Research Output

2010

Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer

Lin, R. K., Wu, C. Y., Chang, J. W., Juan, L. J., Hsu, H. S., Chen, C. Y., Lu, Y. Y., Tang, Y. A., Yang, Y. C., Yang, P. C. & Wang, Y. C., 2010 Jul 15, In : Cancer Research. 70, 14, p. 5807-5817 11 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing

Lee, C. F., Ou, D. S. C., Lee, S. B., Chang, L. H., Lin, R. K., Li, Y. S., Upadhyay, A. K., Cheng, X., Wang, Y. C., Hsu, H. S., Hsiao, M., Wu, C. W. & Juan, L. J., 2010 Aug 2, In : Journal of Clinical Investigation. 120, 8, p. 2920-2930 11 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Involvement of aryl hydrocarbon receptor nuclear translocato in EGF-induced c-Jun/Sp1-mediated gene expression

Huang, W. C., Chen, S. T., Chang, W. C., Chang, K. Y., Chang, W. C. & Chen, B-K., 2010 Oct 1, In : Cellular and Molecular Life Sciences. 67, 20, p. 3523-3533 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Late expression of brain-derived neurotrophic factor in the amygdala is required for persistence of fear memory

Ou, L. C., Yeh, S. H. & Gean, P. W., 2010 Mar 1, In : Neurobiology of Learning and Memory. 93, 3, p. 372-382 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Maternal diabetes programs hypertension and kidney injury in offspring

Chen, Y-W., Chenier, I., Tran, S., Scotcher, M., Chang, S. Y. & Zhang, S. L., 2010 Jul 1, In : Pediatric Nephrology. 25, 7, p. 1319-1329 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

PI3 kinase signaling is involved in Aβ-induced memory loss in Drosophila

Chiang, H. C., Wang, L., Xie, Z., Yau, A. & Zhong, Y., 2010 Apr 13, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 15, p. 7060-7065 6 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Proliferative and protective effects of SurR9-C84A on differentiated neural cells

Baratchi, S., Kanwar, R. K., Cheung, C. H. A. & Kanwar, J. R., 2010 Oct 1, In : Journal of Neuroimmunology. 227, 1-2, p. 120-132 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Recent advances in anti-survivin treatments for cancer

Kanwar, R. K., Cheung, C-H., Chang, J-Y. & Kanwar, J. R., 2010 Jun 18, In : Current Medicinal Chemistry. 17, 15, p. 1509-1515 7 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

SLIT2 attenuation during lung cancer progression deregulates β-catenin and E-cadherin and associates with poor prognosis

Tseng, R. C., Lee, S. H., Hsu, H. S., Chen, B. H., Tsai, W. C., Tzao, C. & Wang, Y-C., 2010 Jan 15, In : Cancer Research. 70, 2, p. 543-551 9 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)
36 Citations (Scopus)

The emerging role of KCl cotransport in tumor biology

Chen, Y. F., Chou, C. Y., Clive Ellory, J. & Shen, M. R., 2010 Oct 8, In : American Journal of Translational Research. 2, 4, p. 345-355 11 p.

Research output: Contribution to journalReview article

20 Citations (Scopus)

The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation

Liu, P. S., Jong, T. H., Maa, M. C. & Leu, T-H., 2010 Jul 8, In : Oncogene. 29, 27, p. 3977-3989 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The role of valproate in metabolic disturbances in bipolar disorder patients

Chang, H. H., Yang, Y. K., Gean, P. W., Huang, H. C., Chen, P. S. & Lu, R. B., 2010 Aug 1, In : Journal of Affective Disorders. 124, 3, p. 319-323 5 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients

Lin, R. K., Hsieh, Y. S., Lin, P., Hsu, H. S., Chen, C. Y., Tang, Y. A., Lee, C. F. & Wang, Y. C., 2010 Feb 1, In : Journal of Clinical Investigation. 120, 2, p. 521-532 12 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

Translational up-regulation of Aurora-A in EGFR-overexpressed cancer

Lai, C. H., Tseng, J. T., Lee, Y. C., Chen, Y. J., Lee, J. C., Lin, B. W., Huang, T. C., Liu, Y. W., Leu, T. H., Liu, Y. W., Chen, Y. P., Chang, W. C. & Hung, L. Y., 2010 Jun 1, In : Journal of Cellular and Molecular Medicine. 14, 6 B, p. 1520-1531 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer

Lin, L. F., Chuang, C. H., Li, C. F., Liao, C. C., Cheng, C. P., Cheng, T. L., Shen, M. R., Tseng, J. T., Chang, W., Lee, W. H. & Wang, J. M., 2010 Jan 1, In : Cancer Research. 70, 1, p. 192-201 10 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2011

Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells

Tsou, J. H., Chang, K. C., Chang-Liao, P. Y., Yang, S. T., Lee, C. T., Chen, Y. P., Lee, Y. C., Lin, B. W., Lee, J. C., Shen, M. R., Chuang, C. K., Chang, W. C., Wang, J. M. & Hung, L. Y., 2011 Oct, In : Journal of Pathology. 225, 2, p. 243-254 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Activation of Toll-like receptors induces macrophage migration via the iNOS/Src/FAK pathway

Maa, M. C. & Leu, T. H., 2011 Dec, In : BioMedicine (Netherlands). 1, 1, p. 11-15 5 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

An E3 ubiquitin ligase: C-Cbl: A new therapeutic target of lung cancer

Lo, F. Y., Tan, Y. H. C., Cheng, H. C., Salgia, R. & Wang, Y. C., 2011 Dec 1, In : Cancer. 117, 23, p. 5344-5350 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Angiotensin II type II receptor deficiency accelerates the development of nephropathy in type i diabetes via oxidative stress and ACE2

Chang, S. Y., Chen, Y. W., Chenier, I., Tran, S. L. M. & Zhang, S. L., 2011 Dec 1, In : Experimental Diabetes Research. 2011, 521076.

Research output: Contribution to journalArticle

35 Citations (Scopus)

A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways

Chen, J. Y., Tang, Y. A., Huang, S. M., Juan, H. F., Wu, L. W., Sun, Y. C., Wang, S. C., Wu, K. W., Balraj, G., Chang, T. T., Li, W. S., Cheng, H. C. & Wang, Y. C., 2011 Jan 15, In : Cancer Research. 71, 2, p. 473-483 11 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

ATM/ATR and SMAD3 pathways contribute to 3-indole-induced G1 arrest in cancer cells and xenograft models

Huang, S. M., Lu, K. T. & Wang, Y. I. C., 2011 Jan 1, In : Anticancer research. 31, 1, p. 203-208 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
7 Citations (Scopus)

Aurora kinase inhibitor patents and agents in clinical testing: An update (2009 - 10)

Cheung, C. H. A., Coumar, M. S., Chang, J. Y. & Hsieh, H. P., 2011 Jun 1, In : Expert Opinion on Therapeutic Patents. 21, 6, p. 857-884 28 p.

Research output: Contribution to journalReview article

34 Citations (Scopus)

BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Cheung, C. H. A., Lin, W. H., HsuJohn, J. T. A., Hour, T. C., Yeh, T. K., Ko, S., Lien, T. W., Coumar, M. S., Liu, J. F., Lai, W. Y., Shiao, H. Y., Lee, T. R., Hsieh, H. P. & Chang, J. Y., 2011 Aug 24, In : PloS one. 6, 8, e23485.

Research output: Contribution to journalArticle

14 Citations (Scopus)
215 Citations (Scopus)

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C. H. A., Chen, L. T. & Chang, J. Y., 2011 Oct 1, In : Cancer Letters. 309, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Functional EGFR germline polymorphisms may confer risk for EGFR somatic mutations in non-small cell lung cancer, with a predominant effect on exon 19 microdeletions

Liu, W., He, L., Ramírez, J., Krishnaswamy, S., Kanteti, R., Wang, Y. C., Salgia, R. & Ratain, M. J., 2011 Apr 1, In : Cancer Research. 71, 7, p. 2423-2427 5 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

GABAA receptor endocytosis in the basolateral amygdala is critical to the reinstatement of fear memory measured by fear-potentiated startle

Lin, H. C., Tseng, Y. C., Mao, S. C., Chen, P. S. & Gean, P. W., 2011 Jun 15, In : Journal of Neuroscience. 31, 24, p. 8851-8861 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

High glucose promotes nascent nephron apoptosis via NF-κB and p53 pathways

Chen, Y-W., Chenier, I., Chang, S. Y., Tran, S., Ingelfinger, J. R. & Zhang, S. L., 2011 Jan 1, In : American Journal of Physiology - Renal Physiology. 300, 1

Research output: Contribution to journalArticle

18 Citations (Scopus)

Investigations of survivin: The past, present and future

Cheung, C. H. A., Cheng, L. T., Chang, K. Y., Chen, H. H. & Chang, J. Y., 2011 Jan 1, In : Frontiers in Bioscience. 16, 3, p. 952-961 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Mechanisms underlying Benzyl alcohol cytotoxicity (triamcinolone acetonide preservative) in human retinal pigment epithelial cells

Chang, Y-S., Lin, C. F., Wu, C-L., Kuo, P. Y., Wu, F. S., Shieh, C-C., Gean, P-W., Chen, S. T., Chen, M. S., Wu, W. C., Tai, M. H. & Tseng, S. H., 2011 Jun 1, In : Investigative Ophthalmology and Visual Science. 52, 7, p. 4214-4222 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Minocycline inhibits the growth of glioma by inducing autophagy

Liu, W. T., Lin, C. H., Hsiao, M. & Gean, P. W., 2011 Feb, In : Autophagy. 7, 2, p. 166-175 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Selective inhibition of early-but not late-expressed HIF-1α is neuroprotective in rats after focal ischemic brain damage

Yeh, S. H., Ou, L. C., Gean, P-W., Hung, J-J. & Chang, W. C., 2011 May 1, In : Brain Pathology. 21, 3, p. 249-262 14 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

The iNOS/Src/FAK axis is critical in Toll-like receptor-mediated cell motility in macrophages

Maa, M. C., Chang, M. Y., Li, J., Li, Y. Y., Hsieh, M. Y., Yang, C. J., Chen, Y. J., Li, Y., Chen, H. C., Cheng, W. E., Hsieh, C. Y., Cheng, C. W. & Leu, T. H., 2011 Jan 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 1, p. 136-147 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
22 Citations (Scopus)

The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism

Wei, W. C., Akerman, C. J., Newey, S. E., Pan, J., Clinch, N. W. V., Jacob, Y., Shen, M. R., Wilkins, R. J. & Ellory, J. C., 2011 Nov 1, In : Journal of Physiology. 589, 22, p. 5349-5359 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients

Wang, H. C., Yeh, T. L., Chang, H. H., Gean, P. W., Chi, M. H., Yang, Y. K., Lu, R. B. & Chen, P. S., 2011 Feb 1, In : Psychopharmacology. 213, 4, p. 773-779 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway

Yeh, S. H., Yang, W. B., Gean, P. W., Hsu, C. Y., Tseng, J. T., Su, T. P., Chang, W. C. & Hung, J. J., 2011 Jul, In : Nucleic acids research. 39, 13, p. 5412-5423 12 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2012
30 Citations (Scopus)

Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms

Wang, C. Y., Chen, C. L., Tseng, Y. L., Fang, Y. T., Lin, Y. S., Su, W. C., Chen, C. C., Chang, K. C., Wang, Y. C. & Lin, C. F., 2012 Sep 21, In : Journal of Biological Chemistry. 287, 39, p. 32512-32524 13 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Cancer epigenomics

Chang, J. W. & Wang, Y-C., 2012 Jan 1, Systems Biology: Applications in Cancer-Related Research. World Scientific Publishing Co., p. 129-159 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Cancer targeted nanoparticles specifically induce apoptosis in cancer cells and spare normal cells

Kanwar, J. R., Kanwar, R. K., Mahidhara, G. & Cheung, C. H. A., 2012 Feb 16, In : Australian Journal of Chemistry. 65, 1, p. 5-14 10 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Catalase prevents maternal diabetes-induced perinatal programming via the Nrf2-HO-1 defense system

Chang, S. Y., Chen, Y. W., Zhao, X. P., Chenier, I., Tran, S., Sauvé, A., Ingelfinger, J. R. & Zhang, S. L., 2012 Oct 1, In : Diabetes. 61, 10, p. 2565-2574 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response

Chang, H. Y., Huang, H. C., Huang, T. C., Yang, P. C., Wang, Y. C. & Juan, H. F., 2012 Sep 15, In : Cancer Research. 72, 18, p. 4696-4706 11 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Epidermal growth factor receptor is a preferred target for treating Amyloid-β-induced memory loss

Wang, L., Chiang, H. C., Wu, W., Liang, B., Xie, Z., Yao, X., Ma, W., Du, S. & Zhong, Y., 2012 Oct 9, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 41, p. 16743-16748 6 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Epithelial-mesenchymal transition in cervical carcinoma

Lee, M. Y. & Shen, M-R., 2012 Feb 9, In : American Journal of Translational Research. 4, 1, p. 1-13 13 p.

Research output: Contribution to journalReview article

92 Citations (Scopus)

Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages

Chen, Y. J., Hsieh, M. Y., Chang, M. Y., Chen, H. C., Jan, M. S., Maa, M. C. & Leu, T. H., 2012 May 25, In : Journal of Biological Chemistry. 287, 22, p. 18806-18819 14 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Expression of Eps8 correlates with poor survival in oral squamous cell carcinoma

Chu, P. Y., Liou, J. H., Lin, Y. M., Chen, C. J., Chen, M. K., Lin, S. H., Yeh, C. M., Wang, H. K., Maa, M. C., Leu, T. H., Chang, N. W., Hsu, N. C. & Yeh, K. T., 2012 Dec 1, In : Asia-Pacific Journal of Clinical Oncology. 8, 4, p. e77-e81

Research output: Contribution to journalArticle

10 Citations (Scopus)