Institute of Basic Medical Sciences

Research Output 1989 2019

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Article
2019
Bisoprolol
neurons
Neurons
Depolarization
Clamping devices
1 Citation (Scopus)
ivabradine
Neurons
linopirdine
Endocrine Cells
Reducing Agents
Neuronal Plasticity
Cognition
Hippocampus
Neurons
Intellectual Disability

Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage

Chao, C. H., Wu, W. C., Lai, Y. C., Tsai, P. J., Perng, G-C., Lin, Y. S. & Yeh, T-M., 2019 Apr 1, In : PLoS pathogens. 15, 4, p. e1007625

Research output: Contribution to journalArticle

Open Access
Dengue Virus
Toll-Like Receptor 4
Thrombocytopenia
Blood Platelets
Hemorrhage
Kaurane Diterpenes
Croton
Diterpenes
Euphorbiaceae
Euphorbia
Nalbuphine
Narcotic Antagonists
Opioid Receptors
Inhibitory Concentration 50
Neurons
1 Citation (Scopus)

Evidence for effective multiple K + current inhibitions by Tolvaptan, a non-peptide antagonist of vasopressin V 2 receptor

Lu, T. L., Chang, W. T., Chan, C. H. & Wu, S-N., 2019 Jan 1, In : Frontiers in Pharmacology. 10, FEB, 76.

Research output: Contribution to journalArticle

Open Access
Vasopressin Receptors
flupirtine
Inappropriate ADH Syndrome
Calcium-Activated Potassium Channels
Neuroendocrine Cells
1 Citation (Scopus)
Cell Hypoxia
Stromal Cells
Apoptosis
Endometriosis
Oxygen Consumption
1 Citation (Scopus)

Infantile Amnesia Is Related to Developmental Immaturity of the Maintenance Mechanisms for Long-Term Potentiation

Tsai, T. C., Huang, C. C. & Hsu, K-S., 2019 Feb 1, In : Molecular Neurobiology. 56, 2, p. 907-919 13 p.

Research output: Contribution to journalArticle

Amnesia
Long-Term Potentiation
Maintenance
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Long-Term Memory

Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance

Kang, E., Song, J., Lin, Y., Park, J., Lee, J. H., Hussani, Q., Gu, Y., Ge, S., Li, W., Hsu, K-S., Berninger, B., Christian, K. M., Song, H. & Ming, G. L., 2019 Aug 6, In : Cell Reports. 28, 6, p. 1419-1428.e3

Research output: Contribution to journalArticle

Open Access
Developmental Genes
Mental Disorders
gamma-Aminobutyric Acid
Neurons
Parvalbumins
3 Citations (Scopus)
Cyclooxygenase 2
Analgesics
Ions
parecoxib
Cyclooxygenase 2 Inhibitors

Perineuronal Nets Restrict the Induction of Long-Term Depression in the Mouse Hippocampal CA1 Region

Khoo, G. H., Lin, Y. T., Tsai, T. C. & Hsu, K-S., 2019 Sep 15, In : Molecular Neurobiology. 56, 9, p. 6436-6450 15 p.

Research output: Contribution to journalArticle

Hippocampal CA1 Region
Depression
Parvalbumins
Neuronal Plasticity
Interneurons
1 Citation (Scopus)

Probiotic treatment restores normal developmental trajectories of fear memory retention in maternally separated infant rats

Peng, H. H., Tsai, T. C., Huang, W. Y., Wu, H. M. & Hsu, K-S., 2019 Jul 15, In : Neuropharmacology. 153, p. 53-62 10 p.

Research output: Contribution to journalArticle

Probiotics
Fear
Mothers
Psychological Stress
Amygdala

Seroepidemiology of dengue virus infection among adults during the ending phase of a severe dengue epidemic in southern Taiwan, 2015

Chien, Y-W., Huang, H. M., Ho, T. C., Tseng, F. C., Ko, N-Y., Ko, W-C. & Perng, G-C., 2019 Apr 24, In : BMC Infectious Diseases. 19, 1, 338.

Research output: Contribution to journalArticle

Open Access
Severe Dengue
Dengue Virus
Virus Diseases
Taiwan
Dengue

Seroprevalence of zika and dengue virus antibodies among migrant workers, taiwan, 2017

Perng, G-C., Ho, T. C., Shih, H-I., Lee, C. H., Huang, P. W., Chung, C. H., Ko, N-Y., Ko, W-C. & Chien, Y-W., 2019 Apr 1, In : Emerging infectious diseases. 25, 4, p. 814-816 3 p.

Research output: Contribution to journalArticle

Open Access
Southeastern Asia
Dengue Virus
Seroepidemiologic Studies
Taiwan
Antibodies
1 Citation (Scopus)

Targeting anthrax toxin receptor 2 ameliorates endometriosis progression

Lin, S-C., Lee, H. C., Hsu, C. T., Huang, Y. H., Li, W. N., Hsu, P. L., Wu, M-H. & Tsai, S-J., 2019 Jan 1, In : Theranostics. 9, 3, p. 620-632 13 p.

Research output: Contribution to journalArticle

Open Access
Endometriosis
Histone Code
Choristoma
Pathologic Processes
Stromal Cells
1 Citation (Scopus)

The Protective Role of Peroxisome Proliferator-Activated Receptor-Gamma in Seizure and Neuronal Excitotoxicity

Hung, T. Y., Chu, F. L., Wu, D. C., Wu, S-N. & Huang, C-W., 2019 Aug 15, In : Molecular Neurobiology. 56, 8, p. 5497-5506 10 p.

Research output: Contribution to journalArticle

pioglitazone
Peroxisome Proliferator-Activated Receptors
PPAR gamma
Seizures
Pilocarpine

Transcranial direct current stimulation induces hippocampal metaplasticity mediated by brain-derived neurotrophic factor

Yu, T. H., Wu, Y-J., Chien, M. E. & Hsu, K-S., 2019 Jan 1, In : Neuropharmacology. 144, p. 358-367 10 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Long-Term Potentiation
Transcranial Direct Current Stimulation
trkB Receptor
Avoidance Learning
2018
Angiotensin II Type 1 Receptor Blockers
Cardiac Myocytes
Potassium
Sodium
Action Potentials
18 Citations (Scopus)

Conditional deletion of hippocampal CA2/CA3a oxytocin receptors impairs the persistence of long-term social recognition memory in mice

Lin, Y. T., Hsieh, T. Y., Tsai, T. C., Chen, C. C., Huang, C. C. & Hsu, K-S., 2018 Jan 31, In : Journal of Neuroscience. 38, 5, p. 1218-1231 14 p.

Research output: Contribution to journalArticle

Oxytocin Receptors
Pyramidal Cells
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Neurons
Dendritic Spines
3 Citations (Scopus)

Defective trafficking of Kv2.1 channels in MPTP-induced nigrostriatal degeneration

Chao, R. Y., Cheng, C. H., Wu, S-N. & Chen, P., 2018 Feb 1, In : Journal of Neurochemistry. 144, 4, p. 483-497 15 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Parkinson Disease
Dopaminergic Neurons
Protein Transport
Neurons
2 Citations (Scopus)
Chemical activation
Cells
Cell Line
Neuroendocrine Cells
Monoterpenes
5 Citations (Scopus)

Genes involved in prostate cancer progression determine MRI visibility

Li, P., You, S., Nguyen, C., Wang, Y., Kim, J., Sirohi, D., Ziembiec, A., Luthringer, D., Lin, S-C., Daskivich, T., Wu, J., Freeman, M. R., Saouaf, R., Li, D. & Kim, H. L., 2018 Jan 1, In : Theranostics. 8, 7, p. 1752-1765 14 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Genes
Heterografts
Disease Progression
Neoplasms
1 Citation (Scopus)

Human glucose-regulated protein 78 modulates intracellular production and secretion of nonstructural protein 1 of dengue virus

Songprakhon, P., Limjindaporn, T., Perng, G-C., Puttikhunt, C., Thaingtamtanha, T., Dechtawewat, T., Saitornuang, S., Uthaipibull, C., Thongsima, S., Yenchitsomanus, P. T., Malasit, P. & Noisakran, S., 2018 Oct 1, In : Journal of General Virology. 99, 10, p. 1391-1406 16 p., 001134.

Research output: Contribution to journalArticle

Dengue Virus
Proteins
Binding Sites
Viruses
glucose-regulated proteins
3 Citations (Scopus)

Huntington mice demonstrate diminished pain response in inflammatory pain model

Lin, Y. C., Hsiao, H. T., Wu, S-N. & Liu, Y-C., 2018 Jan 1, In : Anesthesia and analgesia. 126, 2, p. 661-669 9 p.

Research output: Contribution to journalArticle

Huntington Disease
Pain
Spinal Cord
Spinal Ganglia
Cytokines
3 Citations (Scopus)

Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability

Chen, H. R., Chao, C. H., Liu, C-C., Ho, T-S., Tsai, H. P., Perng, G-C., Lin, Y-S., Wang, J-R. & Yeh, T-M., 2018 Apr 1, In : PLoS pathogens. 14, 4, e1007033.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Glycocalyx
Dengue
Metalloproteases
Proteins

MicroRNA expression pattern as an ancillary prognostic signature for radiotherapy 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis

Li, A. L., Chung, T. S., Chan, Y. N., Chen, C. L., Lin, S-C., Chiang, Y. R., Lin, C. H., Chen, C. C. & Ma, N., 2018 Dec 5, In : Journal of Translational Medicine. 16, 1, 341.

Research output: Contribution to journalArticle

Open Access
Oncology
Radiotherapy
MicroRNAs
Carcinogenesis
Health
3 Citations (Scopus)

Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy

Lai, Y. C., Chuang, Y. C., Chang, C-P., Lin, Y-S., Perng, G-C., Wu, H. C., Hsieh, S. L. & Yeh, T-M., 2018 Jul 1, In : Antiviral Research. 155, p. 28-38 11 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Dengue Virus
Minocycline
Autophagy
Virus Replication
3 Citations (Scopus)
Miniature Postsynaptic Potentials
Rotenone
Electron Transport
Neurons
Niflumic Acid
2 Citations (Scopus)
Acid Sensing Ion Channels
Somatotrophs
Neurons
Large-Conductance Calcium-Activated Potassium Channels
Chemical activation
5 Citations (Scopus)

NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation

Huang, W. Y., Lin, S., Chen, H. Y., Chen, Y. P., Chen, T. Y., Hsu, K-S. & Wu, H. M., 2018 May 12, In : Journal of Neuroinflammation. 15, 1, 140.

Research output: Contribution to journalArticle

NADPH Oxidase
Seizures
Pharmacology
Inflammation
Microglia
4 Citations (Scopus)

Pioglitazone, a PPAR-γ activator, stimulates BK Ca but suppresses IK M in hippocampal neurons

Chen, T. S., Lai, M. C., Hung, T. Y., Lin, K. M., Huang, C-W. & Wu, S-N., 2018 Aug 29, In : Frontiers in Pharmacology. 9, AUG, 977.

Research output: Contribution to journalArticle

pioglitazone
Peroxisome Proliferator-Activated Receptors
Neurons
Large-Conductance Calcium-Activated Potassium Channels
Apamin
3 Citations (Scopus)

Prolonged persistence of IgM against dengue virus detected by commonly used commercial assays

Chien, Y-W., Liu, Z. H., Tseng, F. C., Ho, T. C., Guo, H-R., Ko, N-Y., Ko, W-C. & Perng, G-C., 2018 Apr 2, In : BMC Infectious Diseases. 18, 1, 156.

Research output: Contribution to journalArticle

Dengue Virus
Immunoglobulin M
Dengue
Enzyme-Linked Immunosorbent Assay
Taiwan
2 Citations (Scopus)

Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity

Lai, M. C., Hung, T. Y., Lin, K. M., Sung, P-S., Wu, S. J., Yang, C. S., Wu, Y-J., Tsai, J. J., Wu, S-N. & Huang, C-W., 2018 Jul 1, In : Neurotoxicity Research. 34, 1

Research output: Contribution to journalArticle

Sodium Channels
Pilocarpine
Clamping devices
Neurons
Rats

Stimulatory action of telmisartan, an antagonist of angiotensin II receptor, on voltage-gated Na + current: Experimental and theoretical studies

Chang, T. T., Yang, C. J., Lee, Y. C. & Wu, S-N., 2018 Jan 1, In : Chinese Journal of Physiology. 61, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Angiotensin Receptor Antagonists
Theoretical Models
Neurons
Neuroendocrine Cells
Peroxisome Proliferator-Activated Receptors
4 Citations (Scopus)

The comprehensive electrophysiological study of curcuminoids on delayed-rectifier K+ currents in insulin-secreting cells

Kuo, P-C., Yang, C. J., Lee, Y. C., Chen, P., Liu, Y-C. & Wu, S-N., 2018 Jan 15, In : European Journal of Pharmacology. 819, p. 233-241 9 p.

Research output: Contribution to journalArticle

Curcumin
Insulin-Secreting Cells
Insulin
Membrane Potentials
Nicorandil

The Novel Effect of Immunomodulator-Glatiramer Acetate on Epileptogenesis and Epileptic Seizures

Lai, M. C., Lin, K. M., Yeh, P. S., Wu, S-N. & Huang, C-W., 2018 Oct 1, In : Cellular Physiology and Biochemistry. 50, 1, p. 169-178 10 p.

Research output: Contribution to journalArticle

Immunologic Factors
Epilepsy
Seizures
Interleukin-1
Pilocarpine
2017
14 Citations (Scopus)

A bead-based immunofluorescence-assay on a microfluidic dielectrophoresis platform for rapid dengue virus detection

Iswardy, E., Tsai, T. C., Chang, H-C., Ho, T. C., Perng, G-C. & Chang, H. C., 2017 Sep 15, In : Biosensors and Bioelectronics. 95, p. 174-180 7 p.

Research output: Contribution to journalArticle

Dengue Virus
Microfluidics
Electrophoresis
Viruses
Fluorescent Antibody Technique
5 Citations (Scopus)

Conditional deletion of Eps8 reduces hippocampal synaptic plasticity and impairs cognitive function

Wang, Y. T., Huang, C. C., Lin, Y. S., Huang, W. F., Yang, C. Y., Lee, C. C., Yeh, C. M. & Hsu, K-S., 2017 Jan 1, In : Neuropharmacology. 112, p. 113-123 11 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Cognition
N-Methyl-D-Aspartate Receptors
Excitatory Postsynaptic Potentials
Neurons
4 Citations (Scopus)

Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development

Lee, H. J., Kao, C. Y., Lin, S-C., Xu, M., Xie, X., Tsai, S. Y. & Tsai, M. J., 2017 Dec 1, In : Scientific reports. 7, 1, 3136.

Research output: Contribution to journalArticle

COUP Transcription Factor II
Muscle Development
Cytoplasmic and Nuclear Receptors
Skeletal Muscle
Cell Fusion
4 Citations (Scopus)
Dengue
Viremia
Blood Donors
Taiwan
Dengue Virus
17 Citations (Scopus)

Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness

Hou, P. C., Li, Y. H., Lin, S-C., Lin, S-C., Lee, J-C., Lin, P-W., Liou, J. P., Chang, J-Y., Kuo, C. C., Liu, Y. M., Sun, H-F. & Tsai, S-J., 2017 Aug 15, In : Cancer Research. 77, 16, p. 4305-4316 12 p.

Research output: Contribution to journalArticle

Dual-Specificity Phosphatases
Dual Specificity Phosphatase 2
Colonic Neoplasms
Down-Regulation
Neoplasms
6 Citations (Scopus)

Hypoxia-inhibited DUSP2 expression promotes IL-6/STAT3 signaling in endometriosis

Hsiao, K. Y., Chang, N., Tsai, J. L., Lin, S-C., Tsai, S-J. & Wu, M-H., 2017 Jan 1, In : American Journal of Reproductive Immunology. 78, 4, e12690.

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 2
Endometriosis
Interleukin-6
Stromal Cells
Bromodeoxyuridine
3 Citations (Scopus)

Important modifications by sugammadex, a modified γ-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells

Hsu, H. T., Lo, Y. C., Huang, Y. M., Tseng, Y. T. & Wu, S-N., 2017 Jan 3, In : BMC Neuroscience. 18, 1, 6.

Research output: Contribution to journalArticle

Cyclodextrins
Ions
Sugammadex
Neuromuscular Blocking Agents
Membranes
6 Citations (Scopus)

Important Roles of Ring Finger Protein 112 in Embryonic Vascular Development and Brain Functions

Tsou, J. H., Yang, Y. C., Pao, P. C., Lin, H. C., Huang, N. K., Lin, S. T., Hsu, K-S., Yeh, C. M., Lee, K. H., Kuo, C. J., Yang, D. M., Lin, J. H., Chang, W. C. & Lee, Y. C., 2017 Apr 1, In : Molecular Neurobiology. 54, 3, p. 2286-2300 15 p.

Research output: Contribution to journalArticle

Fingers
Embryonic Development
Blood Vessels
Brain
Proteins
11 Citations (Scopus)

Loss of dual-specificity phosphatase-2 promotes angiogenesis and metastasis via up-regulation of interleukin-8 in colon cancer

Lin, S-C., Hsiao, K. Y., Chang, N., Hou, P. C. & Tsai, S-J., 2017 Apr 1, In : Journal of Pathology. 241, 5, p. 638-648 11 p.

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 2
Interleukin-8
Colonic Neoplasms
Up-Regulation
Neoplasm Metastasis
4 Citations (Scopus)

Neonatal Dexamethasone Treatment Exacerbates Hypoxia/Ischemia-Induced White Matter Injury

Yeh, C. Y., Yeh, C. M., Yu, T. H., Chang, K. H., Huang, C. C. & Hsu, K-S., 2017 Nov 1, In : Molecular Neurobiology. 54, 9, p. 7083-7095 13 p.

Research output: Contribution to journalArticle

Dexamethasone
Ischemia
Wounds and Injuries
Therapeutics
Ceftriaxone
20 Citations (Scopus)

Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons

Lin, Y. T., Chen, C. C., Huang, C. C., Nishimori, K. & Hsu, K-S., 2017 Dec 1, In : Nature communications. 8, 1, 537.

Research output: Contribution to journalArticle

Oxytocin Receptors
Pyramidal Cells
Neurogenesis
Oxytocin
neurons
11 Citations (Scopus)
Neuronal Plasticity
Streptozocin
Prefrontal Cortex
Short-Term Memory
Long-Term Potentiation