Institute of Clinical Pharmacy and Pharmaceutical Sciences

Research Output 1991 2020

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Article
2017
2 Citations (Scopus)

Geographic Variations and Time Trends in Cancer Treatments in Taiwan

Hsu, J. C., Chang, S. M. & Lu, C. Y., 2017 Aug 2, In : BMC Public Health. 18, 1, 89.

Research output: Contribution to journalArticle

Taiwan
Antineoplastic Agents
Neoplasms
Islands
Costs and Cost Analysis
5 Citations (Scopus)
Diabetes Complications
Type 1 Diabetes Mellitus
Taiwan
Diabetic Ketoacidosis
Longitudinal Studies
8 Citations (Scopus)
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Longitudinal Studies
Cohort Studies
Cardiovascular Diseases
HIV
5 Citations (Scopus)
leisure time
health status
Taiwan
quality of life
Group
9 Citations (Scopus)

Mesoporous hydroxyapatite as a carrier of olanzapine for long-acting antidepression treatment in rats with induced depression

Shyong, Y-J., Wang, M. H., Kuo, L. W., Su, C. F., Kuo, W. T., Chang, K. C. & Lin, F. H., 2017 Jun 10, In : Journal of Controlled Release. 255, p. 62-72 11 p.

Research output: Contribution to journalArticle

olanzapine
Durapatite
Aptitude
Locomotion
Depression
6 Citations (Scopus)

New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo

Hsieh, M. T., Chang, L. C., Hung, H. Y., Lin, H. Y., Shih, M. H., Tsai, C. H., Kuo, S. C. & Lee, K. H., 2017 Jan 1, In : European Journal of Medicinal Chemistry. 131, p. 141-151 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Curcumin
Derivatives
Breast Neoplasms
Heterografts
5 Citations (Scopus)

Pharmacoeconomic analysis of antifungal therapy for primary treatment of invasive candidiasis caused by Candida albicans and non-albicans Candida species

Ou, H-T., Lee, T. Y., Chen, Y. C. & Charbonneau, C., 2017 Jul 10, In : BMC Infectious Diseases. 17, 1, 481.

Research output: Contribution to journalArticle

Invasive Candidiasis
Echinocandins
Pharmaceutical Economics
Candida albicans
Candida
14 Citations (Scopus)

Recent trends in the use of antidiabetic medications from 2008 to 2013: A nation-wide population-based study from Taiwan

Ou, H. T., Chang, K. C., Liu, Y. M. & Wu, J. S., 2017 Mar 1, In : Journal of Diabetes. 9, 3, p. 256-266 11 p.

Research output: Contribution to journalArticle

Taiwan
Hypoglycemic Agents
Dipeptidyl-Peptidase IV Inhibitors
Population
Delivery of Health Care
9 Citations (Scopus)

Renoprotective Effect of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers in Diabetic Patients with Proteinuria

Hsu, F. Y., Lin, F. J., Ou, H. T., Huang, S. H. & Wang, C. C., 2017 Jun 1, In : Kidney and Blood Pressure Research. 42, 2, p. 358-368 11 p.

Research output: Contribution to journalArticle

Angiotensin Receptor Antagonists
Proteinuria
Angiotensin-Converting Enzyme Inhibitors
irbesartan
Kidney

Risks of newly onset hemorrhagic stroke in patients with neovascular age-related macular degeneration

Lee, W. J. A., Cheng, C-L., Lee, C-H., Kao, Y-H., Lin, S. J. & Hsieh, C. Y., 2017 Oct, In : Pharmacoepidemiology and drug safety. 26, 10, p. 1277-1285 9 p.

Research output: Contribution to journalArticle

Macular Degeneration
Stroke
International Classification of Diseases
Myocardial Infarction
Mortality
1 Citation (Scopus)

rs2841277 (PLD4) is associated with susceptibility and rs4672495 is associated with disease activity in rheumatoid arthritis

Chen, W. C., Wang, W. C., Lu, H. F., Okada, Y., Chang, W. P., Chou, Y. H., Chang, H. H., Huang, J. D., Chen, D. Y. & Chang, W. C., 2017 Jan 1, In : Oncotarget. 8, 38, p. 64180-64190 11 p.

Research output: Contribution to journalArticle

Phospholipase D
Rheumatoid Arthritis
Ankylosing Spondylitis
Single Nucleotide Polymorphism
Genome-Wide Association Study
16 Citations (Scopus)

Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents

Vijaya Bhaskar Reddy, M., Hung, H. Y., Kuo, P. C., Huang, G. J., Chan, Y. Y., Huang, S. C., Wu, S. J., Morris-Natschke, S. L., Lee, K. H. & Wu, T. S., 2017 Jan 1, In : Bioorganic and Medicinal Chemistry Letters. 27, 7, p. 1547-1550 4 p.

Research output: Contribution to journalArticle

Chalcones
Lead compounds
Chalcone
Macrophages
Peritoneal Macrophages
10 Citations (Scopus)

Trend and geographic analysis of the prevalence of dengue in Taiwan, 2010–2015

Hsu, J. C., Hsieh, C. L. & Lu, C. Y., 2017 Jan 1, In : International Journal of Infectious Diseases. 54, p. 43-49 7 p.

Research output: Contribution to journalArticle

Dengue
Taiwan
Population
Disease Outbreaks
Age Groups
2016
7 Citations (Scopus)

A novel microtubule inhibitor, MT3-037, causes cancer cell apoptosis by inducing mitotic arrest and interfering with microtubule dynamics

Chang, L. C., Yu, Y. L., Hsieh, M. T., Wang, S. H., Chou, R. H., Huang, W. C., Lin, H. Y., Hung, H. Y., Huang, L. J. & Kuo, S. C., 2016 Jan 1, In : American Journal of Cancer Research. 6, 4, p. 747-763 17 p.

Research output: Contribution to journalArticle

Tubulin
Microtubules
CDC2 Protein Kinase
Apoptosis
Neoplasms
10 Citations (Scopus)

Anti-inflammatory neolignans from the roots of Magnolia officinalis

Shih, H. C., Kuo, P. C., Wu, S. J., Hwang, T. L., Hung, H. Y., Shen, D. Y., Shieh, P. C., Liao, Y. R., Lee, E. J., Gu, Q., Lee, K. H. & Wu, T. S., 2016 Apr 1, In : Bioorganic and Medicinal Chemistry. 24, 7, p. 1439-1445 7 p.

Research output: Contribution to journalArticle

Magnolia
Lignans
Anti-Inflammatory Agents
Derivatives
Pancreatic Elastase

Application of flow cytometry for evaluating clinical prognosis and histopathological grade of human glioma

Lin, Y. W., Tai, S. H., Chang, C. C., Chao, L. C., Wen, M. J., Huang, Y. H., Hung, H. Y. & Lee, E. J., 2016 Apr 21, In : Neurological Research. 38, 7, p. 625-633 9 p.

Research output: Contribution to journalArticle

G2 Phase
Glioma
Cell Division
Flow Cytometry
Cyclin B
14 Citations (Scopus)

Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

Lin, C. W., Hwang, T. L., Chen, F. A., Huang, C. H., Hung, H. Y. & Wu, T. S., 2016 Aug 26, In : Journal of Natural Products. 79, 8, p. 1911-1921 11 p.

Research output: Contribution to journalArticle

Phenanthrenes
Rhizome
Bibenzyls
Anti-Inflammatory Agents
Pancreatic Elastase
4 Citations (Scopus)
Metformin
Taiwan
Type 2 Diabetes Mellitus
Cost-Benefit Analysis
Cardiovascular Diseases
7 Citations (Scopus)

Development of gelatin nanoparticles conjugated with phytohemagglutinin erythroagglutinating loaded with gemcitabine for inducing apoptosis in non-small cell lung cancer cells

Kuo, W. T., Huang, J. Y., Chen, M. H., Chen, C. Y., Shyong, Y. J., Yen, K. C., Sun, Y. J., Ke, C. J., Cheng, Y. H. & Lin, F. H., 2016 Apr 14, In : Journal of Materials Chemistry B. 4, 14, p. 2444-2454 11 p.

Research output: Contribution to journalArticle

gemcitabine
Cell death
Gelatin
Cells
Apoptosis
7 Citations (Scopus)

Dipeptidyl peptidase-4 inhibitor use is not associated with elevated risk of severe joint pain in patients with type 2 diabetes: A population-based cohort study

Hou, W. H., Chang, K. C., Li, C-Y. & Ou, H-T., 2016 Sep 1, In : Pain. 157, 9, p. 1954-1959 6 p.

Research output: Contribution to journalArticle

Dipeptidyl-Peptidase IV Inhibitors
Arthralgia
Type 2 Diabetes Mellitus
Cohort Studies
Population
3 Citations (Scopus)

Four new compounds from edible algae Cladosiphon okamuranus and Chlorella sorokiniana and their bioactivities

Cheng, K. C., Kuo, P. C., Hung, H. Y., Yu, K. H., Hwang, T. L., Shieh, P. C., Chang, J. S. & Wu, T. S., 2016 Dec 1, In : Phytochemistry Letters. 18, p. 113-116 4 p.

Research output: Contribution to journalArticle

algae
Chlorella sorokiniana
Chlorella
Eicosapentaenoic Acid
Algae
7 Citations (Scopus)

Lactobacillus pentosus strain LPS16 produces lactic acid, inhibiting multidrug-resistant Helicobacter pylori

Zheng, P. X., Fang, H. Y., Yang, H. B., Tien, N. Y., Wang, M-C. & Wu, J. J., 2016 Apr 1, In : Journal of Microbiology, Immunology and Infection. 49, 2, p. 168-174 7 p.

Research output: Contribution to journalArticle

Helicobacter pylori
Lactic Acid
Stomach
Lactobacillus pentosus
Epithelial Cells
4 Citations (Scopus)
Health Expenditures
Life Expectancy
Type 1 Diabetes Mellitus
Delivery of Health Care
Proportional Hazards Models
6 Citations (Scopus)

Longitudinal trends in use and costs of targeted therapies for common cancers in Taiwan: A retrospective observational study

Hsu, J. C. & Lu, C. Y., 2016 Jun 1, In : BMJ open. 6, 6, e011322.

Research output: Contribution to journalArticle

Taiwan
Observational Studies
Retrospective Studies
Costs and Cost Analysis
Antineoplastic Agents
2 Citations (Scopus)

Longitudinal trends in use of targeted therapies for treatment of malignant neoplasms of the eye: a population-based study in Taiwan

Hsu, J. C., Gonzalez-Gonzalez, L. A., Lu, V. H. & Lu, C. Y., 2016 May 27, In : BMJ open. 6, 5, p. e010706

Research output: Contribution to journalArticle

Eye Neoplasms
Taiwan
Costs and Cost Analysis
Population
Antineoplastic Agents
19 Citations (Scopus)
Pharmaceutical Services
Medical problems
Type 2 Diabetes Mellitus
Randomized Controlled Trials
Pharmacists
8 Citations (Scopus)

Psychometric Properties of the Kidney Disease Quality of Life–36 Questionnaire (KDQOL-36™)

Chao, S., Yen, M-F., Lin, T. C., Sung, J-M., Wang, M-C. & Hung, S. Y., 2016 Aug 1, In : Western Journal of Nursing Research. 38, 8, p. 1067-1082 16 p.

Research output: Contribution to journalArticle

Kidney Diseases
Psychometrics
Peritoneal Dialysis
Taiwan
Chronic Renal Insufficiency
1 Citation (Scopus)

Refined comorbidity index based on dimensionality of comorbidity for use in studies of health-related quality of life

Ou, H-T., Lin, C. Y., Erickson, S. R. & Balkrishnan, R., 2016 Oct 1, In : Quality of Life Research. 25, 10, p. 2543-2557 15 p.

Research output: Contribution to journalArticle

Comorbidity
Quality of Life
Statistical Factor Analysis
Weights and Measures
Risk Adjustment
32 Citations (Scopus)
Dipeptidyl-Peptidase IV Inhibitors
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Longitudinal Studies
Cardiovascular Diseases
5 Citations (Scopus)

Validation of Chinese Version of Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire (Chi-PCOSQ)

Lin, C. Y., Ou, H. T., Wu, M. H. & Chen, P. C., 2016 Jan 1, In : PloS one. 11, 4, p. e0154343

Research output: Contribution to journalArticle

polycystic ovary syndrome
Polycystic Ovary Syndrome
quality of life
questionnaires
Invariance
2015
8 Citations (Scopus)
Antidepressive Agents
Major Depressive Disorder
Depression
Hydrocortisone
Genotype

Barrier abnormalities and keratinocyte-derived cytokine cascade after cessation of long-term topical glucocorticosteroid on hairless mouse skin

Lin, T. K., Wei, K. J., Wu, C. H., Lai, F. J., Lan, C. C. E., Chang, C. H., Peng, A. C. Y., Tsai, J-C. & Sheu, H. M., 2015 Jun 1, In : Dermatologica Sinica. 33, 2, p. 103-111 9 p.

Research output: Contribution to journalArticle

Hairless Mouse
Keratinocytes
Adrenal Cortex Hormones
Cytokines
Skin
45 Citations (Scopus)

Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress

Chiu, H. W., Xia, T., Lee, Y-H., Chen, C. W., Tsai, J-C. & Wang, Y-J., 2015 Jan 14, In : Nanoscale. 7, 2, p. 736-746 11 p.

Research output: Contribution to journalArticle

Nanospheres
Polystyrenes
Cell death
Nanoparticles
Surface charge
9 Citations (Scopus)
Klebsiella pneumoniae
Peritoneal Dialysis
Peritonitis
Taiwan
Urinary Tract Infections
5 Citations (Scopus)

Development of Chinese version of polycystic ovary syndrome health-related quality of life questionnaire (Chi-PCOSQ)

Ou, H-T., Wu, M-H., Lin, C. Y. & Chen, P. C., 2015 Oct 9, In : PLoS ONE. 10, 10, e0137772.

Research output: Contribution to journalArticle

polycystic ovary syndrome
Polycystic Ovary Syndrome
quality of life
questionnaires
Quality of Life
4 Citations (Scopus)

Effects of safety warnings and risk management plan for Thiazolidinediones in Taiwan

Hsu, J. C., Cheng, C. L., Ross-Degnan, D., Wagner, A. K., Zhang, F., Kao Yang, Y. H., Liu, L. L., Tai, H. Y., Chen, K. H., Yang, P. W. & Lu, C. Y., 2015 Oct 1, In : Pharmacoepidemiology and drug safety. 24, 10, p. 1026-1035 10 p.

Research output: Contribution to journalArticle

rosiglitazone
Safety Management
Thiazolidinediones
pioglitazone
Risk Management
3 Citations (Scopus)
reactivity
selectivity
Nucleophiles
Electrons
rings
9 Citations (Scopus)

Human sebum extract induces barrier disruption and cytokine expression in murine epidermis

Guo, J. W., Lin, T. K., Wu, C. H., Wei, K. C., Lan, C. C. E., Peng, A. C. Y., Tsai, J-C. & Sheu, H. M., 2015 Apr 1, In : Journal of Dermatological Science. 78, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

Dermatitis
Sebum
Epidermis
Skin
Irritants
12 Citations (Scopus)

Insulin-loaded hydroxyapatite combined with macrophage activity to deliver insulin for diabetes mellitus

Shyong, Y. J., Tsai, C. C., Lin, R. F., Soung, H. S., Hsieh, H. C., Hsueh, Y. S., Chang, K. C. & Lin, F. H., 2015 Mar 21, In : Journal of Materials Chemistry B. 3, 11, p. 2331-2340 10 p.

Research output: Contribution to journalArticle

Macrophages
Insulin
Durapatite
Medical problems
Hydroxyapatite
6 Citations (Scopus)

Mesoporous Hydroxyapatite as Olanzapine Carrier Provides a Long-Acting Effect in Antidepression Treatment

Shyong, Y-J., Wang, M. H., Tseng, H. C., Cheng, C., Chang, K. C. & Lin, F. H., 2015 Oct 16, In : Journal of Medicinal Chemistry. 58, 21, p. 8463-8474 12 p.

Research output: Contribution to journalArticle

olanzapine
Durapatite
Antidepressive Agents
Therapeutics
Blood Circulation
15 Citations (Scopus)

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects

Wada, K., Lee, J. Y., Hung, H. Y., Shi, Q., Lin, L., Zhao, Y., Goto, M., Yang, P. C., Kuo, S. C., Chen, H. W. & Lee, K. H., 2015 Apr 1, In : Bioorganic and Medicinal Chemistry. 23, 7, p. 1507-1514 8 p.

Research output: Contribution to journalArticle

Curcumin
Epidermal Growth Factor Receptor
Drug Resistance
Phosphorylation
Pharmaceutical Preparations
13 Citations (Scopus)

Risk factors and their interaction on chronic kidney disease: A multi-centre case control study in Taiwan

Su, S. L., Lin, C., Kao, S. Y., Wu, C. C., Lu, K. C., Lai, C. H., Yang, H. Y., Chiu, Y. L., Chen, J. S., Sung, F. C., Ko, Y. C., Lee, C. T., Yang, Y., Yang, C. W., Hwang, S. J., Wang, M-C., Hsu, Y. H., Wu, M. Y., Hsueh, Y. M., Chiou, H. Y. & 1 others, Lin, Y. F., 2015 Jun 16, In : BMC Nephrology. 16, 1, 83.

Research output: Contribution to journalArticle

Taiwan
Chronic Renal Insufficiency
Case-Control Studies
Hypertension
Anemia
1 Citation (Scopus)
Venous Thromboembolism
Hip Fractures
Taiwan
Incidence
Pharmacology
8 Citations (Scopus)

The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1

Chang, L. C., Yu, Y. L., Liu, C. Y., Cheng, Y. Y., Chou, R. H., Hsieh, M. T., Lin, H. Y., Hung, H. Y., Huang, L. J., Wu, Y. C. & Kuo, S. C., 2015 Jun 26, In : Cancer Chemotherapy and Pharmacology. 75, 6, p. 1303-1315 13 p.

Research output: Contribution to journalArticle

CDC2 Protein Kinase
Tubulin
Non-Small Cell Lung Carcinoma
Cells
Apoptosis

There is no better time than the present: Nanotechnology as a disruptive innovation for drug development

Oo, C., Tsai, J-C. & Kao, H. D., 2015 Jun 8, In : Drug Discovery Today. 20, 6, p. 645-647 3 p.

Research output: Contribution to journalArticle

Nanotechnology
Pharmaceutical Preparations
2 Citations (Scopus)

Total synthesis of cordatanine, structural reassignment of drymaritin, and anti-inflammatory activity of synthetic precursor

Fang, H. W., Liao, Y. R., Hwang, T. L., Shieh, P. C., Lee, K. H., Hung, H. Y. & Wu, T. S., 2015 Aug 17, In : Bioorganic and Medicinal Chemistry Letters. 25, 18, p. 3822-3824 3 p., 22963.

Research output: Contribution to journalArticle

Anti-Inflammatory Agents
Inhibitory Concentration 50
Pancreatic Elastase
Skeleton
Superoxides
6 Citations (Scopus)

Utilization of oral antidiabetic medications in Taiwan following strategies to promote access to medicines for chronic diseases in community pharmacies

Hsu, J. C., Ross-Degnan, D., Wagner, A. K., Cheng, C-L., Kao, Y-H., Zhang, F. & Lu, C. Y., 2015 Jan 1, In : Journal of Pharmaceutical Policy and Practice. 8, 1, p. 1-9 9 p., 15.

Research output: Contribution to journalArticle

Pharmacies
Taiwan
Hypoglycemic Agents
Prescriptions
Chronic Disease
121 Citations (Scopus)
National Health Programs
Hospital Mortality
Taiwan
Death Certificates
Electronic Health Records
2014
2 Citations (Scopus)
Prescription Drugs
Taiwan
Antidepressive Agents
Names
Prescriptions
175 Citations (Scopus)

Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts

Lee, Y. H., Cheng, F. Y., Chiu, H. W., Tsai, J. C., Fang, C. Y., Chen, C. W. & Wang, Y. J., 2014 May, In : Biomaterials. 35, 16, p. 4706-4715 10 p.

Research output: Contribution to journalArticle

NIH 3T3 Cells
Oxidative stress
Autophagy
Cell death
Fibroblasts