, P. W., 2009 Jun 15, In : Bioorganic and Medicinal Chemistry Letters. 19, 12, p. 3225-3228 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Neuroprotective Effects of Ugonin K on Hydrogen Peroxide-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells

Lin, Y. C., Huang, Y. C., Chen, S. C., Liaw, C. C., Kuo, S. C., Huang, L. J. & Gean, P-W., 2009 May 1, In : Neurochemical Research. 34, 5, p. 923-930 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Reduced axin protein expression is associated with a poor prognosis in patients with squamous cell carcinoma of esophagus

Li, A. F. Y., Hsu, P. K., Tzao, C., Wang, Y-C., Hung, I. C., Huang, M. H. & Hsu, H. S., 2009 Sep 1, In : Annals of Surgical Oncology. 16, 9, p. 2486-2493 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

Cheung, C. H. A., Chen, H. H., Kuo, C. C., Chang, C. Y., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 Jul 3, In : Molecular cancer. 8, 43.

Research output: Contribution to journalArticle

56 Citations (Scopus)