Research Output

2007

Transcriptional regulation of brain-derived neurotrophic factor in the amygdala during consolidation of fear memory

Ou, L. C. & Gean, P. W., 2007 Aug 1, In : Molecular Pharmacology. 72, 2, p. 350-358 9 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity

Chen, P. S., Wang, C. C., Bortner, C. D., Peng, G. S., Wu, X., Pang, H., Lu, R. B., Gean, P. W., Chuang, D. M. & Hong, J. S., 2007 Oct 12, In : Neuroscience. 149, 1, p. 203-212 10 p.

Research output: Contribution to journalArticle

182 Citations (Scopus)
2006
78 Citations (Scopus)

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

Lai, C., Xie, C., McCormack, S. G., Chiang, H. C., Michalak, M. K., Lin, X., Chandran, J., Shim, H., Shimoji, M., Cookson, M. R., Huganir, R. L., Rothstein, J. D., Price, D. L., Wong, P. C., Martin, L. J., Zhu, J. J. & Cai, H., 2006 Nov 8, In : Journal of Neuroscience. 26, 45, p. 11798-11806 9 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Direct interaction of C/EBPδ and Sp1 at the GC-enriched promoter region synergizes the IL-10 gene transcription in mouse macrophage

Chiang, B. T., Liu, Y. W., Chen, B. K., Wang, J. M. & Chang, W. C., 2006 Sep 1, In : Journal of biomedical science. 13, 5, p. 621-635 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle

Lin, H. C., Mao, S. C. & Gean, P. W., 2006 May 1, In : Learning and Memory. 13, 3, p. 316-321 6 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)
9 Citations (Scopus)

Extinction training in conjunction with a partial agonist of the glycine site on the NMDA receptor erases memory trace

Mao, S. C., Hsiao, Y. H. & Gean, P. W., 2006 Aug 30, In : Journal of Neuroscience. 26, 35, p. 8892-8899 8 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Heterogeneous nuclear ribonucleoprotein K modulates angiotensinogen gene expression in kidney cells

Wei, C. C., Zhang, S. L., Chen, Y. W., Guo, D. F., Ingelfinger, J. R., Bomsztyk, K. & Chan, J. S. D., 2006 Sep 1, In : Journal of Biological Chemistry. 281, 35, p. 25344-25355 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST

Lu, T. J., Lai, W. Y., Huang, C. Y. F., Hsieh, W. J., Yu, J. S., Hsieh, Y. J., Chang, W. T., Leu, T. H., Chang, W. C., Chuang, W. J., Tang, M. J., Chen, T. Y., Lu, T. L. & Lai, M. D., 2006 Dec 15, In : Journal of Biological Chemistry. 281, 50, p. 38405-38417 13 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
70 Citations (Scopus)

Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFα secretion in macrophages

Leu, T. H., Charoenfuprasert, S., Yen, C. K., Fan, C. W. & Maa, M. C., 2006 Feb 1, In : Molecular Immunology. 43, 4, p. 308-316 9 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Molecular diagnostic markers for lung cancer in sputum and plasma

Wang, Y. C., Hsu, H. S., Chen, T. P. & Chen, J. T., 2006 Sep, Circulating Nucleic Acids in Plasma and Serum IV. Blackwell Publishing Inc., p. 179-184 6 p. (Annals of the New York Academy of Sciences; vol. 1075).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

46 Citations (Scopus)

Neuroprotective effect of N-acetylcysteine on neuronal apoptosis induced by a synthetic gingerdione compound: Involvement of ERK and p38 phosphorylation

Lin, C. H., Kuo, S. C., Huang, L. J. & Gean, P-W., 2006 Nov 15, In : Journal of Neuroscience Research. 84, 7, p. 1485-1494 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Polymorphisms of p53 and p21 genes in chronic obstructive pulmonary disease

Lee, Y. L., Chen, W., Tsai, W. K., Lee, J. C., Chiou, H. L., Shih, C. M. & Wang, Y-C., 2006 May 1, In : Journal of Laboratory and Clinical Medicine. 147, 5, p. 228-233 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Reactive oxygen species and nuclear factor-kappa B pathway mediate high glucose-induced Pax-2 gene expression in mouse embryonic mesenchymal epithelial cells and kidney explants

Chen, Y. W., Liu, F., Tran, S., Zhu, Y., Hébert, M. J., Ingelfinger, J. R. & Zhang, S. L., 2006 Nov 1, In : Kidney international. 70, 9, p. 1607-1615 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Reduced Acetylated Histone H4 is Associated With Promoter Methylation of the Fragile Histidine Triad Gene in Resected Esophageal Squamous Cell Carcinoma

Tzao, C., Sun, G. H., Tung, H. J., Hsu, H. S., Hsu, W. H., Wang, Y. C., Cheng, Y. L. & Lee, S. C., 2006 Aug, In : Annals of Thoracic Surgery. 82, 2, p. 396-401 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
94 Citations (Scopus)

Src oncogene activates MMP-2 expression via the ERK/Sp1 pathway

Kuo, L., Chang, H. C., Leu, T. H., Maa, M. C. & Hung, W. C., 2006 Jun 1, In : Journal of Cellular Physiology. 207, 3, p. 729-734 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Synaptic expression of glutamate receptor after encoding of fear memory in the rat amygdala

Yeh, S. H., Mao, S. C., Lin, H. C. & Gean, P. W., 2006 Jan 1, In : Molecular Pharmacology. 69, 1, p. 299-308 10 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

The Role of the Amygdala in the Extinction of Conditioned Fear

Barad, M., Gean, P. W. & Lutz, B., 2006 Aug 15, In : Biological Psychiatry. 60, 4, p. 322-328 7 p.

Research output: Contribution to journalReview article

102 Citations (Scopus)

Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes

Chen, P-S., Peng, G. S., Li, G., Yang, S., Wu, X., Wang, C. C., Wilson, B., Lu, R-B., Gean, P-W., Chuang, D. M. & Hong, J. S., 2006 Dec 1, In : Molecular Psychiatry. 11, 12, p. 1116-1125 10 p.

Research output: Contribution to journalArticle

269 Citations (Scopus)
2005

Activating protein 1-mediated cyclooxygenase-2 expression is independent of N-terminal phosphorylation of c-Jun

Chen, L. C., Chen, B-K. & Chang, W. C., 2005 Jun 1, In : Molecular Pharmacology. 67, 6, p. 2057-2069 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Activation of group II metabotropic glutamate receptors induces depotentiation in amygdala slices and reduces fear-potentiated startle in rats

Lin, C. H., Lee, C. C., Huang, Y. C., Wang, S. J. & Gean, P. W., 2005 Mar 1, In : Learning and Memory. 12, 2, p. 130-137 8 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

A rapid, nongenomic pathway facilitates the synaptic transmission induced by retinoic acid at the developing synapse

Liou, J. C., Ho, S. Y., Shen, M. R., Liao, Y. P., Chiu, W. T. & Kang, K. H., 2005 Oct 15, In : Journal of Cell Science. 118, 20, p. 4721-4730 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions

Laird, F. M., Cai, H., Savonenko, A. V., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H. C., Xu, G., Koliatsos, V. E., Borchelt, D. R., Price, D. L., Lee, H. K. & Wong, P. C., 2005 Dec 14, In : Journal of Neuroscience. 25, 50, p. 11693-11709 17 p.

Research output: Contribution to journalArticle

400 Citations (Scopus)

Butyrate regulates the expression of c-Src and focal adhesion kinase and inhibits cell invasion of human colon cancer cells

Lee, J. C., Maa, M. C., Yu, H. S., Wang, J. H., Yen, C. K., Wang, S. T., Chen, Y. J., Liu, Y., Jin, Y. T. & Leu, T. H., 2005 Aug 1, In : Molecular Carcinogenesis. 43, 4, p. 207-214 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Design and synthesis of 3-aryl-5-alicylic-[1,2,4]-oxadiazoles as novel platelet aggregation inhibitors

Chern, C. Y., Chen, S. J. & Kan, W. M., 2005 Jan 1, In : Journal of the Chinese Chemical Society. 52, 2, p. 331-338 8 p.

Research output: Contribution to journalArticle

Efficient synthesis of 2-(N-Substituted)-2-imidazolines and 2-(N-Substituted)-1,4,5, 6-tetrahydropyrimidines

Kan, W. M., Lin, S. H. & Chern, C. Y., 2005 Nov 10, In : Synthetic Communications. 35, 20, p. 2633-2639 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer

Tseng, R. C., Chang, J. W., Hsien, F. J., Chang, Y. H., Hsiao, C. F., Chen, J. T., Chen, C. Y., Jou, Y. S. & Wang, Y. C., 2005 Nov 1, In : International Journal of Cancer. 117, 2, p. 241-247 7 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

Cai, H., Lin, X., Xie, C., Laird, F. M., Lai, C., Wen, H., Chiang, H. C., Shim, H., Farah, M. H., Hoke, A., Price, D. L. & Wong, P. C., 2005 Aug 17, In : Journal of Neuroscience. 25, 33, p. 7567-7574 8 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Promoter hypermethylation is the predominant mechanism in hMLH1 and hMSH2 deregulation and is a poor prognostic factor in nonsmoking lung cancer

Hsu, H. S., Wen, C. K., Tang, Y. A., Lin, R. K., Li, W. Y., Hsu, W. H. & Wang, Y. C., 2005 Aug 1, In : Clinical Cancer Research. 11, 15, p. 5410-5416 7 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma

Tzao, C., Hsu, H. S., Sun, G. H., Lai, H. L., Wang, Y. C., Tung, H. J., Yu, C. P., Cheng, Y. L. & Lee, S. C., 2005 Nov, In : Journal of Thoracic and Cardiovascular Surgery. 130, 5, p. 1371.e1-1371.e8

Research output: Contribution to journalArticle

34 Citations (Scopus)

Transcription factor Sp1 functions as an anchor protein in gene transcription of human 12(S)-lipoxygenase

Chang, W. C. & Chen, B. K., 2005 Dec 9, In : Biochemical and Biophysical Research Communications. 338, 1, p. 117-121 5 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)

Wild-type p53 overexpression and its correlation with MDM2 and p14ARF alterations: An alternative pathway to non-small-cell lung cancer

Wang, Y. C., Lin, R. K., Tan, Y. H., Chen, J. T., Chen, C. Y. & Wang, Y. C., 2005 Jan 1, In : Journal of Clinical Oncology. 23, 1, p. 154-164 11 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3

Lu, T. J., Huang, C. Y. F., Yuan, C. J., Lee, Y. C., Leu, T. H., Chang, W. C., Lu, T. L., Jeng, W. Y. & Lai, M. D., 2005 Jun 1, In : Journal of Inorganic Biochemistry. 99, 6, p. 1306-1313 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2004

5′CpG island hypermethylation and aberrant transcript splicing both contribute to the inactivation of the FHIT gene in resected non-small cell lung cancer

Tzao, C., Tsai, H. Y., Chen, J. T., Chen, C. Y. & Wang, Y. C., 2004 Sep, In : European Journal of Cancer. 40, 14, p. 2175-2183 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

5′cytosine-Phospho-Guanine island methylation is responsible for p14ARF inactivation and inversely correlates with p53 overexpression in resected non-small cell lung cancer

Hsu, H. S., Wang, Y. C., Tseng, R. C., Chang, J. W., Chen, J. T., Shih, C. M., Chen, C. Y. & Wang, Y. C., 2004 Jul 15, In : Clinical Cancer Research. 10, 14, p. 4734-4741 8 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Acetylation of nuclear factor-κB in rat amygdala improves long-term but not short-term retention of fear memory

Yeh, S. H., Lin, C. H. & Gean, P. W., 2004 May 1, In : Molecular Pharmacology. 65, 5, p. 1286-1292 7 p.

Research output: Contribution to journalArticle

175 Citations (Scopus)
41 Citations (Scopus)

Genetic testing in spinocerebellar ataxia in Taiwan: Expansions of trinucleotide repeats in SCA8 and SCA17 are associated with typical Parkinson's disease

Wu, Y. R., Lin, H. Y., Chen, C. M., Gwinn-Hardy, K., Ro, L. S., Wang, Y. C., Li, S. H., Hwang, J. C., Fang, K., Hsieh-Li, H. M., Li, M. L., Tung, L. C., Su, M. T., Lu, K. T. & Lee-Chen, G. J., 2004 Mar 1, In : Clinical Genetics. 65, 3, p. 209-214 6 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells

Shen, M. R., Lin, A. C., Hsu, Y. M., Chang, T. J., Tang, M. J., Alper, S. L., Ellory, J. C. & Chou, C. Y., 2004 Sep 17, In : Journal of Biological Chemistry. 279, 38, p. 40017-40025 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

One-pot synthesis of ene-lactams via N-debenzylation of keto-containing N-2,4-dimethoxylbenzylamides

Kan, W. M., Cheng, C. L. & Chern, C. Y., 2004 Dec 30, In : Synthetic Communications. 34, 23, p. 4257-4264 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Participation of p97Eps8 in Src-mediated Transformation

Leu, T. H., Yeh, H. H., Huang, C. C., Chuang, Y. C., Su, S. L. & Maa, M. C., 2004 Mar 12, In : Journal of Biological Chemistry. 279, 11, p. 9875-9881 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Synergistic effects of dopamine and Zn 2+ on the induction of PC12 cell death and dopamine depletion in the striatum: Possible implication in the pathogenesis of Parkinson's disease

Lo, H. S., Chinag, H., Lin, A. M. Y., Chiang, H. Y., Chu, Y. C. & Kao, L. S., 2004 Oct 1, In : Neurobiology of Disease. 17, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

The effect of mefloquine and volume-regulated anion channel inhibitors on induced transport in Plasmodium falciparum-infected human red blood cells

Staines, H. M., Dee, B. C., Shen, M. R. & Ellory, J. C., 2004 May 1, In : Blood Cells, Molecules, and Diseases. 32, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The involvement of PTEN in sleep deprivation-induced memory impairment in rats

Su, C. L., Chen, C. H., Lu, H. Y. & Gean, P-W., 2004 Nov 1, In : Molecular Pharmacology. 66, 5, p. 1340-1348 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Three-dimensional power Doppler imaging of early-stage cervical cancer

Hsu, K. F., Su, J. M., Huang, S. C., Cheng, Y. M., Kang, C. Y., Shen, M. R., Chang, F. M. & Chou, C. Y., 2004 Nov 1, In : Ultrasound in Obstetrics and Gynecology. 24, 6, p. 664-671 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2003

Damage formation and repair efficiency in the p53 gene of cell lines and blood lymphocytes assayed by multiplex long quantitative polymerase chain reaction

Wang, Y. C., Lee, P. J., Shih, C. M., Chen, H. Y., Lee, C. C., Chang, Y. Y., Hsu, Y. T., Liang, Y. J., Wang, L. Y., Han, W. H. & Wang, Y. C., 2003 Aug 15, In : Analytical Biochemistry. 319, 2, p. 206-215 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity

Leu, T. H., Su, S. L., Chuang, Y. C. & Maa, M. C., 2003 Dec 15, In : Biochemical Pharmacology. 66, 12, p. 2323-2331 9 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)