Research Output

2009

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

Cheung, C. H. A., Chen, H. H., Kuo, C. C., Chang, C. Y., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 Jul 3, In : Molecular cancer. 8, 43.

Research output: Contribution to journalArticle

56 Citations (Scopus)

The role of prefrontal cortex CB1 receptors in the modulation of fear memory

Lin, H. C., Mao, S. C., Su, C. L. & Gean, P. W., 2009 Jan 1, In : Cerebral Cortex. 19, 1, p. 165-175 11 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)
2008

A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells

Chen, C. T., Munot, Y. S., Salunke, S. B., Wang, Y-C., Lin, R. K., Lin, C. C., Chen, C. C. & Liu, Y. H., 2008 Feb 22, In : Advanced Functional Materials. 18, 4, p. 527-540 14 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
11 Citations (Scopus)

Augmentation of fear extinction by D-cycloserine is blocked by proteasome inhibitors

Mao, S. C., Lin, H. C. & Gean, P-W., 2008 Dec 1, In : Neuropsychopharmacology. 33, 13, p. 3085-3095 11 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Aβ42 mutants with different aggregation profiles induce distinct pathologies in Drosophila

Iijima, K., Chiang, H. C., Hearn, S. A., Hakker, I., Gatt, A., Shenton, C., Granger, L., Leung, A., Iijima-Ando, K. & Zhong, Y., 2008 Feb 27, In : PloS one. 3, 2, e1703.

Research output: Contribution to journalArticle

114 Citations (Scopus)

Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation

Huang, C. C., Wang, J. M., Kikkawa, U., Mukai, H., Shen, M. R., Morita, I., Chen, B. K. & Chang, W. C., 2008 Apr 10, In : Oncogene. 27, 17, p. 2422-2429 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Chronic cannabinoid administration in vivo compromises extinction of fear memory

Lin, H. C., Mao, S. C., Chen, P-S. & Gean, P-W., 2008 Dec 1, In : Learning and Memory. 15, 12, p. 876-884 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
38 Citations (Scopus)

Conditionally replicating E1B-deleted adenovirus driven by the squamous cell carcinoma antigen 2 promoter for uterine cervical cancer therapy

Hsu, K. F., Wu, C. L., Huang, S. C., Hsieh, J. L., Huang, Y. S., Chen, Y. F., Shen, M. R., Chung, W. J., Chou, C. Y. & Shiau, A. L., 2008 Aug 18, In : Cancer Gene Therapy. 15, 8, p. 526-534 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Cytotoxicity and proteomics analyses of OSU03013 in lung cancer

Tan, Y. H., Lee, K. H., Lin, T., Sun, Y. C., Hsieh-Li, H. M., Juan, H. F. & Wang, Y. C., 2008 Mar 15, In : Clinical Cancer Research. 14, 6, p. 1823-1830 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis

Chen, Y-W., Tran, S., Chenier, I., Chan, J. S. D., Ingelfinger, J. R., Inagami, T. & Zhang, S. L., 2008 Jul 9, In : Pediatric Nephrology. 23, 10, p. 1769-1777 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
72 Citations (Scopus)

Emerging methods for analysis of the cancer methylome

Chang, J. W., Huang, T. H. M. & Wang, Y-C., 2008 Dec 1, In : Pharmacogenomics. 9, 12, p. 1869-1878 10 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type β-catenin nuclear accumulation in lung tumorigenesis

Tseng, R. C., Lin, R. K., Wen, C. K., Tseng, C., Hsu, H. S., Hsu, W. H. & Wang, Y. C., 2008 Jul 24, In : Oncogene. 27, 32, p. 4488-4496 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Epigenetic silencing of CCAAT/enhancer-binding protein δ activity by YY1/polycomb group/DNA methyltransferase complex

Ko, C. Y., Hsu, H. C., Shen, M. R., Chang, W. C. & Wang, J. M., 2008 Nov 7, In : Journal of Biological Chemistry. 283, 45, p. 30919-30932 14 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
201 Citations (Scopus)

Eps8 decreases chemosensitivity and affects survival of cervical cancer patients

Chen, Y. J., Shen, M. R., Chen, Y. J., Maa, M. C. & Leu, T. H., 2008 Oct 15, In : Molecular Cancer Therapeutics. 7, 6, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
50 Citations (Scopus)

Hypoxia-inducible factor-1α protects cultured cortical neurons from lipopolysaccharide-induced cell death via regulation of NR1 expression

Yeh, S. H., Hung, J. J., Gean, P. W. & Chang, W., 2008 Dec 24, In : Journal of Neuroscience. 28, 52, p. 14259-14270 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Low substratum rigidity of collagen gel promotes ERK phosphorylation via lipid raft to augment cell migration

Wei, W. C., Hsu, Y. C., Chiu, W. T., Wang, C. Z., Wu, C. M., Wang, Y. K., Shen, M. R. & Tang, M. J., 2008 Mar 1, In : Journal of Cellular Biochemistry. 103, 4, p. 1111-1124 14 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Maternal diabetes modulates renal morphogenesis in offspring

Tran, S., Chen, Y. W., Chenier, I., Chan, J. S. D., Quaggin, S., Hébert, M. J., Ingelfinger, J. R. & Zhang, S. L., 2008 May 1, In : Journal of the American Society of Nephrology. 19, 5, p. 943-952 10 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Mechanosensing machinery for cells under low substratum rigidity

Wei, W. C., Lin, H. H., Shen, M. R. & Tang, M. J., 2008 Dec 1, In : American Journal of Physiology - Cell Physiology. 295, 6, p. C1579-C1589

Research output: Contribution to journalArticle

47 Citations (Scopus)
21 Citations (Scopus)
16 Citations (Scopus)

Novel 2-step synthetic indole compound 1,1,3-tri(3-indolyl)cyclohexane inhibits cancer cell growth in lung cancer cells and xenograft models

Lee, C. H., Yao, C. F., Huang, S. M., Ko, S., Tan, Y. H., Lee-Chen, G. J. & Wang, Y. C., 2008 Aug 15, In : Cancer. 113, 4, p. 815-825 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Nucleolin regulates c-Jun/Sp1-dependent transcriptional activation of cPLA2α in phorbol ester-treated non-small cell lung cancer A549 cells

Tsou, J. H., Chang, K. Y., Wang, W. C., Tseng, J. T., Su, W. C., Hung, L. Y., Chang, W. C. & Chen, B. K., 2008 Jan 1, In : Nucleic acids research. 36, 1, p. 217-227 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
64 Citations (Scopus)

Paxillin is a target for somatic mutations in lung cancer: Implications for cell growth and invasion

Jagadeeswaran, R., Surawska, H., Krishnaswamy, S., Janamanchi, V., Mackinnon, A. C., Seiwert, T. Y., Loganathan, S., Kanteti, R., Reichman, T., Nallasura, V., Schwartz, S., Faoro, L., Wang, Y. C., Girard, L., Tretiakova, M. S., Ahmed, S., Zumba, O., Soulii, L., Bindokas, V. P., Szeto, L. L. & 13 others, Gordon, G. J., Bueno, R., Sugarbaker, D., Lingen, M. W., Sattler, M., Krausz, T., Vigneswaran, W., Natarajan, V., Minna, J., Vokes, E. E., Ferguson, M. K., Husain, A. N. & Salgia, R., 2008 Jan 1, In : Cancer Research. 68, 1, p. 132-142 11 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

Reduced membranous β-catenin protein expression is associated with metastasis and poor prognosis in squamous cell carcinoma of the esophagus

Hsu, P. K., Li, A. F. Y., Wang, Y. C., Hsieh, C. C., Huang, M. H., Hsu, W. H. & Hsu, H. S., 2008 May 1, In : Journal of Thoracic and Cardiovascular Surgery. 135, 5, p. 1029-1035 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Requirement of inducible nitric-oxide synthase in lipopolysaccharide- mediated Src induction and macrophage migration

Maa, M. C., Miao, Y. C., Chen, Y. J., Lin, C. H., Chih, J. Y., Yi, L. Y., Li, J., Chen, P. R., Tang, C. H., Lei, H. Y. & Leu, T-H., 2008 Nov 14, In : Journal of Biological Chemistry. 283, 46, p. 31408-31416 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
30 Citations (Scopus)

Sumoylation of Specificity Protein 1 Augments Its Degradation by Changing the Localization and Increasing the Specificity Protein 1 Proteolytic Process

Wang, Y. T., Chuang, J. Y., Shen, M. R., Yang, W. B., Chang, W. C. & Hung, J. J., 2008 Jul 25, In : Journal of Molecular Biology. 380, 5, p. 869-885 17 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Synthesis of 2-[4-(imidazolin-2-ylideneamino)benzyl]-Indan-1-ones as novel potent prostacyclin antagonists

Chern, C. Y., Yek, Y. L., Chen, Y. L. & Kan, W. M., 2008 Jan 1, In : Journal of the Chinese Chemical Society. 55, 4, p. 846-853 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2007

Alteration of DNA methyltransferases contributes to 5′CpG methylation and poor prognosis in lung cancer

Lin, R. K., Hsu, H. S., Chang, J. W., Chen, C. Y., Chen, J. T. & Wang, Y. C., 2007 Feb 1, In : Lung Cancer. 55, 2, p. 205-213 9 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)
35 Citations (Scopus)

Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma

Hsu, H. S., Chen, T. P., Hung, C. H., Wen, C. K., Lin, R. K., Lee, H. C. & Wang, Y-C., 2007 Nov 1, In : Cancer. 110, 9, p. 2019-2026 8 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)

Elevated p53 and p21waf1 mRNA expression in blood lymphocytes from lung cancer patients with chemoresistance

Shih, C. M., Chen, K., Wang, Y. C., Lee, P. J. & Wang, Y-C., 2007 Dec 4, In : Cancer Detection and Prevention. 31, 5, p. 366-370 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Epigenetic inactivation of the chromosomal stability control genes BRCA1 BRCA2, and XRCC5 in non-small cell lung cancer

Lee, M. N., Tseng, R. C., Hsu, H. S., Chen, J. Y., Tzao, C., Ho, W. L. & Wang, Y. C., 2007 Feb 1, In : Clinical Cancer Research. 13, 3, p. 832-838 7 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

EPS8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase

Maa, M. C., Lee, J-C., Chen, Y. J., Chen, Y. J., Lee, Y. C., Wang, S-T., Huang, C. C., Chow, N-H. & Leu, T-H., 2007 Jul 6, In : Journal of Biological Chemistry. 282, 27, p. 19399-19409 11 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness

Hsu, Y. M., Chou, C-Y., Chen, H. H. W., Lee, W. Y., Chen, Y. F., Lin, P. W., Alper, S. L., Ellory, J. C. & Shen, M-R., 2007 Mar 1, In : Journal of Cellular Physiology. 210, 3, p. 626-636 11 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
27 Citations (Scopus)

KCl cotransporter-3 down-regulates E-cadherin/β-catenin complex to promote epithelial-mesenchymal transition

Hsu, Y. M., Chen, Y. F., Chou, C. Y., Tang, M. J., Chen, J. H., Wilkins, R. J., Clive Ellory, J. & Shen, M. R., 2007 Nov 15, In : Cancer Research. 67, 22, p. 11064-11073 10 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells

Lin, R. K., Hsu, C. H. & Wang, Y-C., 2007 Nov 1, In : Anti-Cancer Drugs. 18, 10, p. 1157-1164 8 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Multiple genetic and epigenetic biomarkers for lung cancer detection in cytologically negative sputum and a nested case-control study for risk assessment

Hsu, H. S., Chen, T. P., Wen, C. K., Hung, C. H., Chen, C. Y., Chen, J. T. & Wang, Y. C., 2007 Dec 1, In : Journal of Pathology. 213, 4, p. 412-419 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Pax-2 and N-myc regulate epithelial cell proliferation and apoptosis in a positive autocrine feedback loop

Zhang, S. L., Chen, Y-W., Tran, S., Liu, F., Nestoridi, E., Hébert, M. J. & Ingelfinger, J. R., 2007 Jun 1, In : Pediatric Nephrology. 22, 6, p. 813-824 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Polymorphism in the hMSH2 gene (gISV12-6T > C) is a prognostic factor in non-small cell lung cancer

Hsu, H. S., Lee, I. H., Hsu, W. H., Kao, W. T. & Wang, Y. C., 2007 Oct 1, In : Lung Cancer. 58, 1, p. 123-130 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

PP2B-mediated dephosphorylation of c-Jun C terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cells

Chen, B. K., Huang, C. C., Chang, W. C., Chen, Y. J., Kikkawa, U., Nakahama, K. I., Morita, I. & Chang, W. C., 2007 Mar 1, In : Molecular Biology of the Cell. 18, 3, p. 1118-1127 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Reactive oxygen species in the presence of high glucose alter ureteric bud morphogenesis

Zhang, S. L., Chen, Y. W., Tran, S., Chenier, I., Hébert, M. J. & Ingelfinger, J. R., 2007 Jul, In : Journal of the American Society of Nephrology. 18, 7, p. 2105-2115 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Role of transcriptional factors Sp1, c-Rel, and c-Jun in LPS-induced C/EBPd gene expression of mouse macrophages

Liu, Y. W., Chen, C. C., Wang, J-M., Chang, W. C., Huang, Y. C., Chung, S. Y., Chen, B-K. & Hung, J-J., 2007 Dec 1, In : Cellular and Molecular Life Sciences. 64, 24, p. 3282-3294 13 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)