Research Output

2014

DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer

Yang, Y. C., Tang, Y. A., Shieh, J. M., Lin, R. K., Hsu, H. S. & Wang, Y. C., 2014 Sep, In : Journal of Thoracic Oncology. 9, 9, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer

Lin, R. K. & Wang, Y. C., 2014 Aug 19, In : Cell and Bioscience. 4, 1, 46.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Erratum: Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Cai, Z., Jitkaew, S., Zhao, J., Chinag, H., Choksi, S., Liu, J., Ward, Y., Wu, L. G. & Liu, Z. G., 2014 Feb 1, In : Nature Cell Biology. 16, 2, 1 p.

Research output: Contribution to journalComment/debate

82 Citations (Scopus)

Exocytosis and endocytosis: Modes, functions, and coupling mechanisms*

Wu, L. G., Hamid, E., Shin, W. & Chiang, H. C., 2014 Feb 1, In : Annual Review of Physiology. 76, p. 301-331 31 p.

Research output: Contribution to journalReview article

170 Citations (Scopus)

HBP1 promoter methylation augments the oncogenic β-catenin to correlate with prognosis in NSCLC

Tseng, R. C., Huang, W. R., Lin, S. F., Wu, P. C., Hsu, H. S. & Wang, Y. C., 2014 Sep 1, In : Journal of Cellular and Molecular Medicine. 18, 9, p. 1752-1761 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Low SOX17 expression is a prognostic factor and drives transcriptional dysregulation and esophageal cancer progression

Kuo, I. Y., Wu, C. C., Chang, J. M., Huang, Y. L., Lin, C. H., Yan, J. J., Sheu, B. S., Lu, P. J., Chang, W. L., Lai, W. W. & Wang, Y. C., 2014 Aug 1, In : International Journal of Cancer. 135, 3, p. 563-573 11 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

MJ-66 induces malignant glioma cells G2/M phase arrest and mitotic catastrophe through regulation of cyclin B1/Cdk1 complex

Liu, W. T., Chen, C., Lu, I. C., Kuo, S. C., Lee, K. H., Chen, T. L., Song, T. S., Lu, Y. L., Gean, P. W. & Hour, M. J., 2014 Aug 19, In : Neuropharmacology. 86, p. 219-227 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Network-based analysis identifies epigenetic biomarkers of esophageal squamous cell carcinoma progression

Cheng, C. P., Kuo, I. Y., Alakus, H., Frazer, K. A., Harismendy, O., Wang, Y. C. & Tseng, V. S., 2014 May 28, In : Bioinformatics. 30, 21, p. 3054-3061 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Pin1 positively affects tumorigenesis of esophageal squamous cell carcinoma and correlates with poor survival of patients

Lin, F. C., Lee, Y. C., Goan, Y. G., Tsai, C. H., Yao, Y. C., Cheng, H. C., Lai, W. W., Wang, Y. C., Sheu, B. S. & Lu, P. J., 2014 Aug 27, In : Journal of biomedical science. 21, 1, 21.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Cai, Z., Jitkaew, S., Zhao, J., Chiang, H. C., Choksi, S., Liu, J., Ward, Y., Wu, L. G. & Liu, Z. G., 2014 Jan 1, In : Nature Cell Biology. 16, 1, p. 55-65 11 p.

Research output: Contribution to journalArticle

457 Citations (Scopus)

Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles

Chiang, H. C., Shin, W., Zhao, W. D., Hamid, E., Sheng, J., Baydyuk, M., Wen, P. J., Jin, A., Momboisse, F. & Wu, L. G., 2014 Feb 24, In : Nature communications. 5, 3356.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Prognostic CpG methylation biomarkers identified by methylation array in esophageal squamous cell carcinoma patients

Kuo, I. Y., Chang, J. M., Jiang, S. S., Chen, C. H., Chang, I. S., Sheu, B. S., Lu, P. J., Chang, W. L., Lai, W. W. & Wang, Y. C., 2014 May 30, In : International Journal of Medical Sciences. 11, 8, p. 779-787 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Roles of testosterone and amygdaloid LTP induction in determining sex differences in fear memory magnitude

Chen, L. S., Tzeng, W. Y., Chuang, J. Y., Cherng, C. G., Gean, P. W. & Yu, L., 2014 Aug, In : Hormones and Behavior. 66, 3, p. 498-508 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis

Tsai, C. H., Cheng, H. C., Wang, Y. S., Lin, P., Jen, J., Kuo, I. Y., Chang, Y. H., Liao, P. C., Chen, R. H., Yuan, W. C., Hsu, H. S., Yang, M. H., Hsu, M. T., Wu, C. Y. & Wang, Y. C., 2014 Sep 3, In : Nature communications. 5, 4804.

Research output: Contribution to journalArticle

24 Citations (Scopus)
61 Citations (Scopus)

SPAK mediates KCC3-enhanced cervical cancer tumorigenesis

Chiu, M. H., Liu, H. S., Wu, Y. H., Shen, M. R. & Chou, C. Y., 2014 May, In : FEBS Journal. 281, 10, p. 2353-2365 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Stimulating ERK/PI3K/NFκB signaling pathways upon activation of mGluR2/3 restores OGD-induced impairment in glutamate clearance in astrocytes

Lin, C. H., You, J. R., Wei, K. C. & Gean, P. W., 2014 Jan 1, In : European Journal of Neuroscience. 39, 1, p. 83-96 14 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The inducible nitric-oxide synthase (iNOS)/Src axis mediates toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to interferon- β synthesis in macrophages

Hsieh, M. Y., Chang, M. Y., Chen, Y. J., Li, Y. K., Chuang, T. H., Yu, G. Y., Cheung, C. H. A., Chen, H. C., Maa, M. C. & Leu, T. H., 2014 Mar 30, In : Journal of Biological Chemistry. 289, 13, p. 9208-9220 13 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Thematic series: Transcriptional regulation and disease

Wang, Y. C., 2014 Jun 20, In : Cell and Bioscience. 4, 1, 42.

Research output: Contribution to journalEditorial

TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7

Lai, C. Y., Liu, Y. L., Yu, G. Y., Maa, M. C., Leu, T. H., Xu, C., Luo, Y., Xiang, R. & Chuang, T. H., 2014 Sep 29, In : Vaccine. 32, 43, p. 5593-5599 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2015

Aging and exercise affect hippocampal neurogenesis via different mechanisms

Yang, T. T., Lo, C. P., Tsai, P. S., Wu, S. Y., Wang, T. F., Chen, Y. W., Jiang-Shieh, Y. F. & Kuo, Y. M., 2015 Jul 6, In : PloS one. 10, 7, e0132152.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Berberine reduces Toll-like receptor-mediated macrophage migration by suppression of Src enhancement

Cheng, W. E., Ying Chang, M., Wei, J. Y., Chen, Y. J., Maa, M. C. & Leu, T. H., 2015 Jun 15, In : European Journal of Pharmacology. 757, p. 1-10 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Clinical aspects for survivin: A crucial molecule for targeting drug-resistant cancers

Singh, N., Krishnakumar, S., Kanwar, R. K., Cheung, C. H. A. & Kanwar, J. R., 2015 May 1, In : Drug Discovery Today. 20, 5, p. 578-587 10 p.

Research output: Contribution to journalReview article

50 Citations (Scopus)

Competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model

Roy, K., Kanwar, R. K., Krishnakumar, S., Cheung, C. H. A. & Kanwar, J. R., 2015 Feb 2, In : International journal of nanomedicine. 10, p. 1019-1043 25 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Deregulation of SLIT2-mediated Cdc42 activity is associated with esophageal cancer metastasis and poor prognosis

Tseng, R. C., Chang, J. M., Chen, J. H., Huang, W. R., Tang, Y. A., Kuo, I. Y., Yan, J. J., Lai, W. W. & Wang, Y. C., 2015 Jan 1, In : Journal of Thoracic Oncology. 10, 1, p. 189-198 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Down-regulation of ARNT promotes cancer metastasis by activating the fibronectin/integrin β1/FAK axis

Huang, C. R., Lee, C. T., Chang, K. Y., Chang, W. C., Liu, Y. W., Lee, J. C. & Chen, B. K., 2015 Jan 1, In : Oncotarget. 6, 13, p. 11530-11546 17 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
3 Citations (Scopus)
15 Citations (Scopus)

Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation

Hsu, J. Y., Chang, K. Y., Chen, S. H., Lee, C. T., Chang, S. T., Cheng, H. C., Chang, W. C. & Chen, B. K., 2015 Jan 1, In : Oncotarget. 6, 3, p. 1723-1739 17 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Erratum: Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles (Nature Communications (2014) 5 (3356) DOI:10.1038/ncomms4356)

Chinag, H., Shin, W., Zhao, W. D., Hamid, E., Sheng, J., Baydyuk, M., Wen, P. J., Jin, A., Momboisse, F. & Wu, L. G., 2015 Jan 1, In : Nature communications. 6, 6016.

Research output: Contribution to journalComment/debate

Factor VII promotes hepatocellular carcinoma progression through ERK-TSC signaling

Tsai, M. C., Chen, K. D., Wang, C. C., Huang, K. T., Wu, C. H., Kuo, I. Y., Chen, L. Y., Hu, T. H., Goto, S., Nakano, T., Dorling, A., McVey, J. H., Chen, C. L. & Lin, C. C., 2015 Dec 21, In : Cell Death Discovery. 1, 1, 15051.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer

Tang, Y. A., Chen, C. H., Sun, H. S., Cheng, C. P., Tseng, V. S., Hsu, H. S., Su, W. C., Lai, W. W. & Wang, Y. C., 2015, In : Nucleic acids research. 43, 3, p. 1593-1608 16 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Glucose regulates amyloid β production via AMPK

Yang, T. T., Shih, Y. S., Chen, Y-W., Kuo, Y-M. & Lee, C. W., 2015 Oct 1, In : Journal of Neural Transmission. 122, 10, p. 1381-1390 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer

Tseng, R. C., Chang, J. W., Mao, J. S., Tsai, C. D., Wu, P. C., Lin, C. J., Lu, Y. L., Liao, S. Y., Cheng, H. C., Hsu, H. S. & Wang, Y. C., 2015 Jan 1, In : Oncotarget. 6, 42, p. 44207-44221 15 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
10 Citations (Scopus)

Involvement of intracellular calcium mobilization in IL-8 activation in human retinal pigment epithelial cells

Yang, I. H., Wong, J. H., Chang, C. M., Chen, B. K., Tsai, Y. T., Chen, W. C., Wang, E. T., Hsu, W. L. & Chang, W. C., 2015 Jan 1, In : Investigative Ophthalmology and Visual Science. 56, 2, p. 761-769 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
8 Citations (Scopus)

Lipopolysaccharide-promoted proliferation of Caco-2 cells is mediated by c-Src induction and ERK activation

Lin, T. Y., Fan, C. W., Maa, M. C. & Leu, T. H., 2015 Mar 1, In : BioMedicine (Netherlands). 5, 1, p. 33-38 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Locked nucleic acid modified bi-specific aptamer-targeted nanoparticles carrying survivin antagonist towards effective colon cancer therapy

Roy, K., Kanwar, R. K., Antonio Cheung, C. H., Lee Fleming, C., Veedu, R. N., Krishnakumar, S. & Kanwar, J. R., 2015 Jan 1, In : RSC Advances. 5, 37, p. 29008-29016 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Mechanical phenotype of cancer cells: Cell softening and loss of stiffness sensing

Lin, H. H., Lin, H. K., Lin, I. H., Chiou, Y. W., Chen, H. W., Liu, C. Y., Harn, H. I. C., Chiu, W. T., Wang, Y. K., Shen, M. R. & Tang, M. J., 2015 Jan 1, In : Oncotarget. 6, 25, p. 20946-20958 13 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Mechanosensitive store-operated calcium entry regulates the formation of cell polarity

Huang, Y. W., Chang, S. J., I-Chen Harn, H., Huang, H. T., Lin, H. H., Shen, M. R., Tang, M. J. & Chiu, W. T., 2015 Sep 1, In : Journal of Cellular Physiology. 230, 9, p. 2086-2097 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

O6-methylguanine DNA methyltransferase repairs platinum-DNA adducts following cisplatin treatment and predicts prognoses of nasopharyngeal carcinoma

Chen, S. H., Kuo, C. C., Li, C. F., Cheung, C. H. A., Tsou, T. C., Chiang, H. C., Yang, Y. N., Chang, S. L., Lin, L. C., Pan, H. Y., Chang, K. Y. & Chang, J. Y., 2015 Sep 1, In : International Journal of Cancer. 137, 6, p. 1291-1305 15 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
46 Citations (Scopus)

PTX3 gene activation in EGF-induced head and neck cancer cell metastasis

Chang, W. C., Wu, S. L., Huang, W. C., Hsu, J. Y., Chan, S. H., Wang, J. M., Tsai, J. P. & Chen, B. K., 2015, In : Oncotarget. 6, 10, p. 7741-7757 17 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Social isolation-induced increase in NMDA receptors in the hippocampus exacerbates emotional dysregulation in mice

Chang, C. H., Hsiao, Y. H., Chen, Y. W., Yu, Y. J. & Gean, P. W., 2015 Apr 1, In : Hippocampus. 25, 4, p. 474-485 12 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Sonic hedgehog signaling regulates amygdalar neurogenesis and extinction of fear memory

Hung, H. C., Hsiao, Y. H. & Gean, P. W., 2015 Oct, In : European Neuropsychopharmacology. 25, 10, p. 1723-1732 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistant cancers

Chi, J. Y., Hsiao, Y. W., Li, C. F., Lo, Y. C., Lin, Z. Y., Hong, J. Y., Liu, Y. M., Han, X., Wang, S. M., Chen, B. K., Tsai, K. K. & Wang, J. M., 2015 Jan 1, In : Oncotarget. 6, 27, p. 23987-24001 15 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

The iNOS/Src/FAK axis contributes to lithium chloride-mediated macrophage migration

Chen, H. C., Chien, W. C., Chang, M. Y., Hsieh, M. Y., Lai, M. D., Maa, M. C. & Leu, T. H., 2015 May 1, In : Nitric Oxide - Biology and Chemistry. 47, p. 58-64 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

TNF up-regulates Pentraxin3 expression in human airway smooth muscle cells via JNK and ERK1/2 MAPK pathways

Zhang, J., Koussih, L., Shan, L., Halayko, A. J., Chen, B. K. & Gounni, A. S., 2015 Dec 7, In : Allergy, Asthma and Clinical Immunology. 11, 1, 37.

Research output: Contribution to journalArticle

11 Citations (Scopus)

YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells

Cheng, S. M., Chang, Y. C., Liu, C. Y., Lee, J. Y. C., Chan, H. H., Kuo, C. W., Lin, K. Y., Tsai, S. L., Chen, S. H., Li, C. F., Leung, E., Kanwar, J. R., Huang, C. C., Chang, J. Y. & Cheung, C. H. A., 2015 Jan, In : British Journal of Pharmacology. 172, 1, p. 214-234 21 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)