Organization profile

Organisation profile

INTRODUCTION The Institute of Molecular Medicine (IMM) at the National Cheng Kung University Medical Center (NCKUMC) was established in 1998 by Professor Ih-Jen Su. Professor Su, now Associate Dean of NCKUMC, envisioned the outstanding challenge in biomedicine in the post-genome era that we must face and the education we must provide to our next generations. Given these specific agenda and goals in mind, this Institute has been keeping a clear focus on basic and integrated translational research, covering problems associated with gene and molecular basis of cancer and infectious diseases. In 2000, 2004 and 2007, Drs. Ting-Tsung Chang, Jiunn-Jong Wu and Christina Chang, respectively, have taken the directorship of IMM. With their great effort in expansion, the total number of faculty has grown to 20. To date, we have trained more than 150 students and published hundreds of articles since 1998. Here, we have and will continue to develop 1) the state-of-the-art research on the molecular pathogenesis and therapy of human diseases (e.g. the endemic or clinically important diseases in southern Taiwan), 2) the power of securing domestic and international research grants, 3) the innovation in our pioneered research projects, and 4) the premier education for our students in their career goals. We are determined to succeed in education and research and to conquer the future challenge. AIMS OF EDUCATION To enhance students in developing their career goals, the aims of our education are 1) to motivate students’ interests in biotechnology and integration with molecular medicine and translational research, and 2) to increase their skill in biomedical research and ambition in international competition. While biomedical science research as well as biomolecular and biotechnology research are active and well established in Taiwan, an integration of basic sciences (molecular biology and biotechnology) with clinical sciences (development of early diagnosis, understanding of disease mechanisms, intervention of disease progress, and therapeutic treatment of diseases) for health benefits are still needed to be developed and promoted. The IMM is committed to (1) the integration of basic molecular science with applied clinical sciences via translational research, (2) integrated education, and (3) multidisciplinary trainings. While our educational base is board, our research is focused onto urgent health issues in Taiwan: cancer and infectious diseases. It is also our hope and goal that trainees at IMM are not only aimed to distinguish themselves in Taiwan but will also acquire strong international views and global concepts during their trainings. Both intramural teamwork and extramural networkings (both national and international) will also be strong characteristics of our institution. We believe that IMM will represent not only as an unique educational and research institute in NCKU, it will also be a very much needed institute for the training of second generation of medical researchers for Taiwan. The curriculum is designed to develop graduate students’ competence in biomedical sciences and to develop critical and innovative thinking in conducting research. The curriculum is organized into Core and Elective Courses. The Core Courses include Molecular Biology, Cell Biology, Seminar, and Research. Elective Courses include, among others, Molecular Pathology of Cancer, Angiogenesis, Genomics, Microbial Pathogenesis, and Viral Entry/Assembly/ Budding. In addition to coursework, graduate students conduct research and write theses in order to fulfill the requirement for the Master Program of IMM. The graduate students are expected to achieve three major goals after finishing the graduate courses: (a) to acquire a global view of current biomedical knowledge including clinical medicine, molecular biology and cell biology, (b) to practice the essential biotechnology and methodology, and (c) to complete a scientific thesis.

Fingerprint Dive into the research topics where Institute of Molecular Medicine is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

Genes Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Proteins Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Bipolar Disorder Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Tumor Necrosis Factor-alpha Medicine & Life Sciences
Chemical activation Chemical Compounds

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Projects 1998 2020

Research Output 1985 2019

A novel proteotoxic combination therapy for EGFR+ and HER2+ cancers

Wang, M., Ferreira, R. B., Law, M. E., Davis, B. J., Yaaghubi, E., Ghilardi, A. F., Sharma, A., Avery, B. A., Rodriguez, E., Chiang, C-W., Narayan, S., Heldermon, C. D., Castellano, R. K. & Law, B. K., 2019 May 30, In : Oncogene. 38, 22, p. 4264-4282 19 p.

Research output: Contribution to journalArticle

Disulfides
Neoplasms
Cyclosporine
Protein Folding
Therapeutics

A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism

Chou, P. Y., Lin, S. R., Lee, M. H., Schultz, L., Sze, C-I. & Chang, N-S., 2019 Jul 17, In : Cell Communication and Signaling. 17, 1, 76.

Research output: Contribution to journalArticle

Open Access
Brain
Agglomeration
Chemical activation
Apoptosis
Cell Movement

Cancer-associated fibroblast-derived interleukin-1β activates protumor C-C motif chemokine ligand 22 signaling in head and neck cancer

Huang, Y. H., Chang, C. Y., Kuo, Y. Z., Fang, W. Y., Kao, H. Y., Tsai, S-T. & Wu, L-W., 2019 Sep 1, In : Cancer Science. 110, 9, p. 2783-2793 11 p.

Research output: Contribution to journalArticle

Open Access
CC Chemokines
Head and Neck Neoplasms
Interleukin-1
Ligands
Mouth Neoplasms

Student theses

Calcium-Binding S100A2 Impaired Cutaneous Wound Healing By Modulating P53 Activity

Author: 哲瑜, 李., 2017 Aug 24

Supervisor: Wu, L. (Supervisor)

Student thesis: Master's Thesis

Cellular gC1qR promotes mitochondria-dependent apoptosis via p38 MAPK activation in Enterovirus A71 infected neuron cell

Author: 佩苓, 蔡., 2018 Sep 1

Supervisor: Wang, S. (Supervisor)

Student thesis: Master's Thesis