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Personal profile


  • 2006 PhD, Division of Medicinal Chemistry and Pharmacognosy, Collage of Pharmacy, The Ohio State University


  • 2013/08~ present Associate Professor,Biochemistry and Molecular Biology, National Cheng Kung University

Research Interests

  • Pathogen-Host interaction, C. elegans Biology

Fingerprint Dive into the research topics where Chang-Shi Chen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 5 Similar Profiles
Caenorhabditis elegans Medicine & Life Sciences
Histone Deacetylase Inhibitors Medicine & Life Sciences
Aeromonas Medicine & Life Sciences
Histone Deacetylases Medicine & Life Sciences
Enterohemorrhagic Escherichia coli Medicine & Life Sciences
troglitazone Medicine & Life Sciences
Celecoxib Medicine & Life Sciences
Prostatic Neoplasms Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2020

Research Output 2000 2018

  • 1692 Citations
  • 23 h-Index
  • 40 Article
  • 1 Review article
2 Citations (Scopus)

A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli

Kuo, C. J., Wang, S. T., Lin, C. M., Chiu, H. C., Huang, C. R., Lee, D. Y., Chang, G. D., Chou, T. C., Chen, J. W. & Chen, C. S., 2018 Mar 1, In : Cell Death and Disease. 9, 3, 381.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Caenorhabditis elegans
Escherichia coli Infections
1 Citation (Scopus)

Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus

Su, J. C., Huang, Y. T., Chen, C. S., Chiu, H. C. & Shiau, C. W., 2018 Jan 1, In : Molecules. 23, 1, 27.

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Anti-Bacterial Agents
Enterohemorrhagic Escherichia coli
Escherichia coli
Hemolytic-Uremic Syndrome

Evaluating virulence and pathogenesis of Aeromonas Infection in a Caenorhabditis elegans model

Chen, Y. W., Ko, W. C., Chen, C. S. & Chen, P. L., 2018 Dec, In : Journal of Visualized Experiments. 2018, 142, e58768.

Research output: Contribution to journalArticle

Caenorhabditis elegans
1 Citation (Scopus)

Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity

Tu, L. H., Tseng, N. H., Tsai, Y. R., Lin, T. W., Lo, Y. W., Charng, J. L., Hsu, H. T., Chen, Y. S., Chen, R. J., Wu, Y. T., Chan, Y. T., Chen, C. S., Fang, J. M. & Chen, Y. R., 2018 Oct 5, In : European Journal of Medicinal Chemistry. 158, p. 393-404 12 p.

Research output: Contribution to journalArticle

Dissociative Disorders
Alzheimer Disease


Analysis of the role of the host factor CYB-3 in the enterohemorrhagic E coli-induced ACT-5 ectopic expression in C elegans

Author: 昱廷, 陳., 2016 Aug 15

Supervisor: Chen, C. (Supervisor)

Student thesis: Master's Thesis

Analyzing the Caenorhabditis elegans mutants confer hypersusceptibility to enterohemorrhagic E coli colonization

Author: 昉蓉, 楊., 2014 Aug 21

Supervisor: Chen, C. (Supervisor)

Student thesis: Master's Thesis

Characterization of hpo-22 in Cry5B Induced HLH-30 Nuclear Localization and Autophagy Activation in C elegans

Author: 叔樺, 林., 2017 Aug 14

Supervisor: Chen, C. (Supervisor)

Student thesis: Master's Thesis