Research Output

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C. H. A., Chen, L. T. & Chang, J. Y., 2011 Oct 1, In : Cancer Letters. 309, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Enhancement of NMDA receptor-mediated synaptic potential by isoproterenol is blocked by Rp-adenosine 3′,5′-cyclic monophosphothioate

Huang, C. C., Tsai, J. J. & Gean, P. W., 1993 Oct 29, In : Neuroscience Letters. 161, 2, p. 207-210 4 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Endogenous serotonin inhibits epileptiform activity in rat hippocampal CA1 neurons via 5-hydroxytryptamine(1A) receptor activation

Lu, K. T. & Gean, P. W., 1998 Jun 8, In : Neuroscience. 86, 3, p. 729-737 9 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Emerging methods for analysis of the cancer methylome

Chang, J. W., Huang, T. H. M. & Wang, Y-C., 2008 Dec 1, In : Pharmacogenomics. 9, 12, p. 1869-1878 10 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)
15 Citations (Scopus)

Elevated p53 and p21waf1 mRNA expression in blood lymphocytes from lung cancer patients with chemoresistance

Shih, C. M., Chen, K., Wang, Y. C., Lee, P. J. & Wang, Y-C., 2007 Dec 4, In : Cancer Detection and Prevention. 31, 5, p. 366-370 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila

Shyu, W. H., Lee, W. P., Chiang, M. H., Chang, C. C., Fu, T. F., Chiang, H. C., Wu, T. & Wu, C. L., 2019, In : PLoS genetics. 15, 5, e1008153.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
72 Citations (Scopus)

Efficient synthesis of 2-(N-Substituted)-2-imidazolines and 2-(N-Substituted)-1,4,5, 6-tetrahydropyrimidines

Kan, W. M., Lin, S. H. & Chern, C. Y., 2005 Nov 10, In : Synthetic Communications. 35, 20, p. 2633-2639 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Effects of phenytoin on the amygdala neurons in vitro

Cheng, L. L., Wang, S. J., Tsai, J. J. & Geana, P. W., 1997 Jan 1, In : Pharmacology. 55, 5, p. 228-234 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Effects of lithium and haloperidol on human sperm motility in‐vitro

Shen, MR. R., Yang, RC. C. & Chen, SS. S., 1992 Jun, In : Journal of Pharmacy and Pharmacology. 44, 6, p. 534-536 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle

Lin, H. C., Mao, S. C. & Gean, P. W., 2006 May 1, In : Learning and Memory. 13, 3, p. 316-321 6 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Effects of a workplace multiple cardiovascular disease risks reduction program

Huang, J. J., Lin, H. S., Yen, M., Kan, W. M., Lee, B. O. & Chen, C. H., 2013 Jun, In : Asian Nursing Research. 7, 2, p. 74-82 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Effects of Antiepileptic Drugs on Sperm Motility of Normal Controls and Epileptic Patients with Long‐Term Therapy

Chen, SS. S., Shen, MR. R., Chen, TJ. J. & Lai, SL. L., 1992 Jan, In : Epilepsia. 33, 1, p. 149-153 5 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Effect of hydroxyzine on the transport of etoposide in rat small intestine

Kan, W. M., Liu, Y. T., Hsiao, C. L., Shieh, C. Y., Kuo, J. H., Huang, J. D. & Su, S. F., 2001 Apr 17, In : Anti-Cancer Drugs. 12, 3, p. 267-273 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response

Chang, H. Y., Huang, H. C., Huang, T. C., Yang, P. C., Wang, Y. C. & Juan, H. F., 2012 Sep 15, In : Cancer Research. 72, 18, p. 4696-4706 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

E-Cadherin Aptamer-Conjugated Delivery of Doxorubicin for Targeted Inhibition of Prostate Cancer Cells

Chaudhary, R., Roy, K., Kanwar, R. K., Veedu, R. N., Krishnakumar, S., Cheung, C-H., Verma, A. K. & Kanwar, J. R., 2016 Jan 1, In : Australian Journal of Chemistry. 69, 10, p. 1108-1116 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis

Tzeng, H. T., Tsai, C. H., Yen, Y. T., Cheng, H. C., Chen, Y. C., Pu, S. W., Wang, Y. S., Shan, Y. S., Tseng, Y. L., Su, W. C., Lai, W. W., Wu, L. W. & Wang, Y. C., 2017 May 1, In : Clinical Cancer Research. 23, 9, p. 2335-2345 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer

Lin, R. K., Wu, C. Y., Chang, J. W., Juan, L. J., Hsu, H. S., Chen, C. Y., Lu, Y. Y., Tang, Y. A., Yang, Y. C., Yang, P. C. & Wang, Y. C., 2010 Jul 15, In : Cancer Research. 70, 14, p. 5807-5817 11 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer

Lin, R. K. & Wang, Y. C., 2014 Aug 19, In : Cell and Bioscience. 4, 1, 46.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies

Ji, X. R., Cheng, K. C., Chen, Y. R., Lin, T. Y., Cheung, C. H. A., Wu, C. L. & Chiang, H. C., 2018 Mar, In : FASEB Journal. 32, 3, p. 1375-1387 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
3 Citations (Scopus)

Down-regulation of ARNT promotes cancer metastasis by activating the fibronectin/integrin β1/FAK axis

Huang, C. R., Lee, C. T., Chang, K. Y., Chang, W. C., Liu, Y. W., Lee, J. C. & Chen, B. K., 2015, In : Oncotarget. 6, 13, p. 11530-11546 17 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus

Young, C., Gean, P. W., Chiou, L. C. & Shen, Y. Z., 2000 Jul 22, In : Synapse. 37, 2, p. 90-94 5 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer

Yang, Y. C., Tang, Y. A., Shieh, J. M., Lin, R. K., Hsu, H. S. & Wang, Y. C., 2014 Sep, In : Journal of Thoracic Oncology. 9, 9, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Distinctive roles of different β-amyloid 42 aggregates in modulation of synaptic functions

Chiang, H. C., Iijima, K., Hakker, I. & Zhong, Y., 2009 Jun, In : FASEB Journal. 23, 6, p. 1969-1977 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients

Tseng, R. C., Lee, C. C., Hsu, H. S., Tzao, C. & Wang, Y. C., 2009 Aug, In : Neoplasia. 11, 8, p. 763-770 8 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Distinct epigenetic domains separated by a CTCF bound insulator between the tandem genes, BLU and RASSF1A

Chang, J. W., Hsu, H. S., Ni, H. J., Chuang, C. T., Hsiung, C. H., Huang, T. H. & Wang, Y. C., 2010, In : PloS one. 5, 9, p. 1-13 13 p., e12847.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Dissociation between synaptic depression and block of long-term depression induced by raising the temperature in rat hippocampal slices

Young, C., Luo, M. Z., Shen, Y. Z. & Gean, P-W., 2001 Mar 10, In : Synapse. 40, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Disruption of protein-protein interactions: Hot spot detection, structure-based virtual screening and: In vitro testing for the anti-cancer drug target-survivin

Sarvagalla, S., Cheung, C. H. A., Tsai, J. Y., Hsieh, H. P. & Coumar, M. S., 2016 Jan 1, In : RSC Advances. 6, 38, p. 31947-31959 13 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Direct interaction of C/EBPδ and Sp1 at the GC-enriched promoter region synergizes the IL-10 gene transcription in mouse macrophage

Chiang, B. T., Liu, Y. W., Chen, B. K., Wang, J. M. & Chang, W. C., 2006 Sep, In : Journal of biomedical science. 13, 5, p. 621-635 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity

Leu, T. H., Su, S. L., Chuang, Y. C. & Maa, M. C., 2003 Dec 15, In : Biochemical Pharmacology. 66, 12, p. 2323-2331 9 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Differential osmosensing signalling pathways and G-protein involvement in human cervical cells with different tumour potential

Shen, M. R., Chou, C. Y., Wu, M. L. & Huang, K. E., 1998 Feb 1, In : Cellular Signalling. 10, 2, p. 113-120 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Differential expression of volume-regulated anion channels during cell cycle progression of human cervical cancer cells

Shen, M. R., Droogmans, G., Eggermont, J., Voets, T., Ellory, J. C. & Nilius, B., 2000 Dec 1, In : Journal of Physiology. 529, 2, p. 385-394 10 p.

Research output: Contribution to journalArticle

148 Citations (Scopus)
1 Citation (Scopus)

Differential Ca2+ mobilization and mast cell degranulation by FcεRI- and GPCR-mediated signaling

Chen, Y. C., Chang, Y. C., Chang, H. A., Lin, Y. S., Tsao, C. W., Shen, M. R. & Chiu, W. T., 2017 Nov, In : Cell Calcium. 67, p. 31-39 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Design and synthesis of 3-aryl-5-alicylic-[1,2,4]-oxadiazoles as novel platelet aggregation inhibitors

Chern, C. Y., Chen, S. J. & Kan, W. M., 2005 Jan 1, In : Journal of the Chinese Chemical Society. 52, 2, p. 331-338 8 p.

Research output: Contribution to journalArticle

Design and synthesis of 1,2,4-oxadiazole derivatives as non-steroidal 5α-reductase inhibitors

Chang, C. S., Kan, W. M., Chen, C. L., Wang, K. C. & Chern, J. W., 2002 Jan 1, In : Journal of the Chinese Chemical Society. 49, 1, p. 83-89 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Deregulation of SLIT2-mediated Cdc42 activity is associated with esophageal cancer metastasis and poor prognosis

Tseng, R. C., Chang, J. M., Chen, J. H., Huang, W. R., Tang, Y. A., Kuo, I. Y., Yan, J. J., Lai, W. W. & Wang, Y. C., 2015 Jan 1, In : Journal of Thoracic Oncology. 10, 1, p. 189-198 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Delivery of a survivin Promoter-Driven antisense Survivin-Expressing plasmid DNA as a cancer therapeutic: A proof-of-concept study

Lin, K. Y., Cheng, S. M., Tsai, S. L., Tsai, J. Y., Lin, C. H. & Cheung, C. H. A., 2016 May 3, In : OncoTargets and Therapy. 9, p. 2601-2613 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis

Chen, Y-W., Tran, S., Chenier, I., Chan, J. S. D., Ingelfinger, J. R., Inagami, T. & Zhang, S. L., 2008 Jul 9, In : Pediatric Nephrology. 23, 10, p. 1769-1777 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Deficiency of electroneutral K+-Cl- cotransporter 3 causes a disruption in impulse propagation along peripheral nerves

Sun, Y-T., Lin, T-S., Tzeng, S-F., Delpire, E. & Shen, M-R., 2010 Oct 1, In : GLIA. 58, 13, p. 1544-1552 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Damage formation and repair efficiency in the p53 gene of cell lines and blood lymphocytes assayed by multiplex long quantitative polymerase chain reaction

Wang, Y. C., Lee, P. J., Shih, C. M., Chen, H. Y., Lee, C. C., Chang, Y. Y., Hsu, Y. T., Liang, Y. J., Wang, L. Y., Han, W. H. & Wang, Y. C., 2003 Aug 15, In : Analytical Biochemistry. 319, 2, p. 206-215 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
19 Citations (Scopus)

Cytotoxicity and proteomics analyses of OSU03013 in lung cancer

Tan, Y. H., Lee, K. H., Lin, T., Sun, Y. C., Hsieh-Li, H. M., Juan, H. F. & Wang, Y. C., 2008 Mar 15, In : Clinical Cancer Research. 14, 6, p. 1823-1830 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Cyclic AMP (cAMP) confers drug resistance against DNA damaging agents via PKAIA in CML cells

Xiao, L. Y. & Kan, W. M., 2017 Jan 1, In : European Journal of Pharmacology. 794, p. 201-208 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
10 Citations (Scopus)

C-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function

Biscardi, J. S., Maa, M. C., Tice, D. A., Cox, M. E., Leu, T. H. & Parsons, S. J., 1999 Mar 19, In : Journal of Biological Chemistry. 274, 12, p. 8335-8343 9 p.

Research output: Contribution to journalArticle

532 Citations (Scopus)