Research Output 1986 2019

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2019

CCN1 triggers adaptive autophagy in cardiomyocytes to curb its apoptotic activities

Su, B. C., Hsu, P. L. & Mo, F. E., 2019 Jan 1, (Accepted/In press) In : Journal of Cell Communication and Signaling.

Research output: Contribution to journalArticle

Curbs
Autophagy
Cardiac Myocytes
Integrins
Acridine Orange
5 Citations (Scopus)
Fibroblast Growth Factor 9
Corpus Striatum
Huntington Disease
Oxidative stress
Oxidative Stress

hnRNPM induces translation switch under hypoxia to promote colon cancer development

Chen, T. M., Lai, M. C., Li, Y. H., Chan, Y. L., Wu, C. H., Wang, Y. M., Chien, C. W., Huang, S. Y., Sun, H-F. & Tsai, S-J., 2019 Mar 1, In : EBioMedicine. 41, p. 299-309 11 p.

Research output: Contribution to journalArticle

Open Access
Colonic Neoplasms
Genes
Switches
Carcinogenesis
Proteins
1 Citation (Scopus)

Hypoxia: The force of endometriosis

Wu, M-H., Hsiao, K. Y. & Tsai, S-J., 2019 Mar 1, In : Journal of Obstetrics and Gynaecology Research. 45, 3, p. 532-541 10 p.

Research output: Contribution to journalArticle

Endometriosis
Gene Regulatory Networks
Uterus
Medical Electronics
Peritoneum
1 Citation (Scopus)
Cell Hypoxia
Stromal Cells
Apoptosis
Endometriosis
Oxygen Consumption

Lactoferrin Protects Hyperoxia-Induced Lung and Kidney Systemic Inflammation in an In Vivo Imaging Model of NF-κB/Luciferase Transgenic Mice

Yen, C. C., Chang, W. H., Tung, M. C., Chen, H. L., Liu, H. C., Liao, C. H., Lan, Y. W., Chong, K. Y., Yang, S-H. & Chen, C. M., 2019 Jan 1, In : Molecular Imaging and Biology.

Research output: Contribution to journalArticle

Hyperoxia
Lactoferrin
Luciferases
Transgenic Mice
Inflammation

Relevance of number and physiological status of conspecifics in preventing stress-induced decreases in newly proliferated cells and neuroblasts

Sun, L. H., Tzeng, W. Y., Liao, Y. H., Deng, W. T., Cherng, C. G. & Yu, L., 2019 Nov 1, In : Psychopharmacology. 236, 11, p. 3329-3339 11 p.

Research output: Contribution to journalArticle

Oxytocin
Dentate Gyrus
Oxytocin Receptors
Neurogenesis
L 371257
1 Citation (Scopus)

Targeting anthrax toxin receptor 2 ameliorates endometriosis progression

Lin, S. C., Lee, H. C., Hsu, C. T., Huang, Y. H., Li, W. N., Hsu, P. L., Wu, M. H. & Tsai, S. J., 2019 Jan 1, In : Theranostics. 9, 3, p. 620-632 13 p.

Research output: Contribution to journalArticle

Open Access
Endometriosis
Histone Code
Choristoma
Pathologic Processes
Stromal Cells

The effect of ASIC3 knockout on corticostriatal circuit and mouse self-grooming behavior

Wu, W. L., Cheng, S. J., Lin, S. H., Chuang, Y. C., Huang, E. Y. K. & Chen, C. C., 2019 Jan 29, In : Frontiers in Cellular Neuroscience. 13, 86.

Research output: Contribution to journalArticle

Open Access
Acid Sensing Ion Channels
Grooming
Proprioception
Phenotype
Neurons

Tks5 and dynamin-2 enhance actin bundle rigidity in invadosomes to promote myoblast fusion

Chuang, M. C., Lin, S. S., Ohniwa, R. L., Lee, G. H., Su, Y. A., Chang, Y. C., Tang, M. J. & Liu, Y. W., 2019 May 1, In : Journal of Cell Biology. 218, 5, p. 1670-1685 16 p.

Research output: Contribution to journalArticle

Open Access
Dynamin II
Myoblasts
Actins
Muscle Development
Actin Cytoskeleton

Vagal baro- and chemoreceptors in middle internal carotid artery and carotid body in rat

Wang, F. B., Liao, Y. H., Kao, C. K. & Fang, C. L., 2019 Nov 1, In : Journal of Anatomy. 235, 5, p. 953-961 9 p.

Research output: Contribution to journalArticle

Glossopharyngeal Nerve
Carotid Body
nerve endings
Pressoreceptors
Vagus Nerve
2018
1 Citation (Scopus)

Axons of Passage and Inputs to Superior Cervical Ganglion in Rat

Wang, F. B., Cheng, P. M., Chi, H. C., Kao, C. K. & Liao, Y. H., 2018 Nov, In : Anatomical Record. 301, 11, p. 1906-1916 11 p.

Research output: Contribution to journalArticle

Superior Cervical Ganglion
axons
Axons
Ganglia
Neurons
10 Citations (Scopus)

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W. T., Chang, H. A., Lin, Y. H., Lin, Y. S., Chang, H. T., Lin, H. H., Huang, S. C., Tang, M. J. & Shen, M. R., 2018 Dec 1, In : Cell Death Discovery. 4, 1, 37.

Research output: Contribution to journalArticle

Open Access
Apoptosis
Tunicamycin
Thapsigargin
Mitochondria
Death Domain Receptors

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W., Chang, H., Lin, Y., Lin, Y., Chang, H., Lin, H., Huang, S., Tang, M. & Shen, M., 2018 Dec 1, In : Cell Death Discovery. 4, 1

Research output: Contribution to journalArticle

10 Citations (Scopus)

Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation in Keloid Fibroblasts

Hsu, C. K., Lin, H. H., Harn, H. I., Ogawa, R., Wang, Y. K., Ho, Y. T., Chen, W. R., Lee, Y. C., Lee, J. Y. Y., Shieh, S. J., Cheng, C. M., McGrath, J. A. & Tang, M. J., 2018 Jan, In : Journal of Investigative Dermatology. 138, 1, p. 208-218 11 p.

Research output: Contribution to journalArticle

Caveolin 1
Keloid
Fibroblasts
Chemical activation
trichostatin A

Caveolin-1 down-regulation is required for Wnt5a-Frizzled 2 signalling in Ha-RasV12-induced cell transformation

Lin, H. K., Lin, H. H., Chiou, Y. W., Wu, C. L., Chiu, W. T. & Tang, M. J., 2018 May 1, In : Journal of Cellular and Molecular Medicine. 22, 5, p. 2631-2643 13 p.

Research output: Contribution to journalArticle

Caveolin 1
Down-Regulation
Madin Darby Canine Kidney Cells
Exosomes
Conditioned Culture Medium
2 Citations (Scopus)
KATP Channels
Palmitic Acid
Insulin
Glucose
Glyburide
5 Citations (Scopus)

Coincidence Detection of Membrane Stretch and Extracellular pH by the Proton-Sensing Receptor OGR1 (GPR68)

Wei, W. C., Bianchi, F., Wang, Y. K., Tang, M. J., Ye, H. & Glitsch, M. D., 2018 Dec 3, In : Current Biology. 28, 23, p. 3815-3823.e4

Research output: Contribution to journalArticle

protons
Protons
Membranes
receptors
Acidification
6 Citations (Scopus)

Defective trafficking of Kv2.1 channels in MPTP-induced nigrostriatal degeneration

Chao, R. Y., Cheng, C. H., Wu, S-N. & Chen, P., 2018 Feb 1, In : Journal of Neurochemistry. 144, 4, p. 483-497 15 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Parkinson Disease
Dopaminergic Neurons
Protein Transport
Neurons
1 Citation (Scopus)

Dopamine D3 receptor blockade rescues hyper-dopamine activity-induced deficit in novel object recognition memory

Chang, P. K., Yu, L. & Chen, J. C., 2018 May 1, In : Neuropharmacology. 133, p. 216-223 8 p.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
Dopamine
Recognition (Psychology)
Dopamine Plasma Membrane Transport Proteins
Episodic Memory
4 Citations (Scopus)
Open Access
Intermediate-Conductance Calcium-Activated Potassium Channels
Motor Neurons
Tretinoin
Diazoxide
Architectural Accessibility
8 Citations (Scopus)

FGF9/FGFR2 increase cell proliferation by activating ERK1/2, Rb/E2F1, and cell cycle pathways in mouse Leydig tumor cells

Chang, M. M., Lai, M. S., Hong, S. Y., Pan, B. S., Huang, H., Yang, S. H., Wu, C. C., Sun, H. S., Chuang, J. I., Wang, C. Y. & Huang, B. M., 2018 Nov 1, In : Cancer Science. 109, 11, p. 3503-3518 16 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Leydig Cell Tumor
Fibroblast Growth Factor Receptors
Retinoblastoma
Fibroblast Growth Factor 2
3 Citations (Scopus)

Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington's Disease

Yusuf, I. O., Cheng, P. H., Chen, H. M., Chang, Y. F., Chang, C. Y., Yang, H. I., Lin, C. W., Tsai, S. J., Chuang, J. I., Wu, C. C., Huang, B. M., Sun, H. S. & Yang, S. H., 2018 Aug 1, In : Cellular Physiology and Biochemistry. 48, 2, p. 605-617 13 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Corpus Striatum
Huntington Disease
Cell Death
MAP Kinase Signaling System
1 Citation (Scopus)
Ganoderma
Reishi
Oxidative stress
Ligation
Oxidative Stress
6 Citations (Scopus)

High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice

Tsai, S. F., Wu, H. T., Chen, P. C., Chen, Y. W., Yu, M., Wang, T. F., Wu, S. Y., Tzeng, S. F. & Kuo, Y. M., 2018 Dec 1, In : Brain Research. 1700, p. 66-77 12 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
High Fat Diet
Neuronal Plasticity
Neuroglia
Hippocampus
2 Citations (Scopus)

Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin

Ko, J., Isas, J. M., Sabbaugh, A., Yoo, J. H., Pandey, N. K., Chongtham, A., Ladinsky, M., Wu, W. L., Rohweder, H., Weiss, A., Macdonald, D., Munoz-Sanjuan, I., Langen, R., Patterson, P. H. & Khoshnan, A., 2018 Jul 1, In : Human Molecular Genetics. 27, 13, p. 2330-2343 14 p.

Research output: Contribution to journalArticle

Epitopes
Neuropil
Antibodies
Brain
Myelin Sheath
2 Citations (Scopus)

mGluR5 upregulation and the effects of repeated methamphetamine administration and withdrawal on the rewarding efficacy of ketamine and social interaction

Liao, Y. H., Wang, Y. H., Sun, L. H., Deng, W. T., Lee, H. T. & Yu, L., 2018 Dec 1, In : Toxicology and Applied Pharmacology. 360, p. 58-68 11 p.

Research output: Contribution to journalArticle

Methamphetamine
Ketamine
Interpersonal Relations
Up-Regulation
Dopamine
20 Citations (Scopus)
Silver
Nanoparticles
Reactive Oxygen Species
Autophagy
Drosophila melanogaster
3 Citations (Scopus)

Suppression of COUP-TFII upregulates angiogenin and promotes angiogenesis in endometriosis

Fu, J. L., Hsiao, K. Y., Lee, H. C., Li, W. N., Chang, N., Wu, M. H. & Tsai, S. J., 2018 Jan 1, In : Human Reproduction. 33, 8, p. 1517-1527 11 p.

Research output: Contribution to journalArticle

COUP Transcription Factor II
Endometriosis
Up-Regulation
Stromal Cells
Down-Regulation
Parahippocampal Gyrus
Dentate Gyrus
Lipopolysaccharides
Hippocampus
Infection
5 Citations (Scopus)

The comprehensive electrophysiological study of curcuminoids on delayed-rectifier K+ currents in insulin-secreting cells

Kuo, P-C., Yang, C. J., Lee, Y. C., Chen, P., Liu, Y-C. & Wu, S-N., 2018 Jan 15, In : European Journal of Pharmacology. 819, p. 233-241 9 p.

Research output: Contribution to journalArticle

Curcumin
Insulin-Secreting Cells
Insulin
Membrane Potentials
Nicorandil
5 Citations (Scopus)

The protective role of Bacteroides fragilis in a murine model of colitis-associated colorectal cancer

Lee, Y. K., Mehrabian, P., Boyajian, S., Wu, W-L., Selicha, J., Vonderfecht, S. & Mazmanian, S. K., 2018 Nov 1, In : mSphere. 3, 6, e00587-18.

Research output: Contribution to journalArticle

Bacteroides fragilis
Colitis
Colorectal Neoplasms
Dextran Sulfate
Inflammation
3 Citations (Scopus)

Time Series Integrative Analysis of RNA Sequencing and MicroRNA Expression Data Reveals Key Biologic Wound Healing Pathways in Keloid-Prone Individuals

Onoufriadis, A., Hsu, C-K., Ainali, C., Ung, C. Y., Rashidghamat, E., Yang, H. S., Huang, H. Y., Niazi, U., Tziotzios, C., Yang, J. C., Nuamah, R., Tang, M-J., Saxena, A., de Rinaldis, E. & McGrath, J. A., 2018 Dec 1, In : Journal of Investigative Dermatology. 138, 12, p. 2690-2693 4 p.

Research output: Contribution to journalArticle

Time series analysis
MicroRNAs
RNA
2017
3 Citations (Scopus)

A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice

Lai, C. W., Chen, H. L., Tu, M. Y., Lin, W. Y., Röhrig, T., Yang, S-H., Lan, Y. W., Chong, K. Y. & Chen, C. M., 2017 Jan 1, In : Oncotarget. 8, 5, p. 7357-7369 13 p.

Research output: Contribution to journalArticle

Ascorbic Acid Deficiency
Gene Knockout Techniques
Knockout Mice
Ascorbic Acid
Osteoporosis
2 Citations (Scopus)

Basolateral amygdalar D2 receptor activation is required for the companions-exerted suppressive effect on the cocaine conditioning

Tzeng, W. Y., Cherng, C. F. G., Yu, L. & Wang, C. Y., 2017 Jan 1, In : Neurobiology of Learning and Memory. 137, p. 48-55 8 p.

Research output: Contribution to journalArticle

Cocaine
Amygdala
Hippocampus
Dopamine
Ibotenic Acid

CCAAT/enhancer-binding protein delta promotes intracellular lipid accumulation in M1 macrophages of vascular lesions

Lai, H., Hsu, L., Tsai, H., Lo, Y., Yang, S., Liu, P. & Wang, Y-M., 2017 Sep 1, In : Cardiovascular Research. 113, 11, p. 1376-1388

Research output: Contribution to journalArticle

4 Citations (Scopus)

CCAAT/enhancer-binding protein delta promotes intracellular lipid accumulation in M1 macrophages of vascular lesions

Lai, H. Y., Hsu, L. W., Tsai, H. H., Lo, Y-C., Yang, S-H., Liu, P-Y. & Wang, J-M., 2017 Jan 1, In : Cardiovascular Research. 113, 11, p. 1376-1388 13 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-delta
Blood Vessels
Macrophages
Lipids
Apolipoproteins E
107 Citations (Scopus)

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

Chan, K. Y., Jang, M. J., Yoo, B. B., Greenbaum, A., Ravi, N., Wu, W. L., Sánchez-Guardado, L., Lois, C., Mazmanian, S. K., Deverman, B. E. & Gradinaru, V., 2017 Aug 1, In : Nature Neuroscience. 20, 8, p. 1172-1179 8 p.

Research output: Contribution to journalArticle

Dependovirus
Peripheral Nervous System
Central Nervous System
Genes
Neurons
5 Citations (Scopus)

Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress

Wu, C. Y., Hsu, W. L., Tsai, M. H., Liang, J. L., Lu, J. H., Yen, C. J., Yu, H. S., Noda, M., Lu, C. Y., Chen, C. H., Yan, S-J. & Yoshioka, T., 2017 Dec 1, In : Scientific reports. 7, 1, 3606.

Research output: Contribution to journalArticle

Oxidative stress
Disulfides
Hydrogen
Gases
Reactive Oxygen Species
21 Citations (Scopus)

Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness

Hou, P. C., Li, Y. H., Lin, S-C., Lin, S-C., Lee, J-C., Lin, P-W., Liou, J. P., Chang, J-Y., Kuo, C. C., Liu, Y. M., Sun, H-F. & Tsai, S-J., 2017 Aug 15, In : Cancer Research. 77, 16, p. 4305-4316 12 p.

Research output: Contribution to journalArticle

Dual-Specificity Phosphatases
Dual Specificity Phosphatase 2
Colonic Neoplasms
Down-Regulation
Neoplasms
6 Citations (Scopus)

Hypoxia-inhibited DUSP2 expression promotes IL-6/STAT3 signaling in endometriosis

Hsiao, K. Y., Chang, N., Tsai, J. L., Lin, S-C., Tsai, S-J. & Wu, M-H., 2017 Jan 1, In : American Journal of Reproductive Immunology. 78, 4, e12690.

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 2
Endometriosis
Interleukin-6
Stromal Cells
Bromodeoxyuridine
11 Citations (Scopus)

Loss of dual-specificity phosphatase-2 promotes angiogenesis and metastasis via up-regulation of interleukin-8 in colon cancer

Lin, S-C., Hsiao, K. Y., Chang, N., Hou, P. C. & Tsai, S-J., 2017 Apr 1, In : Journal of Pathology. 241, 5, p. 638-648 11 p.

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 2
Interleukin-8
Colonic Neoplasms
Up-Regulation
Neoplasm Metastasis
27 Citations (Scopus)

Mechanotransduction of matrix stiffness in regulation of focal adhesion size and number: Reciprocal regulation of caveolin-1 and β1 integrin

Yeh, Y. C., Ling, J. Y., Chen, W. C., Lin, H. H. & Tang, M. J., 2017 Dec 1, In : Scientific reports. 7, 1, 15008.

Research output: Contribution to journalArticle

Caveolin 1
Focal Adhesions
Integrins
Cell Adhesion
Cluster Analysis
3 Citations (Scopus)

miR-196a enhances neuronal morphology through suppressing RANBP10 to provide neuroprotection in Huntington's disease

Her, L-S., Mao, S. H., Chang, C. Y., Cheng, P. H., Chang, Y. F., Yang, H. I., Chen, C. M. & Yang, S-H., 2017 Jan 1, In : Theranostics. 7, 9, p. 2452-2462 11 p.

Research output: Contribution to journalArticle

Huntington Disease
Carrier Proteins
Aptitude
MicroRNAs
Neuronal Plasticity
4 Citations (Scopus)
Reverse Transcriptase Inhibitors
Nucleosides
Mitochondrial DNA
Nucleotides
HIV
3 Citations (Scopus)

NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic Β-cells

Wu, Y., Fortin, D. A., Cochrane, V. A., Chen, P. & Shyng, S. L., 2017 Jan 1, In : Journal of Biological Chemistry. 292, 37, p. 15512-15524 13 p.

Research output: Contribution to journalArticle

Potassium Channels
Leptin
N-Methyl-D-Aspartate Receptors
KATP Channels
AMP-Activated Protein Kinases
155 Citations (Scopus)

Noncoding effects of circular RNA CCDC66 promote colon cancer growth and metastasis

Hsiao, K. Y., Lin, Y. C., Gupta, S. K., Chang, N., Yen, L., Sun, H. S. & Tsai, S. J., 2017 May 1, In : Cancer Research. 77, 9, p. 2339-2350 12 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Neoplasm Metastasis
Growth
Neoplasms
Colorectal Neoplasms
3 Citations (Scopus)

Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease

Wang, E., Chiou, Y. Y., Jeng, W. Y., Lin, H. K., Lin, H. H., Chin, H. J., Leo Wang, C. K., Yu, S. S., Tsai, S. C., Chiang, C. Y., Cheng, P. H., Lin, H. J., Jiang, S. T., Chiu, S. T. & Hsieh-Li, H. M., 2017 Feb 1, In : Kidney international. 91, 2, p. 412-422 11 p.

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Cysts
Kidney
Caspase 3
Transgenic Mice