International Center for Wound Repair and Regeneration

Research Output 2004 2019

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22 Citations (Scopus)

A nanopatterned cell-seeded cardiac patch prevents electro-uncoupling and improves the therapeutic efficacy of cardiac repair

Lin, Y. D., Ko, M. C., Wu, S. T., Li, S. F., Hu, J. F., Lai, Y. J., Harn, H. I. C., Laio, I. C., Yeh, M. L., Yeh, H. I., Tang, M. J., Chang, K. C., Su, F. C., Wei, E. I. H., Lee, S. T., Chen, J. H., Hoffman, A. S., Wu, W. T. & Hsieh, P. C. H., 2014 Apr, In : Biomaterials Science. 2, 4, p. 567-580 14 p.

Research output: Contribution to journalArticle

Endothelial cells
Repair
Anisotropy
Medical nanotechnology
Hemodynamics

A novel zebrafish model to emulate lung injury by folate deficiency-induced swim bladder defectiveness and protease/antiprotease expression imbalance

Lee, G-H., Cheng, N. W., Yu, H. H., Tsai, J. N., Liu, T., Wen, Z. H., Chen, B. H. & Fu, T-F., 2019 Dec 1, In : Scientific reports. 9, 1, 12633.

Research output: Contribution to journalArticle

Open Access
Lung Injury
Zebrafish
Protease Inhibitors
Folic Acid
Urinary Bladder
28 Citations (Scopus)

Aspartic acid-based modified PLGA-PEG nanoparticles for bone targeting: In vitro and in vivo evaluation

Fu, Y. C., Fu, T. F., Wang, H. J., Lin, C. W., Lee, G. H., Wu, S. C. & Wang, C. K., 2014 Nov 1, In : Acta Biomaterialia. 10, 11, p. 4583-4596 14 p.

Research output: Contribution to journalArticle

Aspartic Acid
Nanoparticles
Polyethylene glycols
Bone
Bone and Bones
2 Citations (Scopus)
Open Access
ovaries
Polycystic Ovary Syndrome
Metformin
polymorphism
Polymorphism

A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish

Lee, G. H., Chang, C. L., Chiu, W. T., Hsiao, T. H., Chen, P. Y., Wang, K. C., Kuo, C. H., Chen, B. H., Shi, G. Y., Wu, H. L. & Fu, T. F., 2019 Aug 26, In : Journal of biomedical science. 26, 1, 60.

Research output: Contribution to journalArticle

Open Access
Thrombomodulin
Germ Layers
Blastomeres
Organogenesis
Zebrafish
18 Citations (Scopus)

Autophagy is involved in endogenous and NVP-AUY922-induced KIT degradation in gastrointestinal stromal tumors

Hsueh, Y-S., Yen, C. C., Shih, N. Y., Chiang, N. J., Li, C. F. & Chen, L. T., 2013 Jan 1, In : Autophagy. 9, 2, p. 220-233 14 p.

Research output: Contribution to journalArticle

Open Access
Gastrointestinal Stromal Tumors
Autophagy
Proteins
Proteasome Endopeptidase Complex
Stromal Cells
10 Citations (Scopus)

Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation in Keloid Fibroblasts

Hsu, C. K., Lin, H. H., Harn, H. I., Ogawa, R., Wang, Y. K., Ho, Y. T., Chen, W. R., Lee, Y. C., Lee, J. Y. Y., Shieh, S. J., Cheng, C. M., McGrath, J. A. & Tang, M. J., 2018 Jan, In : Journal of Investigative Dermatology. 138, 1, p. 208-218 11 p.

Research output: Contribution to journalArticle

Caveolin 1
Keloid
Fibroblasts
Chemical activation
trichostatin A
4 Citations (Scopus)

Comparative regenerative biology of spiny (Acomys cahirinus) and laboratory (Mus musculus) mouse skin

Jiang, T. X., Hans, I-C., Ou, K. L., Lei, M. & Chuong, C. M., 2019 Apr 1, In : Experimental Dermatology. 28, 4, p. 442-449 8 p.

Research output: Contribution to journalArticle

Murinae
Hair
Skin
Hair Follicle
Wounds and Injuries
3 Citations (Scopus)

Comparison of the electromyographic activation level and unilateral selectivity of erector spinae during different selected movements

Guo, L. Y., Wang, Y. L., Huang, Y. H., Yang, C. H., Hou, Y. Y., Hans, I-C. & You, Y. L., 2012 Dec 1, In : International Journal of Rehabilitation Research. 35, 4, p. 345-351 7 p.

Research output: Contribution to journalArticle

Exercise
Muscle Strength
Scoliosis
Spinal Diseases
Muscles
7 Citations (Scopus)

Defective phosphatidylinositol 3-kinase signaling in central control of cardiovascular effects in the nucleus tractus solitarii of spontaneously hypertensive rats

Hsiao, M., Lu, P. J., Huang, H. N., Lo, W. C., Ho, W. Y., Lai, T. C., Chiang, H. T. & Tseng, C. J., 2008 Jun 1, In : Hypertension Research. 31, 6, p. 1209-1218 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Solitary Nucleus
Inbred SHR Rats
Inbred WKY Rats
Nitric Oxide Synthase
13 Citations (Scopus)
Open Access
Caveolin 1
NFATC Transcription Factors
Calcium
Gene Expression
Transcription Factors
25 Citations (Scopus)

Enhancement of renal epithelial cell functions through microfluidic-based coculture with adipose-derived stem cells

Huang, H. C., Chang, Y. J., Chen, W. C., Harn, H. I. C., Tang, M. J. & Wu, C. C., 2013 Sep 1, In : Tissue Engineering - Part A. 19, 17-18, p. 2024-2034 11 p.

Research output: Contribution to journalArticle

Microfluidics
Coculture Techniques
Stem cells
Stem Cells
Collagen
22 Citations (Scopus)

Essential roles of basic helix-loop-helix transcription factors, Capsulin and Musculin, during craniofacial myogenesis of zebrafish

Lee, G-H., Chang, M. Y., Hsu, C. H. & Chen, Y. H., 2011 Dec 1, In : Cellular and Molecular Life Sciences. 68, 24, p. 4065-4078 14 p.

Research output: Contribution to journalArticle

Basic Helix-Loop-Helix Transcription Factors
Muscle Development
Zebrafish
Mesoderm
Head
12 Citations (Scopus)

Ethanol-induced upregulation of 10-formyltetrahydrofolate dehydrogenase helps relieve ethanol-induced oxidative stress

Hsiao, T. H., Lin, C. J., Chung, Y. S., Lee, G. H., Kao, T. T., Chang, W. N., Chen, B. H., Hung, J. J. & Fu, T. F., 2014 Feb 1, In : Molecular and Cellular Biology. 34, 3, p. 498-509 12 p.

Research output: Contribution to journalArticle

Oxidative Stress
Ethanol
Up-Regulation
Folic Acid
Embryonic Structures
23 Citations (Scopus)

Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish - Implication in neural tube defects and Alzheimer's diseases

Kao, T. T., Chu, C. Y., Lee, G. H., Hsiao, T. H., Cheng, N. W., Chang, N. S., Chen, B. H. & Fu, T. F., 2014 Jan 1, In : Neurobiology of Disease. 71, 1, p. 234-244 11 p.

Research output: Contribution to journalArticle

Neural Tube Defects
Zebrafish
Folic Acid
Alzheimer Disease
Oxidative Stress
19 Citations (Scopus)

Inactivation of zebrafish mrf4 leads to myofibril misalignment and motor axon growth disorganization

Wang, Y. H., Li, C. K., Lee, G-H., Tsay, H. J., Tsai, H. J. & Chen, Y. H., 2008 Apr 1, In : Developmental Dynamics. 237, 4, p. 1043-1050 8 p.

Research output: Contribution to journalArticle

Open Access
Myofibrils
Zebrafish
Axons
Muscles
Growth
37 Citations (Scopus)

In situ Akt phosphorylation in the nucleus tractus solitarii is involved in central control of blood pressure and heart rate

Huang, H. N., Lu, P. J., Lo, W. C., Lin, C. H., Hsiao, M. & Tseng, C. J., 2004 Oct 19, In : Circulation. 110, 16, p. 2476-2483 8 p.

Research output: Contribution to journalArticle

Solitary Nucleus
Heart Rate
Phosphorylation
Insulin
Blood Pressure
7 Citations (Scopus)

Kit exon 11 codons 557-558 deletion mutation promotes liver metastasis through the CXCL12/ CXCR4 Axis in gastrointestinal stromal tumors

Wang, H. C., Li, T. Y., Chao, Y. J., Hou, Y. C., Hsueh, Y. S., Hsu, K. H. & Shan, Y. S., 2016 Jul 15, In : Clinical Cancer Research. 22, 14, p. 3477-3487 11 p.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Sequence Deletion
Codon
Exons
Stromal Cells
5 Citations (Scopus)

Knocking down 10-formyltetrahydrofolate dehydrogenase increased oxidative stress and impeded zebrafish embryogenesis by obstructing morphogenetic movement

Chang, W. N., Lee, G. H., Kao, T. T., Lin, C. Y., Hsiao, T. H., Tsai, J. N., Chen, B. H., Chen, Y. H., Wu, H. R., Tsai, H. J. & Fu, T. F., 2014 Jan 1, In : Biochimica et Biophysica Acta - General Subjects. 1840, 7, p. 2340-2350 11 p.

Research output: Contribution to journalArticle

Oxidative stress
Zebrafish
Embryonic Development
Oxidative Stress
Folic Acid
14 Citations (Scopus)
Keloid
Elasticity
Fibroblasts
Spatial distribution
Actins
50 Citations (Scopus)

Mechanical phenotype of cancer cells: Cell softening and loss of stiffness sensing

Lin, H. H., Lin, H. K., Lin, I. H., Chiou, Y. W., Chen, H. W., Liu, C. Y., Harn, H. I. C., Chiu, W. T., Wang, Y. K., Shen, M. R. & Tang, M. J., 2015 Jan 1, In : Oncotarget. 6, 25, p. 20946-20958 13 p.

Research output: Contribution to journalArticle

Phenotype
Caveolin 1
Neoplasms
Fibroblasts
Elasticity
17 Citations (Scopus)

Mechanosensitive store-operated calcium entry regulates the formation of cell polarity

Huang, Y. W., Chang, S. J., I-Chen Harn, H., Huang, H. T., Lin, H. H., Shen, M. R., Tang, M. J. & Chiu, W. T., 2015 Sep 1, In : Journal of Cellular Physiology. 230, 9, p. 2086-2097 12 p.

Research output: Contribution to journalArticle

Cell Polarity
Caveolin 1
Cells
Calcium
Polarization
9 Citations (Scopus)

Methotrexate-Induced Decrease in Embryonic 5-Methyl-Tetrahydrofolate Is Irreversible with Leucovorin Supplementation

Kao, T. T., Lee, G. H., Fu, C. C., Chen, B. H., Chen, L. T. & Fu, T. F., 2013 Sep 1, In : Zebrafish. 10, 3, p. 326-337 12 p.

Research output: Contribution to journalArticle

methotrexate
Leucovorin
Folic Acid
Methotrexate
folic acid
33 Citations (Scopus)

MiR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation

Huang, H-N., Chen, S. Y., Hwang, S. M., Yu, C. C., Su, M. W., Mai, W., Wang, H. W., Cheng, W. C., Schuyler, S. C., Ma, N., Lu, F. L. & Lu, J., 2014 Mar 1, In : Stem Cell Research. 12, 2, p. 338-353 16 p.

Research output: Contribution to journalArticle

Open Access
Cell Differentiation
Carrier Proteins
Embryoid Bodies
Down-Regulation
Endoderm
11 Citations (Scopus)

MTOR inhibition enhances NVP-AUY922-induced autophagymediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors

Hsueh, Y. S., Chang, H. H., Chiang, N. J., Yen, C. C., Li, C. F. & Chen, L. T., 2014 Jan 1, In : Oncotarget. 5, 22, p. 11711-11724 14 p.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Sirolimus
Autophagy
Stromal Cells
Proteasome Endopeptidase Complex
21 Citations (Scopus)

Neuronal Nitric Oxide Synthase Activation Is Involved in Insulin-Mediated Cardiovascular Effects in the Nucleus Tractus Solitarii of Rats

Chiang, H. T., Cheng, W. H., Lu, P. J., Huang, H. N., Lo, W. C., Tseng, Y. C., Wang, J. L., Hsiao, M. & Tseng, C. J., 2009 Mar 17, In : Neuroscience. 159, 2, p. 727-734 8 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Solitary Nucleus
Insulin
Inbred WKY Rats
Microinjections
33 Citations (Scopus)

Novel and unexpected functions of zebrafish CCAAT box binding transcription factor (NF-Y) B subunit during cartilages development

Chen, Y. H., Lin, Y. T. & Lee, G-H., 2009 May 1, In : Bone. 44, 5, p. 777-784 8 p.

Research output: Contribution to journalArticle

CCAAT-Binding Factor
Zebrafish
Cartilage
Head
Neural Crest
2 Citations (Scopus)

One crisis, diverse impacts - Tissue-specificity of folate deficiency-induced circulation defects in zebrafish larvae

Tu, H. C., Lee, G. H., Hsiao, T. H., Kao, T. T., Wang, T. Y., Tsai, J. N. & Fu, T. F., 2017 Nov, In : PloS one. 12, 11, e0188585.

Research output: Contribution to journalArticle

Organ Specificity
Zebrafish
Danio rerio
Folic Acid
folic acid
3 Citations (Scopus)

Revealing the three dimensional architecture of focal adhesion components to explain Ca2 +-mediated turnover of focal adhesions

Chang, S. J., Chen, Y. C., Yang, C. H., Huang, S. C., Huang, H. K., Li, C. C., Harn, H. I. C. & Chiu, W. T., 2017 Mar 1, In : Biochimica et Biophysica Acta - General Subjects. 1861, 3, p. 624-635 12 p.

Research output: Contribution to journalArticle

Focal Adhesions
Adhesion
Calpain
Molecules
Talin
13 Citations (Scopus)

Selecting Tyrosine Kinase Inhibitors for Gastrointestinal Stromal Tumor with Secondary KIT Activation-Loop Domain Mutations

Hsueh, Y. S., Lin, C. L., Chiang, N. J., Yen, C. C., Li, C. F., Shan, Y. S., Ko, C. H., Shih, N. Y., Wang, L. M., Chen, T. S. & Chen, L. T., 2013 Jun 20, In : PloS one. 8, 6, e65762.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Protein-Tyrosine Kinases
exons
tyrosine
Tumors

Self-assembly of biological networks via adaptive patterning revealed by avian intradermal muscle network formation

Wu, X. S., Yeh, C. Y., Hans, I-C., Jiang, T. X., Wu, P., Widelitz, R. B., Baker, R. E. & Chuong, C. M., 2019 May 28, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10858-10867 10 p.

Research output: Contribution to journalArticle

Muscles
Feathers
Cues
Chickens
Embryonic Structures
2 Citations (Scopus)

Spatial distribution of filament elasticity determines the migratory behaviors of a cell

Harn, H. I. C., Hsu, C. K., Wang, Y. K., Huang, Y. W., Chiu, W. T., Lin, H. H., Cheng, C. M. & Tang, M. J., 2016 Jul 3, In : Cell Adhesion and Migration. 10, 4, p. 368-377 10 p.

Research output: Contribution to journalArticle

Elasticity
Actin Cytoskeleton
Focal Adhesions
Atomic Force Microscopy
Research
20 Citations (Scopus)

The enhancement of biofilm formation in Group B streptococcal isolates at vaginal pH

Ho, Y. R., Li, C. M., Yu, C. H., Lin, Y. J., Wu, C. M., Harn, I. C., Tang, M. J., Chen, Y. T., Shen, F. C., Lu, C. Y., Tsai, T. C. & Wu, J. J., 2013 Apr 1, In : Medical Microbiology and Immunology. 202, 2, p. 105-115 11 p.

Research output: Contribution to journalArticle

Biofilms
Streptococcus agalactiae
Atomic Force Microscopy
Vagina
Pregnant Women

Tks5 and dynamin-2 enhance actin bundle rigidity in invadosomes to promote myoblast fusion

Chuang, M. C., Lin, S. S., Ohniwa, R. L., Lee, G. H., Su, Y. A., Chang, Y. C., Tang, M. J. & Liu, Y. W., 2019 May 1, In : Journal of Cell Biology. 218, 5, p. 1670-1685 16 p.

Research output: Contribution to journalArticle

Open Access
Dynamin II
Myoblasts
Actins
Muscle Development
Actin Cytoskeleton
23 Citations (Scopus)

Treatment of hereditary epidermolysis bullosa: Updates and future prospects

Hsu, C. K., Wang, S. P., Lee, J. Y. Y. & McGrath, J. A., 2014 Feb 1, In : American Journal of Clinical Dermatology. 15, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa
Skin Diseases
Epidermolysis Bullosa Dystrophica
Biomedical Engineering
Pluripotent Stem Cells
1 Citation (Scopus)

Turing patterning with and without a global wave

Inaba, M., Harn, H. I. C. & Cheng-Ming, C., 2019 Mar, In : PLoS biology. 17, 3, e3000195.

Research output: Contribution to journalArticle

Open Access
Feathers
feathers
Ectodysplasins
Fibroblast Growth Factors
Chickens

Using pulsed dye laser to treat sebaceous hyperplasia: comparison of short and long pulse-duration pulsed dye laser

Wang, S-P., Chang, Y. J., Chi, C. C., Wang, S. H. & Tsai, T. H., 2017 Sep 1, In : Dermatologica Sinica. 35, 3, p. 119-123 5 p.

Research output: Contribution to journalArticle

Open Access
Dye Lasers
Hyperplasia
Purpura
Therapeutics
Pain
17 Citations (Scopus)

Using surfaces to modulate the morphology and structure of attached cells-a case of cancer cells on chitosan membranes

Shuai, H. H., Yang, C. Y., Hans, I-C., York, R. L., Liao, T. C., Chen, W. S., Yeh, J. A. & Cheng, C. M., 2013 Aug 1, In : Chemical Science. 4, 8, p. 3058-3067 10 p.

Research output: Contribution to journalArticle

Chitosan
Cells
Membranes
Fibroblasts
Cell culture
6 Citations (Scopus)

Vibrio vulnificus MARTX cytotoxin causes inactivation of phagocytosis-related signaling molecules in macrophages

Chen, C. L., Chien, S. C., Leu, T. H., Harn, H. I. C., Tang, M. J. & Hor, L. I., 2017 Aug 19, In : Journal of biomedical science. 24, 1, 58.

Research output: Contribution to journalArticle

Vibrio vulnificus
Macrophages
Cytotoxins
Phagocytosis
Focal Adhesion Kinase 2
12 Citations (Scopus)

Zebrafish larvae exposed to ginkgotoxin exhibit seizure like behavior that is relieved by pyridoxal-5′-phosphate, GABA and anti-epileptic drugs

Lee, G. H., Sung, S. Y., Chang, W. N., Kao, T. T., Du, H. C., Hsiao, T. H., Safo, M. K. & Fu, T. F., 2012 Nov 1, In : DMM Disease Models and Mechanisms. 5, 6, p. 785-795 11 p.

Research output: Contribution to journalArticle

Pyridoxal Phosphate
Zebrafish
gamma-Aminobutyric Acid
Larva
Seizures