Research Output

2003

Damage formation and repair efficiency in the p53 gene of cell lines and blood lymphocytes assayed by multiplex long quantitative polymerase chain reaction

Wang, Y. C., Lee, P. J., Shih, C. M., Chen, H. Y., Lee, C. C., Chang, Y. Y., Hsu, Y. T., Liang, Y. J., Wang, L. Y., Han, W. H. & Wang, Y. C., 2003 Aug 15, In : Analytical Biochemistry. 319, 2, p. 206-215 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity

Leu, T. H., Su, S. L., Chuang, Y. C. & Maa, M. C., 2003 Dec 15, In : Biochemical Pharmacology. 66, 12, p. 2323-2331 9 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein β and δ in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages

Liu, Y. W., Tseng, H. P., Chen, L. C., Chen, B. K. & Chang, W. C., 2003 Jul 15, In : Journal of Immunology. 171, 2, p. 821-828 8 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Functional implication of the interaction between egf receptor and C-SRC

Leu, T-H. & Maa, M. C., 2003, In : Frontiers in Bioscience. 8, SUPPL.

Research output: Contribution to journalReview article

60 Citations (Scopus)

Identification of calcineurin as a key signal in the extinction of fear memory

Lin, C. H., Yeh, S. H., Leu, T. H., Chang, W. C., Wang, S. T. & Gean, P. W., 2003 Mar 1, In : Journal of Neuroscience. 23, 5, p. 1574-1579 6 p.

Research output: Contribution to journalArticle

Open Access
135 Citations (Scopus)

Identifying the factors and signal pathways necessary for anchorage-independent growth of Ha-ras oncogene-transformed NIH/3T3 cells

Chang, T. Y., Tsai, W. J., Chou, C. K., Chow, N. H., Leu, T. H. & Liu, H. S., 2003 Jul 25, In : Life Sciences. 73, 10, p. 1265-1274 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples

Wang, Y. C., Lu, Y. P., Tseng, R. C., Lin, R. K., Chang, J. W., Chen, J. T., Shih, C. M. & Chen, C. Y., 2003 Mar, In : Journal of Clinical Investigation. 111, 6, p. 887-895 9 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)

Involvement of a calcineurin cascade in amygdala depotentiation and quenching of fear memory

Lin, C. H., Lee, C. C. & Gean, P-W., 2003 Jan 1, In : Molecular Pharmacology. 63, 1, p. 44-52 9 p.

Research output: Contribution to journalArticle

125 Citations (Scopus)

KCl cotransport is an important modulator of human cervical cancer growth and invasion

Shen, M. R., Chou, C. Y., Hsu, K. F., Hsu, Y. M., Chiu, W. T., Tang, M. J., Alper, S. L. & Ellory, J. C., 2003 Oct 10, In : Journal of Biological Chemistry. 278, 41, p. 39941-39950 10 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Mediation of Amphetamine-Induced Long-Term Depression of Synaptic Transmission by CB1 Cannabinoid Receptors in the Rat Amygdala

Huang, Y. C., Wang, S. J., Chiou, L. C. & Gean, P. W., 2003 Nov 12, In : Journal of Neuroscience. 23, 32, p. 10311-10320 10 p.

Research output: Contribution to journalArticle

Open Access
59 Citations (Scopus)

Molecular and functional identification of the Na + /H + exchange isoforms NHE1 and NHE3 in isolated bovine articular chondrocytes

Tattersall, A. L., Meredith, D., Furla, P., Shen, M-R., Ellory, J. C. & Wilkins, R. J., 2003 Jan 1, In : Cellular Physiology and Biochemistry. 13, 4, p. 215-222 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Selective N-debenzylation of amides with p-TsOH

Chern, C. Y., Huang, Y. P. & Kan, W. M., 2003 Jan 27, In : Tetrahedron Letters. 44, 5, p. 1039-1041 3 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
17 Citations (Scopus)

Synthesis of 4-Aza-3-oxo-androstane-17β-carboxylic Acid, a Key Intermediate for the Preparation of Potent 5α-Reductase Inhibitors

Kan, W-M., Yek, Y. L., Wang, Y. H. & Chern, C. Y., 2003 Jun 1, In : Chinese Pharmaceutical Journal. 55, 3, p. 213-219 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory

Lin, C. H., Yeh, S. H., Lu, H. Y. & Gean, P. W., 2003 Sep 10, In : Journal of Neuroscience. 23, 23, p. 8310-8317 8 p.

Research output: Contribution to journalArticle

Open Access
208 Citations (Scopus)
2002

Alterations of the p16INK4a gene in resected nonsmall cell lung tumors and exfoliated cells within sputum

Chen, J. T., Chen, Y. C., Wang, Y. C., Tseng, R. C., Chen, C. Y. & Wang, Y-C., 2002 Apr 10, In : International Journal of Cancer. 98, 5, p. 724-731 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Anion exchanger isoform 2 operates in parallel with Na+/H+ exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells

Shen, M. R., Wilkins, R. J., Chou, C. Y. & Ellory, J. C., 2002 Feb 13, In : FEBS Letters. 512, 1-3, p. 52-58 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
27 Citations (Scopus)

A requirement of nuclear factor-κB activation in fear-potentiated startle

Yeh, S. H., Lin, C. H., Lee, C. F. & Gean, P. W., 2002 Nov 29, In : Journal of Biological Chemistry. 277, 48, p. 46720-46729 10 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Association of L-myc polymorphism with lung cancer susceptibility and prognosis in relation to age-selected controls and stratified cases

Shih, C. M., Kuo, Y. Y., Wang, Y. C., Jian, S. L., Hsu, Y. T., Wu, H. Y., Guo, M. W. & Wang, Y. C., 2002 Jan 1, In : Lung Cancer. 36, 2, p. 125-132 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Caspase activation of Mammalian Sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis

Huang, C. Y. F., Wu, Y. M., Hsu, C. Y., Lee, W. S., Lai, M. D., Lu, T. J., Huang, C. L., Leu, T. H., Shih, H. M., Fang, H. I., Robinson, D. R., Kungand, H. J. & Yuan, C. J., 2002 Sep 13, In : Journal of Biological Chemistry. 277, 37, p. 34367-34374 8 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Design and synthesis of 1,2,4-oxadiazole derivatives as non-steroidal 5α-reductase inhibitors

Chang, C. S., Kan, W. M., Chen, C. L., Wang, K. C. & Chern, J. W., 2002 Jan 1, In : Journal of the Chinese Chemical Society. 49, 1, p. 83-89 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene

Chen, B-K., Tsai, T. Y., Huang, H-S., Chen, L. C., Chang, W. C., Tsai, S. B. & Chang, W. C., 2002 Apr 6, In : Journal of biomedical science. 9, 2, p. 156-165 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Gene regulation of human 12(S)-lipoxygenase

Chang, W. C. & Chen, B. K., 2002 Nov 1, In : International Congress Series. 1233, C, p. 329-335 7 p.

Research output: Contribution to journalArticle

Loss of heterozygosity at loci of candidate tumor suppressor genes in microdissected primary non-small cell lung cancer

Ho, W. L., Chang, J. W., Tseng, R. C., Chen, J. T., Chen, C. Y., Jou, Y. S. & Wang, Y. C., 2002 Dec 1, In : Cancer Detection and Prevention. 26, 5, p. 343-349 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Myosin light chain kinase modulates hypotonicity-induced Ca2+ entry and Cl- channel activity in human cervical cancer cells

Shen, M-R., Furla, P., Chou, C-Y. & Ellory, C. J., 2002 May 22, In : Pflugers Archiv European Journal of Physiology. 444, 1-2, p. 276-285 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
18 Citations (Scopus)

The molecular mechanisms for the antitumorigenic effect of curcumin

Leu, T-H. & Maa, M. C., 2002 Jun 27, In : Current Medicinal Chemistry - Anti-Cancer Agents. 2, 3, p. 357-370 14 p.

Research output: Contribution to journalReview article

145 Citations (Scopus)

Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397

Leu, T. H. & Maa, M. C., 2002 Jan 1, In : Oncogene. 21, 46, p. 6992-7000 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2001

A Role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala

Lin, C. H., Yeh, S. H., Lin, C. H., Lu, K. T., Leu, T. H., Chang, W. C. & Gean, P. W., 2001 Sep 13, In : Neuron. 31, 5, p. 841-851 11 p.

Research output: Contribution to journalArticle

297 Citations (Scopus)

Dissociation between synaptic depression and block of long-term depression induced by raising the temperature in rat hippocampal slices

Young, C., Luo, M. Z., Shen, Y. Z. & Gean, P-W., 2001 Mar 10, In : Synapse. 40, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Effect of hydroxyzine on the transport of etoposide in rat small intestine

Kan, W. M., Liu, Y. T., Hsiao, C. L., Shieh, C. Y., Kuo, J. H., Huang, J. D. & Su, S. F., 2001 Apr 17, In : Anti-Cancer Drugs. 12, 3, p. 267-273 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Human cervical cancer cells use Ca2+ signalling, protein tyrosine phosphorylation and MAP kinase in regulatory volume decrease

Shen, M. R., Chou, C. Y., Browning, J. A., Wilkins, R. J. & Clive Ellory, J., 2001 Dec 1, In : Journal of Physiology. 537, 2, p. 347-362 16 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Lamotrigine inhibition of glutamate release from isolated cerebrocortical nerve terminals (synaptosomes) by suppression of voltage-activated calcium channel activity

Wang, S. J., Sihra, T. S. & Gean, P. W., 2001 Jul 20, In : NeuroReport. 12, 10, p. 2255-2258 4 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Loss of p16 and/or pRb protein expression in NSCLC: An immunohistochemical and prognostic study

Chen, J. T., Chen, Y. C., Chen, C. Y. & Wang, Y. C., 2001 Feb 10, In : Lung Cancer. 31, 2-3, p. 163-170 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Modulation of voltage-dependent calcium currents by serotonin in acutely isolated rat amygdala neurons

Lin, C. H., Huang, Y. C., Tsai, J. J. & Gean, P. W., 2001 Sep 15, In : Synapse. 41, 4, p. 351-359 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Novel lead generation through hypothetical pharmacophore three-dimensional database searching: Discovery of isoflavonoids as nonsteroidal inhibitors of rat 5α-reductase

Chen, G. S., Chang, C. S., Kan, W-M., Chang, C. L., Wang, K. C. & Chern, J. W., 2001 Nov 8, In : Journal of Medicinal Chemistry. 44, 23, p. 3759-3763 5 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Overexpression of p97Eps8 leads to cellular transformatioan: Implication of pleckstrin homology domain in p97Eps8-mediated ERK activation

Maa, M. C., Hsieh, C. Y. & Leu, T. H., 2001 Jan 1, In : Oncogene. 20, 1, p. 106-112 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Selective enhancement of L-type calcium currents by corticotropin in acutely isolated rat amygdala neurons

Young, C., Huang, Y. C., Lin, C. H., Shen, Y. Z. & Gean, P. W., 2001 Jan 1, In : Molecular Pharmacology. 59, 3, p. 604-611 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
30 Citations (Scopus)

The KCI cotransporter isoform KCC3 can play an important role in cell growth regulation

Shen, M. R., Chou, C. Y., Hsu, K. F., Liu, H. S., Dunham, P. B., Holtzman, E. J. & Ellory, J. C., 2001 Dec 4, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 25, p. 14714-14719 6 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)
2000

Activation of group II metabotropic glutamate receptors induces long-term depression of synaptic transmission in the rat amygdala

Wang, H. C., Lin, S. J., Luo, M. Z. & Gean, P. W., 2000 Dec 15, In : Journal of Neuroscience. 20, 24, p. 9017-9024 8 p.

Research output: Contribution to journalArticle

Open Access
51 Citations (Scopus)

Correlation of genetic instability with mismatch repair protein expression and p53 mutations in non-small cell lung cancer

Chang, J. W., Chen, Y. C., Chen, C. Y., Chen, J. T., Chen, S. K. & Wang, Y-C., 2000 May 1, In : Clinical Cancer Research. 6, 5, p. 1639-1646 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Differential expression of volume-regulated anion channels during cell cycle progression of human cervical cancer cells

Shen, M. R., Droogmans, G., Eggermont, J., Voets, T., Ellory, J. C. & Nilius, B., 2000 Dec 1, In : Journal of Physiology. 529, 2, p. 385-394 10 p.

Research output: Contribution to journalArticle

147 Citations (Scopus)

Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus

Young, C., Gean, P. W., Chiou, L. C. & Shen, Y. Z., 2000 Jul 22, In : Synapse. 37, 2, p. 90-94 5 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Essential role of mitogen-activated protein kinase pathway and c-Jun induction in epidermal growth factor-induced gene expression of human 12- lipoxygenase

Chen, B. K., Kung, H. C., Tsai, T. Y. & Chang, W. C., 2000 Jan 1, In : Molecular Pharmacology. 57, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
62 Citations (Scopus)

Lack of evidence of association of p21(WAF1/CIP1) polymorphism with lung cancer susceptibility and prognosis in Taiwan

Shih, C. M., Lin, P. T., Wang, H. C., Huang, W. C. & Wang, Y. C., 2000 Jan, In : Japanese Journal of Cancer Research. 91, 1, p. 9-15 7 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Volume-sensitive KCl cotransport associated with human cervical carcinogenesis

Shen, M. R., Chou, C. Y. & Ellory, J. C., 2000 Jan 1, In : Pflugers Archiv European Journal of Physiology. 440, 5, p. 751-760 10 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)