Institute of Basic Medical Sciences

2023

Optogenetically engineered Ca²⁺ oscillation-mediated DRP1 activation promotes mitochondrial fission and cell death

Lai, Y. S., Chang, C. C., Chen, Y. Y., Nguyen, T. M. H., Xu, J., Chen, Y. C., Chang, Y. F., Wang, C. Y., Chen, P. S., Lin, S. C., Peng, I. C., Tsai, S. J. & Chiu, W. T., 2023, In: Journal of Cell Science. 136, 12, jcs260819.

Research output: Contribution to journal › Article › peer-review

Open Access

Proteomic characterization of extracellular vesicles derived from lactic acid bacteria

Lee, B. H., Chen, Y. Z., Shen, T. L., Pan, T. M. & Hsu, W. H., 2023 Nov 30, In: Food Chemistry. 427, 136685.

Research output: Contribution to journal › Article › peer-review

Structural basis underlying the synergism of NADase and SLO during group A Streptococcus infection

Tsai, W. J., Lai, Y. H., Shi, Y. A., Hammel, M., Duff, A. P., Whitten, A. E., Wilde, K. L., Wu, C. M., Knott, R., Jeng, U. S., Kang, C. Y., Hsu, C. Y., Wu, J. L., Tsai, P. J., Chiang-Ni, C., Wu, J. J., Lin, Y. S., Liu, C. C., Senda, T. & Wang, S., 2023 Jan 31, In: Communications Biology. 6, 1, 124.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis

Hsu, P. L., Chien, C. W., Tang, Y. A., Lin, B. W., Lin, S. C., Lin, Y. S., Chen, S. Y., Sun, H. S. & Tsai, S. J., 2023 Apr, In: Science Advances. 9, 15, eade3422.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia

Cheng, Y. S., Chen, H. Y., Lin, Y. C., Lin, Y. S., Yeh, Y. C., Yeh, Y. H., Cheng, Y. H., Lin, Y. M., Weng, H. Y., Lin, T. Y. & Lin, S. C., 2023, (Accepted/In press) In: Andrology.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

An innovative targeted therapy for fluoroscopy-induced chronic radiation dermatitis

Wei, K. C., Lai, S. F., Huang, W. L., Yang, K. C., Lai, P. C., Wei, W. J., Chang, T. H., Huang, Y. C., Tsai, Y. C., Lin, S. C., Lin, S. J. & Lin, S. C., 2022 Jan, In: Journal of Molecular Medicine. 100, 1, p. 135-146 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Antibodies against the SARS-CoV-2 S1-RBD cross-react with dengue virus and hinder dengue pathogenesis

Cheng, Y. L., Chao, C. H., Lai, Y. C., Hsieh, K. H., Wang, J. R., Wan, S. W., Huang, H. J., Chuang, Y. C., Chuang, W. J. & Yeh, T. M., 2022 Aug 15, In: Frontiers in Immunology. 13, 941923.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Antrodia cinnamomea Suppress Dengue Virus Infection through Enhancing the Secretion of Interferon-Alpha

Chen, Y. J., Tsao, Y. C., Ho, T. C., Puc, I., Chen, C. C., Perng, G. C. & Lien, H. M., 2022 Oct, In: Plants. 11, 19, 2631.

Research output: Contribution to journal › Article › peer-review

Open Access

ATM- and ATR-induced primary ciliogenesis promotes cisplatin resistance in pancreatic ductal adenocarcinoma

Chao, Y. Y., Huang, B. M., Peng, I. C., Lee, P. R., Lai, Y. S., Chiu, W. T., Lin, Y. S., Lin, S. C., Chang, J. H., Chen, P. S., Tsai, S. J. & Wang, C. Y., 2022 Dec, In: Journal of Cellular Physiology. 237, 12, p. 4487-4503 17 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Factors associated with mortality in patients with super-refractory status epilepticus

Fang, Y. T., Lee, T. L., Tu, Y. H., Lin, S. H., Chien, M. E., Huang, C. W., Hsu, K. S. & Wu, Y. J., 2022 Dec, In: Scientific reports. 12, 1, 9670.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Intracerebroventricular Delivery of Gut-derived Microbial Metabolites in Freely Moving Mice

Liou, C. W., Yao, T. H. & Wu, W. L., 2022 Jun, In: Journal of Visualized Experiments. 2022, 184, e63972.

Research output: Contribution to journal › Article › peer-review

Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients

Chen, Y-L., Lee, K-T., Wang, C-Y., Shen, C-H., Chen, S-C., Chung, W-P., Hsu, Y-T., Kuo, Y-L., Chen, P-S., Cheung, C. H. A., Chang, C-P., Shen, M-R. & Hsu, H-P., 2022, In: American Journal of Cancer Research. 12, 5, p. 2084-2101 18 p.

Research output: Contribution to journal › Article › peer-review

Mitochondrial Transplantation Attenuates Neural Damage and Improves Locomotor Function After Traumatic Spinal Cord Injury in Rats

Lin, M. W., Fang, S. Y., Hsu, J. Y. C., Huang, C. Y., Lee, P. H., Huang, C. C., Chen, H. F., Lam, C. F. & Lee, J. S., 2022 Apr 12, In: Frontiers in Neuroscience. 16, 800883.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

Mobilization of Hematopoietic Stem and Progenitor Cells during Dengue Virus Infection

Puc, I., Ho, T. C., Chien, Y. W., Tan, S. S., Fong, Y. C., Chen, Y. J., Wang, S. H., Li, Y. H., Chen, C. H., Chen, P. L., Perng, G. C. & Tsai, J. J., 2022 Nov, In: International journal of molecular sciences. 23, 22, 14330.

Research output: Contribution to journal › Article › peer-review

Open Access

Predicting the Need for Desmopressin Treatment During Inpatient and After Discharge Following Endoscopic Sellar Surgery

Wong, C. E., Wang, W. H., Lan, M. Y., Lee, P. H., Huang, C. C., Su, P. F. & Lee, J. S., 2022 Feb 17, In: Frontiers in Neurology. 13, 843646.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Profiling antibody signature of schizophrenia by Escherichia coli proteome microarrays

Chen, B. Y., Hsu, C. C., Chen, Y. Z., Lin, J. J., Tseng, H. H., Jang, F. L., Chen, P. S., Chen, W. N., Chen, C. S. & Lin, S. H., 2022 Nov, In: Brain, Behavior, and Immunity. 106, p. 11-20 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Safety and Efficacy of Sorafenib and Lenvatinib in Patients Who Underwent Surgery or Whole-Brain Radiotherapy for Brain Metastasis of Hepatocellular Carcinoma

Perng, P. S., Lai, Y. H., Lee, P. H., Huang, C. C., Hsu, H. H. & Lee, J. S., 2022 Mar 1, In: Journal of Clinical Medicine. 11, 6, 1536.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Short-term, medium-term, and long-term risks of nonvariceal upper gastrointestinal bleeding after dengue virus infection

Chien, Y. W., Chuang, H. N., Wang, Y. P., Perng, G. C., Chi, C. Y. & Shih, H. I., 2022 Jan, In: PLoS neglected tropical diseases. 16, 1, e0010039.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Suppression of annexin A1 and its receptor reduces herpes simplex virus 1 lethality in mice

Wang, L. C., Wu, S. R., Yao, H. W., Ling, P., Perng, G. C., Chiu, Y. C., Hsu, S. M. & Chen, S. H., 2022 Aug, In: PLoS pathogens. 18, 8, e1010692.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

TNFα-mediated necroptosis in brain endothelial cells as a potential mechanism of increased seizure susceptibility in mice following systemic inflammation

Huang, W. Y., Lai, Y. L., Liu, K. H., Lin, S., Chen, H. Y., Liang, C. H., Wu, H. M. & Hsu, K. S., 2022 Dec, In: Journal of Neuroinflammation. 19, 1, 29.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

2021

Cytokine signature of dengue patients at different severity of the disease

Puc, I., Ho, T. C., Yen, K. L., Vats, A., Tsai, J. J., Chen, P. L., Chien, Y. W., Lo, Y. C. & Perng, G. C., 2021 Mar 2, In: International journal of molecular sciences. 22, 6, p. 1-15 15 p., 2879.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

Delta oscillation underlies the interictal spike changes after repeated transcranial direct current stimulation in a rat model of chronic seizures

Wu, Y. J., Chien, M. E., Chiang, C. C., Huang, Y. Z., Durand, D. M. & Hsu, K. S., 2021 Jul 1, In: Brain Stimulation. 14, 4, p. 771-779 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Evidence that hematopoietic stem cells in human umbilical cord blood is infectable by dengue virus: proposing a vertical transmission candidate

Vats, A., Ho, T. C., Puc, I., Chen, Y. J., Chang, C. H., Chien, Y. W. & Perng, G. C., 2021 Apr, In: Heliyon. 7, 4, e06785.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Fibroblast Growth Factor 9 Stimulates Neuronal Length Through NF-kB Signaling in Striatal Cell Huntington’s Disease Models

Yusuf, I. O., Chen, H. M., Cheng, P. H., Chang, C. Y., Tsai, S. J., Chuang, J. I., Wu, C. C., Huang, B. M., Sun, H. S., Chen, C. M. & Yang, S. H., 2021 May, In: Molecular Neurobiology. 58, 5, p. 2396-2406 11 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Inhibiting NTRK2 signaling causes endometriotic lesion regression

Lee, H. C., Lin, S. C., Wu, M. H. & Tsai, S. J., 2021 Jan, In: Reproduction. 161, 1, p. 11-19 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Microbiota regulate social behaviour via stress response neurons in the brain

Wu, W. L., Adame, M. D., Liou, C. W., Barlow, J. T., Lai, T. T., Sharon, G., Schretter, C. E., Needham, B. D., Wang, M. I., Tang, W., Ousey, J., Lin, Y. Y., Yao, T. H., Abdel-Haq, R., Beadle, K., Gradinaru, V., Ismagilov, R. F. & Mazmanian, S. K., 2021 Jul 15, In: Nature. 595, 7867, p. 409-414 6 p.

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Srebp1-induced glutamine synthetase triggers a feedforward loop to upregulate srebp1 through sp1 o-glcnacylation and augments lipid droplet formation in cancer cells

Jhu, J. W., Yan, J. B., Lin, Z. H., Lin, S. C. & Peng, I. C., 2021 Sept, In: International journal of molecular sciences. 22, 18, 9814.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

Suppression of extracellular vesicle VEGF-C-mediated lymphangiogenesis and pancreatic cancer early dissemination by a selective HDAC1/2 inhibitor

Wang, C. A., Li, C. F., Huang, R. C., Li, Y. H., Liou, J. P. & Tsai, S. J., 2021 Sept, In: Molecular cancer therapeutics. 20, 9, p. 1550-1560 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Targeting hr repair as a synthetic lethal approach to increase dna damage sensitivity by a rad52 inhibitor in brca2-deficient cancer cells

Tseng, W. C., Chen, C. Y., Chern, C. Y., Wang, C. A., Lee, W. C., Chi, Y. C., Cheng, S. F., Kuo, Y. T., Chiu, Y. C., Tseng, S. T., Lin, P. Y., Liou, S. J., Li, Y. C. & Chen, C. C., 2021 May 1, In: International journal of molecular sciences. 22, 9, 4422.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

The MicroRNA Prediction Models as Ancillary Diagnosis Biomarkers for Urothelial Carcinoma in Patients With Chronic Kidney Disease

Li, A. L., Chou, C. Y., Chen, C. L., Wu, K. L., Lin, S. C., Chen, H. C., Wang, M. C., Chang, C. C., Hsu, B. G., Wu, M. S., Ma, N. & Huang, C. C., 2021 Oct 1, In: Frontiers in Medicine. 8, 726214.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country

Pan, Y. H., Liao, M. Y., Chien, Y. W., Ho, T. S., Ko, H. Y., Yang, C. R., Chang, S. F., Yu, C. Y., Lin, S. Y., Shih, P. W., Shu, P. Y., Chao, D. Y., Pan, C. Y., Chen, H. M., Perng, G. C., Ku, C. C. & King, C. C., 2021 Apr, In: PLoS neglected tropical diseases. 15, 4, e0009312.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

YAP1 overexpression contributes to the development of enzalutamide resistance by induction of cancer stemness and lipid metabolism in prostate cancer

Lee, H. C., Ou, C. H., Huang, Y. C., Hou, P. C., Creighton, C. J., Lin, Y. S., Hu, C. Y. & Lin, S. C., 2021 Apr 1, In: Oncogene. 40, 13, p. 2407-2421 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Citations (Scopus)

2020

A label-free impedimetric genosensor for the nucleic acid amplification-free detection of extracted RNA of dengue virus

Wu, C. C., Yen, H. Y., Lai, L. T., Perng, G. C., Lee, C. R. & Wu, S. J., 2020 Jul 1, In: Sensors (Switzerland). 20, 13, p. 1-15 15 p., 3728.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

Bacterial otu deubiquitinases regulate substrate ubiquitination upon legionella infection

Shin, D., Bhattacharya, A., Cheng, Y. L., Alonso, M. C., Mehdipour, A. R., van der Heden van Noort, G. J., Ovaa, H., Hummer, G. & Dikic, I., 2020 Oct, In: eLife. 9, p. 1-21 21 p., e58277.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination

Wang, C. A., Chang, I. H., Hou, P. C., Tai, Y. J., Li, W. N., Hsu, P. L., Wu, S. R., Chiu, W. T., Li, C. F., Shan, Y. S. & Tsai, S. J., 2020 Jan 1, In: Journal of Extracellular Vesicles. 9, 1, 1746529.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Citations (Scopus)

Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction

Kao, C. Y., Xu, M., Wang, L., Lin, S. C., Lee, H. J., Duraine, L., Bellen, H. J., Goldstein, D. S., Tsai, S. Y. & Tsai, M. J., 2020 Jun, In: PLoS genetics. 16, 6, e1008868.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

Exposure to Novelty Promotes Long-Term Contextual Fear Memory Formation in Juvenile Mice: Evidence for a Behavioral Tagging

Chen, N., Tsai, T. C. & Hsu, K. S., 2020 Sept 1, In: Molecular Neurobiology. 57, 9, p. 3956-3968 13 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Fibronectin in Cancer: Friend or Foe

Lin, T., Yang, C., Cheng, L., Chang, W., Lin, Y. & Cheng, H., 2020 Jan, In: Cells. 9, 1, p. 27

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Glibenclamide restores dopaminergic reward circuitry in obese mice through interscauplar brown adipose tissue

Kuo, Y. Y., Lin, J. K., Lin, Y. T., Chen, J. C., Kuo, Y. M., Chen, P. S., Wu, S. N. & Chen, P. C., 2020 Aug, In: Psychoneuroendocrinology. 118, 104712.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

High ability of zileuton ((±)-1-(1-benzo[b]thien-2-ylethyl)-1-hydroxyurea) to stimulate I_K(Ca) but suppress I_K(DR) and I_K(M) independently of 5-lipoxygenase inhibition

Hung, T. Y., Huang, C. W. & Wu, S. N., 2020 Nov 15, In: European Journal of Pharmacology. 887, 173482.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Identification of the phytobioactive Polygonum cuspidatum as an antiviral source for restricting dengue virus entry

Kuo, Y. T., Liu, C. H., Li, J. W., Lin, C. J., Jassey, A., Wu, H. N., Perng, G. C., Yen, M. H. & Lin, L. T., 2020 Dec 1, In: Scientific reports. 10, 1, 16378.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells

Yan, J. B., Lai, C. C., Jhu, J. W., Gongol, B., Marin, T. L., Lin, S. C., Chiu, H. Y., Yen, C. J., Wang, L. Y. & Peng, I. C., 2020 Sept 25, In: Molecular Therapy - Oncolytics. 18, p. 282-294 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

NADPH oxidase 2 as a potential therapeutic target for protection against cognitive deficits following systemic inflammation in mice

Huang, W. Y., Liu, K. H., Lin, S., Chen, T. Y., Tseng, C. Y., Chen, H. Y., Wu, H. M. & Hsu, K. S., 2020 Feb, In: Brain, Behavior, and Immunity. 84, p. 242-252 11 p.

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Nicotinamide Increases Intracellular NAD⁺ Content to Enhance Autophagy-Mediated Group A Streptococcal Clearance in Endothelial Cells

Hsieh, C. L., Hsieh, S. Y., Huang, H. M., Lu, S. L., Omori, H., Zheng, P. X., Ho, Y. N., Cheng, Y. L., Lin, Y. S., Chiang-Ni, C., Tsai, P. J., Wang, S. Y., Liu, C. C., Noda, T. & Wu, J. J., 2020 Feb 11, In: Frontiers in Microbiology. 11, 117.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Risk of leukemia after dengue virus infection: A population-based cohort study

Chien, Y. W., Wang, C. C., Wang, Y. P., Lee, C. Y. & Perng, G. C., 2020, In: Cancer Epidemiology Biomarkers and Prevention. 29, 3, p. 558-564 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

2019

Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage

Chao, C. H., Wu, W. C., Lai, Y. C., Tsai, P. J., Perng, G-C., Lin, Y. S. & Yeh, T-M., 2019, In: PLoS pathogens. 15, 4, e1007625.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Citations (Scopus)

Differential suppression of delayed-rectifier and inwardly rectifier K⁺ currents by a group of ent-kaurane-type diterpenoids from Croton tonkinensis, in microglial cells

Hsiao, H. T., Lee, Y. C., Liu, Y. C., Kuo, P. C. & Wu, S. N., 2019 Aug 5, In: European Journal of Pharmacology. 856, 172414.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Dynamic changes of soluble ST2 levels predicted fatality and were involved in coagulopathy in dengue fever in the elderly

Hsieh, C. C., Hong, M. Y., Ho, T. S., Liu, C. C., Perng, G. C. & Chuang, C. C., 2019 Dec 1, In: PLoS neglected tropical diseases. 13, 12, p. e0007974

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Effectiveness of nalbuphine, a κ-opioid receptor agonist and μ-opioid receptor antagonist, in the inhibition of I_Na, I_K(M), and I_K(erg) unlinked to interaction with opioid receptors

Liu, Y. Y., Hsiao, H. T., Wang, J. C. F., Liu, Y. C. & Wu, S. N., 2019 Sept 1, In: Drug Development Research. 80, 6, p. 846-856 11 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

Cheng, Y. L., Kuo, C. F., Lu, S. L., Hiroko, O., Wu, Y. N., Hsie, C. L., Nod, T., Wu, S. R., Anderson, R., Lin, C. F., Chen, C. L., Wu, J. J. & Lin, Y. S., 2019, In: mBio. 10, 5, e02148-19.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

Institute of Basic Medical Sciences

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