Research Output

2004

Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells

Shen, M. R., Lin, A. C., Hsu, Y. M., Chang, T. J., Tang, M. J., Alper, S. L., Ellory, J. C. & Chou, C. Y., 2004 Sep 17, In : Journal of Biological Chemistry. 279, 38, p. 40017-40025 9 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

One-pot synthesis of ene-lactams via N-debenzylation of keto-containing N-2,4-dimethoxylbenzylamides

Kan, W. M., Cheng, C. L. & Chern, C. Y., 2004 Dec 30, In : Synthetic Communications. 34, 23, p. 4257-4264 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Participation of p97Eps8 in Src-mediated Transformation

Leu, T. H., Yeh, H. H., Huang, C. C., Chuang, Y. C., Su, S. L. & Maa, M. C., 2004 Mar 12, In : Journal of Biological Chemistry. 279, 11, p. 9875-9881 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Synergistic effects of dopamine and Zn 2+ on the induction of PC12 cell death and dopamine depletion in the striatum: Possible implication in the pathogenesis of Parkinson's disease

Lo, H. S., Chinag, H., Lin, A. M. Y., Chiang, H. Y., Chu, Y. C. & Kao, L. S., 2004 Oct 1, In : Neurobiology of Disease. 17, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

The effect of mefloquine and volume-regulated anion channel inhibitors on induced transport in Plasmodium falciparum-infected human red blood cells

Staines, H. M., Dee, B. C., Shen, M. R. & Ellory, J. C., 2004 May, In : Blood Cells, Molecules, and Diseases. 32, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The involvement of PTEN in sleep deprivation-induced memory impairment in rats

Su, C. L., Chen, C. H., Lu, H. Y. & Gean, P-W., 2004 Nov 1, In : Molecular Pharmacology. 66, 5, p. 1340-1348 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Three-dimensional power Doppler imaging of early-stage cervical cancer

Hsu, K. F., Su, J. M., Huang, S. C., Cheng, Y. M., Kang, C. Y., Shen, M. R., Chang, F. M. & Chou, C. Y., 2004 Nov 1, In : Ultrasound in Obstetrics and Gynecology. 24, 6, p. 664-671 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2003

Damage formation and repair efficiency in the p53 gene of cell lines and blood lymphocytes assayed by multiplex long quantitative polymerase chain reaction

Wang, Y. C., Lee, P. J., Shih, C. M., Chen, H. Y., Lee, C. C., Chang, Y. Y., Hsu, Y. T., Liang, Y. J., Wang, L. Y., Han, W. H. & Wang, Y. C., 2003 Aug 15, In : Analytical Biochemistry. 319, 2, p. 206-215 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity

Leu, T. H., Su, S. L., Chuang, Y. C. & Maa, M. C., 2003 Dec 15, In : Biochemical Pharmacology. 66, 12, p. 2323-2331 9 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein β and δ in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages

Liu, Y. W., Tseng, H. P., Chen, L. C., Chen, B. K. & Chang, W. C., 2003 Jul 15, In : Journal of Immunology. 171, 2, p. 821-828 8 p.

Research output: Contribution to journalArticle

Open Access
92 Citations (Scopus)

Functional implication of the interaction between egf receptor and C-SRC

Leu, T-H. & Maa, M. C., 2003, In : Frontiers in Bioscience. 8, SUPPL.

Research output: Contribution to journalReview article

60 Citations (Scopus)

Identification of calcineurin as a key signal in the extinction of fear memory

Lin, C. H., Yeh, S. H., Leu, T. H., Chang, W. C., Wang, S. T. & Gean, P. W., 2003 Mar 1, In : Journal of Neuroscience. 23, 5, p. 1574-1579 6 p.

Research output: Contribution to journalArticle

Open Access
136 Citations (Scopus)

Identifying the factors and signal pathways necessary for anchorage-independent growth of Ha-ras oncogene-transformed NIH/3T3 cells

Chang, T. Y., Tsai, W. J., Chou, C. K., Chow, N. H., Leu, T. H. & Liu, H. S., 2003 Jul 25, In : Life Sciences. 73, 10, p. 1265-1274 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples

Wang, Y. C., Lu, Y. P., Tseng, R. C., Lin, R. K., Chang, J. W., Chen, J. T., Shih, C. M. & Chen, C. Y., 2003 Mar, In : Journal of Clinical Investigation. 111, 6, p. 887-895 9 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)

Involvement of a calcineurin cascade in amygdala depotentiation and quenching of fear memory

Lin, C. H., Lee, C. C. & Gean, P-W., 2003 Jan 1, In : Molecular Pharmacology. 63, 1, p. 44-52 9 p.

Research output: Contribution to journalArticle

125 Citations (Scopus)

KCl cotransport is an important modulator of human cervical cancer growth and invasion

Shen, M. R., Chou, C. Y., Hsu, K. F., Hsu, Y. M., Chiu, W. T., Tang, M. J., Alper, S. L. & Ellory, J. C., 2003 Oct 10, In : Journal of Biological Chemistry. 278, 41, p. 39941-39950 10 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Mediation of Amphetamine-Induced Long-Term Depression of Synaptic Transmission by CB1 Cannabinoid Receptors in the Rat Amygdala

Huang, Y. C., Wang, S. J., Chiou, L. C. & Gean, P. W., 2003 Nov 12, In : Journal of Neuroscience. 23, 32, p. 10311-10320 10 p.

Research output: Contribution to journalArticle

Open Access
59 Citations (Scopus)

Molecular and functional identification of the Na + /H + exchange isoforms NHE1 and NHE3 in isolated bovine articular chondrocytes

Tattersall, A. L., Meredith, D., Furla, P., Shen, M. R., Ellory, J. C. & Wilkins, R. J., 2003, In : Cellular Physiology and Biochemistry. 13, 4, p. 215-222 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Selective N-debenzylation of amides with p-TsOH

Chern, C. Y., Huang, Y. P. & Kan, W. M., 2003 Jan 27, In : Tetrahedron Letters. 44, 5, p. 1039-1041 3 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
17 Citations (Scopus)

Synthesis of 4-Aza-3-oxo-androstane-17β-carboxylic Acid, a Key Intermediate for the Preparation of Potent 5α-Reductase Inhibitors

Kan, W-M., Yek, Y. L., Wang, Y. H. & Chern, C. Y., 2003 Jun 1, In : Chinese Pharmaceutical Journal. 55, 3, p. 213-219 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory

Lin, C. H., Yeh, S. H., Lu, H. Y. & Gean, P. W., 2003 Sep 10, In : Journal of Neuroscience. 23, 23, p. 8310-8317 8 p.

Research output: Contribution to journalArticle

Open Access
211 Citations (Scopus)
2002

Alterations of the p16INK4a gene in resected nonsmall cell lung tumors and exfoliated cells within sputum

Chen, J. T., Chen, Y. C., Wang, Y. C., Tseng, R. C., Chen, C. Y. & Wang, Y-C., 2002 Apr 10, In : International Journal of Cancer. 98, 5, p. 724-731 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Anion exchanger isoform 2 operates in parallel with Na+/H+ exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells

Shen, M. R., Wilkins, R. J., Chou, C. Y. & Ellory, J. C., 2002 Feb 13, In : FEBS Letters. 512, 1-3, p. 52-58 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
27 Citations (Scopus)

A requirement of nuclear factor-κB activation in fear-potentiated startle

Yeh, S. H., Lin, C. H., Lee, C. F. & Gean, P. W., 2002 Nov 29, In : Journal of Biological Chemistry. 277, 48, p. 46720-46729 10 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Association of L-myc polymorphism with lung cancer susceptibility and prognosis in relation to age-selected controls and stratified cases

Shih, C. M., Kuo, Y. Y., Wang, Y. C., Jian, S. L., Hsu, Y. T., Wu, H. Y., Guo, M. W. & Wang, Y. C., 2002 Jan 1, In : Lung Cancer. 36, 2, p. 125-132 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Caspase activation of Mammalian Sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis

Huang, C. Y. F., Wu, Y. M., Hsu, C. Y., Lee, W. S., Lai, M. D., Lu, T. J., Huang, C. L., Leu, T. H., Shih, H. M., Fang, H. I., Robinson, D. R., Kungand, H. J. & Yuan, C. J., 2002 Sep 13, In : Journal of Biological Chemistry. 277, 37, p. 34367-34374 8 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Design and synthesis of 1,2,4-oxadiazole derivatives as non-steroidal 5α-reductase inhibitors

Chang, C. S., Kan, W. M., Chen, C. L., Wang, K. C. & Chern, J. W., 2002 Jan 1, In : Journal of the Chinese Chemical Society. 49, 1, p. 83-89 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene

Chen, B-K., Tsai, T. Y., Huang, H-S., Chen, L. C., Chang, W. C., Tsai, S. B. & Chang, W. C., 2002 Apr 6, In : Journal of biomedical science. 9, 2, p. 156-165 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Gene regulation of human 12(S)-lipoxygenase

Chang, W. C. & Chen, B. K., 2002 Nov 1, In : International Congress Series. 1233, C, p. 329-335 7 p.

Research output: Contribution to journalArticle

Loss of heterozygosity at loci of candidate tumor suppressor genes in microdissected primary non-small cell lung cancer

Ho, W. L., Chang, J. W., Tseng, R. C., Chen, J. T., Chen, C. Y., Jou, Y. S. & Wang, Y. C., 2002 Dec 1, In : Cancer Detection and Prevention. 26, 5, p. 343-349 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
23 Citations (Scopus)
18 Citations (Scopus)

The molecular mechanisms for the antitumorigenic effect of curcumin

Leu, T-H. & Maa, M. C., 2002 Jun 27, In : Current Medicinal Chemistry - Anti-Cancer Agents. 2, 3, p. 357-370 14 p.

Research output: Contribution to journalReview article

145 Citations (Scopus)

Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397

Leu, T. H. & Maa, M. C., 2002 Jan 1, In : Oncogene. 21, 46, p. 6992-7000 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2001

A Role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala

Lin, C. H., Yeh, S. H., Lin, C. H., Lu, K. T., Leu, T. H., Chang, W. C. & Gean, P. W., 2001 Sep 13, In : Neuron. 31, 5, p. 841-851 11 p.

Research output: Contribution to journalArticle

299 Citations (Scopus)

Dissociation between synaptic depression and block of long-term depression induced by raising the temperature in rat hippocampal slices

Young, C., Luo, M. Z., Shen, Y. Z. & Gean, P-W., 2001 Mar 10, In : Synapse. 40, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Effect of hydroxyzine on the transport of etoposide in rat small intestine

Kan, W. M., Liu, Y. T., Hsiao, C. L., Shieh, C. Y., Kuo, J. H., Huang, J. D. & Su, S. F., 2001 Apr 17, In : Anti-Cancer Drugs. 12, 3, p. 267-273 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Human cervical cancer cells use Ca2+ signalling, protein tyrosine phosphorylation and MAP kinase in regulatory volume decrease

Shen, M. R., Chou, C. Y., Browning, J. A., Wilkins, R. J. & Clive Ellory, J., 2001 Dec 1, In : Journal of Physiology. 537, 2, p. 347-362 16 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Lamotrigine inhibition of glutamate release from isolated cerebrocortical nerve terminals (synaptosomes) by suppression of voltage-activated calcium channel activity

Wang, S. J., Sihra, T. S. & Gean, P. W., 2001 Jul 20, In : NeuroReport. 12, 10, p. 2255-2258 4 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Loss of p16 and/or pRb protein expression in NSCLC: An immunohistochemical and prognostic study

Chen, J. T., Chen, Y. C., Chen, C. Y. & Wang, Y. C., 2001 Feb 10, In : Lung Cancer. 31, 2-3, p. 163-170 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Modulation of voltage-dependent calcium currents by serotonin in acutely isolated rat amygdala neurons

Lin, C. H., Huang, Y. C., Tsai, J. J. & Gean, P. W., 2001 Sep 15, In : Synapse. 41, 4, p. 351-359 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Novel lead generation through hypothetical pharmacophore three-dimensional database searching: Discovery of isoflavonoids as nonsteroidal inhibitors of rat 5α-reductase

Chen, G. S., Chang, C. S., Kan, W-M., Chang, C. L., Wang, K. C. & Chern, J. W., 2001 Nov 8, In : Journal of Medicinal Chemistry. 44, 23, p. 3759-3763 5 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Overexpression of p97Eps8 leads to cellular transformatioan: Implication of pleckstrin homology domain in p97Eps8-mediated ERK activation

Maa, M. C., Hsieh, C. Y. & Leu, T. H., 2001 Jan 1, In : Oncogene. 20, 1, p. 106-112 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Selective enhancement of L-type calcium currents by corticotropin in acutely isolated rat amygdala neurons

Young, C., Huang, Y. C., Lin, C. H., Shen, Y. Z. & Gean, P. W., 2001 Jan 1, In : Molecular Pharmacology. 59, 3, p. 604-611 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
30 Citations (Scopus)

The KCI cotransporter isoform KCC3 can play an important role in cell growth regulation

Shen, M. R., Chou, C. Y., Hsu, K. F., Liu, H. S., Dunham, P. B., Holtzman, E. J. & Ellory, J. C., 2001 Dec 4, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 25, p. 14714-14719 6 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)
2000

Activation of group II metabotropic glutamate receptors induces long-term depression of synaptic transmission in the rat amygdala

Wang, H. C., Lin, S. J., Luo, M. Z. & Gean, P. W., 2000 Dec 15, In : Journal of Neuroscience. 20, 24, p. 9017-9024 8 p.

Research output: Contribution to journalArticle

Open Access
51 Citations (Scopus)